LOCUS       NM_020594               1615 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus zinc finger CCCH type containing 8 (Zc3h8), mRNA.
ACCESSION   NM_020594
VERSION     NM_020594.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1615)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1615)
  AUTHORS   Schmidt,J.A., Danielson,K.G., Duffner,E.R., Radecki,S.G.,
            Walker,G.T., Shelton,A., Wang,T. and Knepper,J.E.
  TITLE     Regulation of the oncogenic phenotype by the nuclear body protein
            ZC3H8
  JOURNAL   BMC Cancer 18 (1), 759 (2018)
   PUBMED   30041613
  REMARK    GeneRIF: Using RNA silencing to decrease expression of ZC3H8 in a
            mouse tumor cell line in vitro, then studied phenotype and cell
            behavior of the tumor cell line, and further studied ability of
            those cells to form tumors in mice in vivo.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1615)
  AUTHORS   Wiese,C.B., Ireland,S., Fleming,N.L., Yu,J., Valerius,M.T.,
            Georgas,K., Chiu,H.S., Brennan,J., Armstrong,J., Little,M.H.,
            McMahon,A.P. and Southard-Smith,E.M.
  TITLE     A genome-wide screen to identify transcription factors expressed in
            pelvic Ganglia of the lower urinary tract
  JOURNAL   Front Neurosci 6, 130 (2012)
   PUBMED   22988430
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1615)
  AUTHORS   Guo,G., Huss,M., Tong,G.Q., Wang,C., Li Sun,L., Clarke,N.D. and
            Robson,P.
  TITLE     Resolution of cell fate decisions revealed by single-cell gene
            expression analysis from zygote to blastocyst
  JOURNAL   Dev Cell 18 (4), 675-685 (2010)
   PUBMED   20412781
REFERENCE   5  (bases 1 to 1615)
  AUTHORS   Hwang,E.S. and Ho,I.C.
  TITLE     Regulation of thymocyte homeostasis by Fliz1
  JOURNAL   Immunology 106 (4), 464-469 (2002)
   PUBMED   12153508
REFERENCE   6  (bases 1 to 1615)
  AUTHORS   Hwang,E.S., Choi,A. and Ho,I.C.
  TITLE     Transcriptional regulation of GATA-3 by an intronic regulatory
            region and fetal liver zinc finger protein 1
  JOURNAL   J Immunol 169 (1), 248-253 (2002)
   PUBMED   12077251
  REMARK    GeneRIF: Fliz1 binds specifically to a negative cis-acting element
            in the intronic regulatory region of GATA-3 and, when
            overexpressed, can function as a transcriptional repressor of the
            GATA-3 promoter in vitro and in vivo.
REFERENCE   7  (bases 1 to 1615)
  AUTHORS   Dahm,K., Nielsen,P.J. and Muller,A.M.
  TITLE     Transcripts of Fliz1, a nuclear zinc finger protein, are expressed
            in discrete foci of the murine fetal liver
  JOURNAL   Genomics 73 (2), 194-202 (2001)
   PUBMED   11318609
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ167668.1 and BC048687.1.
            
            On Jan 26, 2006 this sequence version replaced NM_020594.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC048687.1, AF061961.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849375,
                                           SAMN00849380 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-68                CJ167668.1         2-69
            69-1615             BC048687.1         1-1547
FEATURES             Location/Qualifiers
     source          1..1615
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 62.63 cM"
     gene            1..1615
                     /gene="Zc3h8"
                     /gene_synonym="E130108N08Rik; Fliz1; Zc3hdc8"
                     /note="zinc finger CCCH type containing 8"
                     /db_xref="GeneID:57432"
                     /db_xref="MGI:MGI:1930128"
     exon            1..173
                     /gene="Zc3h8"
                     /gene_synonym="E130108N08Rik; Fliz1; Zc3hdc8"
                     /inference="alignment:Splign:2.1.0"
     exon            174..267
                     /gene="Zc3h8"
                     /gene_synonym="E130108N08Rik; Fliz1; Zc3hdc8"
                     /inference="alignment:Splign:2.1.0"
     exon            268..502
                     /gene="Zc3h8"
                     /gene_synonym="E130108N08Rik; Fliz1; Zc3hdc8"
                     /inference="alignment:Splign:2.1.0"
     exon            503..636
                     /gene="Zc3h8"
                     /gene_synonym="E130108N08Rik; Fliz1; Zc3hdc8"
                     /inference="alignment:Splign:2.1.0"
     exon            637..759
                     /gene="Zc3h8"
                     /gene_synonym="E130108N08Rik; Fliz1; Zc3hdc8"
                     /inference="alignment:Splign:2.1.0"
     exon            760..871
                     /gene="Zc3h8"
                     /gene_synonym="E130108N08Rik; Fliz1; Zc3hdc8"
                     /inference="alignment:Splign:2.1.0"
     exon            872..981
                     /gene="Zc3h8"
                     /gene_synonym="E130108N08Rik; Fliz1; Zc3hdc8"
                     /inference="alignment:Splign:2.1.0"
     exon            982..1023
                     /gene="Zc3h8"
                     /gene_synonym="E130108N08Rik; Fliz1; Zc3hdc8"
                     /inference="alignment:Splign:2.1.0"
     exon            1024..1567
                     /gene="Zc3h8"
                     /gene_synonym="E130108N08Rik; Fliz1; Zc3hdc8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1541..1546
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zc3h8"
                     /gene_synonym="E130108N08Rik; Fliz1; Zc3hdc8"
                     /note="hexamer: AATAAA"
     polyA_site      1567
                     /gene="Zc3h8"
                     /gene_synonym="E130108N08Rik; Fliz1; Zc3hdc8"
                     /note="major polyA site"
ORIGIN      
        1 gggcggagcg tgtggccctt ggcgcgactg tagcctccgc ttcgctggtt gttcagtacc
       61 tgctcggcgt ggagaggaac ggtccctgtc tgagttatgg attttgaaaa tctcttttca
      121 aagcccccca atccggccct cggcaaaaaa ccggccgccg accctgagga aagaattgat
      181 gaaatagatg gtactgaagt tgaagaaaca cagacagaga aagtcaaatg gaaagtaaaa
      241 cgggaccgtg aacaaattcc caagaaattt aagcaccttg gaaacgctgc aacatcacca
      301 aagagtttgc tacgtaaaaa atcaagaagt aaggactatg acccatatag tgatggtgag
      361 acatgcagcc aggggtcaga agataacttt gacaaagagc ttcaacagta catacaagcc
      421 aaagaaatgg caaacgcagc tcaaccctca ttacttcctg aagagtctgt gaagaaagca
      481 ggagcagaag gtacccagca gactgctaaa caaaaaaata aaaaatctaa agctggtcac
      541 aagaaagtta aacagaagaa aatgaagcga aagtggcctg gcactggaga caaagggtca
      601 agggccttgc tgaagaacag tggctcccgg gaacagactg atgaacctga agagaagcag
      661 ccacgtgtga ggatgagtca aggctttatc aaccagcaca cggtggaacg caaagggaag
      721 caagtttgca aatatttcct tgaaaggaaa tgtattaagg gagaccagtg taagtttgat
      781 catgatgcag agatagagaa gaaaaaggaa atgtgtaagt attatgtaca aggatattgt
      841 accaaaggag agaactgcct gtatttacat agtgaatacc cttgcaagtt ttatcacaca
      901 ggaaccaaat gttatcaggg cgatcactgt aatttttctc acgccccgct gactgcggaa
      961 acacaagaac tattggctaa agttttggat actgacaaga agtcatgtaa atagactaaa
     1021 aagcatgtag aggacaaagc tattcccgct cgggactttt gaaggctggt ggtttggaat
     1081 agttcataag gttcctcagt taaggcgcct tcctgtgtcg tcgtgatcgt gtgcagctcc
     1141 cgttcgacac gcagagtggt ggatcaagtg ctcaatcgaa ggctggttct gcactgggcc
     1201 aggagaggag cacatgtgtg ctggctagag ctcagtgctg tgctgggcta ggttgcagaa
     1261 gtctcctcca gtcgagagct atgatggagc aagcacaaaa taggccaaga gcagttgagg
     1321 atgggaggac catcaggaag ggtgatgaca gagctgctag ggggttattt attggggtaa
     1381 caaataagtc acacctctac gtgtcagtaa atactttgca caatgttttt aacagtaatt
     1441 cagagttcca ctttatggtt tagcacagaa tgtggttcta tggtctcttg aaaaaaacat
     1501 atttcctgtt ggatatttat ttctaattat tactgttata aataaagtga gatgatattt
     1561 cttgctaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaa
//
