LOCUS       NM_175428               6011 bp    mRNA    linear   ROD 01-AUG-2024
DEFINITION  Mus musculus zinc finger and BTB domain containing 21 (Zbtb21),
            transcript variant 1, mRNA.
ACCESSION   NM_175428
VERSION     NM_175428.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6011)
  AUTHORS   Qiao,M., Huang,Q., Wang,X. and Han,J.
  TITLE     ZBTB21 suppresses CRE-mediated transcription to impair synaptic
            function in Down syndrome
  JOURNAL   Sci Adv 10 (27), eadm7373 (2024)
   PUBMED   38959316
  REMARK    GeneRIF: ZBTB21 suppresses CRE-mediated transcription to impair
            synaptic function in Down syndrome.
REFERENCE   2  (bases 1 to 6011)
  AUTHORS   Medeiros de Araujo,J.A., Barao,S., Mateos-White,I., Espinosa,A.,
            Costa,M.R., Gil-Sanz,C. and Muller,U.
  TITLE     ZBTB20 is crucial for the specification of a subset of callosal
            projection neurons and astrocytes in the mammalian neocortex
  JOURNAL   Development 148 (16) (2021)
   PUBMED   34351428
REFERENCE   3  (bases 1 to 6011)
  AUTHORS   Guo,G., Huss,M., Tong,G.Q., Wang,C., Li Sun,L., Clarke,N.D. and
            Robson,P.
  TITLE     Resolution of cell fate decisions revealed by single-cell gene
            expression analysis from zygote to blastocyst
  JOURNAL   Dev Cell 18 (4), 675-685 (2010)
   PUBMED   20412781
REFERENCE   4  (bases 1 to 6011)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   5  (bases 1 to 6011)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
REFERENCE   6  (bases 1 to 6011)
  AUTHORS   Gitton,Y., Dahmane,N., Baik,S., Ruiz i Altaba,A., Neidhardt,L.,
            Scholze,M., Herrmann,B.G., Kahlem,P., Benkahla,A., Schrinner,S.,
            Yildirimman,R., Herwig,R., Lehrach,H. and Yaspo,M.L.
  CONSRTM   HSA21 expression map initiative
  TITLE     A gene expression map of human chromosome 21 orthologues in the
            mouse
  JOURNAL   Nature 420 (6915), 586-590 (2002)
   PUBMED   12466855
REFERENCE   7  (bases 1 to 6011)
  AUTHORS   Reymond,A., Marigo,V., Yaylaoglu,M.B., Leoni,A., Ucla,C.,
            Scamuffa,N., Caccioppoli,C., Dermitzakis,E.T., Lyle,R., Banfi,S.,
            Eichele,G., Antonarakis,S.E. and Ballabio,A.
  TITLE     Human chromosome 21 gene expression atlas in the mouse
  JOURNAL   Nature 420 (6915), 582-586 (2002)
   PUBMED   12466854
REFERENCE   8  (bases 1 to 6011)
  AUTHORS   Davisson,M.T., Bechtel,L.J., Akeson,E.C., Fortna,A., Slavov,D. and
            Gardiner,K.
  TITLE     Evolutionary breakpoints on human chromosome 21
  JOURNAL   Genomics 78 (1-2), 99-106 (2001)
   PUBMED   11707078
REFERENCE   9  (bases 1 to 6011)
  AUTHORS   Akeson,E.C., Lambert,J.P., Narayanswami,S., Gardiner,K.,
            Bechtel,L.J. and Davisson,M.T.
  TITLE     Ts65Dn -- localization of the translocation breakpoint and trisomic
            gene content in a mouse model for Down syndrome
  JOURNAL   Cytogenet Cell Genet 93 (3-4), 270-276 (2001)
   PUBMED   11528125
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC226122.3 and AK034057.1.
            
            On Feb 23, 2016 this sequence version replaced NM_175428.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK034057.1, SRR9219381.199657.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164142 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1                 AC226122.3         198979-198979       c
            2-3319              AK034057.1         2-3319
            3320-4064           AK034057.1         3321-4065
            4065-6011           AC226122.3         183792-185738       c
FEATURES             Location/Qualifiers
     source          1..6011
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 57.75 cM"
     gene            1..6011
                     /gene="Zbtb21"
                     /gene_synonym="5430437K12Rik; B430213I24Rik; mKIAA1227;
                     Zfp295; Znf295"
                     /note="zinc finger and BTB domain containing 21"
                     /db_xref="GeneID:114565"
                     /db_xref="MGI:MGI:1927240"
     exon            1..209
                     /gene="Zbtb21"
                     /gene_synonym="5430437K12Rik; B430213I24Rik; mKIAA1227;
                     Zfp295; Znf295"
                     /inference="alignment:Splign:2.1.0"
     exon            210..352
                     /gene="Zbtb21"
                     /gene_synonym="5430437K12Rik; B430213I24Rik; mKIAA1227;
                     Zfp295; Znf295"
                     /inference="alignment:Splign:2.1.0"
     CDS             281..3565
                     /gene="Zbtb21"
                     /gene_synonym="5430437K12Rik; B430213I24Rik; mKIAA1227;
                     Zfp295; Znf295"
                     /note="isoform 1 is encoded by transcript variant 1; zinc
                     finger protein 295"
                     /codon_start=1
                     /product="zinc finger and BTB domain-containing protein 21
                     isoform 1"
                     /protein_id="NP_780637.2"
                     /db_xref="CCDS:CCDS37418.1"
                     /db_xref="GeneID:114565"
                     /db_xref="MGI:MGI:1927240"
                     /translation="MMHSVQRAHKHSGEEERRKMCACQIKCRMEGLLHYINPAHAISL
                     LSALNEERLKGQLCDVLLIVGDQKFRAHKNVLAASSEYFQSLFTNKENEAQTVFQLDF
                     CEPDAFDNVLNYIYSSSLFVEKGSLAAVQELGYSLGISFLTNIVAKAPQAPFPACPNR
                     KRVPVEDDETSSQKRSVIVCQGRSEVPGKASGPAMQDLSHTARASPSASVKTTISKPH
                     VAKPPEQLHSLPLTEKSWTKDSAAVYAKSLEQAGALDDPNRGSLVKRNTVLPPKPSQD
                     REATDDKPGVSSQLPKGKAIELALKRPRPPVLSLHSSSETPYLLKETSKGGGQGEDRN
                     LLYYSKLGLVVPSGGPASANQSIDRSGPLVKSLLRRSLSMDSQVPVYSPSIDLKSSQG
                     SSTAANEAPGSVFCSMSQKSSLKDCSEKKALDDRPQVLQPHRLRSFSASQSTDREEAS
                     PVTEVRIKTEPSSPLSDPSDIIRVTVGGDAAAAAVAAAAAAAATRDLPLKTEEDQRDM
                     SRLPAKRRFQTDRRSPLKKAKANEHGPAVSEENCEEGRSPPSLDSNFPDSDLNREEFG
                     ELEGTRPNKKFKCKHCLKIFRSTAGLHRHVNMYHNPEKPYACDICHKRFHTNFKVWTH
                     CQTQHGIVKNPSPASSSHAVLDEKFQRKLIDIVREREIKKALIIKLRRSKPGFQGQSS
                     SPAQQVIKRNLRSRAKGAYICAYCGKAYRFLSQFKQHIKMHPGERPLGVSRAAKPKER
                     ALARAVENKEVYPCRLCNAKLSSLLEQGNHERLCRNATVCPYCSLRFFSPALKQEHED
                     RCEYKKLTCLECMRTFKSSFSIWRHQVEVHNQNNMALAENFALATLDHNGEVAAASRP
                     QTEPSKVNHVATPKEDTAFSDSSEQVNFDSEDSSCLPEDLSLSKQLKVQVKEEPVEEA
                     EEEAPEASAAPREAGPSKETGLWPCEKCGKMFTAHKQLERHQELLCSVKPFICHVCYK
                     AFRTNFRLWSHFQTHMSQATEEPVQKESEVCPVPTNSPSPPPLPPPPPLPKIQPLEPD
                     SPTGLPENPTPATEKLFAPQESDTLFYHAPPLSAITFKRQFMCKLCHRTFKTAFSLWS
                     HEQTHN"
     exon            353..6011
                     /gene="Zbtb21"
                     /gene_synonym="5430437K12Rik; B430213I24Rik; mKIAA1227;
                     Zfp295; Znf295"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3654..3659
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zbtb21"
                     /gene_synonym="5430437K12Rik; B430213I24Rik; mKIAA1227;
                     Zfp295; Znf295"
                     /note="hexamer: AATAAA"
     polyA_site      3682
                     /gene="Zbtb21"
                     /gene_synonym="5430437K12Rik; B430213I24Rik; mKIAA1227;
                     Zfp295; Znf295"
                     /note="major polyA site"
     regulatory      5588..5593
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zbtb21"
                     /gene_synonym="5430437K12Rik; B430213I24Rik; mKIAA1227;
                     Zfp295; Znf295"
                     /note="hexamer: AATAAA"
     polyA_site      5608
                     /gene="Zbtb21"
                     /gene_synonym="5430437K12Rik; B430213I24Rik; mKIAA1227;
                     Zfp295; Znf295"
     regulatory      5986..5991
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zbtb21"
                     /gene_synonym="5430437K12Rik; B430213I24Rik; mKIAA1227;
                     Zfp295; Znf295"
                     /note="hexamer: AATATA"
     polyA_site      6010
                     /gene="Zbtb21"
                     /gene_synonym="5430437K12Rik; B430213I24Rik; mKIAA1227;
                     Zfp295; Znf295"
                     /note="major polyA site"
ORIGIN      
        1 tgacgtcaaa ttcaagatgg atggaatcac agcggcagtg gaggctgcgg gttgcgcgag
       61 ccgagtgtga gcggaaaggg gcttggcgcc tgccccaggg ctgaagagcg gtgagtaacc
      121 gtcacgctcc gcgccctagg aggacgtcgg gcccggtcgg ggactacggc ctctccgcaa
      181 aacgcggcct ttcctgacgt aactctgagt cacaggaatg tgaggtgcag gagaacagga
      241 agccagccaa cgagctcacc tcccaccatc agcacctctt atgatgcaca gtgtacagcg
      301 ggctcacaaa cactcgggag aggaagagag aagaaagatg tgtgcttgcc agataaagtg
      361 caggatggag ggactgctgc attacatcaa cccagcacat gctatctctc tgctcagtgc
      421 cctcaatgag gagcgcctca agggacagct gtgtgacgtg ctcctgattg ttggggacca
      481 gaaattccga gctcataaga acgtcttggc tgccagcagt gagtacttcc agagtttatt
      541 cacgaataag gagaacgagg cacagactgt ctttcagctg gacttctgtg agcctgacgc
      601 ttttgacaac gttctgaact acatttactc ttcttccctt tttgtggaga agggcagcct
      661 tgctgctgtg caggagctgg ggtatagcct tggtatctcc ttcctgacca acatcgttgc
      721 caaagcccct caggctcctt ttccagcctg tcccaacagg aaaagagtgc cagtggaaga
      781 tgatgaaacc agctctcaaa agcgaagtgt cattgtgtgt cagggcagaa gtgaagtgcc
      841 agggaaagcc agtggtccag ccatgcagga cctcagccat actgcccggg cctcccccag
      901 tgcttcagtc aagaccacca tcagtaagcc acatgtggcc aagccgccag agcagcttca
      961 tagtctgccc ttaactgaaa agagctggac aaaggatagt gctgcagtat atgcaaagtc
     1021 tctggaacag gctggggctt tggatgatcc taataggggc agtttggtaa agagaaatac
     1081 agtcctgccc ccaaagcctt cacaggacag ggaggccaca gatgataaac caggggtgag
     1141 cagccagctt cccaagggga aagctataga gctggctctg aagagaccac ggccccctgt
     1201 tctgtctctt catagctcat cagagactcc atatctccta aaagaaacta gcaaaggagg
     1261 cggtcaggga gaggatagga acttgctcta ctactctaag ctagggctgg tggtcccttc
     1321 tggtgggcct gcttctgcaa accagagcat tgacagaagt ggcccactag tgaaaagcct
     1381 cctcaggcgg tcactgtcta tggacagcca ggttcctgtt tactccccct ccatagattt
     1441 gaagtcatcc cagggatcat ccacagcggc aaatgaggca ccgggtagtg tgttctgttc
     1501 gatgtctcaa aagtcatctt taaaagattg cagtgaaaaa aaagctctgg atgacaggcc
     1561 tcaagtgctc cagcctcatc gcctcaggtc ctttagtgct tcccagtcaa cagacaggga
     1621 ggaagcctcc cctgtgactg aggtacgcat taagacggaa cccagcagcc cactgtcaga
     1681 cccctcagac atcatccggg tcactgtggg aggagacgca gcagcagcag cagtagcagc
     1741 agcagcagca gcagcagcta cgagagacct gcccctcaaa acagaggaag accagagaga
     1801 tatgagcaga ctcccagcaa agagaaggtt ccagacagac agaaggtcac ccttgaagaa
     1861 ggcaaaggca aatgaacacg ggcctgctgt ctcagaagag aactgtgaag agggcaggag
     1921 ccctccttcc cttgacagca acttcccaga ttctgactta aacagagagg agtttggtga
     1981 gttggagggg acgagaccaa acaaaaaatt taaatgcaaa cattgcctta agatttttag
     2041 atcaactgcg ggtcttcacc gccatgttaa catgtaccat aacccagaga agccttacgc
     2101 ttgtgacatc tgtcacaaga ggtttcacac caacttcaaa gtgtggacac actgtcagac
     2161 ccaacacggc atagtgaaga acccatcgcc agcctctagt tcccatgcag ttttggatga
     2221 gaaattccaa agaaagctga ttgacatagt gagagagagg gagattaaga aggccctgat
     2281 cattaagctg aggcgcagca agcctggctt ccagggacag agtagctccc cagcacagca
     2341 agtcatcaag aggaacttgc gctcccgagc caaaggggcc tacatttgtg cctactgtgg
     2401 caaggcatac cgctttctct ctcagtttaa gcagcacata aagatgcacc caggagagag
     2461 gcccctcgga gtaagcagag ctgctaagcc aaaagagcgg gctctggcac gcgcggtaga
     2521 gaacaaggag gtttacccgt gccgcctctg taatgctaag ctctcttctc ttctagagca
     2581 aggcaaccac gagcgcttgt gccggaacgc caccgtttgc ccttactgca gcctcaggtt
     2641 cttctctccc gcactgaagc aggaacatga ggacaggtgt gagtacaaaa agctgacttg
     2701 cctggagtgc atgcgcacct tcaagtcctc cttcagcatc tggcggcacc aggtagaagt
     2761 gcataaccag aacaacatgg ctttagcaga gaacttcgcc ctggccaccc tggaccacaa
     2821 cggtgaagtg gcagccgctt ccaggcctca gactgagccc agcaaggtaa accatgtggc
     2881 cactccaaaa gaggatacag catttagcga ctcttcagag caagtgaact ttgattctga
     2941 ggattcctcc tgcctccctg aagacttgag tctttcaaag caactgaaag tccaagtcaa
     3001 agaggagcct gtggaggagg cagaggagga ggctcctgag gctagtgcag ctcccaggga
     3061 ggctggcccc agcaaggaga ccggcctatg gccctgtgag aaatgcggaa agatgttcac
     3121 ggcacacaag cagctggagc ggcaccagga gctgctgtgt tctgtgaagc ccttcatctg
     3181 ccacgtatgc tacaaagcct tccgtaccaa cttccgactc tggagtcact tccagaccca
     3241 catgtctcag gctacagagg agcctgtgca gaaagaatca gaggtgtgtc ctgtgcccac
     3301 aaactccccc tccccaccac ctctgccacc tccgccaccc ttgcccaaga ttcagcccct
     3361 ggagccagac agccccacag gcctgcctga gaacccaacc ccagctacag agaagctgtt
     3421 tgcaccccag gagtcagata ccctcttcta ccacgcccca cccctttcag caatcacatt
     3481 taaaagacag ttcatgtgca agctctgcca taggacattc aagacggcct tcagtctttg
     3541 gagtcatgag cagacacaca attaaaggac ctaccccttt cacctatcac aaagtagcag
     3601 gcccttggct tgtaaactgt gtcctaagac agaatatttg aaaaaataat aataataaag
     3661 gttggaaatt attatgtttg aattttaagt ttgggatgaa ttaatactgg ctagaaatga
     3721 cctcacagct ttctggacct cagcagcagg ggtttgattc tattactatt gaagttggac
     3781 taatgttggt gattgaggtt tttggtttct gagtagtggg atgcttggga agtgggtttt
     3841 ttgtttgttt ggttggttgg ttttggtttt tttttgttgt tggttttgtt ttgtttttga
     3901 ttattgcaga cacctaaatt tgaggtaacc tttagccatg tttctaaggc caaaaaaaca
     3961 tacaaggaag aaggggagtc atttgcagta ttgagtcaga ttttagacta ctttagcaat
     4021 aagaaaaggc aagccccaac tttagtaaag tatcctaaca cttgataaga aaaaaacttg
     4081 gtattttgtg gtcctataaa acttcctttt tgtatgaaaa ttgtgagact ttaaatcagc
     4141 aatagtcaca cttagatttt ttttaataaa agaacaatct gtcaattaca tcatacaatc
     4201 agtgatggtc tgttctaagg gaggcagagc aatagaagcg tgtttgtggg gtcctctaca
     4261 gtcagctgca acagcttagt tgtgaaagcc gctaaagtct gtggtgtgtt catagcatgg
     4321 ctttcaactg gggctttaga actgacaatg tctgctctct gtcagcttga aactcgggtg
     4381 tcattgagat aagcagtgct agcatgaggt tagcagagca tagccttacc acatcctaga
     4441 ccaccattct ctctctagag gcttcagaga ttggaggaaa tgccgtgttg cagtttccat
     4501 gtgctttcca agaactgtac acacaacata gacatttcct gcctgtcttt tgtgagtact
     4561 tctgtggggt tattggagtg gacagcagtg gaaatgtcac tacatgatat gcaagcgtgg
     4621 attaaagcac tagcaagagg ccaaaattag tttttgctac ttgatttggt accttagggt
     4681 ttgggctcct ctggtttttt cttgtttttt tgtttgtttg tttgtttgtt tttttgtttt
     4741 tttttttttt tttttttgct ttttgttttg ttccttgcag gttataatta aatctctcca
     4801 taggcagaat ccaaagttca gtgaaatatt tcaaaagaca aagggaagat cactcctgga
     4861 aaggaaatta gggggatgca aattccctat tcacttttgc tacaagctgt ttcttcacat
     4921 tttcaaggtg tgatctaaca gagacactgg cccatctgct caccagcatt ctacacccat
     4981 ggtagcaaag gcaatcttga tattgaaact ttttttttaa taaattacta attgactttg
     5041 tatattatag aagctatatg tggaattttg ccttttatct tttcacttga aaaagcaatc
     5101 agaaatccct aaatatgtct gcatttccta ttttgtttct taaattttgc aaagaaggga
     5161 aataaaatta ggttgcagtt attaattctt gccatctgct ttcttaaact atgcatttta
     5221 gagatgaaac taaaagtgtc caccatgtga tgaatgaagc tagtgccagg ctaggtagct
     5281 gtccactgaa cttcttccct gtggtgagtg aatggtctct cctcagagtg ttacttcttt
     5341 taagaccatc tctctgcatg gtcatctcct gtgtagttac agagtgataa cctccagacc
     5401 tggcattgcc agctcctgcc ccaacacttg aacctgtgct acgtttttga agatttataa
     5461 agtaacattg ttgcaaaaaa aaaaaatgta tttttgatct aaatacaggt tctgcatatc
     5521 tgttaggttt tacaaattac cagtgtttgt cacctttttt tgtctaggaa gaaaacataa
     5581 gatttcaaat aaatttttga accaaaaaca tttataatgc agttgtggtt tttctattgc
     5641 tttttatact gtatcttgaa agacatcggg ctgcaagaat ttattttgat gtcaaactct
     5701 atccttccat tcatgtaact atttcaaatg ctaagaaact aataaaaaac agtaatcact
     5761 ttttgcagta aacagttttt tagagaatgt ttatctcagc tagcaggcag atgtttagtg
     5821 aaataaatag gtctttcacc actgtaaatc tttagatagt agagatattc ttgtaaatgt
     5881 ttttctaatt gtactaattt ttacaagtat agaaagctca ttgttttttg taattattta
     5941 agatgcctgc ttttttatgc agttgtggaa agaatgtaaa cttttaatat attctttgtt
     6001 aacctgcaaa c
//
