LOCUS       NM_001359959            3772 bp    mRNA    linear   ROD 06-AUG-2023
DEFINITION  Mus musculus zinc finger and BTB domain containing 38 (Zbtb38),
            transcript variant 2, mRNA.
ACCESSION   NM_001359959 XM_006511192
VERSION     NM_001359959.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3772)
  AUTHORS   Nishio M, Matsuura T, Hibi S, Ohta S, Oka C, Sasai N, Ishida Y and
            Matsuda E.
  TITLE     Heterozygous loss of Zbtb38 leads to early embryonic lethality via
            the suppression of Nanog and Sox2 expression
  JOURNAL   Cell Prolif 55 (4), e13215 (2022)
   PUBMED   35297517
  REMARK    GeneRIF: Heterozygous loss of Zbtb38 leads to early embryonic
            lethality via the suppression of Nanog and Sox2 expression.
REFERENCE   2  (bases 1 to 3772)
  AUTHORS   Medeiros de Araujo JA, Barao S, Mateos-White I, Espinosa A, Costa
            MR, Gil-Sanz C and Muller U.
  TITLE     ZBTB20 is crucial for the specification of a subset of callosal
            projection neurons and astrocytes in the mammalian neocortex
  JOURNAL   Development 148 (16) (2021)
   PUBMED   34351428
REFERENCE   3  (bases 1 to 3772)
  AUTHORS   Wong R and Bhattacharya D.
  TITLE     ZBTB38 is dispensable for antibody responses
  JOURNAL   PLoS One 15 (9), e0235183 (2020)
   PUBMED   32956421
  REMARK    GeneRIF: ZBTB38 is dispensable for antibody responses.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3772)
  AUTHORS   Ocsko T, Toth DM, Hoffmann G, Tubak V, Glant TT and Rauch TA.
  TITLE     Transcription factor Zbtb38 downregulates the expression of
            anti-inflammatory IL1r2 in mouse model of rheumatoid arthritis
  JOURNAL   Biochim Biophys Acta Gene Regul Mech 1861 (11), 1040-1047 (2018)
   PUBMED   30343694
  REMARK    GeneRIF: Our studies demonstrate that Zbtb38 forms a molecular
            bridge between an arthritis-associated epimutation (DNA
            hypomethylation in Zbtb38 promoter) and transcriptional silencing
            of the IL1r2 gene in B cells. In this way, disease-associated DNA
            hypomethylation can support autoimmune arthritis by interfering
            with an anti-inflammatory pathway.
REFERENCE   5  (bases 1 to 3772)
  AUTHORS   Nishii T, Oikawa Y, Ishida Y, Kawaichi M and Matsuda E.
  TITLE     CtBP-interacting BTB zinc finger protein (CIBZ) promotes
            proliferation and G1/S transition in embryonic stem cells via Nanog
  JOURNAL   J Biol Chem 287 (15), 12417-12424 (2012)
   PUBMED   22315219
  REMARK    GeneRIF: CIBZ post-transcriptionally regulates the expression of
            Nanog.
REFERENCE   6  (bases 1 to 3772)
  AUTHORS   Barrett CW, Smith JJ, Lu LC, Markham N, Stengel KR, Short SP, Zhang
            B, Hunt AA, Fingleton BM, Carnahan RH, Engel ME, Chen X, Beauchamp
            RD, Wilson KT, Hiebert SW, Reynolds AB and Williams CS.
  TITLE     Kaiso directs the transcriptional corepressor MTG16 to the Kaiso
            binding site in target promoters
  JOURNAL   PLoS One 7 (12), e51205 (2012)
   PUBMED   23251453
REFERENCE   7  (bases 1 to 3772)
  AUTHORS   Oikawa Y, Omori R, Nishii T, Ishida Y, Kawaichi M and Matsuda E.
  TITLE     The methyl-CpG-binding protein CIBZ suppresses myogenic
            differentiation by directly inhibiting myogenin expression
  JOURNAL   Cell Res 21 (11), 1578-1590 (2011)
   PUBMED   21625269
  REMARK    GeneRIF: CIBZ binds to a Myog promoter-proximal region and inhibits
            Myog transcription in a methylation-dependent manner.
REFERENCE   8  (bases 1 to 3772)
  AUTHORS   Yokoyama S, Ito Y, Ueno-Kudoh H, Shimizu H, Uchibe K, Albini S,
            Mitsuoka K, Miyaki S, Kiso M, Nagai A, Hikata T, Osada T, Fukuda N,
            Yamashita S, Harada D, Mezzano V, Kasai M, Puri PL, Hayashizaki Y,
            Okado H, Hashimoto M and Asahara H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   9  (bases 1 to 3772)
  AUTHORS   Oikawa Y, Matsuda E, Nishii T, Ishida Y and Kawaichi M.
  TITLE     Down-regulation of CIBZ, a novel substrate of caspase-3, induces
            apoptosis
  JOURNAL   J Biol Chem 283 (21), 14242-14247 (2008)
   PUBMED   18375381
  REMARK    GeneRIF: CIBZ plays an important role by participating in the
            negative regulation of apoptosis in murine cells
REFERENCE   10 (bases 1 to 3772)
  AUTHORS   Sasai N, Matsuda E, Sarashina E, Ishida Y and Kawaichi M.
  TITLE     Identification of a novel BTB-zinc finger transcriptional
            repressor, CIBZ, that interacts with CtBP corepressor
  JOURNAL   Genes Cells 10 (9), 871-885 (2005)
   PUBMED   16115196
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK054096.1 and AC121951.3.
            
            On Jan 20, 2018 this sequence version replaced XM_006511192.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK054096.1, BB665853.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849378, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1052              AK054096.1         2-1053
            1053-3772           AC121951.3         101137-103856
FEATURES             Location/Qualifiers
     source          1..3772
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 50.71 cM"
     gene            1..3772
                     /gene="Zbtb38"
                     /gene_synonym="A930014K01Rik; CIBZ"
                     /note="zinc finger and BTB domain containing 38"
                     /db_xref="GeneID:245007"
                     /db_xref="MGI:MGI:2442866"
     exon            1..65
                     /gene="Zbtb38"
                     /gene_synonym="A930014K01Rik; CIBZ"
                     /inference="alignment:Splign:2.1.0"
     exon            66..165
                     /gene="Zbtb38"
                     /gene_synonym="A930014K01Rik; CIBZ"
                     /inference="alignment:Splign:2.1.0"
     exon            166..3772
                     /gene="Zbtb38"
                     /gene_synonym="A930014K01Rik; CIBZ"
                     /inference="alignment:Splign:2.1.0"
     CDS             166..3759
                     /gene="Zbtb38"
                     /gene_synonym="A930014K01Rik; CIBZ"
                     /note="CtBP-interacting BTB zinc finger protein; Zenon
                     homolog"
                     /codon_start=1
                     /product="zinc finger and BTB domain-containing protein
                     38"
                     /protein_id="NP_001346888.1"
                     /db_xref="CCDS:CCDS40731.1"
                     /db_xref="GeneID:245007"
                     /db_xref="MGI:MGI:2442866"
                     /translation="MTVMSLSRDLKDDFHSDTVLSILNEQRIRGILCDVTIIVEDTKF
                     KAHSNVLAASSLYFKNIFWSHTICISSHVLELDDLKAEVFTEILNYIYSSTVVVKRQE
                     TVTDLAAAGKKLGISFLEDLSDRNFSNSPGPYVVCITEKGVVKEEKNEKRHEEPAVTN
                     GPRITNAFSIIETENSNNMFSPLDLRASFKKVSDSMRTASLCQERASVCHEVEPVRTL
                     AEHSYAVSSITEAYRSQPPREQDSSSSAKTGKETGDALATKAKPCRKPKPQTQDSDST
                     TENMPLSLVTCPEVNQERSPQPAPDLSHSEPPSNEGDIHFPREDENQPSDAPGPGAAE
                     VPPLVYNCSCCSKSFDSSTLLSAHMQLHKPTQEPFVCKYCNKQFTTLNRLDRHEQICM
                     RSSHVPIPGGNPPFLENYPTIGQDGTSFRSPESLGPENRIGELSSAGSALSDADHMVK
                     FVNGQMLYSCIVCKRSYVTLSSLRRHANVHSWRRTYPCHYCNKVFALAEYRTRHEIWH
                     TGERRYQCIFCLETFMTYYILKNHQKSFHAIDHRLSINKKTANGGLKPTVYPYKLYRL
                     LPMRCKRAPYKSYRNSSYVSAQGSSQRGESAPDTFIVPNLQSSEMPTLDFQDGRNTLP
                     SSPAVPVETPSRQGAPTSARVKNAEGIKWRKQAVKTNLVDNFDSTEVSVSSTGNTVSA
                     TLQTEPACVSSVGKGSEHSASVISYSGSVPSVIVHSSQFSSVIKHSNTIASLTNSNHK
                     SPSQPVVSPSLIKDSKPETDKASKPASRPKSIKEKKKTAPSNRGEITEEAKYIADHGG
                     SSGKTTNAEETSKIETYIAKPALPGTSTNSNVAPLCQITVKIGNEAIVKRHILGSKLF
                     YKRGRKPKYQMQEETLPRENDPETPGDSPLGLCQAECVEMSEAFDEVSDQDSTDKPWR
                     PYYNYKPKKKSKQLRKMRKVKWRKERRSRSPVGRCRYPAELDRAEVKLPPDKAFEEEE
                     EEEENKEMPKLQCELCDGCPDGAAGAGAEGKPHQHLTSKPYICELCAKQFQSSSTLKM
                     HMRCHTGEKPYQCKTCGRCFSVQGNLQKHERIHLGVKEFICQYCNKAFTLNETLKIHE
                     RIHTGEKRYHCQFCFQGFLYLSTKRNHERRHIREHDGKGFACFQCPKICKTAAALRMH
                     QKKHLYKTLPKQEETGDTCHENADLLESQLCTDSEDSEQKDDIKAFAENVL"
ORIGIN      
        1 ggactcgcag gtccggaagc gccatggacc ccgcgggaag cgcgcgggcg gcggagcgga
       61 gccccatctt gatatggaag acatggcggg ctcagaacca aggatttccg agtgatttct
      121 gccaaagcac agaagctaac tccgtcaagg ctggcgtgtt ctgagatgac agtcatgtcc
      181 ctctccaggg acctcaagga cgactttcac agtgacacag tactctccat cttaaatgag
      241 cagcgcattc ggggcatctt atgtgatgtc accatcatcg tggaagacac caagtttaaa
      301 gcccacagca atgtcctggc cgcctcaagt ctttatttca aaaacatctt ttggagccat
      361 acgatctgca tttccagtca cgtcttggag ctggatgatc tgaaagccga agtgtttaca
      421 gaaatactta attatatcta cagctctacc gttgtggtca aaagacagga aaccgtcact
      481 gatcttgcag ctgcagggaa aaagctggga atatcattct tagaagacct tagtgaccgc
      541 aacttctcaa attccccagg tccttacgta gtctgcatta ctgaaaaggg agtggttaaa
      601 gaagaaaaaa atgagaaaag gcacgaagaa ccagctgtca ctaatgggcc aaggatcaca
      661 aacgcgtttt ccatcattga gacggaaaat agtaataaca tgttttctcc cctggacttg
      721 agagcaagct tcaaaaaggt gtctgattcc atgaggacag ccagcctttg ccaggagaga
      781 gccagcgtct gccatgaggt agagcctgtc cgcacgcttg ctgagcactc gtatgccgtc
      841 tcgtccatca ctgaggccta caggagtcag cctccgaggg aacaggacag cagctcatct
      901 gctaaaacag gaaaagaaac tggtgatgct cttgccacaa aagcgaagcc atgccgaaag
      961 ccaaagcccc aaacccagga ttctgactca accacagaaa atatgccact ctctctagta
     1021 acctgcccag aggtgaatca agaaagaagc ccacagccag ctccagatct gtcacactca
     1081 gagcctccca gcaatgaagg ggatatccat tttcccaggg aagatgaaaa tcagccctct
     1141 gatgctccgg gtccaggagc agcagaggtc ccgcccctcg tttataactg cagctgttgt
     1201 tccaagtcct ttgacagcag cacgctgctc agtgcccaca tgcagctcca caagccgacc
     1261 caggagcctt ttgtgtgcaa gtactgcaac aagcagttca ccaccctcaa cagactggac
     1321 cggcacgagc agatctgcat gaggtctagc cacgtgccca tcccaggagg aaacccaccg
     1381 ttcttggaaa actaccccac tattggtcaa gatggaactt cattcagaag cccggaatca
     1441 ttagggccag aaaataggat tggcgaacta tccagcgcgg ggagtgcctt gtcagacgcg
     1501 gaccacatgg tgaaatttgt gaacgggcag atgctctaca gctgcatcgt gtgcaaacgt
     1561 agttatgtga ctttgtccag cctccggcgg catgcaaatg ttcactcgtg gagaagaaca
     1621 tacccttgcc attactgcaa caaggtcttt gcgctggctg agtacaggac gcgacatgaa
     1681 atctggcaca ctggggagag gcggtaccag tgcattttct gtcttgaaac ttttatgacc
     1741 tactacatac taaaaaacca tcagaagtcc tttcatgcca tagatcacag actctccatc
     1801 aataaaaaaa cagcgaacgg aggcttgaag cctactgtct atccatacaa actttacagg
     1861 ctcttgccta tgagatgcaa gagggcacct tataagagct accggaattc ttcctatgta
     1921 agtgctcaag gaagcagtca aaggggtgaa tctgcccctg atacgttcat cgttccgaat
     1981 ctgcaaagct ctgaaatgcc cacactggac ttccaagatg gcagaaacac gttgcccagc
     2041 agccctgccg tgccagtgga aacaccttca cggcagggcg cacccacttc tgccagagta
     2101 aaaaatgcag aaggcatcaa atggaggaag caggcagtga aaaccaatct cgtcgataac
     2161 ttcgattcaa ctgaggtgtc agtttcttcc actggaaaca ccgtcagcgc caccctacag
     2221 acagagcccg catgtgtttc atctgtgggc aaaggcagtg agcactcggc ctctgtgatc
     2281 agctacagcg gctcggtgcc ctccgtcatt gtgcacagca gccagttctc gtcggtgatc
     2341 aagcacagca acaccatcgc tagcctgacc aacagcaacc acaagtcccc ttcacaaccg
     2401 gtggtcagcc cgtccctgat caaggacagc aagcccgaga cagataaagc cagtaaacct
     2461 gcaagcagac ccaaaagcat taaggagaaa aagaaaactg ctccgagtaa caggggagaa
     2521 ataacagagg aggcaaaata tattgctgat cacggagggt cttcaggcaa aaccacaaac
     2581 gctgaagaaa ccagtaagat tgaaacttat atcgcaaaac ctgctctgcc cggtacctcc
     2641 acaaatagca atgttgcacc cctttgccag ataacagtaa aaattgggaa cgaagccatc
     2701 gtgaaaaggc atatccttgg gtctaagctg ttttacaaaa gagggagaaa acctaagtat
     2761 caaatgcagg aagagacact gcctcgggag aatgacccag aaacccctgg ggacagcccc
     2821 cttgggcttt gccaggctga atgtgtagag atgagtgaag catttgatga agtgagtgac
     2881 caggactcca ctgataagcc gtggcgccca tactacaact acaaacccaa gaagaaatcc
     2941 aaacagctga gaaaaatgag gaaagtcaaa tggaggaagg aacgcaggag cagaagcccc
     3001 gtcggccggt gcagataccc agccgaactg gatcgtgcag aggtgaaact gcccccagat
     3061 aaggccttcg aagaagaaga agaagaagaa gagaataaag agatgcccaa gctgcagtgt
     3121 gagctctgtg atggctgccc tgatggggca gcaggggcgg gagccgaagg caagccccac
     3181 cagcatctca cttcgaagcc ttacatctgc gagctctgtg caaagcagtt ccagagctcc
     3241 tccacactca agatgcacat gagatgccac actggagaaa agccgtatca gtgcaagacc
     3301 tgtgggcggt gcttctcggt gcaggggaac ctacagaagc acgagcgcat acacctgggc
     3361 gtgaaggagt tcatctgtca gtattgtaac aaggcattca cactcaacga gacgctcaag
     3421 atccacgaga gaatccacac tggggagaag cgctaccact gtcagttctg ctttcagggt
     3481 ttcttgtatc tctccaccaa acggaaccac gagcggaggc acatccggga gcatgatggg
     3541 aaaggctttg cttgcttcca gtgccccaaa atatgcaaaa cagctgctgc cctcagaatg
     3601 caccaaaaga aacacttata caagacctta cctaagcaag aggaaacagg cgacacgtgc
     3661 cacgagaacg cggatctctt ggaaagtcag ctttgcactg attccgaaga cagcgaacaa
     3721 aaggatgaca taaaagcctt tgctgaaaac gtcctttgag tgacaacaac ag
//
