LOCUS       NM_172785               4093 bp    mRNA    linear   ROD 19-AUG-2024
DEFINITION  Mus musculus zinc finger CCCH type containing 12D (Zc3h12d), mRNA.
ACCESSION   NM_172785
VERSION     NM_172785.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4093)
  AUTHORS   Long,J., Li,X., Yao,C., Liu,X., Li,N., Zhou,Y., Li,D., Su,S.,
            Wang,L., Liu,H., Xiang,Y., Yi,L., Tan,Y., Luo,P. and Cai,T.
  TITLE     The role of ZC3H12D-regulated TLR4-NF-kappaB pathway in LPS-induced
            pro-inflammatory microglial activation
  JOURNAL   Neurosci Lett 832, 137800 (2024)
   PUBMED   38697601
  REMARK    GeneRIF: The role of ZC3H12D-regulated TLR4-NF-kappaB pathway in
            LPS-induced pro-inflammatory microglial activation.
REFERENCE   2  (bases 1 to 4093)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 4093)
  AUTHORS   Minagawa,K., Wakahashi,K., Fukui,C., Kawano,Y., Kawano,H.,
            Suzuki,T., Ishii,S., Sada,A., Nishikawa,S., Asada,N., Katayama,Y.
            and Matsui,T.
  TITLE     Tfl deletion induces extraordinary Cxcl13 secretion and cachexia in
            VavP-Bcl2 transgenic mice
  JOURNAL   Front Immunol 14, 1197112 (2023)
   PUBMED   37304286
  REMARK    GeneRIF: Tfl deletion induces extraordinary Cxcl13 secretion and
            cachexia in VavP-Bcl2 transgenic mice.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4093)
  AUTHORS   Tomita,T., Kato,M., Mishima,T., Matsunaga,Y., Sanjo,H., Ito,K.I.,
            Minagawa,K., Matsui,T., Oikawa,H., Takahashi,S., Takao,T., Iwai,N.,
            Mino,T., Takeuchi,O., Maru,Y. and Hiratsuka,S.
  TITLE     Extracellular mRNA transported to the nucleus exerts
            translation-independent function
  JOURNAL   Nat Commun 12 (1), 3655 (2021)
   PUBMED   34135341
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4093)
  AUTHORS   Zhang,H., Wang,W.C., Chen,J.K., Zhou,L., Wang,M., Wang,Z.D.,
            Yang,B., Xia,Y.M., Lei,S., Fu,E.Q. and Jiang,T.
  TITLE     ZC3H12D attenuated inflammation responses by reducing mRNA
            stability of proinflammatory genes
  JOURNAL   Mol Immunol 67 (2 Pt B), 206-212 (2015)
   PUBMED   26059755
  REMARK    GeneRIF: The data indicated that ZC3H12D could suppress both the
            initial inflammation storm and chronic inflammation by targeting
            the mRNA of cytokines as well as NF-kappaB and c-fos.
REFERENCE   6  (bases 1 to 4093)
  AUTHORS   Huang,S., Liu,S., Fu,J.J., Tony Wang,T., Yao,X., Kumar,A., Liu,G.
            and Fu,M.
  TITLE     Monocyte Chemotactic Protein-induced Protein 1 and 4 Form a Complex
            but Act Independently in Regulation of Interleukin-6 mRNA
            Degradation
  JOURNAL   J Biol Chem 290 (34), 20782-20792 (2015)
   PUBMED   26134560
REFERENCE   7  (bases 1 to 4093)
  AUTHORS   Minagawa,K., Wakahashi,K., Kawano,H., Nishikawa,S., Fukui,C.,
            Kawano,Y., Asada,N., Sato,M., Sada,A., Katayama,Y. and Matsui,T.
  TITLE     Posttranscriptional modulation of cytokine production in T cells
            for the regulation of excessive inflammation by TFL
  JOURNAL   J Immunol 192 (4), 1512-1524 (2014)
   PUBMED   24415781
  REMARK    GeneRIF: TFL (Zc3h12d) may play an important role in attenuating
            local inflammation by suppressing the infiltration of Th17 cells in
            the central nervous system during the resolution phase of
            experimental autoimmune encephalitis.
REFERENCE   8  (bases 1 to 4093)
  AUTHORS   Huang,S., Qi,D., Liang,J., Miao,R., Minagawa,K., Quinn,T.,
            Matsui,T., Fan,D., Liu,J. and Fu,M.
  TITLE     The putative tumor suppressor Zc3h12d modulates toll-like receptor
            signaling in macrophages
  JOURNAL   Cell Signal 24 (2), 569-576 (2012)
   PUBMED   22036805
  REMARK    GeneRIF: Zc3h12d is a novel negative feedback regulator of TLR
            signaling and macrophage activation and thus may play a role in
            host immunity and inflammatory diseases.
REFERENCE   9  (bases 1 to 4093)
  AUTHORS   Liang,J., Song,W., Tromp,G., Kolattukudy,P.E. and Fu,M.
  TITLE     Genome-wide survey and expression profiling of CCCH-zinc finger
            family reveals a functional module in macrophage activation
  JOURNAL   PLoS One 3 (8), e2880 (2008)
   PUBMED   18682727
  REMARK    Publication Status: Online-Only
REFERENCE   10 (bases 1 to 4093)
  AUTHORS   Liang,J., Wang,J., Azfer,A., Song,W., Tromp,G., Kolattukudy,P.E.
            and Fu,M.
  TITLE     A novel CCCH-zinc finger protein family regulates proinflammatory
            activation of macrophages
  JOURNAL   J Biol Chem 283 (10), 6337-6346 (2008)
   PUBMED   18178554
  REMARK    GeneRIF: MCPIP1, 2, 3, and 4, encoded by four genes, Zc3h12a,
            Zc3h12b, Zc3h12c, and Zc3h12d, respectively, regulates macrophage
            activation.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB661745.1, AK052806.1 and AC092856.26.
            
            On Apr 7, 2009 this sequence version replaced NM_172785.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK052806.1, ERR3765653.380559.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-590               BB661745.1         2-591
            591-2570            AK052806.1         593-2572
            2571-4093           AC092856.26        85259-86781
FEATURES             Location/Qualifiers
     source          1..4093
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 2.44 cM"
     gene            1..4093
                     /gene="Zc3h12d"
                     /gene_synonym="D730019B10Rik; TFL"
                     /note="zinc finger CCCH type containing 12D"
                     /db_xref="GeneID:237256"
                     /db_xref="MGI:MGI:3045313"
     exon            1..93
                     /gene="Zc3h12d"
                     /gene_synonym="D730019B10Rik; TFL"
                     /inference="alignment:Splign:2.1.0"
     exon            94..477
                     /gene="Zc3h12d"
                     /gene_synonym="D730019B10Rik; TFL"
                     /inference="alignment:Splign:2.1.0"
     CDS             164..1765
                     /gene="Zc3h12d"
                     /gene_synonym="D730019B10Rik; TFL"
                     /note="transformed follicular lymphoma homolog"
                     /codon_start=1
                     /product="probable ribonuclease ZC3H12D"
                     /protein_id="NP_766373.2"
                     /db_xref="CCDS:CCDS48496.1"
                     /db_xref="GeneID:237256"
                     /db_xref="MGI:MGI:3045313"
                     /translation="MEHRSKMEFFQKLGYSQEDVVRVLGKLGDSALVNDVLQELIQTG
                     SRPRAQEDPASGTGVVLIPRGCCGVQDSAQQGLGPGLEEAGGDPARFLRPIVIDGSNV
                     AMSHGNKEAFSCRGIRLAVDWFRDRGHTYIKVFVPSWRKEPSRSDTPIREQHVLEELE
                     RQAVLVYTPSRKVNGKRVVCYDDRYIVKVAYEKDGIIVSNDNYRDLQNENPEWKWFIE
                     QRLLMFSFVNDRFMPPDDPLGRRGPTLSNFLSKKPRPPEPSWQHCPYGKKCTYGVKCR
                     FYHPERPHHGQLSVADELRAKTRAWLGGGAEEPRTPSARSRPTTARLLPQEPGEHDLP
                     PAPQPAVLAALNRSFARLTFSDTAASGVVSQSRGPDWMPTGVPTSWAPPSLRAGSAAT
                     IGLPGMRSLRTPNNPLSPGDLGSPICPQARLSERHRSRDMHSDLPPQRRPLEDPWALL
                     PSSYCYLNHSVWSESAWGEDIFRGPSESAQPVANGGGTRPVHCSFFPPDQDHPVMASG
                     PPLSDMALLTLLQRSQKTGAPLGDP"
     exon            478..617
                     /gene="Zc3h12d"
                     /gene_synonym="D730019B10Rik; TFL"
                     /inference="alignment:Splign:2.1.0"
     exon            618..852
                     /gene="Zc3h12d"
                     /gene_synonym="D730019B10Rik; TFL"
                     /inference="alignment:Splign:2.1.0"
     exon            853..959
                     /gene="Zc3h12d"
                     /gene_synonym="D730019B10Rik; TFL"
                     /inference="alignment:Splign:2.1.0"
     exon            960..4093
                     /gene="Zc3h12d"
                     /gene_synonym="D730019B10Rik; TFL"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4068..4073
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zc3h12d"
                     /gene_synonym="D730019B10Rik; TFL"
                     /note="hexamer: AATAAA"
     polyA_site      4093
                     /gene="Zc3h12d"
                     /gene_synonym="D730019B10Rik; TFL"
                     /note="major polyA site"
ORIGIN      
        1 agagcactcc ctagctgaaa agagaggggc actgggaagg ctcaggcagc tgggccaagt
       61 ctgctgtgag agcccgaggg acacaccctg ctgctcatgc ctgtgctgtt ctgccaggag
      121 gaagcttggg gcaggagccg ggccaagcaa cagctggcac aatatggagc atcggagcaa
      181 gatggaattt ttccagaaac tgggctacag ccaggaggac gtggtcaggg tgctgggcaa
      241 actgggtgac agtgccttgg tcaatgacgt gcttcaagag ttgatccaga ccggcagtcg
      301 cccaagggcc caggaggatc cagccagtgg caccggggta gtgctgattc cccggggatg
      361 ctgcggggtc caagactctg cccagcaggg cctgggacca ggcctagaag aggctggcgg
      421 agatccagcc cgcttcctgc ggcccatagt gatcgatggc agcaatgtgg ctatgagcca
      481 tggaaataaa gaagccttct cttgccgggg aattcgtctg gctgtggact ggtttagaga
      541 cagaggacac acctacatca aggtttttgt cccatcttgg aggaaagagc catcaaggtc
      601 tgatactcct atcagagagc aacacgtgct ggaggaactg gagcggcaag ctgtgttggt
      661 gtatacccca tcccgcaagg tgaacggcaa gcgagtggtc tgctacgatg accgctacat
      721 cgtgaaggtg gcctatgaga aggatggcat cattgtctcc aatgacaact accgagacct
      781 gcagaacgaa aacccagagt ggaaatggtt catcgagcag cggctgctca tgttctcctt
      841 tgtaaatgac aggttcatgc ctcctgatga ccccctgggc cgccgtggac caacactaag
      901 caacttccta agcaagaagc caaggccccc agagccatcc tggcaacact gtccctatgg
      961 caagaaatgc acctacgggg tcaagtgcag attctaccac cccgagagac cacaccatgg
     1021 gcagctgtct gtggccgacg aactccgtgc caagacgcgg gcctggctgg gtggtggcgc
     1081 cgaggagccg cggacaccga gcgcccggag ccgtcctaca acagcccggc tgcttcccca
     1141 ggagcccggc gagcacgacc tcccgccagc cccgcagccc gcggtcctgg cagctttgaa
     1201 taggagcttc gctcggctca ccttcagcga caccgcggcc agcggcgtcg tgtctcagtc
     1261 tcgtgggccg gactggatgc ccacgggtgt ccccacgtcc tgggccccac catcccttcg
     1321 cgcgggcagc gctgccacca tagggttgcc aggtatgcgg agcctccgga ctccgaacaa
     1381 cccgctttct ccgggcgatc tcgggtctcc aatctgccca caggcccggc tgtcggagag
     1441 acaccgttcc agggacatgc acagtgacct gcctccccag cgcagaccgc tggaagatcc
     1501 gtgggctctc ctgcccagct cctattgtta tctgaaccac tcggtctggt ccgagtcggc
     1561 ttggggtgag gacatcttta gaggaccttc ggagtcagca caacctgtcg ccaatggtgg
     1621 gggaacacgc cctgtgcact gcagcttctt cccacctgac caagaccacc ctgtgatggc
     1681 ctcgggtcct ccgctctccg acatggctct gctcaccctc ctgcagagat cccaaaagac
     1741 cggtgctccg ttgggggatc cttaggagac aggttcataa cattgtaagg ggtggtggcc
     1801 caggcttgac tggcagcttg gacgggtggg atacaagacg cttgttagtc tggatgtgtc
     1861 attaggttgg acgccgtttt cttcaaaggt agtcggtgga gacttctttc tcatcctcag
     1921 tggtggatac ccgtggggac cttggggatg ctccctgaag ccaggacctg ctgcatggac
     1981 agggtgattt ctgctgtgtt tggaaggctt tgtcgggaat acatctgtat ctggttctaa
     2041 gcatctacaa atgtttcagc tggtcatcac cgctaatcaa ggagatcaag ctgagtttga
     2101 tataaactct tgttgtgtaa gtgtgtgtgt gtgtatgtgt gtgtgtgtgt gtgtgtgtgt
     2161 gtgtgtttag aattctagaa agccatgaga acttaacatg tcattgtagt tgaaagattg
     2221 aaaaaggctg gtaaatcagt cttgactttt gtggtgccca atgatgttta acatacatgt
     2281 tcaggtgaca cgagaaggaa ggcattgctg cctgagttta caagtcacta ttgataattt
     2341 cactcataag ggaacccagc cttgttgtgt aaattttact gtggggctgt cccagggaca
     2401 cctgatccca agggtcttct cactggggct ttattctttt tgtacatgca taccatatta
     2461 cccacacatc acaacacaca catacacaca cacacacaca tgcatgcaca tgtacacatg
     2521 cacacggcct tgcttaagac tcagcctggc tctttttttt tttttttttt aatcagcctt
     2581 tctttgtggt gattttataa actcttctaa attgcacctt acagagataa gattccagtc
     2641 tacccaccac cccctcaaaa aacaaaaaca aacaaaaaca aaaacaaccc aaaaacccca
     2701 gcaacaacaa aaatcagttt ttgggtgggt cagcatagat ttggattccg gcggagtttt
     2761 ttgcaacttc acttagttgt gtcttctaga taactttggc tctgggtttt gggggaaaag
     2821 aagctcattc atttacaagg gacaagaaat gatacggtgt tttcggggca tgggcccagc
     2881 atcctgaggg acccctagca tctgtaggca gcacccatat gttccaatta caatggtagc
     2941 ctgccagatt gtaactcatt tgttcatgag ggagttggta gttcacttgg tcagagagag
     3001 tcagaaggga cctgccagtg ggaactcttt gccaaagcct ccgagcccct gcagtgtgat
     3061 aggtacattt gggaaacacc cctttattac tagtcacatt tgttggcata gcaaaggtat
     3121 gcctcaggaa aaactcggct gcggtattca tggtaaactc aactccttgg taccagggca
     3181 gccatatggc ttcctggaag tcctccctct tttaaaaaca cagtcttagc atggctcatt
     3241 agagatcgtt cctcacctcc ttttcaaagc atgtgctgtt ctcagagtgt tgcttctacc
     3301 tttagtcccc ggtcctgaag acggtccact ctttctagat cctttgaatt ttttccctcg
     3361 agtgcgtgtg tgtgcctgtg catgtgtgtg tgcatgtatg tgtgggtgca tgtgtgtttg
     3421 tgtgtgtttc ctttccacaa gactgttaga gtaggtgtag ccttctgact tagatggcta
     3481 tgttgttatg tcagctaccg cttgcttctg ctcttctccg agactgctac ctgctgagag
     3541 acccttgaga cattccagag acatatccta tcctacaggc tgactccagg caccaagaat
     3601 ggatcagcgg gggatgggcc tccccactcc cccttttaag cacattctct tagtaaactt
     3661 gccggccttg attagagaaa acttgtcttg gcctcattat ttctcttgca gtctagtctc
     3721 tttcagcccc agcctgcctt ccagaaatac tcggttcatt taggccacgg ttccatgctt
     3781 cgaatcaatg cattgcaaat tgatagttgg gaacgtttaa actgctcctc tgaaggcaag
     3841 tttgagtttt agtaagctgt aaagctattt tatttggttc actgtgatta agcaaagtac
     3901 aagagggggg aaaggaggtg tgtgcggggg ggggggacaa caacacatct cggatgtaat
     3961 cacctttgga aaattccaaa gtcttagtat gtccttgtga cacaaaaccg tggatgagag
     4021 acatagatgg gctatctcta gttgcataac tgttaccatg ctccaaaaat aaaccacctt
     4081 ttccacacct gga
//
