LOCUS       NM_021397               1783 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus zinc finger and BTB domain containing 32 (Zbtb32),
            transcript variant 1, mRNA.
ACCESSION   NM_021397
VERSION     NM_021397.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1783)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1783)
  AUTHORS   Medeiros de Araujo,J.A., Barao,S., Mateos-White,I., Espinosa,A.,
            Costa,M.R., Gil-Sanz,C. and Muller,U.
  TITLE     ZBTB20 is crucial for the specification of a subset of callosal
            projection neurons and astrocytes in the mammalian neocortex
  JOURNAL   Development 148 (16) (2021)
   PUBMED   34351428
REFERENCE   3  (bases 1 to 1783)
  AUTHORS   Van Wyngene,L., Vanderhaeghen,T., Petta,I., Timmermans,S.,
            Corbeels,K., Van der Schueren,B., Vandewalle,J., Van Looveren,K.,
            Wallaeys,C., Eggermont,M., Dewaele,S., Catrysse,L., van Loo,G.,
            Beyaert,R., Vangoitsenhoven,R., Nakayama,T., Tavernier,J., De
            Bosscher,K. and Libert,C.
  TITLE     ZBTB32 performs crosstalk with the glucocorticoid receptor and is
            crucial in glucocorticoid responses to starvation
  JOURNAL   iScience 24 (7), 102790 (2021)
   PUBMED   34337361
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1783)
  AUTHORS   Jash,A., Zhou,Y.W., Gerardo,D.K., Ripperger,T.J., Parikh,B.A.,
            Piersma,S., Jamwal,D.R., Kiela,P.R., Boon,A.C.M., Yokoyama,W.M.,
            Hsieh,C.S. and Bhattacharya,D.
  TITLE     ZBTB32 restrains antibody responses to murine cytomegalovirus
            infections, but not other repetitive challenges
  JOURNAL   Sci Rep 9 (1), 15257 (2019)
   PUBMED   31649328
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1783)
  AUTHORS   Adams,N.M., Lau,C.M., Fan,X., Rapp,M., Geary,C.D., Weizman,O.E.,
            Diaz-Salazar,C. and Sun,J.C.
  TITLE     Transcription Factor IRF8 Orchestrates the Adaptive Natural Killer
            Cell Response
  JOURNAL   Immunity 48 (6), 1172-1182 (2018)
   PUBMED   29858012
REFERENCE   6  (bases 1 to 1783)
  AUTHORS   Miaw,S.C., Kang,B.Y., White,I.A. and Ho,I.C.
  TITLE     A repressor of GATA-mediated negative feedback mechanism of T cell
            activation
  JOURNAL   J Immunol 172 (1), 170-177 (2004)
   PUBMED   14688323
  REMARK    GeneRIF: ROG is a critical part of a transcription factor
            NF-ATc2-initiated negative feedback mechanism of T cell activation.
REFERENCE   7  (bases 1 to 1783)
  AUTHORS   Omori,M., Yamashita,M., Inami,M., Ukai-Tadenuma,M., Kimura,M.,
            Nigo,Y., Hosokawa,H., Hasegawa,A., Taniguchi,M. and Nakayama,T.
  TITLE     CD8 T cell-specific downregulation of histone hyperacetylation and
            gene activation of the IL-4 gene locus by ROG, repressor of GATA
  JOURNAL   Immunity 19 (2), 281-294 (2003)
   PUBMED   12932361
  REMARK    GeneRIF: ROG may confer CD8 T cell-specific repression of histone
            hyperacetylation and activation of the IL-4 gene locus.
REFERENCE   8  (bases 1 to 1783)
  AUTHORS   Sutherland,H.G., Mumford,G.K., Newton,K., Ford,L.V., Farrall,R.,
            Dellaire,G., Caceres,J.F. and Bickmore,W.A.
  TITLE     Large-scale identification of mammalian proteins localized to
            nuclear sub-compartments
  JOURNAL   Hum Mol Genet 10 (18), 1995-2011 (2001)
   PUBMED   11555636
REFERENCE   9  (bases 1 to 1783)
  AUTHORS   Tang,C.J., Chuang,C.K., Hu,H.M. and Tang,T.K.
  TITLE     The zinc finger domain of Tzfp binds to the tbs motif located at
            the upstream flanking region of the Aie1 (aurora-C) kinase gene
  JOURNAL   J Biol Chem 276 (22), 19631-19639 (2001)
   PUBMED   11279021
REFERENCE   10 (bases 1 to 1783)
  AUTHORS   Miaw,S.C., Choi,A., Yu,E., Kishikawa,H. and Ho,I.C.
  TITLE     ROG, repressor of GATA, regulates the expression of cytokine genes
  JOURNAL   Immunity 12 (3), 323-333 (2000)
   PUBMED   10755619
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY349526.1, AF241232.1, AC167970.4 and AK015881.1.
            
            On Mar 23, 2007 this sequence version replaced NM_021397.1.
            
            Transcript Variant: This variant (1) represents the protein-coding
            transcript.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: AF241232.1, BC137687.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMN00849375, SAMN00849380 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-205               BY349526.1         2-206
            206-1038            AF241232.1         115-947
            1039-1083           AC167970.4         29614-29658
            1084-1773           AK015881.1         167-856
            1774-1783           AF241232.1         1683-1692
FEATURES             Location/Qualifiers
     source          1..1783
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 18.72 cM"
     gene            1..1783
                     /gene="Zbtb32"
                     /gene_synonym="4930524C15Rik; FAXF; FAZF; PLZP; Rog; Tzfp"
                     /note="zinc finger and BTB domain containing 32"
                     /db_xref="GeneID:58206"
                     /db_xref="MGI:MGI:1891838"
     exon            1..31
                     /gene="Zbtb32"
                     /gene_synonym="4930524C15Rik; FAXF; FAZF; PLZP; Rog; Tzfp"
                     /inference="alignment:Splign:2.1.0"
     exon            32..940
                     /gene="Zbtb32"
                     /gene_synonym="4930524C15Rik; FAXF; FAZF; PLZP; Rog; Tzfp"
                     /inference="alignment:Splign:2.1.0"
     CDS             129..1526
                     /gene="Zbtb32"
                     /gene_synonym="4930524C15Rik; FAXF; FAZF; PLZP; Rog; Tzfp"
                     /note="repressor of GATA; GATA repressor; testis zinc
                     finger protein"
                     /codon_start=1
                     /product="zinc finger and BTB domain-containing protein
                     32"
                     /protein_id="NP_067372.2"
                     /db_xref="CCDS:CCDS21102.1"
                     /db_xref="GeneID:58206"
                     /db_xref="MGI:MGI:1891838"
                     /translation="MPQTPTRLISPYGSDRLVQLAARLRPALCDTLITVGGLEFPAHS
                     LVLAGASPRLGCRGRWALVEDISPSTFAQILTFVYGESIELQPGELGDLEEAAKALGV
                     QALEEACQRAQKGKDEDELDPGLKRHQQSEDFMRGSERGLGSPGEKQKPEKDFRSNGR
                     EQEMSHKHKAPGERPEMAGATRMMSSEEVMRGIESHKGSEESLRGCPDPLSPPGSLLT
                     SLIPRPWWAEVPRLGEGQSALWSILLWPSRYGAPFSHSTPITAAWQVRPQDQRIPLTL
                     NHSKALWSQNQLASSSPTPGSFPQGTETLSPWQIETSGQGFTGTLATCVSQERTLNCP
                     SHQHPPLPSPARSRPYSCSVCGKRFSLKHQMETHYRVHTGEKPFSCSLCPQRSRDFSA
                     MTKHLRTHGAAPYRCPLCRAGCPSLASMQAHMRGHSPSRLPPGWTIRSTFLYSSSRPT
                     RASSSPGSPTSSAAT"
     exon            941..1014
                     /gene="Zbtb32"
                     /gene_synonym="4930524C15Rik; FAXF; FAZF; PLZP; Rog; Tzfp"
                     /inference="alignment:Splign:2.1.0"
     exon            1015..1083
                     /gene="Zbtb32"
                     /gene_synonym="4930524C15Rik; FAXF; FAZF; PLZP; Rog; Tzfp"
                     /inference="alignment:Splign:2.1.0"
     exon            1084..1248
                     /gene="Zbtb32"
                     /gene_synonym="4930524C15Rik; FAXF; FAZF; PLZP; Rog; Tzfp"
                     /inference="alignment:Splign:2.1.0"
     exon            1249..1775
                     /gene="Zbtb32"
                     /gene_synonym="4930524C15Rik; FAXF; FAZF; PLZP; Rog; Tzfp"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1751..1756
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zbtb32"
                     /gene_synonym="4930524C15Rik; FAXF; FAZF; PLZP; Rog; Tzfp"
                     /note="hexamer: AATAAA"
     polyA_site      1775
                     /gene="Zbtb32"
                     /gene_synonym="4930524C15Rik; FAXF; FAZF; PLZP; Rog; Tzfp"
                     /note="major polyA site"
ORIGIN      
        1 gagcatgcgg tactaggagg cagctacaga ggccagagag tatgcggttt ctctcccact
       61 tcaatcatgg atcccccatt gtggctttcc tctcagagcc tgtgaaactg gtagattagc
      121 caggaacaat gccccagacc cccacaagac taatcagccc atatggctct gataggttgg
      181 tacagttagc ggctagactc cggccagcac tgtgtgatac cctgatcaca gtagggggcc
      241 tggagttccc ggctcacagc ctagtgctgg caggtgcaag cccaaggctt ggctgcaggg
      301 gccggtgggc tctggttgaa gacataagcc cttccacctt tgctcagatt ctgacctttg
      361 tctatggaga gagtatagag ctacagcctg gggagctggg ggaccttgaa gaggcagcca
      421 aagccttggg ggtacaggcc ttggaagagg cctgtcagag agctcaaaag ggcaaggatg
      481 aagatgagct ggatccagga ctgaagaggc accagcaatc agaagacttc atgaggggct
      541 ctgagagagg acttgggagt cctggagaga aacagaagcc agagaaggat tttagaagta
      601 atgggagaga acaggagatg tcacacaagc ataaagcacc cggagagagg cctgagatgg
      661 caggagcaac taggatgatg agctcagagg aggtcatgcg aggtatcgag agccacaagg
      721 gctctgagga gagtcttcgt gggtgccctg atcccctttc cccaccaggt tccctcctaa
      781 ctagcctcat tcccaggccc tggtgggctg aagtccctag gttgggggag ggccagtcgg
      841 ccttgtggag catcttgttg tggccctcca gatacggtgc tcccttctcc catagtaccc
      901 ccatcactgc ggcctggcag gtccggcctc aagatcagag gatcccactg accttgaacc
      961 actccaaagc tctctggagt cagaatcagc tggcttcctc tagccccact ccaggatctt
     1021 ttccccaggg cactgaaacc ctcagccctt ggcagataga aacgtctggg caagggttca
     1081 caggcacact ggcaacctgt gtgagtcagg agcgcacact gaactgccca tctcaccaac
     1141 accctccttt accctctcct gctcgctctc ggccctattc ttgctctgtg tgtggaaaga
     1201 ggttttcact caagcatcag atggagacac attaccgagt ccacacagga gagaagccct
     1261 tctcctgtag cctctgtcct cagcgctccc gggatttctc tgccatgacc aagcacctga
     1321 ggacacatgg ggctgctccc tatcgatgcc ctctgtgcag ggctggctgc cctagcctgg
     1381 cctccatgca ggcgcacatg cgtggccact cgcccagccg gctgccgcct ggatggacca
     1441 tacgctccac cttcctctac tcttcctcga ggccgacccg ggcctccagc tctcccggta
     1501 gtcctacctc ctctgctgcc acctgaccgg gtgttggtag cttctctggc ttgacaaaga
     1561 gtccaaagaa tgaaaggcag aagggctcag ctagggcggc ctggcaaatt taaccacaga
     1621 agaactgcga gacaggagct acgaaccctt ccgggacaag cgagttgcag aagcctcggc
     1681 ctggcgagcc cgagttaaag gacaattaac tcggtgaaga ttaactgggg actgtcaatt
     1741 tcatcactat aataaagttt cctgtgctcc agtcaaaaaa aaa
//
