LOCUS       NM_001311086            1836 bp    mRNA    linear   ROD 01-AUG-2024
DEFINITION  Mus musculus zinc finger, C3HC type 1 (Zc3hc1), transcript variant
            1, mRNA.
ACCESSION   NM_001311086 XM_006505063
VERSION     NM_001311086.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1836)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1836)
  AUTHORS   Kreutmair,S., Erlacher,M., Andrieux,G., Istvanffy,R.,
            Mueller-Rudorf,A., Zwick,M., Ruckert,T., Pantic,M., Poggio,T.,
            Shoumariyeh,K., Mueller,T.A., Kawaguchi,H., Follo,M.,
            Klingeberg,C., Wlodarski,M., Baumann,I., Pfeifer,D., Kulinski,M.,
            Rudelius,M., Lemeer,S., Kuster,B., Dierks,C., Peschel,C.,
            Cabezas-Wallscheid,N., Duque-Afonso,J., Zeiser,R., Cleary,M.L.,
            Schindler,D., Schmitt-Graeff,A., Boerries,M., Niemeyer,C.M.,
            Oostendorp,R.A., Duyster,J. and Illert,A.L.
  TITLE     Loss of the Fanconi anemia-associated protein NIPA causes bone
            marrow failure
  JOURNAL   J Clin Invest 130 (6), 2827-2844 (2020)
   PUBMED   32338640
  REMARK    GeneRIF: Loss of the Fanconi anemia-associated protein NIPA causes
            bone marrow failure.
REFERENCE   3  (bases 1 to 1836)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1836)
  AUTHORS   Geyer,S.H., Reissig,L., Rose,J., Wilson,R., Prin,F., Szumska,D.,
            Ramirez-Solis,R., Tudor,C., White,J., Mohun,T.J. and Weninger,W.J.
  TITLE     A staging system for correct phenotype interpretation of mouse
            embryos harvested on embryonic day 14 (E14.5)
  JOURNAL   J Anat 230 (5), 710-719 (2017)
   PUBMED   28185240
REFERENCE   5  (bases 1 to 1836)
  AUTHORS   Illert,A.L., Zech,M., Moll,C., Albers,C., Kreutmair,S., Peschel,C.,
            Bassermann,F. and Duyster,J.
  TITLE     Extracellular signal-regulated kinase 2 (ERK2) mediates
            phosphorylation and inactivation of nuclear interaction partner of
            anaplastic lymphoma kinase (NIPA) at G2/M
  JOURNAL   J Biol Chem 287 (45), 37997-38005 (2012)
   PUBMED   22955283
  REMARK    GeneRIF: Data show that cell cycle-dependent phosphorylation of
            nuclear interaction partner of anaplastic lymphoma kinase (NIPA)is
            mediated by extracellular signal-regulated kinase 2 (ERK2).
REFERENCE   6  (bases 1 to 1836)
  AUTHORS   Illert,A.L., Kawaguchi,H., Antinozzi,C., Bassermann,F.,
            Quintanilla-Martinez,L., von Klitzing,C., Hiwatari,M., Peschel,C.,
            de Rooij,D.G., Morris,S.W., Barchi,M. and Duyster,J.
  TITLE     Targeted inactivation of nuclear interaction partner of ALK
            disrupts meiotic prophase
  JOURNAL   Development 139 (14), 2523-2534 (2012)
   PUBMED   22696294
  REMARK    GeneRIF: Results reveal a novel role for NIPA in meiosis.
REFERENCE   7  (bases 1 to 1836)
  AUTHORS   Klitzing,Cv., Huss,R., Illert,A.L., Froschl,A., Wotzel,S.,
            Peschel,C., Bassermann,F. and Duyster,J.
  TITLE     APC/C(Cdh1)-mediated degradation of the F-box protein NIPA is
            regulated by its association with Skp1
  JOURNAL   PLoS One 6 (12), e28998 (2011)
   PUBMED   22205987
  REMARK    GeneRIF: phosphorylated NIPA is degraded in late mitosis in an
            APC/C(Cdh1)-dependent manner
REFERENCE   8  (bases 1 to 1836)
  AUTHORS   Ouyang,T., Bai,R.Y., Bassermann,F., von Klitzing,C., Klumpen,S.,
            Miething,C., Morris,S.W., Peschel,C. and Duyster,J.
  TITLE     Identification and characterization of a nuclear interacting
            partner of anaplastic lymphoma kinase (NIPA)
  JOURNAL   J Biol Chem 278 (32), 30028-30036 (2003)
   PUBMED   12748172
  REMARK    GeneRIF: NIPA has an antiapoptotic role in NPM-ALK-mediated
            signaling events
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY235523.1, AK151694.1 and BC050141.1.
            
            On Jul 24, 2015 this sequence version replaced XM_006505063.1.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC050141.1, AK168071.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-17                BY235523.1         1-17
            18-1816             AK151694.1         4-1802
            1817-1836           BC050141.1         1800-1819
FEATURES             Location/Qualifiers
     source          1..1836
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 12.52 cM"
     gene            1..1836
                     /gene="Zc3hc1"
                     /gene_synonym="1110054L24Rik; HSPC216; Nipa"
                     /note="zinc finger, C3HC type 1"
                     /db_xref="GeneID:232679"
                     /db_xref="MGI:MGI:1916023"
     exon            1..164
                     /gene="Zc3hc1"
                     /gene_synonym="1110054L24Rik; HSPC216; Nipa"
                     /inference="alignment:Splign:2.1.0"
     CDS             19..1524
                     /gene="Zc3hc1"
                     /gene_synonym="1110054L24Rik; HSPC216; Nipa"
                     /note="isoform 1 is encoded by transcript variant 1;
                     nuclear interacting partner of anaplastic lymphoma kinase
                     (Alk); nuclear-interacting partner of ALK; zinc finger
                     C3HC-type protein 1"
                     /codon_start=1
                     /product="zinc finger C3HC-type protein 1 isoform 1"
                     /protein_id="NP_001298015.1"
                     /db_xref="CCDS:CCDS80508.1"
                     /db_xref="GeneID:232679"
                     /db_xref="MGI:MGI:1916023"
                     /translation="MAATSEGPLFAASIEKTWGSVVRSPEGTPQKVRELIDEGIVPEE
                     GGTEPKDTAATFQSVDGSPQAEQSPLESTSKEAFFHRVETFSSLKWAGKPPELSPLIC
                     AKYGWVTVECDMLKCSSCQAFLCASLQPTFDFGRYKERCAELKKSLCSAHEKFCFWPD
                     SPSPDRFGMLPLGEPAVLISEFLDRFQSLCHLDLQLPSLRPEDLKTMCLTEDAVSALL
                     HLLEDELDFHADDRKTTSKLGSDVQVQATACVLSLCGWACSSLEPTQLSLITCYQCMR
                     KVGLWGFQQIESSMTDLEASFGLTSSPIPGVEGRPEHFPLVPESPRRMMTRSQDATVS
                     PGSEQSEKSPGPIVSRTRSWESSSPVDRPELEAASPTTRSRPVTRSMGTGDSAGVEVP
                     SSPLRRTKRARLCSSSSSDTSPRSFFDPTSQHRDWCPWVNITLVKETKENGETEVDAC
                     TPAEPGWKAVLTILLAHKRSNQPAETDSMSLSEKSRKVFRIFRQWESSSSS"
     exon            165..276
                     /gene="Zc3hc1"
                     /gene_synonym="1110054L24Rik; HSPC216; Nipa"
                     /inference="alignment:Splign:2.1.0"
     exon            277..427
                     /gene="Zc3hc1"
                     /gene_synonym="1110054L24Rik; HSPC216; Nipa"
                     /inference="alignment:Splign:2.1.0"
     exon            428..511
                     /gene="Zc3hc1"
                     /gene_synonym="1110054L24Rik; HSPC216; Nipa"
                     /inference="alignment:Splign:2.1.0"
     exon            512..639
                     /gene="Zc3hc1"
                     /gene_synonym="1110054L24Rik; HSPC216; Nipa"
                     /inference="alignment:Splign:2.1.0"
     exon            640..794
                     /gene="Zc3hc1"
                     /gene_synonym="1110054L24Rik; HSPC216; Nipa"
                     /inference="alignment:Splign:2.1.0"
     exon            795..1035
                     /gene="Zc3hc1"
                     /gene_synonym="1110054L24Rik; HSPC216; Nipa"
                     /inference="alignment:Splign:2.1.0"
     exon            1036..1248
                     /gene="Zc3hc1"
                     /gene_synonym="1110054L24Rik; HSPC216; Nipa"
                     /inference="alignment:Splign:2.1.0"
     exon            1249..1455
                     /gene="Zc3hc1"
                     /gene_synonym="1110054L24Rik; HSPC216; Nipa"
                     /inference="alignment:Splign:2.1.0"
     exon            1456..1817
                     /gene="Zc3hc1"
                     /gene_synonym="1110054L24Rik; HSPC216; Nipa"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1799..1804
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zc3hc1"
                     /gene_synonym="1110054L24Rik; HSPC216; Nipa"
                     /note="hexamer: AATAAA"
     polyA_site      1817
                     /gene="Zc3hc1"
                     /gene_synonym="1110054L24Rik; HSPC216; Nipa"
                     /note="major polyA site"
ORIGIN      
        1 atttacggcc ggaccaagat ggcggctacc agtgaggggc cgctgtttgc tgcgagtatt
       61 gaaaagactt ggggttcagt cgttcgttcc cctgaaggga caccccagaa agttcgggag
      121 ctgatagatg aaggaattgt cccggaagag ggaggcacag aaccaaagga cacagctgcc
      181 acattccagt cagttgatgg atcgcctcaa gcagaacagt ctccattgga atccacaagc
      241 aaagaagcct tctttcacag agtggaaacc ttttcttctt tgaagtgggc agggaagccc
      301 cctgagctgt ctccacttat ctgcgctaaa tatggttggg tcacagttga atgtgacatg
      361 ctcaagtgct ccagctgcca ggctttcctc tgtgccagcc tgcagcccac gtttgacttt
      421 ggcagatata aggagcgatg tgctgagctc aagaaatcct tgtgcagtgc ccatgagaag
      481 ttctgttttt ggccagacag cccctctcca gatagatttg ggatgttgcc attgggtgag
      541 cctgctgttc tcatcagtga gttcctggac cggtttcaaa gcctttgcca tttggacctc
      601 caacttcctt ctctgaggcc agaggacttg aaaactatgt gcttgacaga agacgcggtc
      661 agtgccctgc tgcacctgct ggaggatgag cttgatttcc acgccgatga caggaaaact
      721 acaagcaagt taggctccga cgtccaagtc caagccactg cgtgtgttct ctctctgtgc
      781 ggctgggcgt gtagttcctt ggaacctact cagctctccc tgataacatg ttaccagtgt
      841 atgaggaagg tcggtctctg gggctttcag cagattgaat catccatgac agatctggag
      901 gcttcctttg gcctgaccag ctccccgatt ccaggtgtgg agggccggcc tgaacacttc
      961 cctctggtgc ctgaatcccc taggcggatg atgacccgaa gccaggatgc tacagtttct
     1021 ccaggctctg agcagtctga aaaaagtcct ggtcctattg tttcccgaac ccggagttgg
     1081 gagtcttcca gtcctgttga ccggcctgag ctagaggcag ccagtcctac taccaggagc
     1141 cgcccagtga cccgaagcat gggaacagga gattctgctg gcgtggaagt tccctcgagc
     1201 cctctccgga gaaccaagcg agctcgcctc tgctcttcca gcagctctga cacctctccc
     1261 cgaagcttct ttgatcccac ctctcagcat agagattggt gcccgtgggt gaatatcaca
     1321 ctcgtcaaag aaaccaagga gaatggggaa acagaagtgg atgcctgtac cccagcagag
     1381 ccaggttgga aggcagtgtt gaccatcctg ttggcccaca agcgttctaa ccagccagct
     1441 gagacagact ccatgagtct ctctgaaaaa tcaaggaaag tgttccgaat attccggcag
     1501 tgggagtctt catcctcatc gtgaagatgc tccggacaga actgagggga ctttgataaa
     1561 caagtctgag ttcctttggt cagctgctgc tgctgttctt cattctggtt tcactgcaca
     1621 tgcgaaggcc tgcatgtgat gatgaagagg agacccgata gctctgtgtg gggtgtggac
     1681 agggtaagac acagcaggcc cagttccgtc aggggactgc agggttagaa cacccattca
     1741 gcggctttgg ttcggcagtg ttctgagcat gtagctcagc aatgtgacag tatttcttaa
     1801 taaagtgttt gctaagaaaa aaaaaaaaaa aaaaaa
//
