LOCUS       NM_027656               2014 bp    mRNA    linear   ROD 24-SEP-2024
DEFINITION  Mus musculus zinc finger and BTB domain containing 46 (Zbtb46),
            transcript variant 1, mRNA.
ACCESSION   NM_027656
VERSION     NM_027656.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2014)
  AUTHORS   Guak,H., Weiland,M., Ark,A.V., Zhai,L., Lau,K., Corrado,M.,
            Davidson,P., Asiedu,E., Mabvakure,B., Compton,S., DeCamp,L.,
            Scullion,C.A., Jones,R.G., Nowinski,S.M. and Krawczyk,C.M.
  TITLE     Transcriptional programming mediated by the histone demethylase
            KDM5C regulates dendritic cell population heterogeneity and
            function
  JOURNAL   Cell Rep 43 (8), 114506 (2024)
   PUBMED   39052479
REFERENCE   2  (bases 1 to 2014)
  AUTHORS   Zhivaki,D., Kennedy,S.N., Park,J., Boriello,F., Devant,P., Cao,A.,
            Bahleda,K.M., Murphy,S., McCabe,C., Evavold,C.L., Chapman,K.L.,
            Zanoni,I., Ashenberg,O., Xavier,R.J. and Kagan,J.C.
  TITLE     Correction of age-associated defects in dendritic cells enables
            CD4+ T cells to eradicate tumors
  JOURNAL   Cell 187 (15), 3888-3903 (2024)
   PUBMED   38870946
REFERENCE   3  (bases 1 to 2014)
  AUTHORS   Rodrigues,P.F., Trsan,T., Cvijetic,G., Khantakova,D., Panda,S.K.,
            Liu,Z., Ginhoux,F., Cella,M. and Colonna,M.
  TITLE     Progenitors of distinct lineages shape the diversity of mature type
            2 conventional dendritic cells
  JOURNAL   Immunity 57 (7), 1567-1585 (2024)
   PUBMED   38821051
REFERENCE   4  (bases 1 to 2014)
  AUTHORS   Ashraf,M.I., Mengwasser,J., Reutzel-Selke,A., Polenz,D., Fuhrer,K.,
            Lippert,S., Tang,P., Michaelis,E., Catar,R., Pratschke,J.,
            Witzel,C., Sauer,I.M., Tullius,S.G. and Kern,B.
  TITLE     Depletion of donor dendritic cells ameliorates immunogenicity of
            both skin and hind limb transplants
  JOURNAL   Front Immunol 15, 1395945 (2024)
   PUBMED   38799435
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2014)
  AUTHORS   De Giovanni,M., Vykunta,V.S., Biram,A., Chen,K.Y., Taglinao,H.,
            An,J., Sheppard,D., Paidassi,H. and Cyster,J.G.
  TITLE     Mast cells help organize the Peyer's patch niche for induction of
            IgA responses
  JOURNAL   Sci Immunol 9 (93), eadj7363 (2024)
   PUBMED   38427721
REFERENCE   6  (bases 1 to 2014)
  AUTHORS   Meredith,M.M., Liu,K., Darrasse-Jeze,G., Kamphorst,A.O.,
            Schreiber,H.A., Guermonprez,P., Idoyaga,J., Cheong,C., Yao,K.H.,
            Niec,R.E. and Nussenzweig,M.C.
  TITLE     Expression of the zinc finger transcription factor zDC (Zbtb46,
            Btbd4) defines the classical dendritic cell lineage
  JOURNAL   J Exp Med 209 (6), 1153-1165 (2012)
   PUBMED   22615130
  REMARK    GeneRIF: expression of the Btbd4 defines the classical dendritic
            cell lineage
REFERENCE   7  (bases 1 to 2014)
  AUTHORS   Satpathy,A.T., KC,W., Albring,J.C., Edelson,B.T., Kretzer,N.M.,
            Bhattacharya,D., Murphy,T.L. and Murphy,K.M.
  TITLE     Zbtb46 expression distinguishes classical dendritic cells and their
            committed progenitors from other immune lineages
  JOURNAL   J Exp Med 209 (6), 1135-1152 (2012)
   PUBMED   22615127
  REMARK    GeneRIF: Zbtb46 may help enforce dendritic cell identity by
            restricting responsiveness to non-dendritic cells growth factors
            and may serve as a useful marker to identify rare dendritic cell
            progenitors
REFERENCE   8  (bases 1 to 2014)
  AUTHORS   Shin,E.J., Shin,H.M., Nam,E., Kim,W.S., Kim,J.H., Oh,B.H. and
            Yun,Y.
  TITLE     DeSUMOylating isopeptidase: a second class of SUMO protease
  JOURNAL   EMBO Rep 13 (4), 339-346 (2012)
   PUBMED   22370726
REFERENCE   9  (bases 1 to 2014)
  AUTHORS   Guo,G., Huss,M., Tong,G.Q., Wang,C., Li Sun,L., Clarke,N.D. and
            Robson,P.
  TITLE     Resolution of cell fate decisions revealed by single-cell gene
            expression analysis from zygote to blastocyst
  JOURNAL   Dev Cell 18 (4), 675-685 (2010)
   PUBMED   20412781
REFERENCE   10 (bases 1 to 2014)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK011461.1, AK016700.1 and AL928965.35.
            
            [WARNING] On Oct 22, 2024 this sequence was replaced by
            NM_027656.3.
            
            On Apr 30, 2010 this sequence version replaced NM_027656.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK016700.1, SRR10223969.3511.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-636               AK011461.1         173-808
            637-1849            AK016700.1         2-1214
            1850-1850           AL928965.35        85284-85284         c
            1851-2014           AK016700.1         1216-1379
FEATURES             Location/Qualifiers
     source          1..2014
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 103.63 cM"
     gene            1..2014
                     /gene="Zbtb46"
                     /gene_synonym="2610019F01Rik; 4933406L05Rik; Btbd4; BZEL"
                     /note="zinc finger and BTB domain containing 46"
                     /db_xref="GeneID:72147"
                     /db_xref="MGI:MGI:1919397"
     exon            1..970
                     /gene="Zbtb46"
                     /gene_synonym="2610019F01Rik; 4933406L05Rik; Btbd4; BZEL"
                     /inference="alignment:Splign:2.1.0"
     CDS             34..1836
                     /gene="Zbtb46"
                     /gene_synonym="2610019F01Rik; 4933406L05Rik; Btbd4; BZEL"
                     /note="isoform 1 is encoded by transcript variant 1; BTB
                     (POZ) domain containing 4; zinc finger and BTB
                     domain-containing protein 46; BTB/POZ domain-containing
                     protein 4; BTB-ZF protein expressed in effector
                     lymphocytes"
                     /codon_start=1
                     /product="zinc finger and BTB domain-containing protein 46
                     isoform 1"
                     /protein_id="NP_081932.1"
                     /db_xref="CCDS:CCDS50854.1"
                     /db_xref="GeneID:72147"
                     /db_xref="MGI:MGI:1919397"
                     /translation="MNNRKEDMEITSHYRHLLRELNEQRQHGVLCDACVVVEGKVFKA
                     HKNVLLGSSRYFKTLYCQVQKTSDQATVTHLDIVTAQGFKAIIDFMYSAHLALTSRNV
                     IEVMSAASFLQMTDIVQACHDFIKAALDISIKSDASDELSEFEIGTPASNSTEALISA
                     VMAGRSISPWLARRTSPANSSGDSAIASCHEGGSSYGKEDQEPKADGPDDVSSQSLWP
                     GDVGYGSLRIKEEQISPSHYGGSELPSSKDTAIQNSLSEQGSGDGWQPTGRRKNRKNK
                     ETVRHITQQVEEDSQAGSPVPSFLPTSGWPFSSRDSNVDLTVTEASSLDSRGERAELY
                     AHIDEGLLGGETSYLGPPLTPEKEEALHQATAVANLRAALMSKNSLLSLKADVLGDDG
                     SLLFEYLPKGAHSLSLNEFTVIRKKFKCPYCSFSAMHQCILKRHMRSHTGERPYPCEI
                     CGKKFTRREHMKRHTLVHSKDKKYVCKVCSRVFMSAASVGIKHGSRRHGVCADCAGRG
                     VGTPLDHGGGGEGSPEALFAGEGPYLEDPDDPRGEAEEELVEDEDEDVAKWKDDVGLA
                     HEDALLGDDKDDEDSPQGPHSPSGEPDKDFAWIS"
     exon            971..1255
                     /gene="Zbtb46"
                     /gene_synonym="2610019F01Rik; 4933406L05Rik; Btbd4; BZEL"
                     /inference="alignment:Splign:2.1.0"
     exon            1256..1431
                     /gene="Zbtb46"
                     /gene_synonym="2610019F01Rik; 4933406L05Rik; Btbd4; BZEL"
                     /inference="alignment:Splign:2.1.0"
     exon            1432..2014
                     /gene="Zbtb46"
                     /gene_synonym="2610019F01Rik; 4933406L05Rik; Btbd4; BZEL"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtctataga agacacagca gcaagactcc cagatgaaca accgaaagga agatatggaa
       61 atcacttctc actaccggca tctgcttcga gagctcaatg agcagaggca gcacggagtc
      121 ctctgtgatg cgtgcgtcgt ggtggagggc aaggtcttca aggcacataa gaacgtcttg
      181 cttgggagca gccgctactt taagacgctc tactgccagg tacagaagac atctgaccag
      241 gccaccgtca ctcacttgga cattgttaca gcccagggct tcaaggccat tattgacttc
      301 atgtactccg cccatctggc tctcactagt aggaatgtca tcgaggtgat gtcagctgcc
      361 agcttcctac agatgactga cattgtgcag gcctgccatg atttcatcaa ggctgcactg
      421 gacatcagca taaagtcaga tgcctccgat gaactctcag aatttgagat tggcacccca
      481 gccagcaaca gtacagaggc gttgatctca gctgtgatgg ctggaaggag tatctcccca
      541 tggttggctc ggagaacaag tcctgccaat tcttctggag actctgccat tgccagctgt
      601 catgaaggag gaagcagcta tgggaaggag gaccaggaac ccaaagctga tggccctgat
      661 gacgtttctt cacagtcttt gtggcctgga gatgtaggct atgggtctct gcgcatcaag
      721 gaagaacaga tttcaccatc acattatgga gggagtgagc ttccatcttc caaggacact
      781 gcaatacaga attctttatc agaacagggt tctggggatg gctggcagcc cacaggccgg
      841 aggaagaatc ggaaaaacaa agagactgtc cgacacatca cccagcaggt ggaggaggac
      901 agccaggctg gctctccagt accttcattc ctacccacat cgggatggcc tttcagcagc
      961 cgagactcaa atgtagacct gacggtcact gaggccagca gcttggacag ccgaggcgag
     1021 agagcagagc tctatgctca catcgatgag ggcctactag gaggagaaac cagctacttg
     1081 ggcccacccc tcaccccaga gaaggaagaa gcactacacc aggctactgc agtggccaat
     1141 cttcgtgctg cactcatgag taagaacagt ctgctgtcac tcaaggctga cgtgctcggt
     1201 gatgatggct cacttctgtt cgagtacctg cccaaaggtg cccactcact gtctctgaac
     1261 gaattcacgg tgatcaggaa gaagttcaag tgcccctact gcagcttctc agccatgcac
     1321 cagtgcatcc ttaagcgaca catgcgctca catactggag agcggcccta cccttgtgag
     1381 atctgtggca agaagttcac taggagagag cacatgaagc gacatactct ggtccacagc
     1441 aaggacaaga agtacgtgtg caaagtgtgc agccgtgtgt tcatgtctgc agccagcgtg
     1501 ggcattaagc acggctctcg tcgccatggg gtgtgtgcag actgtgctgg ccggggtgtg
     1561 ggcacgccac tggaccatgg tggaggtggc gagggctccc ctgaggcgct gtttgctggt
     1621 gaagggccgt acctggagga cccggatgat ccacgagggg aggctgagga ggagctggtt
     1681 gaggatgagg atgaggacgt ggccaagtgg aaggatgacg tgggcttggc ccatgaggat
     1741 gcactgctgg gggatgacaa ggatgatgaa gactctccac aggggcctca cagcccctct
     1801 ggggagcccg ataaagactt tgcctggatc tcctaggggc tctgctctag tgggcagggt
     1861 gagtgatggc tgaatcgctt tgtccacctg tgtgtgtgtc ttagtggatc tttacttacc
     1921 caggagcagg gctatgctta ctccttgaag ctcctcctaa aggcctctcc tccatgctat
     1981 acccctctcc attacagaaa ctggtcctgt gagc
//
