LOCUS       NM_029334               3556 bp    mRNA    linear   ROD 07-JAN-2025
DEFINITION  Mus musculus zinc finger CCCH type containing 14 (Zc3h14),
            transcript variant 1, mRNA.
ACCESSION   NM_029334 XM_484169
VERSION     NM_029334.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3556)
  AUTHORS   Li,Q., Yang,G., Ren,B., Liu,X., Tang,L.Q., Shi,Q., Shan,G. and
            Wang,X.
  TITLE     ZC3H14 facilitates backsplicing by binding to exon-intron boundary
            and 3' UTR
  JOURNAL   Mol Cell 84 (22), 4314-4333 (2024)
   PUBMED   39461343
REFERENCE   2  (bases 1 to 3556)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 3556)
  AUTHORS   Corgiat,E.B., List,S.M., Rounds,J.C., Corbett,A.H. and Moberg,K.H.
  TITLE     The RNA-binding protein Nab2 regulates the proteome of the
            developing Drosophila brain
  JOURNAL   J Biol Chem 297 (1), 100877 (2021)
   PUBMED   34139237
REFERENCE   4  (bases 1 to 3556)
  AUTHORS   Wheeler,J.M., McMillan,P., Strovas,T.J., Liachko,N.F.,
            Amlie-Wolf,A., Kow,R.L., Klein,R.L., Szot,P., Robinson,L.,
            Guthrie,C., Saxton,A., Kanaan,N.M., Raskind,M., Peskind,E.,
            Trojanowski,J.Q., Lee,V.M.Y., Wang,L.S., Keene,C.D., Bird,T.,
            Schellenberg,G.D. and Kraemer,B.
  TITLE     Activity of the poly(A) binding protein MSUT2 determines
            susceptibility to pathological tau in the mammalian brain
  JOURNAL   Sci Transl Med 11 (523) (2019)
   PUBMED   31852801
REFERENCE   5  (bases 1 to 3556)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3556)
  AUTHORS   Rha,J., Jones,S.K., Fidler,J., Banerjee,A., Leung,S.W.,
            Morris,K.J., Wong,J.C., Inglis,G.A.S., Shapiro,L., Deng,Q.,
            Cutler,A.A., Hanif,A.M., Pardue,M.T., Schaffer,A., Seyfried,N.T.,
            Moberg,K.H., Bassell,G.J., Escayg,A., Garcia,P.S. and Corbett,A.H.
  TITLE     The RNA-binding protein, ZC3H14, is required for proper poly(A)
            tail length control, expression of synaptic proteins, and brain
            function in mice
  JOURNAL   Hum Mol Genet 26 (19), 3663-3681 (2017)
   PUBMED   28666327
  REMARK    GeneRIF: Among the proteins increased in the hippocampi of
            Zc3h14Deltaex13/Deltaex13 mice compared to control are key synaptic
            proteins including CaMK2a. This newly generated mouse serves as a
            tool to study the function of ZC3H14 in vivo.
REFERENCE   7  (bases 1 to 3556)
  AUTHORS   Watanabe,K., Takebayashi,H., Bepari,A.K., Esumi,S., Yanagawa,Y. and
            Tamamaki,N.
  TITLE     Dpy19l1, a multi-transmembrane protein, regulates the radial
            migration of glutamatergic neurons in the developing cerebral
            cortex
  JOURNAL   Development 138 (22), 4979-4990 (2011)
   PUBMED   22028030
  REMARK    Erratum:[Development. 2012 Mar;139(6):1225]
REFERENCE   8  (bases 1 to 3556)
  AUTHORS   Pak,C., Garshasbi,M., Kahrizi,K., Gross,C., Apponi,L.H., Noto,J.J.,
            Kelly,S.M., Leung,S.W., Tzschach,A., Behjati,F., Abedini,S.S.,
            Mohseni,M., Jensen,L.R., Hu,H., Huang,B., Stahley,S.N., Liu,G.,
            Williams,K.R., Burdick,S., Feng,Y., Sanyal,S., Bassell,G.J.,
            Ropers,H.H., Najmabadi,H., Corbett,A.H., Moberg,K.H. and Kuss,A.W.
  TITLE     Mutation of the conserved polyadenosine RNA binding protein,
            ZC3H14/dNab2, impairs neural function in Drosophila and humans
  JOURNAL   Proc Natl Acad Sci U S A 108 (30), 12390-12395 (2011)
   PUBMED   21734151
REFERENCE   9  (bases 1 to 3556)
  AUTHORS   Leung,S.W., Apponi,L.H., Cornejo,O.E., Kitchen,C.M.,
            Valentini,S.R., Pavlath,G.K., Dunham,C.M. and Corbett,A.H.
  TITLE     Splice variants of the human ZC3H14 gene generate multiple isoforms
            of a zinc finger polyadenosine RNA binding protein
  JOURNAL   Gene 439 (1-2), 71-78 (2009)
   PUBMED   19303045
REFERENCE   10 (bases 1 to 3556)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK076066.1, AK160937.1, AK048046.1 and AC159193.2.
            
            On May 12, 2009 this sequence version replaced NM_029334.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC034760.1, AK048046.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-24                AK076066.1         2-25
            25-116              AK160937.1         11-102
            117-3494            AK048046.1         83-3460
            3495-3556           AC159193.2         154410-154471       c
FEATURES             Location/Qualifiers
     source          1..3556
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 49.88 cM"
     gene            1..3556
                     /gene="Zc3h14"
                     /gene_synonym="1010001P15Rik; 1700016A15Rik;
                     2700069A02Rik"
                     /note="zinc finger CCCH type containing 14"
                     /db_xref="GeneID:75553"
                     /db_xref="MGI:MGI:1919824"
     exon            1..191
                     /gene="Zc3h14"
                     /gene_synonym="1010001P15Rik; 1700016A15Rik;
                     2700069A02Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             156..2363
                     /gene="Zc3h14"
                     /gene_synonym="1010001P15Rik; 1700016A15Rik;
                     2700069A02Rik"
                     /note="isoform a is encoded by transcript variant 1; zinc
                     finger CCCH domain-containing protein 14"
                     /codon_start=1
                     /product="zinc finger CCCH domain-containing protein 14
                     isoform a"
                     /protein_id="NP_083610.2"
                     /db_xref="CCDS:CCDS26100.1"
                     /db_xref="GeneID:75553"
                     /db_xref="MGI:MGI:1919824"
                     /translation="MEIGTEISRKIRSAIKGKLQELGAYVDEELPDYIMVMVANKKSQ
                     DQMTEDLSLFLGNNTIRFTVWLHGVLDKLRSVTTEPSSLKSPDASIFDSHVPSNKSSF
                     SRGDERRHEAAVPPLAVSSSRPEKRDSRVSTSSQEQKSTNVRHSYDDGASTRLMSTVK
                     PLREPAPSEDVIDIKPEPDDLIDEDLNFVQENPLSQKKPTVTLTYGSSRPSIEIYRPP
                     ASRNADTGTHLNRLQLHPQQSSAHAAKQLDVQSSQVSEAGRLCEPPVLSSVEDTYSPF
                     FRNNLDKMSIEDENFRKRKLPVVSSVVKVKRFSHDGEEEEEDEDYGTRIGSLSSSVSV
                     PAKPERRPSLPPSKQANKNLILKAISEAQESVTKTTNYSAVPQKQTLPVAPRTRTSQE
                     ELLAEMVQGQNRAPRISPPVKEEEAKGDNTGKSQGTQQRQLLSRLQIDPVMVETMEMS
                     QDYYDMESMVHADTRSFILKKPKLSEEIVVTPNQDSGMKTADALRVLSGHLMQTRDLV
                     QPDKPASPKFIVTLDGVPSPPGYMSDQEEEMCFEGMKPVNQTSASNKGLRGLLHPQQL
                     HLLSRQLEDPDGSFSNAEMTDLSVAQKPEKLLERCKYWPACKNGDECVYHHPISPCKA
                     FPNCKFAEKCLFVHPNCKYDTKCTKADCPFTHMSRRASILTPKPVSSPAPSSNGQLCR
                     YFPACKKMECPFYHPKHCRFNTQCTRPDCTFYHPTITVPPRHALKWIRPQSSE"
     exon            192..234
                     /gene="Zc3h14"
                     /gene_synonym="1010001P15Rik; 1700016A15Rik;
                     2700069A02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            235..349
                     /gene="Zc3h14"
                     /gene_synonym="1010001P15Rik; 1700016A15Rik;
                     2700069A02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            350..390
                     /gene="Zc3h14"
                     /gene_synonym="1010001P15Rik; 1700016A15Rik;
                     2700069A02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            391..586
                     /gene="Zc3h14"
                     /gene_synonym="1010001P15Rik; 1700016A15Rik;
                     2700069A02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            587..1016
                     /gene="Zc3h14"
                     /gene_synonym="1010001P15Rik; 1700016A15Rik;
                     2700069A02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1017..1177
                     /gene="Zc3h14"
                     /gene_synonym="1010001P15Rik; 1700016A15Rik;
                     2700069A02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1178..1278
                     /gene="Zc3h14"
                     /gene_synonym="1010001P15Rik; 1700016A15Rik;
                     2700069A02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1279..1434
                     /gene="Zc3h14"
                     /gene_synonym="1010001P15Rik; 1700016A15Rik;
                     2700069A02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1435..1509
                     /gene="Zc3h14"
                     /gene_synonym="1010001P15Rik; 1700016A15Rik;
                     2700069A02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1510..1669
                     /gene="Zc3h14"
                     /gene_synonym="1010001P15Rik; 1700016A15Rik;
                     2700069A02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1670..1902
                     /gene="Zc3h14"
                     /gene_synonym="1010001P15Rik; 1700016A15Rik;
                     2700069A02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1903..2023
                     /gene="Zc3h14"
                     /gene_synonym="1010001P15Rik; 1700016A15Rik;
                     2700069A02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2024..2160
                     /gene="Zc3h14"
                     /gene_synonym="1010001P15Rik; 1700016A15Rik;
                     2700069A02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2161..2249
                     /gene="Zc3h14"
                     /gene_synonym="1010001P15Rik; 1700016A15Rik;
                     2700069A02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2250..2356
                     /gene="Zc3h14"
                     /gene_synonym="1010001P15Rik; 1700016A15Rik;
                     2700069A02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2357..3556
                     /gene="Zc3h14"
                     /gene_synonym="1010001P15Rik; 1700016A15Rik;
                     2700069A02Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2605..2610
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zc3h14"
                     /gene_synonym="1010001P15Rik; 1700016A15Rik;
                     2700069A02Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      2630
                     /gene="Zc3h14"
                     /gene_synonym="1010001P15Rik; 1700016A15Rik;
                     2700069A02Rik"
                     /note="major polyA site"
     regulatory      3515..3520
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zc3h14"
                     /gene_synonym="1010001P15Rik; 1700016A15Rik;
                     2700069A02Rik"
                     /note="hexamer: AATAAA"
     regulatory      3529..3534
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zc3h14"
                     /gene_synonym="1010001P15Rik; 1700016A15Rik;
                     2700069A02Rik"
                     /note="hexamer: TATAAA"
     polyA_site      3535
                     /gene="Zc3h14"
                     /gene_synonym="1010001P15Rik; 1700016A15Rik;
                     2700069A02Rik"
     polyA_site      3556
                     /gene="Zc3h14"
                     /gene_synonym="1010001P15Rik; 1700016A15Rik;
                     2700069A02Rik"
ORIGIN      
        1 ggggacgcgc acggcggagg cggagcggcg gcggcagcgg cggcagcggc agcggcagcg
       61 gcgtaggggg cccaggctgc agggtggcag cccgcggcgg gctccaggta accgaggcgc
      121 cgcgcagtgc cgagccggcc gcccgccgcc gagccatgga aatcggcacc gagatcagcc
      181 gcaagatccg gagtgccatt aaggggaaat tacaagaatt aggagcttac gtagatgaag
      241 aacttcctga ttacattatg gtgatggtgg ccaacaagaa aagtcaggac caaatgacag
      301 aggacctgtc cctgtttcta gggaacaaca caattcgatt caccgtatgg ctccatggtg
      361 tattagataa actgcgctct gtcacgactg agccctctag tctaaagtct cctgacgcca
      421 gcatcttcga tagtcacgtg ccttcaaaca agagcagttt cagtcgggga gatgagagaa
      481 ggcacgaagc tgccgtccct ccccttgctg tttctagttc tagacctgaa aagagggatt
      541 ccagagtttc tacaagttca caggagcaga aatccactaa tgtcagacat tcatatgatg
      601 atggagcttc cacccggcta atgtcaacag tgaaacctct gagggaacca gcaccctctg
      661 aagatgtgat tgatatcaag ccagaaccag atgatctcat tgatgaagac ctcaattttg
      721 tgcaggagaa tcccttatct cagaaaaaac ctacagtgac acttacatac ggttcttctc
      781 gcccttctat tgaaatttat cgaccacctg caagtagaaa tgcagacact ggtactcact
      841 taaacaggct gcaacttcat ccgcagcaaa gcagtgctca cgctgccaag cagctggatg
      901 tacaaagcag ccaggtatcc gaagcaggac ggttgtgtga gccaccagtg cttagcagcg
      961 tagaagacac ttatagcccc ttcttcagaa acaacttgga taaaatgagt attgaggacg
     1021 aaaactttcg aaagagaaaa ttgcctgtgg taagttcggt tgttaaagta aaaagattta
     1081 gccatgatgg agaagaggag gaagaagatg aggattatgg gacccgcata ggaagcttgt
     1141 ccagcagcgt gtcagtacca gcaaagcctg agaggagacc ttctcttcca ccttctaaac
     1201 aagctaacaa gaatctaatt ttgaaggcta tctctgaagc tcaagagtct gtaacaaaga
     1261 caactaacta ttctgcagtt ccacagaaac agacacttcc agttgctccc agaactcgaa
     1321 cttctcaaga agaattgcta gcagaaatgg tccaggggca aaacagggcc cccagaataa
     1381 gtccccctgt taaagaagag gaagcaaaag gagataatac aggaaaaagt caaggaactc
     1441 aacagaggca attgttatcc cgactgcaaa ttgatccagt aatggtagaa acaatggaga
     1501 tgagtcaaga ttactatgac atggaatcca tggtccatgc agacacaaga tcatttattc
     1561 tgaagaagcc aaagctgtct gaggaaatag tagtgacacc caaccaggat tcggggatga
     1621 agactgcaga tgcccttcgg gtcctttcag gacaccttat gcagacacga gatcttgtac
     1681 aaccagataa acctgcaagt cccaagttta tagtgacgct ggatggtgtc cccagccccc
     1741 caggatacat gtcagatcaa gaggaggaga tgtgctttga aggaatgaaa cccgtaaacc
     1801 aaacttcagc ctcaaacaag ggactcagag gtctcctcca cccacagcag ttgcatttgc
     1861 tgagcaggca gcttgaggac ccagatggta gcttttccaa cgccgagatg actgacctga
     1921 gtgtggcaca gaaaccagaa aaacttctgg agcgctgcaa gtactggcct gcctgtaaaa
     1981 atggggatga gtgtgtatac catcatccca tttcaccttg caaagccttt cccaactgta
     2041 aatttgctga gaaatgtttg tttgtgcatc caaattgtaa atatgacaca aagtgtacta
     2101 aagcagattg tcccttcact cacatgagta gaagagcctc gatactgact ccaaaaccag
     2161 tgtcgtcacc agcaccgtct tctaatggcc agctctgccg ttacttccct gcttgtaaga
     2221 aaatggaatg tcccttctac cacccaaaac actgtaggtt taacactcag tgtacgagac
     2281 ctgactgcac attttatcac cccaccatta ctgtgccacc aagacacgcc ttgaaatgga
     2341 ttcgacctca gagcagtgag tgatgcccta gtcctacctg gcagaagatc atgcagtttg
     2401 aaagcttcca tcttctgatg agagatgttc tacagaactt gtcacgtctt tgaaatttag
     2461 aatatattgc tttcataata cgaattttac tgccccactg aagtgtctaa tttttcaagt
     2521 ttgtaagttt attaagtggt ttcaacattt tttgtttgtt cgttttgact atgaaaaaga
     2581 cagtttaaag aaaagccaaa ttctattaaa acatttgcgg catgtttgta cattgctgtt
     2641 taatatcatt tttggtaatg gtacttgcag cttagggctg tagtgctgtg ggaaggccag
     2701 tgtcctcaga gctgaagcac ttttcagctt ttcccaaagg taatgcagtg tctgtaaccc
     2761 agcgtggtaa cagtggccag gctttgaaac tgaggcagct ttggaacaac tagtttaaat
     2821 ttcttttttt agtgtctaaa tgaatttgct ctgagaagca taatgcagac tttattttga
     2881 gtgctacttt ggtagagtgg accgaggtcc tgtgcctttc tgaaagtgag cagagacatg
     2941 gtcataaagg gtaagcatag ttggaatgac gatgtaaaaa tatatggaca gttctttgga
     3001 atgctcccat ttactattag cttatcattt tataagtaat tttggaggga ctacattatc
     3061 acaaaagtat acaaaaattt ttacaggcat atgtacagaa agtatcagaa aacagacttt
     3121 gaactcacaa gaatataaat atacgtatat attcccatat tctgaaaaat atcatcagaa
     3181 ataaccccac agaaaatata cttatgttat tactaaagat cattcttgaa atgtagaagt
     3241 tgagatttaa gtggtatatt ttaaatgaca gaactatatt gcagagatag gaaggtaaac
     3301 ttgacaatag gatgaaactt ggcctactgt actatggagt tttatgtgtg gtttttgaaa
     3361 ctgttaaggc aagatgtgtc atgttttaga actaaataac agacaactga tttcaaaaac
     3421 gtgttgtttt aaaaattaaa gtgtaaacgg tggttagcaa aggggataat aaaagctcaa
     3481 acattttgag gaccaaattt aactgttaag atacaataaa gtcacatcta taaaagtctg
     3541 tgtttaataa tgtgaa
//
