LOCUS       NM_020256               5122 bp    mRNA    linear   ROD 13-AUG-2024
DEFINITION  Mus musculus zinc finger and BTB domain containing 33 (Zbtb33),
            transcript variant 1, mRNA.
ACCESSION   NM_020256
VERSION     NM_020256.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5122)
  AUTHORS   Matsuzaki,H., Kimura,M., Morihashi,M. and Tanimoto,K.
  TITLE     Imprinted DNA methylation of the H19 ICR is established and
            maintained in vivo in the absence of Kaiso
  JOURNAL   Epigenetics Chromatin 17 (1), 20 (2024)
   PUBMED   38840164
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5122)
  AUTHORS   Horiguchi,H., Xu,H., Duvert,B., Ciuculescu,F., Yao,Q., Sinha,A.,
            McGuinness,M., Harris,C., Brendel,C., Troeger,A., Chiarle,R. and
            Williams,D.A.
  TITLE     Deletion of murine Rhoh leads to de-repression of Bcl-6 via
            decreased KAISO levels and accelerates a malignancy phenotype in a
            murine model of lymphoma
  JOURNAL   Small GTPases 13 (1), 267-281 (2022)
   PUBMED   34983288
  REMARK    GeneRIF: Deletion of murine Rhoh leads to de-repression of Bcl-6
            via decreased KAISO levels and accelerates a malignancy phenotype
            in a murine model of lymphoma.
REFERENCE   3  (bases 1 to 5122)
  AUTHORS   Medeiros de Araujo,J.A., Barao,S., Mateos-White,I., Espinosa,A.,
            Costa,M.R., Gil-Sanz,C. and Muller,U.
  TITLE     ZBTB20 is crucial for the specification of a subset of callosal
            projection neurons and astrocytes in the mammalian neocortex
  JOURNAL   Development 148 (16) (2021)
   PUBMED   34351428
REFERENCE   4  (bases 1 to 5122)
  AUTHORS   Illarionova,N.B., Borisova,M.A., Bazhenova,E.Y., Zabelina,D.S.,
            Fursenko,D.V. and Kulikov,A.V.
  TITLE     [Zbtb33 Gene Knockout Changes Transcription of the Fgf9, Fgfr3,
            small es, Cyrillic-capital EM, Cyrillicsmall u, Cyrillicsmall es,
            Cyrillic and FoxG1 Genes in the Developing Mouse Brain]
  JOURNAL   Mol Biol (Mosk) 55 (3), 422-430 (2021)
   PUBMED   34097677
  REMARK    GeneRIF: [Zbtb33 Gene Knockout Changes Transcription of the Fgf9,
            Fgfr3, small es, Cyrillic-capital EM, Cyrillicsmall u,
            Cyrillicsmall es, Cyrillic and FoxG1 Genes in the Developing Mouse
            Brain].
REFERENCE   5  (bases 1 to 5122)
  AUTHORS   Kaplun,D.S., Fok,R.E., Korostina,V.S., Prokhortchouk,E.B. and
            Zhenilo,S.V.
  TITLE     Kaiso Gene Knockout Promotes Somatic Cell Reprogramming
  JOURNAL   Biochemistry (Mosc) 84 (3), 283-290 (2019)
   PUBMED   31221066
  REMARK    GeneRIF: The proposed mechanisms for the increase in the efficiency
            of somatic reprogramming associated with the Kaiso gene knockout is
            a decrease in the methylation level of the Oct4 promoter region in
            mouse embryonic fibroblasts before reprogramming.
REFERENCE   6  (bases 1 to 5122)
  AUTHORS   Kim,S.W., Park,J.I., Spring,C.M., Sater,A.K., Ji,H., Otchere,A.A.,
            Daniel,J.M. and McCrea,P.D.
  TITLE     Non-canonical Wnt signals are modulated by the Kaiso
            transcriptional repressor and p120-catenin
  JOURNAL   Nat Cell Biol 6 (12), 1212-1220 (2004)
   PUBMED   15543138
  REMARK    GeneRIF: p120-catenin and Kaiso are essential components of a new
            developmental gene regulatory pathway that controls vertebrate
            morphogenesis.
REFERENCE   7  (bases 1 to 5122)
  AUTHORS   Rodova,M., Kelly,K.F., VanSaun,M., Daniel,J.M. and Werle,M.J.
  TITLE     Regulation of the rapsyn promoter by kaiso and delta-catenin
  JOURNAL   Mol Cell Biol 24 (16), 7188-7196 (2004)
   PUBMED   15282317
  REMARK    GeneRIF: These results provide the first experimental evidence that
            rapsyn is a direct sequence-specific target of Kaiso and
            delta-catenin.
REFERENCE   8  (bases 1 to 5122)
  AUTHORS   Kelly,K.F., Spring,C.M., Otchere,A.A. and Daniel,J.M.
  TITLE     NLS-dependent nuclear localization of p120ctn is necessary to
            relieve Kaiso-mediated transcriptional repression
  JOURNAL   J Cell Sci 117 (Pt 13), 2675-2686 (2004)
   PUBMED   15138284
  REMARK    Erratum:[J Cell Sci. 2004 Jul 1;117(Pt 15):3405]
REFERENCE   9  (bases 1 to 5122)
  AUTHORS   Daniel,J.M., Spring,C.M., Crawford,H.C., Reynolds,A.B. and Baig,A.
  TITLE     The p120(ctn)-binding partner Kaiso is a bi-modal DNA-binding
            protein that recognizes both a sequence-specific consensus and
            methylated CpG dinucleotides
  JOURNAL   Nucleic Acids Res 30 (13), 2911-2919 (2002)
   PUBMED   12087177
REFERENCE   10 (bases 1 to 5122)
  AUTHORS   Daniel,J.M. and Reynolds,A.B.
  TITLE     The catenin p120(ctn) interacts with Kaiso, a novel BTB/POZ domain
            zinc finger transcription factor
  JOURNAL   Mol Cell Biol 19 (5), 3614-3623 (1999)
   PUBMED   10207085
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY200826.1, AK089423.1, AK087417.1 and AL512346.41.
            
            On Nov 29, 2006 this sequence version replaced NM_020256.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC138647.1, AK089423.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-116               BY200826.1         2-117
            117-2144            AK089423.1         77-2104
            2145-2760           AK087417.1         1953-2568
            2761-5122           AL512346.41        210138-212499
FEATURES             Location/Qualifiers
     source          1..5122
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 22.45 cM"
     gene            1..5122
                     /gene="Zbtb33"
                     /gene_synonym="E130014G12Rik; Kaiso; Znf-kaiso"
                     /note="zinc finger and BTB domain containing 33"
                     /db_xref="GeneID:56805"
                     /db_xref="MGI:MGI:1927290"
     exon            1..290
                     /gene="Zbtb33"
                     /gene_synonym="E130014G12Rik; Kaiso; Znf-kaiso"
                     /inference="alignment:Splign:2.1.0"
     exon            291..5122
                     /gene="Zbtb33"
                     /gene_synonym="E130014G12Rik; Kaiso; Znf-kaiso"
                     /inference="alignment:Splign:2.1.0"
     CDS             293..2308
                     /gene="Zbtb33"
                     /gene_synonym="E130014G12Rik; Kaiso; Znf-kaiso"
                     /note="zinc finger transcription factor Kaiso; zinc finger
                     and BTB domain-containing protein 33"
                     /codon_start=1
                     /product="transcriptional regulator Kaiso"
                     /protein_id="NP_064652.2"
                     /db_xref="CCDS:CCDS30088.1"
                     /db_xref="GeneID:56805"
                     /db_xref="MGI:MGI:1927290"
                     /translation="MESRKLISATDIQYSASLLNSLNEQRGHGLFCDVTVIVEDRKFR
                     AHRNILSASSTYFHQLFSVAGQVVELSFIRAEIFAEILNYIYSSKVVRVRADLLDELI
                     KSGQLLGVKFIAELGVPLSQVKSISGTEQDGTAETLPSSSSDKSLDMEKSKDEAQDNG
                     ATVMPIITESFSLSAEDNEMKKIIVTDSDDDDDDDVIFCSEILPAKEDLPSNNTATQV
                     QPNPASVAISEVTPCASNNSPPVTNITPTQLPTPVNQATLSQTQGSEELLVSSASTHL
                     TPNIILLNQAPLTAPPSASSSLPNHMSSSVNVLVQNQQTPNSAVLTGNKAEEEEEIID
                     DDDDIISSSPDSAVSNTSLVPQADNSKSTTLDGSLTQKMQIPVLPQEPPSNSLKISDV
                     ITRNTNDPGLRSKHVMEGQKIITLDTATEIEGLSTGCKVYANIGEDTYDIVIPVKDDP
                     DGGEAKLDNELPKTSGSEPPNKRMKVKHDDHYELIVDGRVYYICIVCKRSYVCLTSLR
                     RHFNIHSWEKKYQCRYCDKVFPLAEYRTKHEIHHTGERRYQCLTCGKSFINYQFMSSH
                     IKSVHSQDPSGDSKLYRLHPCKSLQIRQYAYLSNKSSAMPVMKDDAVGYKVDAGKEPP
                     VGTTSTPPQNKSTFWEDIFIQQENDSIFKQNVTDGSTEFEFIIPESY"
     regulatory      5102..5107
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zbtb33"
                     /gene_synonym="E130014G12Rik; Kaiso; Znf-kaiso"
                     /note="hexamer: AATAAA"
     polyA_site      5122
                     /gene="Zbtb33"
                     /gene_synonym="E130014G12Rik; Kaiso; Znf-kaiso"
                     /note="major polyA site"
ORIGIN      
        1 ggaaactgga gcgacattta aagcggcagc agcggcgctg cggagtccgg ctgcttgggg
       61 taggactctg accctgcctc ggccccgagg aggagaaagc ggccgccgcg gagcaggtga
      121 ggagtgggct gggcaccggg cccgggagac ggagcccgcc tacgccttcc atgccctggc
      181 cgcgcctacg cttgcggccg cctcgcttga accaggaagc agcggagccc gaggccttgg
      241 ctcctctgct ctttctttgt gtgggtcccg gagctctacc aagagaaccg gcatggagag
      301 tagaaaactg atttctgcta cagacattca gtactctgcc agtctgctga actccttgaa
      361 tgaacagcgt ggccatggtc tcttttgtga tgttactgtt attgtggaag accgaaaatt
      421 ccgggcccat aggaacatcc tttcagcctc gagtacatac ttccatcagc tcttctcagt
      481 tgctgggcaa gttgttgaac taagctttat aagagctgag atttttgcag aaattctgaa
      541 ctatatctac agttccaaag ttgtccgtgt tagagcagat ttgcttgacg agttaattaa
      601 atcagggcag ttactaggcg tgaaatttat agcagagctt ggtgtcccac tgtcacaggt
      661 taaaagcata tcaggtacag aacaggatgg tactgctgag accttacctt ctagttctag
      721 tgacaaaagc cttgacatgg aaaaatcaaa agatgaagcc caagataatg gggctacagt
      781 aatgcccatt ataactgagt ctttttcact atctgctgaa gataatgaaa tgaaaaagat
      841 cattgttact gactcagatg atgatgatga tgacgatgtc attttctgct ctgaaatttt
      901 gcctgcaaag gaggatttgc caagtaacaa cacagcaaca caggtccagc ctaacccagc
      961 ctctgttgct atttcggaag tgacaccttg cgctagcaat aactcgcccc ctgtaacaaa
     1021 catcacacct actcaacttc ccactcctgt gaatcaggca actctaagcc aaacacaagg
     1081 aagtgaagaa ttgctagtgt cttcagcttc aacacatctg actcctaaca ttattttgtt
     1141 aaatcaggct ccacttactg caccaccgag tgccagttct tcactcccaa atcatatgtc
     1201 ctcttcagtc aatgtccttg tacagaatca gcagacgcct aacagtgctg ttttaacagg
     1261 aaacaaggct gaggaagagg aagaaattat agatgatgat gatgacatca ttagctccag
     1321 tccagactca gcagtcagta atacatctct ggtccctcag gctgataact ccaaaagtac
     1381 cactttagat ggatcattga cacagaagat gcagattcct gtacttcctc aagagccacc
     1441 ttctaattct ttaaaaattt cagatgtcat tactagaaac actaatgatc caggcttaag
     1501 gtcaaaacat gtaatggagg gtcagaagat cattacatta gatacagcta ctgaaatcga
     1561 aggcttgtca actggttgca aggtttatgc aaatatcggt gaagatactt acgatatagt
     1621 gatccctgtc aaagatgacc ctgatggagg ggaggccaaa cttgataatg agctaccaaa
     1681 aacatctggc agtgagccac caaacaagcg tatgaaagta aaacatgatg atcactatga
     1741 gttaatagta gatggaaggg tctattatat ttgcattgta tgcaaaaggt cctatgtctg
     1801 tctgacaagc ttgcgaagac attttaacat tcattcttgg gagaagaagt atcagtgccg
     1861 ttactgtgat aaagtatttc ctcttgcaga ataccgcacc aagcatgaaa tccatcacac
     1921 aggggagcga aggtatcagt gtttaacgtg tggcaaatct ttcatcaact atcagtttat
     1981 gtcttcacac ataaagtcag ttcatagtca agatccttct ggggactcaa agctttatcg
     2041 cttacatcca tgcaagtctt tacagatcag acagtatgca tacctttcta ataagtcaag
     2101 tgctatgcct gtcatgaagg atgatgctgt tggatacaag gttgatgctg gaaaagagcc
     2161 tccagtaggg accacatcta ctcctcctca gaacaagtca acgttctggg aagatatttt
     2221 tattcagcaa gaaaatgatt ccatttttaa acagaatgta accgatggca gtactgagtt
     2281 tgaatttata ataccagaat cttactgaac tcttggaata tcagaaagtt tgggttgaat
     2341 taaggggtgt ggatttcaga agacctgtaa aacaagtcaa ggtagaaacg tgttaatttg
     2401 atctaccatg tcctctgaaa gtagactagt tgcattgtta atttttagaa acagttttcc
     2461 ttaaaagttt gagtagagat tgaacacccc tgaagtatct gtatagttta gctttccgct
     2521 catttgaaaa ggtaaatttt taaaggtgca gggacatagt tttctgagta gactttgaag
     2581 aaatctaact gttctttgag aattactgga gttactaata tataccctag tacagctgat
     2641 aatgttcccc ttccaggtta acactctact gctgattttt caattttctt aatgttaagt
     2701 ctaagtgtgt tgtgttttat atggcataag aagtaataaa tgtccaaaag ttgtgctagt
     2761 aaataccaga gtaagtcctc acttggttta ttctgtcagt ccaaatggag atcagccttc
     2821 tgcttctctc ccactgtgaa atagccatgc aaacaagtct ctcctatgaa gactgagttc
     2881 gttttagcta actaggatta accatagtct gcttttgatg gcaaggccac tatatgcctt
     2941 taaactatgg tcctggggtt acagggagct agcaaacatg catgtggtgt agccggggga
     3001 ttcctttgtg cttatcattg ctcttctgcc tttatatgct agcagcagtc aagttgaatg
     3061 gagagctcct tttgttaatt atgaaaacgt tcccacaaaa tgctgtgaat ttattatctg
     3121 aaagccacca aatgcatctt tatatgtaat gctagtaaat gttgcgattc catagatgag
     3181 acttgtggtt tgggggcggg gggcgggggg gggggcggcg aggaggggga gggaggctgc
     3241 tggcacagct ttttaaatgc tcatgttaga atctccagtg ggaagttttc attttaagta
     3301 atttaaatgg caatctagaa ttgtcatttc aacaaggtct tttgagtttt tttaacccct
     3361 taaaataagt tccaatctgt gtgcaaactg ctgctatatt atagcagaaa ccataactgg
     3421 aatactggag gcaaatggct tcttgtttat tttgacaata atgccagctt tcctcctttt
     3481 aagatgacac atatttaaac acttagaaga atttaaaatt tacccaaaag ctagtaataa
     3541 aagaaagcag gttggaacag atatatagtt tagcatttat aacagattta atacaactct
     3601 gtaaaaaaat taatgttttg caatggaaaa aataatagat actgaaaatg gttgttgttg
     3661 gatagttgtt agtcatttgt gatcttgctt atatatttct tagttcagca taaggtattt
     3721 tcattctctg tgtatttttg tctatttctt gacattgaac gtaaagcttt aatcatgctc
     3781 ttttatatat aggtcattct tctggttaaa ctaggtgtga agatgaagtt ttcagtgttt
     3841 cttaagttgg tagctgaggg tatcaagaat cagtatttgc aggaatacaa aggaagagga
     3901 tagtcccggc ttaccaagag gtagaatgct gtacatttat gttttggttt ttggtaagct
     3961 taagcctacc atcataagct aactcttaga aaacttaaaa tcactttata gctcaagact
     4021 ctgatttctc tcacaatatt catttccttt ctctgtagct attgatggca ctaccttttg
     4081 aatatagggt ctgctcaaaa gcagctctca attgaaaaat gtgtttcatg aatgcagtct
     4141 cagcagttag acataattgc ttctaccagt gtcggtgata aggatgtttt ggtgtcaact
     4201 gctaggtaaa atcagtttgt cataataaga cttgctaatt cctacaagcc tattacaaca
     4261 aactgggaat tttataatga aaaactatct gttctgaata acattggtca aatgattcac
     4321 tactactgct gtgctctgct ctgtcaagtc tctaataaga acttttaaac tttgtgccta
     4381 ctgaaaagca gcttctagag tttgcaggga ggacaagaac tagaaagtta aattgtaatt
     4441 ttgccaggaa gactcttcca tgtgttcggg gattttttaa atagctttat atatccaacc
     4501 ttgagaggtt tttgtggaat actcctctgg acaataactc tttactccta gccattatta
     4561 gattggaatt ttgtagcaaa atgctattta aaatctactg tgaatatttt tctacttagc
     4621 tttctgacta ctgatttttt ttttttttac tgttctttca agttggcttc aatttcactc
     4681 aacttctaaa ttatctgtag ttatttttgg tagaatctat ttgaaatagt aaatttgttc
     4741 aaagtataag ccaacatttt aaaaaggtta tagcattctt gcaagattaa atagggataa
     4801 ttttgttatc attttggtgg tcactatcct ccactcagag tcactgaaga atttgttcaa
     4861 ttgggctaaa aagataaaaa caaatgaacc ctgctgtagg catttaaaat gttatagtgt
     4921 gtgcattttg aggaattaaa tgtaaattca atagcactgg cttctttacc tctgttagtc
     4981 atatgaaacc ttgttcattt ccccaattac tgtacatttt catatttgta caatcttcct
     5041 tatcataagt tctgcttttc attaactgtt acctgatatt agttcataga gtttatcaca
     5101 aaataaaaca tattcattct aa
//
