LOCUS       NM_001404864            5974 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Mus musculus zinc finger and BTB domain containing 7a (Zbtb7a),
            transcript variant 5, mRNA.
ACCESSION   NM_001404864 XM_030244921
VERSION     NM_001404864.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5974)
  AUTHORS   Xu,X., Shobuike,T., Shiraki,M., Kamohara,A., Hirata,H.,
            Murayama,M., Mawatari,D., Ueno,M., Morimoto,T., Kukita,T.,
            Mawatari,M. and Kukita,A.
  TITLE     Leukemia/lymphoma-related factor (LRF) or osteoclast zinc finger
            protein (OCZF) overexpression promotes osteoclast survival by
            increasing Bcl-xl mRNA: A novel regulatory mechanism mediated by
            the RNA binding protein SAM68
  JOURNAL   Lab Invest 102 (9), 1000-1010 (2022)
   PUBMED   35474350
  REMARK    GeneRIF: Leukemia/lymphoma-related factor (LRF) or osteoclast zinc
            finger protein (OCZF) overexpression promotes osteoclast survival
            by increasing Bcl-xl mRNA: A novel regulatory mechanism mediated by
            the RNA binding protein SAM68.
REFERENCE   2  (bases 1 to 5974)
  AUTHORS   Yuan,W., Ma,S., Brown,J.R., Kim,K., Murek,V., Trastulla,L.,
            Meissner,A., Lodato,S., Shetty,A.S., Levin,J.Z., Buenrostro,J.D.,
            Ziller,M.J. and Arlotta,P.
  TITLE     Temporally divergent regulatory mechanisms govern neuronal
            diversification and maturation in the mouse and marmoset neocortex
  JOURNAL   Nat Neurosci 25 (8), 1049-1058 (2022)
   PUBMED   35915179
REFERENCE   3  (bases 1 to 5974)
  AUTHORS   Medeiros de Araujo,J.A., Barao,S., Mateos-White,I., Espinosa,A.,
            Costa,M.R., Gil-Sanz,C. and Muller,U.
  TITLE     ZBTB20 is crucial for the specification of a subset of callosal
            projection neurons and astrocytes in the mammalian neocortex
  JOURNAL   Development 148 (16) (2021)
   PUBMED   34351428
REFERENCE   4  (bases 1 to 5974)
  AUTHORS   Zhou,J.P., Ren,Y.D., Xu,Q.Y., Song,Y., Zhou,F., Chen,M.Y.,
            Liu,J.J., Chen,L.G. and Pan,J.S.
  TITLE     Obesity-Induced Upregulation of ZBTB7A Promotes Lipid Accumulation
            through SREBP1
  JOURNAL   Biomed Res Int 2020, 4087928 (2020)
   PUBMED   31998789
  REMARK    GeneRIF: Obesity-Induced Upregulation of ZBTB7A Promotes Lipid
            Accumulation through SREBP1.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5974)
  AUTHORS   Guarnerio,J., Zhang,Y., Cheloni,G., Panella,R., Mae Katon,J.,
            Simpson,M., Matsumoto,A., Papa,A., Loretelli,C., Petri,A.,
            Kauppinen,S., Garbutt,C., Nielsen,G.P., Deshpande,V.,
            Castillo-Martin,M., Cordon-Cardo,C., Dimitrios,S., Clohessy,J.G.,
            Batish,M. and Pandolfi,P.P.
  TITLE     Intragenic antagonistic roles of protein and circRNA in
            tumorigenesis
  JOURNAL   Cell Res 29 (8), 628-640 (2019)
   PUBMED   31209250
  REMARK    GeneRIF: Intragenic antagonistic roles of protein and circRNA in
            tumorigenesis.
            Erratum:[Cell Res. 2020 Feb;30(2):188. doi:
            10.1038/s41422-019-0262-4.. PMID: 31911670]
REFERENCE   6  (bases 1 to 5974)
  AUTHORS   He,X., He,X., Dave,V.P., Zhang,Y., Hua,X., Nicolas,E., Xu,W.,
            Roe,B.A. and Kappes,D.J.
  TITLE     The zinc finger transcription factor Th-POK regulates CD4 versus
            CD8 T-cell lineage commitment
  JOURNAL   Nature 433 (7028), 826-833 (2005)
   PUBMED   15729333
REFERENCE   7  (bases 1 to 5974)
  AUTHORS   Maeda,T., Hobbs,R.M., Merghoub,T., Guernah,I., Zelent,A.,
            Cordon-Cardo,C., Teruya-Feldstein,J. and Pandolfi,P.P.
  TITLE     Role of the proto-oncogene Pokemon in cellular transformation and
            ARF repression
  JOURNAL   Nature 433 (7023), 278-285 (2005)
   PUBMED   15662416
  REMARK    GeneRIF: Pokemon can specifically repress the transcription of the
            tumour suppressor gene ARF through direct binding
REFERENCE   8  (bases 1 to 5974)
  AUTHORS   Liu,C.J., Prazak,L., Fajardo,M., Yu,S., Tyagi,N. and Di Cesare,P.E.
  TITLE     Leukemia/lymphoma-related factor, a POZ domain-containing
            transcriptional repressor, interacts with histone deacetylase-1 and
            inhibits cartilage oligomeric matrix protein gene expression and
            chondrogenesis
  JOURNAL   J Biol Chem 279 (45), 47081-47091 (2004)
   PUBMED   15337766
  REMARK    GeneRIF: LRF is the first transcription factor found to bind
            directly to the COMP gene promoter, to recruit HDAC1, and to
            regulate both COMP gene expression and chondrogenic differentiation
REFERENCE   9  (bases 1 to 5974)
  AUTHORS   Laudes,M., Christodoulides,C., Sewter,C., Rochford,J.J.,
            Considine,R.V., Sethi,J.K., Vidal-Puig,A. and O'Rahilly,S.
  TITLE     Role of the POZ zinc finger transcription factor FBI-1 in human and
            murine adipogenesis
  JOURNAL   J Biol Chem 279 (12), 11711-11718 (2004)
   PUBMED   14701838
  REMARK    GeneRIF: may contribute to adipogenesis through influencing the
            switch from cellular proliferation to terminal differentiation
REFERENCE   10 (bases 1 to 5974)
  AUTHORS   Davies,J.M., Hawe,N., Kabarowski,J., Huang,Q.H., Zhu,J.,
            Brand,N.J., Leprince,D., Dhordain,P., Cook,M., Morriss-Kay,G. and
            Zelent,A.
  TITLE     Novel BTB/POZ domain zinc-finger protein, LRF, is a potential
            target of the LAZ-3/BCL-6 oncogene
  JOURNAL   Oncogene 18 (2), 365-375 (1999)
   PUBMED   9927193
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC155932.6.
            
            On Apr 15, 2022 this sequence version replaced XM_030244921.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13422589.422305.1,
                                           SRR17784648.1234678.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-465               AC155932.6         96184-96648
            466-1721            AC155932.6         103568-104823
            1722-5974           AC155932.6         107576-111828
FEATURES             Location/Qualifiers
     source          1..5974
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 39.72 cM"
     gene            1..5974
                     /gene="Zbtb7a"
                     /gene_synonym="9030619K07Rik; 9130006G12Rik; FBI-1; Lrf;
                     Pokemon; Zbtb7"
                     /note="zinc finger and BTB domain containing 7a"
                     /db_xref="GeneID:16969"
                     /db_xref="MGI:MGI:1335091"
     exon            1..465
                     /gene="Zbtb7a"
                     /gene_synonym="9030619K07Rik; 9130006G12Rik; FBI-1; Lrf;
                     Pokemon; Zbtb7"
                     /inference="alignment:Splign:2.1.0"
     exon            466..1721
                     /gene="Zbtb7a"
                     /gene_synonym="9030619K07Rik; 9130006G12Rik; FBI-1; Lrf;
                     Pokemon; Zbtb7"
                     /inference="alignment:Splign:2.1.0"
     CDS             478..2187
                     /gene="Zbtb7a"
                     /gene_synonym="9030619K07Rik; 9130006G12Rik; FBI-1; Lrf;
                     Pokemon; Zbtb7"
                     /note="leukemia/lymphoma related factor; POK erythroid
                     myeloid ontogenic factor; POZ and Krueppel erythroid
                     myeloid ontogenic factor"
                     /codon_start=1
                     /product="zinc finger and BTB domain-containing protein
                     7A"
                     /protein_id="NP_001391793.1"
                     /db_xref="GeneID:16969"
                     /db_xref="MGI:MGI:1335091"
                     /translation="MAGGVDGPIGIPFPDHSSDILSGLNEQRTQGLLCDVVILVEGRE
                     FPTHRSVLAACSQYFKKLFTSGAVVDQQNVYEIDFVSAEALTALMDFAYTATLTVSTA
                     NVGDILSAARLLEIPAVSHVCADLLERQILAADDVGDASQPDGAGPTDQRNLLRAKEY
                     LEFFRSNPMNSLPPTAFPWSGFGAPDDDLDATKEAVAAAVAAVAAGDCNGLDFYGPGP
                     PADRPPAGDGDEGDSTPGLWPERDEDAPPGGLFPPPTAPPATTQNGHYGRAGAGTGEE
                     EAAALSEAAPEPGDSPGFLSGAAEGEDGDAADVDGLAASTLLQQMMSSVGRAGDSDEE
                     SRTDDKGVMDYYLKYFSGAHEGDVYPAWSQKGEKKIRAKAFQKCPICEKVIQGAGKLP
                     RHIRTHTGEKPYECNICKVRFTRQDKLKVHMRKHTGEKPYLCQQCGAAFAHNYDLKNH
                     MRVHTGLRPYQCDSCCKTFVRSDHLHRHLKKDGCNGVPSRRGRKPRVRGVPPDVPAGA
                     GAPPGLPDAPRNGQEKHFKDEEEDEEEASPDGSGRLNVAGSGGDDGAGGPAVATAEGN
                     FAT"
     exon            1722..5974
                     /gene="Zbtb7a"
                     /gene_synonym="9030619K07Rik; 9130006G12Rik; FBI-1; Lrf;
                     Pokemon; Zbtb7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5937..5942
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zbtb7a"
                     /gene_synonym="9030619K07Rik; 9130006G12Rik; FBI-1; Lrf;
                     Pokemon; Zbtb7"
                     /note="hexamer: AAGAAA"
     polyA_site      5974
                     /gene="Zbtb7a"
                     /gene_synonym="9030619K07Rik; 9130006G12Rik; FBI-1; Lrf;
                     Pokemon; Zbtb7"
                     /note="major polyA site"
ORIGIN      
        1 agtgacgccg ccgcccgccc gagcgaggtc cgcgccgcgg gctgccccga tcgcgcgtcc
       61 tccgggctcg ggtccccgcg aggtaagctg cccgggctga aggggactcc tctcccggag
      121 aggtgggttt tgtttttctt ttttttttcc tttctttcct ttttaatttc cttgcagggt
      181 ggggacgcgg ccgggggcgc agtgcgcacc ccgagagccc gtacggagcg gaacggactg
      241 gatgggggat ctggggcgcc tccgtagctc aggggttctg gagaccaaga ttgcccggcc
      301 agagccgaag aggagtcggg aggcgggggg gctccgcccg ggtccctccg gggcgaaggg
      361 cacaagcccg ctcccgatcc ctcctcccta ctcgggcggc acggcctcag ggttcccggc
      421 gcgcggcccg cgggggaggg gagccgggcc tcaccgaagg cgaaggtgtc gcggaagatg
      481 gctggcggcg tggacggccc catcgggatc ccgttcccgg accacagcag cgacatcctg
      541 agcggcctga acgagcagcg gactcagggg ctgctttgcg acgtggtgat tcttgtggaa
      601 ggacgtgagt tccccacgca ccgctcggtg ctggccgcct gcagccagta cttcaagaag
      661 ctgttcacgt cgggagctgt agtggaccag cagaacgtgt acgagatcga cttcgtgagt
      721 gccgaggcac tgacggcgct catggacttc gcctacaccg ccacgctcac ggtcagcacg
      781 gccaatgtgg gcgacatcct gagtgcagca cggctgctgg agatcccggc cgtgagccac
      841 gtgtgcgccg acctgctgga gcgtcagatt ctggcggctg atgatgtggg cgacgcgagc
      901 cagcccgacg gggcgggccc cactgaccag cgcaacctgc tgcgtgccaa ggagtacctg
      961 gagttcttcc gcagtaaccc catgaatagc ctgcccccca ctgccttccc atggtctggc
     1021 ttcggtgccc ccgacgacga cctggacgcc accaaggagg ctgtggccgc cgctgtggcc
     1081 gctgtggccg caggcgactg caatggcttg gacttctatg gcccagggcc cccggctgat
     1141 cggcccccag ccggcgatgg agatgagggt gacagtaccc cagggctgtg gcctgagaga
     1201 gatgaagatg ccccgcccgg agggctcttc ccacctccta ctgccccacc ggccaccaca
     1261 cagaacggcc actatggccg tgcaggggct ggcaccggtg aagaagaagc ggcggctctc
     1321 tctgaggccg ctccagagcc gggcgactcc ccgggcttcc tgtcaggcgc tgcagagggc
     1381 gaggatgggg acgccgctga tgtggatggg ctagcggcca gcacgctgct acagcagatg
     1441 atgtcatcgg tgggccgggc cggggacagt gatgaggagt cgcgaaccga cgacaagggc
     1501 gtcatggact actacctgaa gtacttcagt ggagcccacg agggggatgt gtacccagcc
     1561 tggtcacaga agggtgagaa gaaaatccgg gccaaggcct tccagaagtg tcccatctgc
     1621 gagaaggtga ttcagggtgc cggcaagctg ccccgtcaca tccgcacgca cacgggcgag
     1681 aagccctacg agtgtaacat ctgtaaagtt cgattcacca gacaggacaa gctgaaggtg
     1741 cacatgcgga agcacacggg tgagaagccg tacctgtgcc agcagtgcgg cgccgccttc
     1801 gcgcacaact acgacctgaa gaaccacatg cgggtgcaca cggggctgcg gccataccag
     1861 tgcgatagct gctgcaagac ctttgtgcgc tccgaccatc tgcacagaca cctcaagaag
     1921 gacggctgca atggggtccc ctcgcgccgc ggccgcaagc cccgtgtgcg gggtgtgcca
     1981 cccgatgtcc ctgccggggc cggcgcaccc cccgggctcc cggacgcccc gcgcaatggc
     2041 caggagaagc actttaagga cgaggaggag gacgaggagg aggccagccc ggacggctca
     2101 ggccgcctga atgtagcggg cagcggagga gacgatggtg caggtggccc ggcggtggcc
     2161 accgccgagg gtaacttcgc aacctgactc gtattaaaac aaaccaaaaa caaaacaaaa
     2221 caaaaaacta agaacagaga gaaaccacca cccaccccca gcaccacgag taagcagttc
     2281 tctgtccaga cgccctccat ccacctgcgc ggacgtgtgt gcgtgtatat accatggccg
     2341 cgggcgcctg cctttctcag atccttagga tgtggcccca tctgctcctg tgtccctcgt
     2401 cccatccacc aaggggtccc acgcaggggc ccagcctgct cttggctaag gcgagggtga
     2461 tggggacccc aggacaggcg cccggctcct tgctggttgg ttttaggggg tcttagacag
     2521 accttaaatg ctctgtccac tatgagtgga cgttaaaatg gtccccaccc tccttcctca
     2581 gggcacttac taaagagggg ggtgtcccct cggcctccct cccggcctgt ggcctccgca
     2641 tctctgcaca tccaccctgg ccaccactga catacaaatc tatttattcc caagcctgga
     2701 tggccagagc ggggattggg ggggggccgc tggggtcccc gccaccctcc ttcacggcac
     2761 ttacacctga cggggccctc ggggccactg ctcagggcga cccccccccc aaccttccca
     2821 tctctgcttg gccatgcccc caccccgtgt tcagagattg aaaatttgtc gtcaccccac
     2881 tccccacttt ttaaggcact ttttagatcg atttcccctt tgactcctta aagacagttt
     2941 atatagagat atatatagag agagatatat aaaatattct tttcctcaga ggagccggca
     3001 gcagttttgg gtggacatag ccaagatcag aggtaacccc agggactcag gcagagacag
     3061 acaagggagt gagagaggcc acagcttaat gtcacaaaac agcaataaaa ccccaagatt
     3121 ttagtaaaca cgaaggcaga acatttttta aaaaatcagc aaaagcggtg acagccacgt
     3181 ggggatcttg gcactttgta actgaacggg tacttttcat tcttaacttg agaaatgttt
     3241 acaagttgca cccagcttct atgaaaaatt gaagagagag cgagagagtg ggaagtaact
     3301 aagtcaattt atttttgtat aaaataaaag aaccccaacc catcgctccg gtagaatcca
     3361 cttgcgctcc cgagactcag ggtggggcgt ccagggcgcc atgggaaggg acccgtgggt
     3421 cccccagtct gccaggggcc tctgtccccc aggttatttt attttctcat tgtctctgta
     3481 ggagaccaca ggcctgggag ccgcaggcca cctgtgctgt ccttcccagc tcagggatgt
     3541 ccccgagaga gggctggtcc tcgactagcc agatccccat gccccatgtc tgtcccctcc
     3601 ccatgtggtg gtccccctct taggcacccc ctctttttac tcaaaggcac tgactgtaac
     3661 ccaggggcta gcacccgagc cccccatacc ccaaactctg gcttccccca aaggcccggt
     3721 attgaccgag ccacaggcca cggacagggg ccggggttgg gggacatggc tgctgggtgc
     3781 cagggcgccc cccgtcaaac cccgtggcca aggtggaacc aaacttggga ccttgtccat
     3841 gcacactctg tccagccctt ccccatgggt gccggcgggg gtagcgggtg ttcctgtgtc
     3901 ccccgctgac aaatgtcttt ctttggtttt aaaaggaagc tcactaagaa ggtcgctttc
     3961 cagtttctag cagaggggtt ttcctttcta actcctccta ccacgcgagc cctccccccc
     4021 cccccagatg tctcaggatc cccccttggg gccagcagaa tgggcccagg ggcggggtgg
     4081 tgctggcctc ccctcgcacc ccacttccgc agtgagctgt cccgggaact gtgctgtgga
     4141 ggccaagttg ggcccccagc ccccattccc agacaggtca gcccctccac cttctcgcaa
     4201 taaaaccaac tttaatcaca tgtcatcctg gccagtggcc actagacttg gggtggatgg
     4261 agcccttggg gactatggta gggtgcccca taacccgcca gcgaaaccgc aacccccttg
     4321 ggaattgcac taaacccttg acccccgctc cgcgctcagc ttctgcccac ccacacccac
     4381 cttgccttaa ccgccagccc gtcctagggg gccgcagcca ccgcatgggc ccagcgccgg
     4441 gacatccccc agccccctaa aggcccgccc gtaccccgcc ccccaatata ctgcaatcac
     4501 atactgtata tagaatgcgg atcaattttt acaaattttt attctttaaa ttaaggccgt
     4561 gataaaagtt gccaaagaga attgtggaat tcactagagg tttgagcgga gggtgctgta
     4621 gaaaggtttt atttggttgt ttggggttta ttttgtgtgt gtgtgtgtgt gtgtgtgtgt
     4681 gtgtgtgtgg tttttttgtt tgtttgtttt tttgcttttt tttctttttc cttttccctc
     4741 tacttttttt ttttttttta attgcctggt accaataaca aaaaggaaaa aaaaaacaca
     4801 acagaaattt gttacttcca ttatggtgaa tttgcgtgtg tgtgtgtgtg agtgtgtgag
     4861 acagacagaa gggcccaggc tgtggggttc tggggacccc agtgctgggg aggggaccag
     4921 cctgcagctg gccccaagcc tgtgacctga gcaaggccac ccctgctgag tagttgctgc
     4981 tctttgcctt cctatcccta caggcctttc gagattaaga aaaaagaaaa aaaaaggcaa
     5041 aaaataaaaa aataaaaatg aaaaaaaaaa aactatatat ctatagaacc caatgaatgt
     5101 acatggcaga cctggcccag ccatggttcc gtcatggtgg gatcgagtgg tagaaccaaa
     5161 gtgggtgccc tggggtgctc attcaccctg tgtgagcaca gctgacctga gggtgctcgg
     5221 tgggtgccct tgggtagcca gggaaggctg tcacttgtgg caggcataat ggcagcctcg
     5281 aagcccaggt ggagccccgg ctggtcgttc agggaataga cagtgtaagt agggggtgtg
     5341 taggagggac acaggctgaa aggaaaaata gaaaaaaaac aaaaaaaaaa aaccaaaacc
     5401 acaaaaacca acaaaaaaaa aaaaaagaaa aagcaaaatc ctattttttg agaaagaaag
     5461 atatttatat ttgcagtttt attttaaaaa gttatttaag ctgaggaaac ggccttcccg
     5521 gagttcgggg tggctggcac cggacgggtc aggggtcttg gggggctcct caccccagga
     5581 atgattatct cagttcagaa ctagctcgca ctaaatatat attgatttac ctttgtgggg
     5641 ggcagggggg ccaagagaca gagggtcagg ggagccccgc cccaggccca gaatgaggtg
     5701 ccttggaatt tgggggccca ggcctggttc atgggggtcc agagcacaga acagacattc
     5761 cactgactgg atgtaagaat ctttataaaa agtgtgggag gcagaacgaa aaaaaaatca
     5821 attgattaaa ggaaaatgca cttttttggg ggtgggggga caagctttaa aagtaattaa
     5881 aaaacaaaag attatgaaaa atccgaaaaa atagaattca tttttcttgt acataaaaga
     5941 aaaacccaac cactaaatgc agcctgttac gata
//
