LOCUS       NM_001410679            3815 bp    mRNA    linear   ROD 07-MAY-2024
DEFINITION  Mus musculus zinc finger and BTB domain containing 7B (Zbtb7b),
            transcript variant 6, mRNA.
ACCESSION   NM_001410679 XM_006501314
VERSION     NM_001410679.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3815)
  AUTHORS   Schwartz,B., Levi,H., Menon,G., Maria,R., Upcher,A., Kotlovski,Y.,
            Oss-Ronen,L. and Cohen,I.
  TITLE     ZNF750 Regulates Skin Barrier Function by Driving Cornified
            Envelope and Lipid Processing Pathways
  JOURNAL   J Invest Dermatol 144 (2), 296-306 (2024)
   PUBMED   37660780
REFERENCE   2  (bases 1 to 3815)
  AUTHORS   Zhu,Y., Wang,Q., Xie,X., Ma,C., Qiao,Y., Zhang,Y., Wu,Y., Gao,Y.,
            Jiang,J., Liu,X., Chen,J., Li,C. and Ge,G.
  TITLE     ZBTB7B is a permissive regulator of hepatocellular carcinoma
            initiation by repressing c-Jun expression and function
  JOURNAL   Cell Death Dis 15 (1), 55 (2024)
   PUBMED   38225233
  REMARK    GeneRIF: ZBTB7B is a permissive regulator of hepatocellular
            carcinoma initiation by repressing c-Jun expression and function.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3815)
  AUTHORS   Malin,J., Martinez-Ruiz,G.U., Zhao,Y., Shissler,S.C., Cowan,J.E.,
            Ding,Y., Morales-Sanchez,A., Ishikawa,M., Lavaert,M., Das,A.,
            Butcher,D., Warner,A.C., Kallarakal,M., Chen,J., Kedei,N.,
            Kelly,M., Brinster,L.R., Allman,D. and Bhandoola,A.
  TITLE     Expression of the transcription factor Klf6 by thymic epithelial
            cells is required for thymus development
  JOURNAL   Sci Adv 9 (46), eadg8126 (2023)
   PUBMED   37967174
REFERENCE   4  (bases 1 to 3815)
  AUTHORS   Taniuchi,I.
  TITLE     Views on helper/cytotoxic lineage choice from a bottom-up approach
  JOURNAL   Immunol Rev 271 (1), 98-113 (2016)
   PUBMED   27088909
  REMARK    Review article
REFERENCE   5  (bases 1 to 3815)
  AUTHORS   Tanaka,H. and Taniuchi,I.
  TITLE     The CD4/CD8 lineages: central decisions and peripheral
            modifications for T lymphocytes
  JOURNAL   Curr Top Microbiol Immunol 373, 113-129 (2014)
   PUBMED   23612990
  REMARK    Review article
REFERENCE   6  (bases 1 to 3815)
  AUTHORS   Cheroutre,H. and Husain,M.M.
  TITLE     CD4 CTL: living up to the challenge
  JOURNAL   Semin Immunol 25 (4), 273-281 (2013)
   PUBMED   24246226
  REMARK    Review article
REFERENCE   7  (bases 1 to 3815)
  AUTHORS   Dave,V.P., Allman,D., Keefe,R., Hardy,R.R. and Kappes,D.J.
  TITLE     HD mice: a novel mouse mutant with a specific defect in the
            generation of CD4(+) T cells
  JOURNAL   Proc Natl Acad Sci U S A 95 (14), 8187-8192 (1998)
   PUBMED   9653162
REFERENCE   8  (bases 1 to 3815)
  AUTHORS   Widom,R.L., Culic,I., Lee,J.Y. and Korn,J.H.
  TITLE     Cloning and characterization of hcKrox, a transcriptional regulator
            of extracellular matrix gene expression
  JOURNAL   Gene 198 (1-2), 407-420 (1997)
   PUBMED   9370309
REFERENCE   9  (bases 1 to 3815)
  AUTHORS   Galera,P., Park,R.W., Ducy,P., Mattei,M.G. and Karsenty,G.
  TITLE     c-Krox binds to several sites in the promoter of both mouse type I
            collagen genes. Structure/function study and developmental
            expression analysis
  JOURNAL   J Biol Chem 271 (35), 21331-21339 (1996)
   PUBMED   8702912
REFERENCE   10 (bases 1 to 3815)
  AUTHORS   Galera,P., Musso,M., Ducy,P. and Karsenty,G.
  TITLE     c-Krox, a transcriptional regulator of type I collagen gene
            expression, is preferentially expressed in skin
  JOURNAL   Proc Natl Acad Sci U S A 91 (20), 9372-9376 (1994)
   PUBMED   7937772
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC171273.1.
            
            On Aug 13, 2022 this sequence version replaced XM_006501314.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17784649.402400.1,
                                           SRR17784644.1042868.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-193               AC171273.1         148504-148696
            194-294             AC171273.1         149038-149138
            295-1466            AC171273.1         160658-161829
            1467-3815           AC171273.1         162179-164527
FEATURES             Location/Qualifiers
     source          1..3815
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 39.09 cM"
     gene            1..3815
                     /gene="Zbtb7b"
                     /gene_synonym="c-Krox; Thpok; Zfp67"
                     /note="zinc finger and BTB domain containing 7B"
                     /db_xref="GeneID:22724"
                     /db_xref="MGI:MGI:102755"
     exon            1..193
                     /gene="Zbtb7b"
                     /gene_synonym="c-Krox; Thpok; Zfp67"
                     /inference="alignment:Splign:2.1.0"
     exon            194..294
                     /gene="Zbtb7b"
                     /gene_synonym="c-Krox; Thpok; Zfp67"
                     /inference="alignment:Splign:2.1.0"
     exon            295..1466
                     /gene="Zbtb7b"
                     /gene_synonym="c-Krox; Thpok; Zfp67"
                     /inference="alignment:Splign:2.1.0"
     CDS             301..1935
                     /gene="Zbtb7b"
                     /gene_synonym="c-Krox; Thpok; Zfp67"
                     /note="zinc finger protein 67; zinc finger protein Th-POK;
                     T-helper-inducing POZ/Krueppel-like factor;
                     krueppel-related zinc finger protein cKrox; Vzinc finger
                     and BTB domain containing 7B"
                     /codon_start=1
                     /product="zinc finger and BTB domain-containing protein
                     7B"
                     /protein_id="NP_001397608.1"
                     /db_xref="GeneID:22724"
                     /db_xref="MGI:MGI:102755"
                     /translation="MGSPEDDLIGIPFPDHSSELLSCLNEQRQLGHLCDLTIRTQGLE
                     YRTHRAVLAACSHYFKKLFTEGGGGTVMGTGGGGTASGGAGAGVCELDFVGPEALGAL
                     LEFAYTATLTTSSANMPAVLQAARLLEIPCVIAACMEILQGSGLEAPSPDEDDCERAR
                     QYLEAFATATTTASTSGMPNGEDSPPQVPLLPPPPPPPRPVARRSRKPRKAFLQTKGA
                     RANHLVPEAPTVLTHPLTYEEEEMVGRLGNSGGSGLGDSYSPPTGAASPAEGPLNYEV
                     FEGEEEEEEMAYPPGYGLAQSNEPSLSPEELGSDEDPIDPDLMAYLSSLHQDALTPGL
                     DGQDKLVRKRRSQMPQECPVCHKIIHGAGKLPRHMRTHTGEKPFACEVCGVRFTRNDK
                     LKIHMRKHTGERPYSCPHCPARFLHSYDLKNHMHLHTGDRPYECHLCHKAFAKEDHLQ
                     RHLKGQNCLEVRTRRRRKDDVAAPHYPPPSTTTSSPAGLDLSNGHLDTFHLSLARFWE
                     QSATTGPPVTTQGPPEEEEEEGTPTTPQAEGAMESS"
     exon            1467..3815
                     /gene="Zbtb7b"
                     /gene_synonym="c-Krox; Thpok; Zfp67"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2314
                     /gene="Zbtb7b"
                     /gene_synonym="c-Krox; Thpok; Zfp67"
     regulatory      3800..3805
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zbtb7b"
                     /gene_synonym="c-Krox; Thpok; Zfp67"
                     /note="hexamer: AATAAT"
     polyA_site      3815
                     /gene="Zbtb7b"
                     /gene_synonym="c-Krox; Thpok; Zfp67"
                     /note="major polyA site"
ORIGIN      
        1 aaggtggacc ggaggagata gtggtagaaa gcagagaggg agagggatcg cggcaggtga
       61 agggagtttg aaggaaagaa gggaaaggaa aagggtggga aaggctcagg gagcgaagca
      121 aaatctcgga gaaaagggac gaaaaggagg gagggaccca tatgctccct gctggaacta
      181 gctgttggaa gaggaccgga gcagagcccc aagcccccca gcctggcggg ggacgcgctt
      241 cttcctacac cctgtgcctc tgcagctcca gcgaacggac ccaacggctg aaaggagaag
      301 atggggagcc ccgaggatga cctgattgga atcccattcc cagaccacag cagcgagctc
      361 ctgagctgcc tgaacgagca gcgccagctg ggccatctgt gcgacctcac catcaggacg
      421 cagggtcttg agtaccgcac ccacagggct gtgctggctg cctgtagcca ctacttcaag
      481 aagctcttta cggagggagg agggggaacc gtgatgggaa cagggggtgg tgggacggct
      541 tctgggggag caggggccgg tgtgtgtgag ctggactttg tagggccaga ggccctaggt
      601 gccctgctcg agtttgctta cacagccaca ctgaccacca gcagcgccaa tatgccggct
      661 gtactccaag ctgctcggct actggaaatc ccgtgtgtca tcgctgcttg catggagatt
      721 ctacaaggca gtgggctgga agcccccagc cccgatgagg atgactgtga gcgagcccga
      781 cagtacctgg aggcttttgc cactgccacc accacagcct caacctcagg aatgcccaac
      841 ggtgaagaca gccctccaca ggtgcccctc ctaccgccgc cgccaccgcc acctcgacct
      901 gttgcccgtc gcagccgcaa accccggaaa gcttttcttc aaaccaaagg ggcccgagca
      961 aaccatctgg tccctgaggc acccacagta ctcacccatc ccttgaccta cgaagaagaa
     1021 gagatggttg gtagattggg taacagtggg ggcagtgggc tcggagatag ctatagtcct
     1081 cctacaggtg ccgcctcacc tgccgagggg cccctgaact atgaagtctt tgaaggtgag
     1141 gaagaagagg aggagatggc atacccccca ggctacgggc tagcccagag taatgagccc
     1201 tcgctatcac cagaggagct gggctcagat gaagatccca tcgaccccga cctgatggct
     1261 tacctaagtt cgctgcacca ggacgccctg acaccaggcc tggatggcca agacaagctg
     1321 gtgcgtaaac gccgttcaca gatgccccaa gagtgcccag tctgtcacaa gataatccac
     1381 ggggcaggca aactgcctcg gcacatgagg acccacactg gtgagaagcc ctttgcctgt
     1441 gaggtctgcg gcgtccgctt caccaggaat gacaagctga agatccacat gcggaagcac
     1501 acaggagaac gcccctactc gtgcccccac tgcccagccc gcttcctgca tagctacgac
     1561 ctcaagaacc acatgcacct gcacaccggg gaccggccct atgagtgcca cctgtgccac
     1621 aaggccttcg ccaaggagga ccacctgcag cgccatctca agggtcagaa ctgcctggag
     1681 gtgcgcaccc gaaggcgccg caaggatgac gtggcagccc ctcactaccc accgccctcg
     1741 accaccacct catcccctgc tggcctcgac ctttccaatg gccacctgga caccttccac
     1801 ctctctctgg ctcgattctg ggagcagtcg gccaccacgg gacccccagt cactacacaa
     1861 gggccccctg aggaggagga agaggaaggg acacccacca caccacaggc cgaaggtgcc
     1921 atggagtcct cttaaaagag ggatgaatgg gcaggctgga acagcctggg acaccacgcc
     1981 aagcaacggg gagcacataa aacaagtggt atcggggtcg ggggtgctga accttgttgg
     2041 tatcagaatc gaacgcctct tccccccaga gccttcattc caattacaag ctgaggtttt
     2101 ggggcacaag ctctctagat tggggtgatc acccaaggag ttaaacatga aatatatgtc
     2161 tgtttgtctg tctgtgtgtg tatatatata tgtgtgtgtg tgtgcacgcg cgtgtgtgtg
     2221 ttacacacac tctctgcaca cacacacata tatatacaca cacaataaag gtgggtccct
     2281 gtccccagcc actactgggg aattgaagca ataatctatc tctgatttgt ggggtcccac
     2341 ttcggctatg cgggtttcta ggaggctggg gcttaggacc aaatccttgc tctactccca
     2401 tgccccctgg gttttggctg tgaaggggtg gactgcccct cccttccgag acccctcctt
     2461 cctggtttct gttccttttt cctggccgta aattatgcaa aggggggtgg caaaggaagg
     2521 gtaagagggg ggaaacaagg tagaggcttg aaagactggg gtggcggcgg tggggactgg
     2581 gcctgtaagg acggagccat cccagtcccc ctccacccag ttccaacgct gagtcatggg
     2641 gtcctggaga agaggagggc agggtggcct gattggctcg cccgcccctg ggggtagcag
     2701 aaggtctccg cccagctaag ggagctctcc acctcttccc tcccgcgtcc cggggcaggg
     2761 aatgtcttgt tcctggcgct ccctccctgg ggccagaggg cagggcgggc cgggcgtctt
     2821 accctcttct cctccctacc tccccgccca ggtgcaagcg ggagccgcct ctgctgcttg
     2881 ctgcccctga ctcacgccgc ccccgggctg gcgggcgctg ggtgtgggat ggggtgaggg
     2941 gttgaggtag ccttgtaggg agcggacaag ctagcgccat ctggtggcca tgccctgtaa
     3001 gggcgagcgc taccccccaa ccccaccccc cagcgaccac ttttcatgag ctagggtcac
     3061 acccagccat ctaggcctgt gaacgggtgc ccccttgcca acatggtggc taggcaaggc
     3121 aactcacttg cccctgggaa aagtgagctg cggagcagac ccagaggtaa gggaaccttt
     3181 cctcagacct tgcctggcac tcttaggact gagtccaccc ccgttctgta catagcctct
     3241 tctgatggtc ttgttgaaat ccaatttcac atttttaact atcagttttc ctggggtggg
     3301 gaagagtctt caccccaccc cttcctcgct gggtgctgga cccccattgc ggcctgggct
     3361 ctgccttgca ctatttaccc ctttggccta gtggcccttc cccctcctgg aaaggggcag
     3421 gttcaggggc ccggtgctct cctctcccca tgcacctcca tgcccatttg cacagctgcc
     3481 caggtacccc caacagtggg gaagggccac acagggaggg gtggcgggac cagtccctgt
     3541 atctatttaa aaagtgatga tgtaatatat taggagggag gtcaggtacc ctgggcctca
     3601 tcttagcatt tcaggtgata ggggagccca gggctggaga aacctggggc ttagtcccag
     3661 agagtggaga cagtggcctc cactctctct ccttgtggct tccccactca gtgccttagt
     3721 gggggaacgc attcccctcc cccattccct tcatctaccc ctgcccctgc ctcgggtgta
     3781 agtgacagga agaaataata ataatttaag attca
//
