LOCUS       NP_064652                671 aa            linear   ROD 27-APR-2025
DEFINITION  transcriptional regulator Kaiso [Mus musculus].
ACCESSION   NP_064652
VERSION     NP_064652.2
DBSOURCE    REFSEQ: accession NM_020256.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 671)
  AUTHORS   Matsuzaki,H., Kimura,M., Morihashi,M. and Tanimoto,K.
  TITLE     Imprinted DNA methylation of the H19 ICR is established and
            maintained in vivo in the absence of Kaiso
  JOURNAL   Epigenetics Chromatin 17 (1), 20 (2024)
   PUBMED   38840164
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 671)
  AUTHORS   Horiguchi,H., Xu,H., Duvert,B., Ciuculescu,F., Yao,Q., Sinha,A.,
            McGuinness,M., Harris,C., Brendel,C., Troeger,A., Chiarle,R. and
            Williams,D.A.
  TITLE     Deletion of murine Rhoh leads to de-repression of Bcl-6 via
            decreased KAISO levels and accelerates a malignancy phenotype in a
            murine model of lymphoma
  JOURNAL   Small GTPases 13 (1), 267-281 (2022)
   PUBMED   34983288
  REMARK    GeneRIF: Deletion of murine Rhoh leads to de-repression of Bcl-6
            via decreased KAISO levels and accelerates a malignancy phenotype
            in a murine model of lymphoma.
REFERENCE   3  (residues 1 to 671)
  AUTHORS   Medeiros de Araujo,J.A., Barao,S., Mateos-White,I., Espinosa,A.,
            Costa,M.R., Gil-Sanz,C. and Muller,U.
  TITLE     ZBTB20 is crucial for the specification of a subset of callosal
            projection neurons and astrocytes in the mammalian neocortex
  JOURNAL   Development 148 (16) (2021)
   PUBMED   34351428
REFERENCE   4  (residues 1 to 671)
  AUTHORS   Illarionova,N.B., Borisova,M.A., Bazhenova,E.Y., Zabelina,D.S.,
            Fursenko,D.V. and Kulikov,A.V.
  TITLE     [Zbtb33 Gene Knockout Changes Transcription of the Fgf9, Fgfr3,
            small es, Cyrillic-capital EM, Cyrillicsmall u, Cyrillicsmall es,
            Cyrillic and FoxG1 Genes in the Developing Mouse Brain]
  JOURNAL   Mol Biol (Mosk) 55 (3), 422-430 (2021)
   PUBMED   34097677
  REMARK    GeneRIF: [Zbtb33 Gene Knockout Changes Transcription of the Fgf9,
            Fgfr3, small es, Cyrillic-capital EM, Cyrillicsmall u,
            Cyrillicsmall es, Cyrillic and FoxG1 Genes in the Developing Mouse
            Brain].
REFERENCE   5  (residues 1 to 671)
  AUTHORS   Kaplun,D.S., Fok,R.E., Korostina,V.S., Prokhortchouk,E.B. and
            Zhenilo,S.V.
  TITLE     Kaiso Gene Knockout Promotes Somatic Cell Reprogramming
  JOURNAL   Biochemistry (Mosc) 84 (3), 283-290 (2019)
   PUBMED   31221066
  REMARK    GeneRIF: The proposed mechanisms for the increase in the efficiency
            of somatic reprogramming associated with the Kaiso gene knockout is
            a decrease in the methylation level of the Oct4 promoter region in
            mouse embryonic fibroblasts before reprogramming.
REFERENCE   6  (residues 1 to 671)
  AUTHORS   Kim,S.W., Park,J.I., Spring,C.M., Sater,A.K., Ji,H., Otchere,A.A.,
            Daniel,J.M. and McCrea,P.D.
  TITLE     Non-canonical Wnt signals are modulated by the Kaiso
            transcriptional repressor and p120-catenin
  JOURNAL   Nat Cell Biol 6 (12), 1212-1220 (2004)
   PUBMED   15543138
  REMARK    GeneRIF: p120-catenin and Kaiso are essential components of a new
            developmental gene regulatory pathway that controls vertebrate
            morphogenesis.
REFERENCE   7  (residues 1 to 671)
  AUTHORS   Rodova,M., Kelly,K.F., VanSaun,M., Daniel,J.M. and Werle,M.J.
  TITLE     Regulation of the rapsyn promoter by kaiso and delta-catenin
  JOURNAL   Mol Cell Biol 24 (16), 7188-7196 (2004)
   PUBMED   15282317
  REMARK    GeneRIF: These results provide the first experimental evidence that
            rapsyn is a direct sequence-specific target of Kaiso and
            delta-catenin.
REFERENCE   8  (residues 1 to 671)
  AUTHORS   Kelly,K.F., Spring,C.M., Otchere,A.A. and Daniel,J.M.
  TITLE     NLS-dependent nuclear localization of p120ctn is necessary to
            relieve Kaiso-mediated transcriptional repression
  JOURNAL   J Cell Sci 117 (Pt 13), 2675-2686 (2004)
   PUBMED   15138284
  REMARK    Erratum:[J Cell Sci. 2004 Jul 1;117(Pt 15):3405]
REFERENCE   9  (residues 1 to 671)
  AUTHORS   Daniel,J.M., Spring,C.M., Crawford,H.C., Reynolds,A.B. and Baig,A.
  TITLE     The p120(ctn)-binding partner Kaiso is a bi-modal DNA-binding
            protein that recognizes both a sequence-specific consensus and
            methylated CpG dinucleotides
  JOURNAL   Nucleic Acids Res 30 (13), 2911-2919 (2002)
   PUBMED   12087177
REFERENCE   10 (residues 1 to 671)
  AUTHORS   Daniel,J.M. and Reynolds,A.B.
  TITLE     The catenin p120(ctn) interacts with Kaiso, a novel BTB/POZ domain
            zinc finger transcription factor
  JOURNAL   Mol Cell Biol 19 (5), 3614-3623 (1999)
   PUBMED   10207085
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY200826.1, AK089423.1, AK087417.1 and AL512346.41.
            
            On Nov 29, 2006 this sequence version replaced NP_064652.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC138647.1, AK089423.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..671
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 22.45 cM"
     Protein         1..671
                     /product="transcriptional regulator Kaiso"
                     /note="zinc finger transcription factor Kaiso; zinc finger
                     and BTB domain-containing protein 33"
                     /calculated_mol_wt=73919
     Region          1..136
                     /region_name="Self-association"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BN78.1)"
     Region          1..103
                     /region_name="Interaction with NCOR1.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BN78.1)"
     Region          11..116
                     /region_name="BTB_POZ_ZBTB33_KAISO"
                     /note="BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ
                     (poxvirus and zinc finger) domain found in Kaiso; cd18219"
                     /db_xref="CDD:349528"
     Region          127..161
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BN78.1)"
     Site            251
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q86T24; propagated from
                     UniProtKB/Swiss-Prot (Q8BN78.1)"
     Region          298..571
                     /region_name="Interaction with CBFA2T3.
                     /evidence=ECO:0000250|UniProtKB:Q86T24"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BN78.1)"
     Region          332..365
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BN78.1)"
     Region          451..474
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BN78.1)"
     Region          452..671
                     /region_name="Interaction with CTNND1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BN78.1)"
     Region          469..478
                     /region_name="Nuclear localization signal.
                     /evidence=ECO:0000269|PubMed:15564377"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BN78.1)"
     Region          494..514
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(499,501,503,505..506,509..510,513,527,529,533..534,
                     537..538,541,555,557,559,561..562,565..566,570)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          506..529
                     /region_name="zf-H2C2_2"
                     /note="Zinc-finger double domain; pfam13465"
                     /db_xref="CDD:463886"
     Region          512..637
                     /region_name="Required for DNA-binding"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BN78.1)"
     Region          522..542
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          537..559
                     /region_name="zf-H2C2_2"
                     /note="Zinc-finger double domain; pfam13465"
                     /db_xref="CDD:463886"
     Region          550..571
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     CDS             1..671
                     /gene="Zbtb33"
                     /gene_synonym="E130014G12Rik; Kaiso; Znf-kaiso"
                     /coded_by="NM_020256.2:293..2308"
                     /db_xref="CCDS:CCDS30088.1"
                     /db_xref="GeneID:56805"
                     /db_xref="MGI:MGI:1927290"
ORIGIN      
        1 mesrklisat diqysaslln slneqrghgl fcdvtvived rkfrahrnil sasstyfhql
       61 fsvagqvvel sfiraeifae ilnyiysskv vrvradllde liksgqllgv kfiaelgvpl
      121 sqvksisgte qdgtaetlps sssdksldme kskdeaqdng atvmpiites fslsaednem
      181 kkiivtdsdd dddddvifcs eilpakedlp snntatqvqp npasvaisev tpcasnnspp
      241 vtnitptqlp tpvnqatlsq tqgseellvs sasthltpni illnqaplta ppsassslpn
      301 hmsssvnvlv qnqqtpnsav ltgnkaeeee eiidddddii ssspdsavsn tslvpqadns
      361 ksttldgslt qkmqipvlpq eppsnslkis dvitrntndp glrskhvmeg qkiitldtat
      421 eieglstgck vyanigedty divipvkddp dggeakldne lpktsgsepp nkrmkvkhdd
      481 hyelivdgrv yyicivckrs yvcltslrrh fnihswekky qcrycdkvfp laeyrtkhei
      541 hhtgerryqc ltcgksfiny qfmsshiksv hsqdpsgdsk lyrlhpcksl qirqyaylsn
      601 kssampvmkd davgykvdag keppvgttst ppqnkstfwe difiqqends ifkqnvtdgs
      661 tefefiipes y
//
