LOCUS       NM_153398               2877 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus zinc finger and BTB domain containing 24 (Zbtb24),
            transcript variant 1, mRNA.
ACCESSION   NM_153398
VERSION     NM_153398.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2877)
  AUTHORS   Gao,H., Zhao,Y., Zhao,S., Dai,X.Q., Qin,X.Y., Zheng,W.L., He,T.T.,
            Zhang,N., Zhu,C., Wang,H.M., Pan,W., Zhu,X.M., Gao,X.M., Dai,J.F.,
            Gong,F.Y. and Wang,J.
  TITLE     The ICF2 gene Zbtb24 specifically regulates the differentiation of
            B1 cells via promoting heme synthesis
  JOURNAL   Cell Mol Biol Lett 29 (1), 123 (2024)
   PUBMED   39277732
  REMARK    GeneRIF: The ICF2 gene Zbtb24 specifically regulates the
            differentiation of B1 cells via promoting heme synthesis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2877)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2877)
  AUTHORS   Ying,Z., Hardikar,S., Plummer,J.B., Hamidi,T., Liu,B., Chen,Y.,
            Shen,J., Mu,Y., McBride,K.M. and Chen,T.
  TITLE     Enhanced CD19 activity in B cells contributes to immunodeficiency
            in mice deficient in the ICF syndrome gene Zbtb24
  JOURNAL   Cell Mol Immunol 20 (12), 1487-1498 (2023)
   PUBMED   37990035
  REMARK    GeneRIF: Enhanced CD19 activity in B cells contributes to
            immunodeficiency in mice deficient in the ICF syndrome gene Zbtb24.
            Erratum:[Cell Mol Immunol. 2024 Jan;21(1):100. doi:
            10.1038/s41423-023-01114-w.. PMID: 38114748]
REFERENCE   4  (bases 1 to 2877)
  AUTHORS   Medeiros de Araujo,J.A., Barao,S., Mateos-White,I., Espinosa,A.,
            Costa,M.R., Gil-Sanz,C. and Muller,U.
  TITLE     ZBTB20 is crucial for the specification of a subset of callosal
            projection neurons and astrocytes in the mammalian neocortex
  JOURNAL   Development 148 (16) (2021)
   PUBMED   34351428
REFERENCE   5  (bases 1 to 2877)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2877)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   7  (bases 1 to 2877)
  AUTHORS   Wu,H., Thijssen,P.E., de Klerk,E., Vonk,K.K., Wang,J., den
            Hamer,B., Aytekin,C., van der Maarel,S.M. and Daxinger,L.
  TITLE     Converging disease genes in ICF syndrome: ZBTB24 controls
            expression of CDCA7 in mammals
  JOURNAL   Hum Mol Genet 25 (18), 4041-4051 (2016)
   PUBMED   27466202
  REMARK    GeneRIF: Transcriptome analysis identified Cdca7 as the top
            down-regulated gene in Zbtb24 homozygous mutant mESCs, which can be
            restored by ectopic ZBTB24 expression. Finally, we show that this
            regulation is conserved between species and that CDCA7 levels are
            reduced in patients carrying ZBTB24 nonsense mutations
REFERENCE   8  (bases 1 to 2877)
  AUTHORS   Nagamachi,A., Matsui,H., Asou,H., Ozaki,Y., Aki,D., Kanai,A.,
            Takubo,K., Suda,T., Nakamura,T., Wolff,L., Honda,H. and Inaba,T.
  TITLE     Haploinsufficiency of SAMD9L, an endosome fusion facilitator,
            causes myeloid malignancies in mice mimicking human diseases with
            monosomy 7
  JOURNAL   Cancer Cell 24 (3), 305-317 (2013)
   PUBMED   24029230
REFERENCE   9  (bases 1 to 2877)
  AUTHORS   de Greef,J.C., Wang,J., Balog,J., den Dunnen,J.T., Frants,R.R.,
            Straasheijm,K.R., Aytekin,C., van der Burg,M., Duprez,L.,
            Ferster,A., Gennery,A.R., Gimelli,G., Reisli,I., Schuetz,C.,
            Schulz,A., Smeets,D.F.C.M., Sznajer,Y., Wijmenga,C., van
            Eggermond,M.C., van Ostaijen-Ten Dam,M.M., Lankester,A.C., van
            Tol,M.J.D., van den Elsen,P.J., Weemaes,C.M. and van der
            Maarel,S.M.
  TITLE     Mutations in ZBTB24 are associated with immunodeficiency,
            centromeric instability, and facial anomalies syndrome type 2
  JOURNAL   Am J Hum Genet 88 (6), 796-804 (2011)
   PUBMED   21596365
  REMARK    GeneRIF: mutation of human Zbtb24 causes ICF syndrome
REFERENCE   10 (bases 1 to 2877)
  AUTHORS   Edgar,A.J., Dover,S.L., Lodrick,M.N., McKay,I.J., Hughes,F.J. and
            Turner,W.
  TITLE     Bone morphogenetic protein-2 induces expression of murine zinc
            finger transcription factor ZNF450
  JOURNAL   J Cell Biochem 94 (1), 202-215 (2005)
   PUBMED   15526281
  REMARK    GeneRIF: consistent induction of ZNF450 by BMP-2 after 4 h in three
            murine pluripotent cell lines suggests that ZNF450 may play a role
            in the BMP-2 signalling pathway
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC153360.6 and BC050933.1.
            
            On Mar 22, 2013 this sequence version replaced NM_153398.2.
            
            Summary: This gene encodes a protein containing eight C2H2-type
            zinc fingers and a BTB domain. Expression of this gene is induced
            by bone morphogenetic protein-2 signaling. Mutation of the related
            gene in humans causes immunodeficiency-centromeric
            instability-facial anomalies syndrome-2. Alternative splicing
            results in multiple transcript variants. [provided by RefSeq, Mar
            2013].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC050933.1, AY210402.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-38                AC153360.6         174841-174878
            39-2869             BC050933.1         1-2831
            2870-2877           AC153360.6         190058-190065
FEATURES             Location/Qualifiers
     source          1..2877
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 22.38 cM"
     gene            1..2877
                     /gene="Zbtb24"
                     /gene_synonym="Bif1; Bsg1; ZNF450"
                     /note="zinc finger and BTB domain containing 24"
                     /db_xref="GeneID:268294"
                     /db_xref="MGI:MGI:3039618"
     exon            1..173
                     /gene="Zbtb24"
                     /gene_synonym="Bif1; Bsg1; ZNF450"
                     /inference="alignment:Splign:2.1.0"
     exon            174..1153
                     /gene="Zbtb24"
                     /gene_synonym="Bif1; Bsg1; ZNF450"
                     /inference="alignment:Splign:2.1.0"
     CDS             205..2337
                     /gene="Zbtb24"
                     /gene_synonym="Bif1; Bsg1; ZNF450"
                     /note="isoform 1 is encoded by transcript variant 1; zinc
                     finger protein 450; zinc finger and BTB domain-containing
                     protein 24; BMP-induced factor 1; brain specific protein
                     1; bone morphogenetic protein-induced factor 1"
                     /codon_start=1
                     /product="zinc finger and BTB domain-containing protein 24
                     isoform 1"
                     /protein_id="NP_700447.2"
                     /db_xref="CCDS:CCDS23804.1"
                     /db_xref="GeneID:268294"
                     /db_xref="MGI:MGI:3039618"
                     /translation="MADTTPEPCGQLMVHSDTHSDTVLASLEDQRKKGFLCDITLIVE
                     NVHFRAHKALLAASSEYFSMMFAEEGEIGQSIYMLEGMVADTFGILLEFIYTGYLHAS
                     EKTTEQILATAQFLKVYDLVKAYADFQDNHSAPKPPALNCTGTPVVVISNKKNDPLKR
                     KRGRPRKANGLQEGRSELAAEGELQLRVNNSVQNRQNFVFKEEDSVKLSEQTPEDKES
                     EPAGEPGSVEEVPAEKDENFDPKAGDGQESQSRCSRRRIRRSVKLKDYKLLGDEDDQS
                     TAKRLCGRKKRSSGPEARCKDCDRVFKYSHFLAIHQRRHTGERPFKCNECGKGFAQKH
                     SLQVHTRMHTGERPYTCTVCGKALTTKHSLLEHMSLHSGQKSFTCDQCGKYFSQKRQL
                     KSHYRVHTGHSLPECSHCHRKFMDVSQLKKHLRTHTGEKPFTCEICGKSFTAKSSLQT
                     HIRIHRGEKPYSCSICGKCFSDSSAKRRHCILHTGKKPFSCPECGLQFARLDNLKAHL
                     KIHSKEKHTADSSSVSGSNVDEGRNILQLQPYQLSTSGEQEIQLLVTDSVHNINFMPG
                     PSQGVSIVAAESPQSMATDPAANITLLTQQPEQLQGLILSAQQEQAEHIQSLSVIGGQ
                     MESSQTEPVHVITLSKETLEHLHAHQEQTTSSVPAADTGARATPVPSTRPGAELTQAP
                     LAVPLDPSPGATVAGWPFGPSSYRSLKM"
     exon            1154..1321
                     /gene="Zbtb24"
                     /gene_synonym="Bif1; Bsg1; ZNF450"
                     /inference="alignment:Splign:2.1.0"
     exon            1322..1405
                     /gene="Zbtb24"
                     /gene_synonym="Bif1; Bsg1; ZNF450"
                     /inference="alignment:Splign:2.1.0"
     exon            1406..1489
                     /gene="Zbtb24"
                     /gene_synonym="Bif1; Bsg1; ZNF450"
                     /inference="alignment:Splign:2.1.0"
     exon            1490..1571
                     /gene="Zbtb24"
                     /gene_synonym="Bif1; Bsg1; ZNF450"
                     /inference="alignment:Splign:2.1.0"
     exon            1572..2877
                     /gene="Zbtb24"
                     /gene_synonym="Bif1; Bsg1; ZNF450"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2790..2795
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zbtb24"
                     /gene_synonym="Bif1; Bsg1; ZNF450"
                     /note="hexamer: ATTAAA"
     polyA_site      2821
                     /gene="Zbtb24"
                     /gene_synonym="Bif1; Bsg1; ZNF450"
     regulatory      2849..2854
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zbtb24"
                     /gene_synonym="Bif1; Bsg1; ZNF450"
                     /note="hexamer: AATAAA"
     polyA_site      2875
                     /gene="Zbtb24"
                     /gene_synonym="Bif1; Bsg1; ZNF450"
                     /note="major polyA site"
ORIGIN      
        1 ggggtcacgt gatgctacgg cccttgtgcg cgcttccggg ttgacagacg ccgggagtcc
       61 ggagctacag cgtagtggtg gcgggggcgg ggaccggcga caggcccggt tagtgccctc
      121 tgggcagccg ggtgggctga ccgtagcaag tccctgcggg gcggccctga cagatttaag
      181 cctcttcaga gtcttctgga gaaaatggca gacacaaccc cggagccttg tgggcagctt
      241 atggtacact cagacactca cagtgacact gtgctggcca gtctggagga tcaaaggaag
      301 aagggctttc tttgtgatat tactttaatc gtggagaatg tgcatttccg agcccataaa
      361 gccttgctgg ccgccagtag cgagtatttc tcaatgatgt ttgcggaaga gggcgagatt
      421 ggccagtcta tctacatgct ggaaggcatg gttgcagaca cctttggcat cctgctggaa
      481 tttatctata caggttatct acatgccagt gagaaaacga cagagcagat cctggctact
      541 gctcagttct taaaagtcta tgacctggta aaggcatacg cagacttcca ggataaccat
      601 agcgccccaa agccaccagc tttgaactgc actgggacgc cagtggtggt tatttccaat
      661 aagaagaacg atcctctgaa acggaaacgg ggaagaccaa gaaaagccaa tggtttgcag
      721 gaagggagat cagaactggc tgcagaggga gagctgcagc tgagagtgaa caattcagtt
      781 cagaatagac aaaactttgt gtttaaagaa gaagacagtg tcaagctgag tgagcagact
      841 ccagaagaca aggaatcaga gcctgctggt gagccaggaa gcgtggagga ggtgcctgct
      901 gaaaaggacg agaactttga ccccaaggct ggggatggac aggagagcca gagtaggtgc
      961 agcaggcgga gaatccgcag gtctgtcaag ctcaaagact acaagcttct tggagatgaa
     1021 gatgaccaga gtactgccaa gaggctatgt ggaagaaaaa agcgctccag cggtcccgag
     1081 gcccggtgta aagactgcga cagagtcttt aaatatagtc acttcttagc aatccaccag
     1141 agacgccaca cgggggaacg acccttcaaa tgtaatgagt gtgggaaggg ctttgctcag
     1201 aagcactcct tgcaggtcca taccaggatg cacacggggg agcggccata cacctgcacc
     1261 gtgtgcggca aggcgctgac caccaagcac tccctgctgg agcacatgag cctgcactca
     1321 ggacagaagt cttttacctg tgatcagtgt ggaaaatatt tcagccagaa aagacagcta
     1381 aagagccatt atcgtgtcca tacaggccac tcactaccag aatgcagcca ctgccaccga
     1441 aagtttatgg acgtgtccca gctgaagaag cacctgcgga cacacacagg cgagaagcca
     1501 tttacttgtg aaatctgtgg gaaatctttc acagcaaaga gctcccttca gacccacatc
     1561 aggatccacc gaggagaaaa gccatactcc tgcagcatct gtggcaaatg cttctctgac
     1621 tccagtgcca agaggagaca ctgcatcctg catacgggca agaagccctt ctcctgcccc
     1681 gagtgtggct tacagttcgc tcgcctagac aatttgaagg cacacttgaa aatccacagc
     1741 aaagagaagc acacggcaga ctccagcagt gtttctggca gtaatgtgga cgagggcagg
     1801 aacattcttc agctgcaacc ataccagctc tccacgtcgg gagagcagga gattcagctt
     1861 cttgtcaccg actctgtgca taacattaac ttcatgccag gtcccagcca gggggtcagc
     1921 atcgtggctg ccgagagccc ccagagcatg gccacagacc cggctgccaa catcaccctg
     1981 ctcacacagc agcctgagca gctgcagggc ctgatccttt ccgctcagca ggagcaggca
     2041 gagcacattc agagcctcag tgtgattgga ggccagatgg agtcctccca gactgagcca
     2101 gtgcatgtca tcacactttc caaggaaacg ctggagcatc tccacgccca ccaggagcaa
     2161 acaaccagct cagtacctgc agctgacaca ggagcccgag ccacccctgt cccctccact
     2221 aggccaggag cagagctgac ccaagcgcct ctggccgttc cactagaccc ttcccctgga
     2281 gcaacagtgg cagggtggcc ttttgggcca tcatcttaca gatccttaaa gatgtgagcc
     2341 agccattctt tatcgtgggc tccatcaggg cagaaactgt cttatctgta ataccaactc
     2401 atacttaaat gagggggggt tccaatttga tctactttgt ctcttcaaga ttggtagctt
     2461 ttctttgggg tcattggttt tatatgtttc tataagtgtt gaatgtccac agccatagag
     2521 tatggtcttg tttagaacaa acactcatgc ataggttgaa tcattgggta gagagggtcc
     2581 atcctggtac ttctcttagg cgtaactttt gcccctcaga gtccacctct tgaattttat
     2641 ctttgtgtgg tacagctgac caagttgtac tgaaggtaga ttcatactca gaaaccgtac
     2701 tcatgacgta aaagccaaag tacctttaaa ttgtttgagt tcaactttgc ttcaaaacat
     2761 gtatctatac attttttaaa gaagcagcta ttaaatttta ttttaaaaaa tctccaaagt
     2821 atgaaactgg atctagacac tcattccaaa taaaccaaat tttgtcagac actgata
//
