LOCUS       NM_001393399           26492 bp    mRNA    linear   ROD 08-MAR-2025
DEFINITION  Mus musculus zinc finger and BTB domain containing 20 (Zbtb20),
            transcript variant 6, mRNA.
ACCESSION   NM_001393399 XM_036160073
VERSION     NM_001393399.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 26492)
  AUTHORS   Kim,T.A., Cruz,G., Syty,M.D., Wang,F., Wang,X., Duan,A.,
            Halterman,M., Xiong,Q., Palop,J.J. and Ge,S.
  TITLE     Neural circuit mechanisms underlying aberrantly prolonged
            functional hyperemia in young Alzheimer's disease mice
  JOURNAL   Mol Psychiatry 30 (2), 367-378 (2025)
   PUBMED   39043843
REFERENCE   2  (bases 1 to 26492)
  AUTHORS   Lin,Y.Y., Chang,W.H., Hsieh,S.L. and Cheng,I.H.
  TITLE     The deficient CLEC5A ameliorates the behavioral and pathological
            deficits via the microglial Abeta clearance in Alzheimer's disease
            mouse model
  JOURNAL   J Neuroinflammation 21 (1), 273 (2024)
   PUBMED   39443966
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 26492)
  AUTHORS   Rentsch,P., Ganesan,K., Langdon,A., Konen,L.M. and Vissel,B.
  TITLE     Toward the development of a sporadic model of Alzheimer's disease:
            comparing pathologies between humanized APP and the familial J20
            mouse models
  JOURNAL   Front Aging Neurosci 16, 1421900 (2024)
   PUBMED   39040546
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 26492)
  AUTHORS   Milham,L.T., Morris,G.P., Konen,L.M., Rentsch,P., Avgan,N. and
            Vissel,B.
  TITLE     Quantification of AMPA receptor subunits and RNA editing-related
            proteins in the J20 mouse model of Alzheimer's disease by capillary
            western blotting
  JOURNAL   Front Mol Neurosci 16, 1338065 (2024)
   PUBMED   38299128
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 26492)
  AUTHORS   L'Esperance,O.J., McGhee,J., Davidson,G., Niraula,S., Smith,A.S.,
            Sosunov,A.A., Yan,S.S. and Subramanian,J.
  TITLE     Functional Connectivity Favors Aberrant Visual Network c-Fos
            Expression Accompanied by Cortical Synapse Loss in a Mouse Model of
            Alzheimer's Disease
  JOURNAL   J Alzheimers Dis 101 (1), 111-131 (2024)
   PUBMED   39121131
REFERENCE   6  (bases 1 to 26492)
  AUTHORS   Wyss-Coray,T., Yan,F., Lin,A.H., Lambris,J.D., Alexander,J.J.,
            Quigg,R.J. and Masliah,E.
  TITLE     Prominent neurodegeneration and increased plaque formation in
            complement-inhibited Alzheimer's mice
  JOURNAL   Proc Natl Acad Sci U S A 99 (16), 10837-10842 (2002)
   PUBMED   12119423
REFERENCE   7  (bases 1 to 26492)
  AUTHORS   Mitchelmore,C., Kjaerulff,K.M., Pedersen,H.C., Nielsen,J.V.,
            Rasmussen,T.E., Fisker,M.F., Finsen,B., Pedersen,K.M. and
            Jensen,N.A.
  TITLE     Characterization of two novel nuclear BTB/POZ domain zinc finger
            isoforms. Association with differentiation of hippocampal neurons,
            cerebellar granule cells, and macroglia
  JOURNAL   J Biol Chem 277 (9), 7598-7609 (2002)
   PUBMED   11744704
REFERENCE   8  (bases 1 to 26492)
  AUTHORS   Yu,H., Saura,C.A., Choi,S.Y., Sun,L.D., Yang,X., Handler,M.,
            Kawarabayashi,T., Younkin,L., Fedeles,B., Wilson,M.A., Younkin,S.,
            Kandel,E.R., Kirkwood,A. and Shen,J.
  TITLE     APP processing and synaptic plasticity in presenilin-1 conditional
            knockout mice
  JOURNAL   Neuron 31 (5), 713-726 (2001)
   PUBMED   11567612
REFERENCE   9  (bases 1 to 26492)
  AUTHORS   Mucke,L., Masliah,E., Yu,G.Q., Mallory,M., Rockenstein,E.M.,
            Tatsuno,G., Hu,K., Kholodenko,D., Johnson-Wood,K. and McConlogue,L.
  TITLE     High-level neuronal expression of abeta 1-42 in wild-type human
            amyloid protein precursor transgenic mice: synaptotoxicity without
            plaque formation
  JOURNAL   J Neurosci 20 (11), 4050-4058 (2000)
   PUBMED   10818140
REFERENCE   10 (bases 1 to 26492)
  AUTHORS   Ko,M.S., Threat,T.A., Wang,X., Horton,J.H., Cui,Y., Wang,X.,
            Pryor,E., Paris,J., Wells-Smith,J., Kitchen,J.R., Rowe,L.B.,
            Eppig,J., Satoh,T., Brant,L., Fujiwara,H., Yotsumoto,S. and
            Nakashima,H.
  TITLE     Genome-wide mapping of unselected transcripts from extraembryonic
            tissue of 7.5-day mouse embryos reveals enrichment in the t-complex
            and under-representation on the X chromosome
  JOURNAL   Hum Mol Genet 7 (12), 1967-1978 (1998)
   PUBMED   9811942
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CT010517.11, CT010512.8 and AC120871.12.
            
            On Feb 8, 2021 this sequence version replaced XM_036160073.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.178568.1,
                                           SRR12282455.18594437.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-215               CT010517.11        150114-150328       c
            216-262             CT010517.11        83576-83622         c
            263-302             CT010512.8         159062-159101       c
            303-403             CT010512.8         52267-52367         c
            404-591             CT010512.8         44300-44487         c
            592-2196            CT010512.8         11117-12721         c
            2197-5921           CT010512.8         1-3725              c
            5922-26492          AC120871.12        16535-37105         c
FEATURES             Location/Qualifiers
     source          1..26492
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 28.44 cM"
     gene            1..26492
                     /gene="Zbtb20"
                     /gene_synonym="1300017A20Rik; 7330412A13Rik;
                     A930017C21Rik; D16Wsu73e; DPZF; HOF; J20; ODA-8S; Oda8;
                     Tg(PDGFB-APPSwInd)20Lms; Zfp288"
                     /note="zinc finger and BTB domain containing 20"
                     /db_xref="GeneID:56490"
                     /db_xref="MGI:MGI:1929213"
     exon            1..215
                     /gene="Zbtb20"
                     /gene_synonym="1300017A20Rik; 7330412A13Rik;
                     A930017C21Rik; D16Wsu73e; DPZF; HOF; J20; ODA-8S; Oda8;
                     Tg(PDGFB-APPSwInd)20Lms; Zfp288"
                     /inference="alignment:Splign:2.1.0"
     exon            216..262
                     /gene="Zbtb20"
                     /gene_synonym="1300017A20Rik; 7330412A13Rik;
                     A930017C21Rik; D16Wsu73e; DPZF; HOF; J20; ODA-8S; Oda8;
                     Tg(PDGFB-APPSwInd)20Lms; Zfp288"
                     /inference="alignment:Splign:2.1.0"
     exon            263..302
                     /gene="Zbtb20"
                     /gene_synonym="1300017A20Rik; 7330412A13Rik;
                     A930017C21Rik; D16Wsu73e; DPZF; HOF; J20; ODA-8S; Oda8;
                     Tg(PDGFB-APPSwInd)20Lms; Zfp288"
                     /inference="alignment:Splign:2.1.0"
     exon            303..403
                     /gene="Zbtb20"
                     /gene_synonym="1300017A20Rik; 7330412A13Rik;
                     A930017C21Rik; D16Wsu73e; DPZF; HOF; J20; ODA-8S; Oda8;
                     Tg(PDGFB-APPSwInd)20Lms; Zfp288"
                     /inference="alignment:Splign:2.1.0"
     exon            404..591
                     /gene="Zbtb20"
                     /gene_synonym="1300017A20Rik; 7330412A13Rik;
                     A930017C21Rik; D16Wsu73e; DPZF; HOF; J20; ODA-8S; Oda8;
                     Tg(PDGFB-APPSwInd)20Lms; Zfp288"
                     /inference="alignment:Splign:2.1.0"
     exon            592..2196
                     /gene="Zbtb20"
                     /gene_synonym="1300017A20Rik; 7330412A13Rik;
                     A930017C21Rik; D16Wsu73e; DPZF; HOF; J20; ODA-8S; Oda8;
                     Tg(PDGFB-APPSwInd)20Lms; Zfp288"
                     /inference="alignment:Splign:2.1.0"
     CDS             612..2618
                     /gene="Zbtb20"
                     /gene_synonym="1300017A20Rik; 7330412A13Rik;
                     A930017C21Rik; D16Wsu73e; DPZF; HOF; J20; ODA-8S; Oda8;
                     Tg(PDGFB-APPSwInd)20Lms; Zfp288"
                     /note="isoform S is encoded by transcript variant 6; zinc
                     finger protein 288; zinc finger and BTB domain-containing
                     protein 20; BTB/POZ domain zinc finger factor HOF;
                     POZ/zinc finger transcription factor ODA-8; PDGF-APPSwInd;
                     PDGF-hAPP695,751,770V171F, KM670/671NL; APP Tg"
                     /codon_start=1
                     /product="zinc finger and BTB domain-containing protein 20
                     isoform S"
                     /protein_id="NP_001380328.1"
                     /db_xref="GeneID:56490"
                     /db_xref="MGI:MGI:1929213"
                     /translation="MTERIHSINLHNFSNSVLETLNEQRNRGHFCDVTVRIHGSMLRA
                     HRCVLAAGSPFFQDKLLLGYSDIEIPSVVSVQSVQKLIDFMYSGVLRVSQSEALQILT
                     AASILQIKTVIDECTRIVSQNVGDVFPGIQDSGQDTPRGTPESGTSGQSSDTESGYLQ
                     SHPQHSVDRIYSALYACSMQNGSGERSFYSGAVVSHHETALGLPRDHHMEDPSWITRI
                     HERSQQMERYLSTTPETTHCRKQPRPVRIQTLVGNIHIKQEMEDDYDYYGQQRVQILE
                     RNESEECTEDTDQAEGTESEPKGESFDSGVSSSIGTEPDSVEQQFGAAAPRDGQAEPA
                     QPEQAAEAPAESSAQPNQLEPGASSPERSNESEMDNTVITVSNSSDKGVLQQPSVNTS
                     IGQPLPSTQLYLRQTETLTSNLRMPLTLTSNTQVIGTAGNTYLPALFTTQPAGSGPKP
                     FLFSLPQPLTGQQTQFVTVSQPGLSTFTAQLPAPQPLASSAGHSTASGQGDKKPYECT
                     LCNKTFTAKQNYVKHMFVHTGEKPHQCSICWRSFSLKDYLIKHMVTHTGVRAYQCSIC
                     NKRFTQKSSLNVHMRLHRGEKSYECYICKKKFSHKTLLERHVALHSASNGTPPAGTPP
                     GARAGPPGVVACTEGTTYVCSVCPAKFDQIEQFNDHMRMHVSDG"
     exon            2197..26492
                     /gene="Zbtb20"
                     /gene_synonym="1300017A20Rik; 7330412A13Rik;
                     A930017C21Rik; D16Wsu73e; DPZF; HOF; J20; ODA-8S; Oda8;
                     Tg(PDGFB-APPSwInd)20Lms; Zfp288"
                     /inference="alignment:Splign:2.1.0"
     regulatory      14336..14341
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zbtb20"
                     /gene_synonym="1300017A20Rik; 7330412A13Rik;
                     A930017C21Rik; D16Wsu73e; DPZF; HOF; J20; ODA-8S; Oda8;
                     Tg(PDGFB-APPSwInd)20Lms; Zfp288"
                     /note="hexamer: AACAAA"
     polyA_site      14355
                     /gene="Zbtb20"
                     /gene_synonym="1300017A20Rik; 7330412A13Rik;
                     A930017C21Rik; D16Wsu73e; DPZF; HOF; J20; ODA-8S; Oda8;
                     Tg(PDGFB-APPSwInd)20Lms; Zfp288"
                     /note="major polyA site"
     polyA_site      15140
                     /gene="Zbtb20"
                     /gene_synonym="1300017A20Rik; 7330412A13Rik;
                     A930017C21Rik; D16Wsu73e; DPZF; HOF; J20; ODA-8S; Oda8;
                     Tg(PDGFB-APPSwInd)20Lms; Zfp288"
                     /note="major polyA site"
     regulatory      20315..20320
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zbtb20"
                     /gene_synonym="1300017A20Rik; 7330412A13Rik;
                     A930017C21Rik; D16Wsu73e; DPZF; HOF; J20; ODA-8S; Oda8;
                     Tg(PDGFB-APPSwInd)20Lms; Zfp288"
                     /note="hexamer: TATAAA"
     polyA_site      20336
                     /gene="Zbtb20"
                     /gene_synonym="1300017A20Rik; 7330412A13Rik;
                     A930017C21Rik; D16Wsu73e; DPZF; HOF; J20; ODA-8S; Oda8;
                     Tg(PDGFB-APPSwInd)20Lms; Zfp288"
     polyA_site      22311
                     /gene="Zbtb20"
                     /gene_synonym="1300017A20Rik; 7330412A13Rik;
                     A930017C21Rik; D16Wsu73e; DPZF; HOF; J20; ODA-8S; Oda8;
                     Tg(PDGFB-APPSwInd)20Lms; Zfp288"
     regulatory      25082..25087
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zbtb20"
                     /gene_synonym="1300017A20Rik; 7330412A13Rik;
                     A930017C21Rik; D16Wsu73e; DPZF; HOF; J20; ODA-8S; Oda8;
                     Tg(PDGFB-APPSwInd)20Lms; Zfp288"
                     /note="hexamer: AATAAA"
     polyA_site      25100
                     /gene="Zbtb20"
                     /gene_synonym="1300017A20Rik; 7330412A13Rik;
                     A930017C21Rik; D16Wsu73e; DPZF; HOF; J20; ODA-8S; Oda8;
                     Tg(PDGFB-APPSwInd)20Lms; Zfp288"
     regulatory      26290..26295
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zbtb20"
                     /gene_synonym="1300017A20Rik; 7330412A13Rik;
                     A930017C21Rik; D16Wsu73e; DPZF; HOF; J20; ODA-8S; Oda8;
                     Tg(PDGFB-APPSwInd)20Lms; Zfp288"
                     /note="hexamer: AATAAA"
     polyA_site      26309
                     /gene="Zbtb20"
                     /gene_synonym="1300017A20Rik; 7330412A13Rik;
                     A930017C21Rik; D16Wsu73e; DPZF; HOF; J20; ODA-8S; Oda8;
                     Tg(PDGFB-APPSwInd)20Lms; Zfp288"
ORIGIN      
        1 gcagtcaggg acggattatt gaatatgcaa gttagaagaa aaatcacagg acaagcaaat
       61 tgagtattta ctggcaaata attgcgctct taaactgtgg ctctcttcct aaattcttaa
      121 cattcccgag ggttagaaag aaacacagaa aaatgcatcg gtacagagtt catttcaaaa
      181 aaccacccat agactgatgt ttgaggcttg tgcagactct tttatcatca gcaattgaat
      241 atttcacaca acttgctggc tgtcccttga ccaccagtct gttgcctgtt gctgctcttc
      301 atatgcagcc actctctgtc ccctgcccca atgaacatct gcactaggcc caagccttgg
      361 agtgatttac ctgaagagtg acaccaatta tctggaaact actgaagaaa cccaagacag
      421 ctgaaaacca gaaggcatct gaggagaatg agattactca gccgggcgga tccagcgcca
      481 agccggccct tccctgcctg aactttgaag ctgttttgtc tccagcccca gccctcatcc
      541 actcgacaca ttcactgaca aactctcacg ctcacaccgg gtcatctgat tgtgacatca
      601 gttgcaaggg gatgaccgag cgcattcaca gcatcaacct tcacaacttc agcaattccg
      661 tgctcgagac cctcaacgag cagcgcaacc gtggccactt ctgtgacgtg acggttcgca
      721 tccacgggag catgctgcgc gcacatcgct gcgtgctggc agccggcagc cccttcttcc
      781 aagacaagct gctgctgggc tacagcgaca tcgaaatccc gtcggtggtg tccgtacaat
      841 cggtgcaaaa gctcattgac ttcatgtaca gcggtgtgct gagagtctca cagtcggaag
      901 ctctgcagat cctcacagcc gccagcatcc tgcagatcaa aacagtcata gatgagtgca
      961 ctcgcatcgt gtcacagaac gtgggcgatg tgttcccagg catccaggat tctggccagg
     1021 acacaccaag aggcacacca gagtcaggca catctggcca gagcagtgac acggaatcag
     1081 gctacctgca gagccaccca cagcatagtg tggaccgaat ctactccgca ctctacgcct
     1141 gctccatgca gaatggcagc ggcgagcgct ccttctacag tggtgcagtg gtcagccacc
     1201 acgaaacagc tctcggcctg ccccgtgacc accacatgga agaccctagc tggatcacac
     1261 gcattcatga gcgctcccag caaatggagc gctacctgtc caccacccct gagaccacgc
     1321 actgccggaa gcagccccgg cctgtgcgta tccagaccct ggtgggtaac atccacatca
     1381 agcaggaaat ggaagatgac tatgactact atgggcagca aagggtgcag atcctagaac
     1441 gcaatgaatc cgaggagtgc acagaagaca ctgaccaagc agagggcact gagagcgagc
     1501 ccaaaggtga aagctttgat tctggggtca gctcctccat cggcaccgaa cctgactcag
     1561 tggagcaaca gtttggggca gcagccccaa gggacggtca ggcagaaccc gcccaacctg
     1621 agcaggcagc agaagcccca gctgagagca gtgcccagcc aaaccagcta gaaccaggtg
     1681 cctcctctcc tgagagaagc aacgagtcag agatggacaa cacagtcatc actgtcagta
     1741 acagctccga taagggcgtc ctacagcagc cttcagtcaa cacatccatc gggcagccat
     1801 tgccaagtac ccagctctat ttacgccaga cagaaaccct caccagcaac ctgaggatgc
     1861 ctctgacctt gaccagcaac acacaggtca ttggcaccgc tggcaacacc tatctgccag
     1921 ccctcttcac tacccaaccc gcgggcagtg gccccaagcc ttttctcttc agcctgccgc
     1981 agcccctgac aggccagcag acccagtttg tgacagtgtc ccagcccggt ctgtccacct
     2041 ttactgcaca gctgccagcg ccacagcccc tggcctcatc tgcaggccac agcacagcca
     2101 gtgggcaagg cgacaaaaag ccttatgagt gcactctctg caacaagact ttcacagcca
     2161 aacagaacta cgtcaagcac atgttcgtac atacaggtga gaagccccac cagtgcagca
     2221 tctgctggcg ctccttctcc ttgaaggatt accttatcaa gcacatggtg acgcacaccg
     2281 gcgtgagagc gtaccagtgt agcatctgca acaagcgctt cacccagaag agttccctca
     2341 acgtgcacat gcgcctgcac cgcggggaga agtcctatga gtgctacatc tgcaaaaaga
     2401 agttctccca caagaccctg ctggagcgac acgtggccct gcacagtgcc agcaacggga
     2461 cccctccggc aggcacgccc ccaggtgccc gcgcgggtcc gccaggcgtg gtggcctgca
     2521 cagaggggac cacttacgtc tgctccgtct gcccagcaaa gtttgaccaa atcgagcagt
     2581 tcaacgacca catgaggatg catgtgtctg acggataagt agtacctttc tctctttctt
     2641 acgaaccaaa caaaacgaca acaaaagaaa taaacaagca aacaaacaga caaaaagcta
     2701 tggcactaga atttaagaaa tgttttggtt tcctttttac tttctgtttt tgtttctgtt
     2761 ccgtttcatt ttgtactaca tgaagaactg ttttttgcct gctggtacat tacatttccg
     2821 ggggcttggg tggataatac ttttcccagt cccccttgga tggtggcctt aaggcctggt
     2881 agtgcttcag gaggtccact ggttggatct ctagctactg gcctctaaat acaacccttc
     2941 tttacaaaaa caaaaaacaa acaaacaaaa aaaaagacaa aaacaaaaac aaaacaaaaa
     3001 aagcaaaaaa accacacaca tacacacaca cacaaaaaaa aagaaacaaa aaaatctttt
     3061 aaaaaagttt taaaaaaatg tttaaaaaaa aaagaaaaat tgtttttcca ctcgtgaaga
     3121 gcactacaga gtttcttagg agctgtaagg cctgctgtct ttaaatacac cgctcacagt
     3181 gtttcagaga acagttcact cttctggcca cttggacttc acagtaagca gtttaaactg
     3241 tggaatatca cttctggttg aaaacccaga ggaatggccc tgctgtttcc acctaccatg
     3301 ctgtctgatg tcattaaagg gctctgggat gggaggggtc ggtgagccca gtggtgtcaa
     3361 caaaggcggg gtggcaggct tctcccccag gtctgcctgg tccacacacc ctggcccacc
     3421 tcctccacat cccgcccctt tcagcagaag ccaggaagac tcggacaagc aacagtggct
     3481 atcgtattta ttcagtgtct tggctgagcc acagcctcag cacaatcaag agggactttc
     3541 atgaaaggca ggaatgcaga gaaaaacaaa gattacagat ttgcacctat gtttctaggt
     3601 acaagagaag gattatttcc aacaatcttt gcaaaaaaaa aaaaagtgtc aggatatatt
     3661 cttgtggaag agaaaaagaa agagaaatgg agggtggggg gaacagtaaa agttcttgag
     3721 gcttttttaa ttcaaaaatt tatagagggg caaaagtgat gtttaccaga tagaatgctg
     3781 atttttttaa tatatttaca acagtatttg tgtaaaaaaa acaaaaaagt gagattgtta
     3841 aaagtgattt ttttctcctt ttggttccgc atacactgcc gtcgttccct ttactttgtc
     3901 tcacacatat atatattttt tggtaagtca agactgttaa ggttagcgat actgcttcca
     3961 gatagaaaga atagaaggca actaaagtta tatttgaaag agaggaagga tattttcttc
     4021 atattttttt tcttaatttt tattatttta aagtattgcc tgggttgcta agggcctccg
     4081 aggcccgccc accctgctgt aatttcaact gctgctctgt tttcgatgca tagatctttg
     4141 acttctagca ggcttcagtg gagcgagcca ctgaacagtt atcacctatc tatctagaat
     4201 tctgtccttt atcatgggag gggtgtgctc ttttacaagc agatttcttc cttctccaaa
     4261 atttcactga gctcttagga ttctagagtt ccatgagcct tgctttgttt cctctggtga
     4321 aacactagtg gtccagacac cttgacacag gggtctgttt ccttcatggt cctcactcct
     4381 ctcccctgcc tgctcaccct ctcagagcac tgtgtgggcg tcactctgag aagcctgtta
     4441 caaaccacag tgcattgatg ccaaaactcc tcccttcctt tcacggcctc tgactgccca
     4501 ccatagctca cagggctgag ttaggatggt cattctttag ttgattgttg actcttgctt
     4561 ttttggagga attaacagtt tctctgtgct aacatccaac tttcaaaagg ccatgaatct
     4621 ccagcatcat cctggatgct gctctttcta gttgggattt ctctctttgg tgttgatcaa
     4681 gaaatcataa gattttccaa ttatatacag agtcctgaag gggttccagc ttaaaaaaaa
     4741 aaaaaacggg acttttaaaa cctagataat actcactaag taattttatg actggccatg
     4801 ttttagcaca cttaaaagga aaagtaacta ttccaataac acagaaacac aaaactacat
     4861 ttttttttaa aaaggagatt ttctttttaa attgctctac attttaaatc agttttcttc
     4921 ctaattttcc tgttagcatt ttatttacaa aaaaaaaaaa tgcagcaaat gagggaaaat
     4981 tttccaaggc aagcaactct ataatgacta aattggtttt attcatatat tttagacaat
     5041 tggttaactt gaatcttttc cataagttct ttgtgatgtt tagtagtttg tgcaactgga
     5101 gtatttgtgg cgttgaagtt ggtcttatgg tgcttaattc agtggatttt ttgctagaag
     5161 ttgtagtgtg gctttggatg ggtaacttac tactgagtat cacttatcgt gatttctaag
     5221 aaggggacac ccaaaaaact tgtgtgacct gttttaaaaa ttagcttcag aaatgcaaaa
     5281 gttctcccta ttaccccccc ctgctgtttt gctgttgtta atattggaag tcaggcgtga
     5341 cctgatgttc ctgtaccacc gagagaggga gcattaggtc acaaggtcat ggaatcattt
     5401 ggaaatatga gttgttcaac ccatcaagga ggaaaaaaaa aaaaaactga tgctgtgata
     5461 ttcttttctt aatctggagg gaaaaaagac atgaaatcac tcaccatata aagcaaggga
     5521 aagaaagcag aggcccagcg tcaggcatcc tcactgttga cgggagcaca ttgaaagatg
     5581 tgtttccagt cagagctcag taaagtagcc agcactcaga ctgatcctgg gaacacttaa
     5641 ccttgcgtgc cattcggtcc cattcccatc tgctcactac acctgaaaga atcccgtttg
     5701 tcttcatgct aatgtgccat tgtcaaaaag ctaagcaact gggttaaaga tccaacattt
     5761 gttgtagagc atgggaaaga aaagaaaaga aaagaaaaga aaagaaaaga aaagaaaaga
     5821 aaagaaaagg acaccagatg acttgaaact ctgagacaca ttcttttcct ataaagggaa
     5881 tatcttcttt taaaacgtgt gaggagatcc ctgaggaatt cttggtcagg tcctacctac
     5941 tgtacaggct cagtcctact gtacaggctc agtcctgctg ttttacccca aacatctccc
     6001 aacctaaaat actgctttct agaactgaag gacactccgt tggcatcaga actctaaagg
     6061 aaagtcgctt ctatagtgct ggtgctgtat acctggcctc tcgagggctg ttttccaact
     6121 gcactgcatt gtagaagata agccagtctg cacctacttc aaaaggttac agatgcttcc
     6181 aggattgccc atgcacactc gatatttaac aatcacaaat aagagaagat gagaaagagt
     6241 gccgcttttt tttttgtttg tttgttttgt tttctgtcct gccgttttta tgatgggatg
     6301 ctatcagttc ttttaaaact agaaaacaaa caaacaaaaa aggtcatttt agtattcagg
     6361 aacacttgcg caagtgtgca tgcacacatg tgcacacgct cacacacgat ggaagcagat
     6421 gttccaggca gaagacctct tgagaagttt agggaacaag agctggcatt caaaagaata
     6481 ctagtatata tttttttaat caatctacaa tttaaacaag aaatttgtta aatacaaaaa
     6541 caaaatagta ccagcatttg tacaaaaaaa gagcccctaa ttgtgtaaaa catatccccc
     6601 aaaagacaat aattagaact ggaggatatg attcagctct acagtaaaaa acaaaaacaa
     6661 ccaagcccca cccccacact cacacctagt aatcctaaag gaaaatcttt atagaagttt
     6721 ttcacggtgt gaacttaccc tcctgcagcc tctcccatcg caggtctttc gccctcagga
     6781 gggagggtgg caggtaatcc tggctcatgc cccagaagct cccatcccct ctcccctatc
     6841 taggaggcca cagtcactgt tggctttaga aagacttggg cttgccttct ttctctgtaa
     6901 gtaagagaca ctttattata tatcataata tcatgtaagg accaagaaaa ctcttttcaa
     6961 tccatgagca gggagaggct gtgtgtctga gacgggagag caagagtttt ctctgggcgt
     7021 gcctgtttca tatcactctc cctgtcagga tctatgtgtg cttccatctc acacaccatc
     7081 tactaccatc atacggcctg cttatgcccc aaagcactgt tttctttcag cagtagaagt
     7141 taaaccagaa atgtgtgcct catcaaagcc ctcaggtccc cgggaaaata caggaaagtt
     7201 ccctgttgca gtcctccaag atacgcccaa cactgttgtc ctgaggaatg atggcaggga
     7261 agtcgccctg gcaaggatgc atagcagaca atgcccttgc tgagccttcc cctgaagttg
     7321 cagtgggagt tggtttgatt agttagggct agccatgtga ggtgtgtggt gctaacatca
     7381 cgtcaggccg atgctgccct gaccagtgtg cagctgcagc taagggaaca aaaaggtgta
     7441 gcccaggagc agacaggaga tgccctggga ggaaagagaa cacagggtag gtgccctttc
     7501 tgctgtgact tgactcttaa aagaaaaccc tctaaaaaga attctttaat ttagtaatga
     7561 gttgaagtcc agggtaatgg aagctctagg gaagagaaca aaagaattgc aaaatgtatt
     7621 cagtacccaa caataccaaa ccagaaaaca tccaatcaca aagctaggaa gtttggcaag
     7681 aggtacttag ggaaacctcc agtcttttcc atgggtaggg tccgcagact ttcttttgag
     7741 tgatttctgg ctcagagaaa cctctttact cactagaaaa gaactttgtt taaatggcca
     7801 attttgtccc ccaggagggg agaaagaatt aaaaaaaaaa aaaaaagaca gaaaagaaaa
     7861 ataggacact aaagacggaa ccatgtgagt tggtgacaaa caaaagaaag gggacactag
     7921 aatttcaata gactccctat tggatagatt tttttttaaa aaagcaaagc tacccaaggg
     7981 ccccccagct ccagactccc agtcttgagc tgacccagct gctggctttc tagggctgga
     8041 cataacttcc caactgggac cctggcaact ttcattctgt gttttcataa ggaaaaggga
     8101 ctgttctctt aagtgccctg gaaataggta gtggcatggg gcaaactttc aaaacccacc
     8161 tctgctctag tgctcaggat gccccaggag ctcgtgaaaa tacttaaata ttcccaaggg
     8221 ctttgtgtgc ggagttatca tttccagtgc accttaaaca tccacctgag ctgactgcgt
     8281 ttctgtaaaa ctgcacaatt actaacccga agcatcatcg tttctagccc tgagtagcaa
     8341 gatgatcaac ccaagcaaac tagcccacgg ggtactttaa gtttctcaag atgcttctct
     8401 gcttgaacac tgaatccaca gcaggaagag atgtgcatta tccagtgctc agagtgccct
     8461 tggggctgta gagctaggct ccattctctc taaggtgaac aagcaaaatg gaggcttgca
     8521 gggcatacga tttttttcaa aactgtatgt ctcctcctca tgaaaggaag actagaaaag
     8581 gcccaggact ggagcaagag tcttaattta tgacttactg atagctgccc tttccccaga
     8641 gtttctttag ggcccaacta tgctccactg actactggca taaccccagc taagaaactt
     8701 tcacaaaaaa atccattggg ttgtaggatt attgccttaa gttagaaacc ctggaggaaa
     8761 gcagacaaca cacacacaca gaaaatgaaa gactgtgaag atagataggg acatttcttg
     8821 gtttgtaatg gattcataat cacaaaaata agctctattc atgactgagg actatggaat
     8881 cagtgacttc ctgggaggca ccaaacttgt aggggaacca gctgctttca ggaagcagct
     8941 atttcctgtc tgctcctttc tttggtaggt cgaggctgac tgtaaaataa ccgtgttgct
     9001 aagtagcaag tcctgttaaa cataagcaca ggtgcctgga tggctcttaa atgtctcctt
     9061 aacagggagc ccaaatctca aaatacagct ttctctctct acagagatcg tatcaataca
     9121 gactgctctc tgtcccacct cggttttgag gtgcattggg tttgtcttgt gaacttttgt
     9181 ttaaatacaa aatcaaaact tttacatctt taattgagac acataatctg cagatcatag
     9241 acaaactcta gccctagtca tgaaatccta gcttcagcag tgcctgaaaa cagtccaagt
     9301 ctctccttgg atctctttca gactgagaag tttcttgatt cagagtgctt acatgatcct
     9361 gatagtccta aggcacagag aaaaagaacc ccacagaaga catctgcttc tactgctgtt
     9421 gcgacagttg ttatagccca aagcataact gtcatttgca cacagatgct aataacaaaa
     9481 gtggcttaac ccatccagtt tgtcacagct gctgtccaga atgtctgtct gtgagtgtac
     9541 cttatccgtg tgcacacatg gtgtgaggtg cttgtaccac aaaacttcat tcatattctc
     9601 cagtgacagc agcagacact tgagaatttc cagctcgagt caaaggcctg acaccatgca
     9661 tagccctgct ctctgcttcg tcgctgtctg tgaggaggct ttacagcatt cagaagtagc
     9721 ccaaccatca gtagtttgtg tatagccccg tgaggaaaaa cttgaacaaa tgctacactt
     9781 ctgtggattt actggtgaat gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gcgcgcacac
     9841 atgacctgca tctttgtatg tttatgtata tttatgttgt ctgagtgtgt gtgtatctct
     9901 caaatgaagc acacacggtt cctggtgcgt agatacagtt gcctcttcta ccagtgtgct
     9961 cagactcatg gctttcttcc caggaagcag tcacctgccc actctgttgc tttttgtagc
    10021 atttcagagt tgggagaaac aaaggcagct tgttggctcc acagcaaacc cacagggaca
    10081 ggctgttttt ctccagaaga gggtggagta cacacactca accagaagca gaccagaggg
    10141 agccatccag gcaacctcac aggactccca gagaggacct agccaggcag gtgacacaca
    10201 aacatcccag gattaagtcg gagctcaaag actattcctg tcctctctgg aaccttcgag
    10261 gctttagaga agggacaagg tctacagatc atagataagt ctagccccag gcatggagac
    10321 ccagctccca gccagtgcgc acactcacac acaggaacca cgtgggagtc ctactcccaa
    10381 actgaagttc cctgatgctg cctgcacctc tggaacatca ctaccattca caagctgtgt
    10441 ctcctgaaac cagtgtggcc ttcacccaag tctttctagg aatgggtggc ttaccatgtc
    10501 tagcaaacca atagaatatc agggagtatc ttgcgggcag tctataagaa tcagtggctc
    10561 ttgcccatgt cagacattaa agtagaatgc tactctagcg taatatactg aatgactgga
    10621 cttagctttc ataggtaact cttgatggct tggtgacctg gaaacagttg gatttcgttt
    10681 tctcattcgc atgcctctct tttactaaac agtctcttcc ttccctcctt cccacgtccc
    10741 ttccttccct tgtccctttc ttccttcctt ccaatatata gattatttct gccttacaga
    10801 attcagagga cttttcattc ctcttgtgtt tttgcgacat ttttccttcc cccatgcagt
    10861 aaggctactt accattgcaa ctattttttt tgtttattat ttttaaaatg tatattgtct
    10921 ttctgtatcc aaaagaagtc tgtgaccata gccacaggaa tttcttttta ctggaaaaaa
    10981 gttcatttct tgtttttttt gtttttcttg ttttaattaa cagtactagt gactttgtgg
    11041 aagactatgg ttactattta ggtatgctta cttacgtaca atacactaca ttgcagtgtt
    11101 tctgaaacct agaacatacg gattatatat aacagctcta tattgacgta tattacatta
    11161 tattcatttt aactttgaat ctgccatatg atcatcagtt gattgaaata ttatttcttc
    11221 acatatatca cccatcacca cctgctgcag ttaatctggt gcatttaatg ctcctatttg
    11281 ccttttatat tatcagcttc agtattgtct ttataacatt ttagaacttt ttttttaaag
    11341 ctcagacata gcacacgtag taaagtggaa actgcttaaa cttttttaaa agttattttt
    11401 ctgtggctaa taccaagaag ttcatattgc acgtgatcgt gtttagctgg ccctattaac
    11461 atctgaagaa caatggaagt gcatatgaac atatctgtga tcttcctgta taggactgcc
    11521 atcatctgta tttgcttcag aagagtataa ccaaggagct gcatgtccac cacatgatct
    11581 gaccaactgt aataagctgc atttccaaag ggctgctttg gtgagacaca aagacaggaa
    11641 catgccttcc atcctgtccc aactgtatct tcaaacattg gctctcagta ttgatcatac
    11701 agggtctgct ctctctcttc accgtgcttg ttttcattag tcttcagcat ttccctggag
    11761 gcatcttggc aataatacac tgttgatttt ccctaagaga tttattttaa agtaaaacca
    11821 catttctagg aactttttat tgacagaact cgaaaacata tatgacattc tcagccttcg
    11881 gaatctgtaa gtaggtgaca cttggttacc tggccctcgg catctctact tgctttcttc
    11941 tttagttagg ccaccatgga gcactcagag ctcagacagc ccatcttcta acaaaaacac
    12001 ttgcaggcgg ttttcaaagg agctttcttc agctgtccca gctctcccac tgcaagcctg
    12061 gaagtcagaa tcaagctagc cgaacctggt ctcattgtcc acattttatg ttcaggacca
    12121 agtgacgaca gctttgataa aactcagtag gaaccctccc cacaatggac caatatttag
    12181 gcttttcggt gtgaacatac cactctctcc ttcaatcttc ccttgtcaat cattatcttc
    12241 aagtctcatc acgttctgct gtgcctatcc agtgtgtctc ttgcccccaa cgcatccaaa
    12301 ctcttctcag catcctccac ttgtaaagct tgacattcat taaggaactt tccattccta
    12361 gtctcctttg atgatgctaa accagagtct actaggaaac tacttatgta gcatctattc
    12421 tcaatgaaag acgtggcaga gggaaagcgt gagtgtgagc ttcgtggtag tgaggctggc
    12481 cctttggtga tcgcaggcac gaggtagatg gtcccaactc cattgttctt gctttctctt
    12541 tcttaccaaa aattttctca tttcttattt ccttttaaag acaactacgt gctacccaat
    12601 catctcttca cttccccacc cctgaaaatc ttacattatg acccctaact gttcgtgaat
    12661 ttctcctacc actcttctta gcatctttct ttaaacgagt tcataaactt gagacttgta
    12721 ggcagaatga agcatgtctt cctttccgct gcagatttta aaggttgtca gcatctgaga
    12781 gtaggaggac ctgagtcaga gttttaaatg tcaactgtac tagttgagat cattaattcc
    12841 tctcaccttt acattaaacc aaagataagt atttttcttt tctttccttt tttaatacca
    12901 cagttttcaa attcttggta tgagtagacg atttctgagg gagggaaaaa aaaactccct
    12961 tgttgattat ttctgcttgt gctaatattt agctaatggc atgtttgcca gatactagat
    13021 ttacaggaat ctgaatcaag agataccatt tcaaaataac cttggtagct attcaagcca
    13081 aaagctactt ccactcaaac acactgtaag aaaagtttgg gagaattttt tcatgtatta
    13141 cactttgaaa agccaaatat ttgttggtct gaagcattga gggataattt attaaagaat
    13201 aaaaggattt atgaagttta tcagatgctt gttttacaac aaaaattgat ataaacctaa
    13261 taagtgttaa aaaacaaaac caagactaaa tgggtactat attaaatttt aagtacagta
    13321 ctcagtttat aaatacatac tatattattt ggccataatt ctagagttta ttccaatttt
    13381 tgctgtctgg tctccagaac actggtgaag aagactgaag tcactcactg taggtgtctg
    13441 cctctgggga tccttgcagt gtcctttcac agtgaccctt tagcacaatg cctgactctc
    13501 tgtgctgccc ccttacctct ctgctcatat gaagatggag agtctaagac acaatttgga
    13561 gtacacaggc actcacttct tgctctacct tgacactcaa aatccacact tcatatgaaa
    13621 aaaatgtatt gttgcttgac ttaaggcttg atccagactt tgacttaaac cactttatag
    13681 cttcagttcc cacatagagc aatgagataa atgtcaagtt caaaagcctc gctgaggtag
    13741 gcatctatca ggcatctatc tatctatctt aggccaatgt ttgaatcact tttccttcct
    13801 atatcctccc accgagtttt accctcactt ctttcttctt ccatttgggc tcctgccatc
    13861 tcttttgaaa gcattctata tctaaagctc tcttgccctc tggcattgcc ttctgaagtg
    13921 tagaagactc ttctgaatca ccaaacacta tcatctcaag tacactgtgg aatgggagag
    13981 agctgggtca ggaagatcgc tgttggtcca gttgatccag gctgccttct ggtcattgtt
    14041 ccttcaagct ctcaaatcaa tccaaccctg agatccagaa tttctcacca caacctctta
    14101 agtcccagat gaatgtctaa atcctgttta atattctaga ggctcagggg tgtgaattct
    14161 tcttgttcat gagcctcctg tttttgtaag ctgacacctg tcaagagcac caacagcccg
    14221 aacaataact aatgcagcaa aaataatggt cagaaacact atagtatata tttgagagat
    14281 taggaagtga tttttcttct tttattcatt aaaaaaaaca cacacacaaa aacaaaacaa
    14341 aacaaaacaa aaaaacagcg tgcgtacccc ctccccaaca catttcagaa aacctgcatc
    14401 tcattttaca gttagatagt tttagttttt gtgactatag attaggaaat gttctggaat
    14461 tgaagctggt agcaaacaca tttttttttc tgcactggac attaggacat gtgtgcatgg
    14521 atgcgattcc ttcaaagaaa gtgaaacatg gcaaagcaaa gggacaatac tttcacacat
    14581 taaaacagtt gtctgctatc tgtaaacctt gatttaagca taattataac ttcatagaaa
    14641 tctgaaactg gaggaatgtg tattttatag tttgtttgtt gatttgtttt cctttatgtc
    14701 tgtcttctca agctagggaa atattttgat tctctgattt gatgctgtcc ccgtatgtca
    14761 ggcaactgcc ctctacccca gagtagtctt ctgcccctta gaaaagcctt cagttttcca
    14821 tcaaggggtc atttctcatg gaagtcttac cttccttttc tgctgttgct tagagctttg
    14881 aaaatgaaag aatttctgca ctttggggat tggaatagtt aaaacagagc atagtccttg
    14941 gaggaaaaac tatctttacc tgaactgaca ggtctggggc caaagaatgg agccaaccac
    15001 tgataaaagt cattgatttt atacttcata tcatcatggc ctcctcaaat cctttttgga
    15061 ataaagctgg ggacaaattt attttctttt ctttggatgt ttcttgtgag tatccaggac
    15121 agaattccca gaaaggaaaa ggaagacgca ttagtaaaaa tactcacggc atctgatctt
    15181 cccactttca cagtagtggg gacttcagtc atggccactt aaagctctct atggtcctaa
    15241 ggcccctccc tggcacagag atggtagtaa gaaggacatc tccaggctgc cagcactcgc
    15301 ctatccatgc ctagcaacac aaaagaagaa aacagcaaat taagactggg aaaggggtcg
    15361 tagtcccttg tcaaagcatg ctctgtacag ctcagcttag cttacagata gcttggcaac
    15421 ctttttataa cctggctttt gtgctataat ttacattttt ggctcaaatt tgggaaataa
    15481 atgcaatttc agttaaggga acagacggga agtggggtgg gggatggcat aactcaatgg
    15541 acccaaatag aattcaattc taaaatccta aaatccattc tcgggattac caaagaatga
    15601 tcttactggt cctgtcaggg ttcctcatct ctctgtgtaa tgggtctgag agttaacaca
    15661 actatactcc tctgtgattc atggcttctc tccatctatc ctgactatct gaagaggtta
    15721 tagaaattct tggctgctct gctccttatc tgccctccag gacgcatgtg atgtatgcat
    15781 ccagatgacc aaaaacagac tagggctttg ataaggtttt gcaataggct gaagtgcttc
    15841 agctcacagc tagggaacct ttaaaaacaa agctagctat tttactcttt gctcttcatg
    15901 gaatacatct tggcttgaag tcagcaatga agtcaggaga aagttcccaa agatgcttga
    15961 gcagttaaat ttcattcttg ctcccattga tttagacttc aggtttcgag aagagcctat
    16021 tgaagtgtac attaaggata atttgcttag gcatatctaa ttaagattca tctttgcacc
    16081 attgttgaaa gaatcatggt tgtcagagta gatgagcgtg gaatctctca gaaatccaca
    16141 cccatcacag caaacaggta agaagctgat gacagagaac atctaaattg ctttgtttta
    16201 aaaagcccca ggatgccaaa catccttctt cctttctgtt ctcctcaagc tccagcggga
    16261 gtgtgggtgt gagcactaag gcagattcac atgtgcagag ggagggttca gacccgatga
    16321 agggacagac ctggaggtta ccaccaagtg ctcctccaga atcactcaag tgatcacatc
    16381 ccaaactgac tgtcaacctg cagaagaagt ctgtaaggaa tcccactacc gatgctttcc
    16441 ttttttaact gaatggtaca agaggaggat aggatgcaga gtctgcatcc tagtataata
    16501 attcactttg tatttaatac ttctaccttt ctgcatggag ttatttgtgc caactttaaa
    16561 gtccatcatt ctgagggagg ccttggaaaa cttctttgta tgtggatgtg gatctgtatc
    16621 tttgtagcca ggcaaacaaa acaaacaatc aaaaaaaaaa aaaatatgga agaatggcgg
    16681 gagggaaaga gggaaagaga accatctaga aggtggaccc ttcgatgtca tggaaggtgg
    16741 ttgctgcttg tagtctttga agaacagctg attctgctac tcacaaagaa gggtccagga
    16801 ctgctaaatg taggaccgag tttaggagac aggaaagctt gctctcttcc tcccatccct
    16861 atctccctta gcaccagtca gctggcaaga taaaatcact aagacgcact actgaccttt
    16921 gcattgaatc gatgtttccc tcctctaact ttggtttcaa ctcaactgta ggtctgcctt
    16981 ttctgcctac tggcttcata ttttatagaa taatacagag gtccaagctg gttgtttctc
    17041 tcctttgagc tgaaacaaac aggggccaca gagaggtgag tcacggacgt ttgagccaag
    17101 gcctgcttcc acttttgtag ctcaccttca agagctgttc atggctgacc tttgagtctg
    17161 taattgtttt gttgttgttg ttggtggtgg tggtgttttt tttttcttag ttgttttttt
    17221 gtttgtagga tctttccccc tcccccttct ttgttgtttt gttttgtttg cactaagcgt
    17281 gactgcaatg tgttgcacta ctgagctgta ttgagtcgtg acaggagagt gtgttaggta
    17341 aggaaagaag aacaagctag gagaccagta gcatcgcaga ggaggaggtg ctttctgtta
    17401 ttatttctca cagagggagt gagaatctgt gaaatttttg ccaactcttg atcaagtcta
    17461 gagaactgct aagctggaaa aaaaaaccat tttcttattg tatggcagtg ggttagtaca
    17521 gcaagtggag gatatttcag aagaaactta tccaattttg tttccaactc agcttacaat
    17581 aagagcccca agagtgagga agctggctga tgtgacatga agtcttcatc ttggctcaca
    17641 agaagacaga aactccccca ctacagcata tcccagtgtg cctggggtca tagtgtctgt
    17701 gttcagatat cctgtcactc tgagcatact tttctatcat ggtaagacct agatctctgg
    17761 gtaaccaaag aggaaggcca tgcatgtggt agagccctgt gaggtggcat aagggaacag
    17821 tgcaataaac actgcccgcc atgaggggaa aggcttattc tgacacaagg taggccaact
    17881 ggaaaactgg agaaagggtt ggacatgtcc tcagagtcca caagctgctc catcctagac
    17941 catccttaag cagagacctt gatatagtgc ctaaaagtta aaagttgttg ctcccccccc
    18001 ccaacttttc tgtgttcaat ttacatttat tgccttttta aatcttagaa gcaatcgggg
    18061 ttgacagcgc tttcgtaatt actaatgaga ggatcttgtg ctaccggaag agcaatagac
    18121 tgtgtggcga ctcaaacaag tgtggggatg ctgaggggct cctccagagt cccggatgac
    18181 agctcttgga aacccttgtt tgctaagaat cacagccctt gtaaacacct aatgttgagt
    18241 ttctttgaac actgtcccac ctgaggggat tcgtttggaa agcttccatt tcaggcctct
    18301 ttaacagagt atcaatctga tgctttctcc ttcctcctta tgataggtct cattctactt
    18361 tcccatgtca gagtttcttt ttatatatac aaaagtgcca gccttgctag tttaacccta
    18421 cagagaccat tcagaactaa cttaagcagc aacttaggag aactcaaagc attatctgta
    18481 tttcaagcag gctcctgaat cagatctcat agcagatgcc tgggaatgcg tggtgggaaa
    18541 gcactaacag gacatggaga cacccaacca aagctatgag aggaaacagt tgacctttaa
    18601 aacagtctca ccttaacttt ccttgaggca ttggggacaa gtttttcttg aaacttgcat
    18661 atccactcca gttccttcac caaagatttt cttctccaga gcccagcctc ctttctccca
    18721 ggcagaacca taacaggcct gagggtgtcc ttgcagtggt ccacagagtt caccttctgt
    18781 tcacaggggt atttacagac cttatagtag aagggtttcc aaacagtctg tatggaaaac
    18841 atacacagta ctacttggca ctgcgagctt tgtgagactc atctgttgcc tggaggcttg
    18901 tagtcagaaa tatccatgga agggagagtg cgaagtcatt tagagccaaa caggaccgct
    18961 ggtgagagga tcattgggca gtatgagtca agagcagatc aaggctccgt gtgcccaggg
    19021 ccaatggcag tggcctatga ggatgttaga caacacatca atggagtcac attctgagaa
    19081 gctaaagtgt gggctttgct gtaatggctg acattgttga aatgttcgtg ccacagcaag
    19141 ggaactactt ggaagtagac ctgttgtgat agtgccttct tgttgtagca agtcatttat
    19201 tcagttaggc ttttctggac cattgccccc atcttctgaa gaggtctgag atgaagggat
    19261 aggacactgc ccctgaaatg ctgtgatttg aagatatttg cactagattc tatcctctcc
    19321 tttaaactgg agcaactgaa tgagagggga aaaattaaca aggacagctc aaaatgaaaa
    19381 gaaacccaaa gtaatgtgtt ctgataacat tatctcccct cactgctaca tctttcctcc
    19441 ccccttcctc ccttccctcc tagatctact tttttttcct tcctcttaaa ggaaacttcc
    19501 attttcttat taccaaatcc aacaattact tctctttgtt tctccccagt actgaatcat
    19561 aagcttatta atcactcatg agctaggaat atctagtaaa gagcctctgc cttgacagtg
    19621 ttgctggcct tctctgtcca tcacgggtga acaacgaggg gtaataggga gactagactg
    19681 gcccagctct tatggaagcc agagtctgga tttcacacct ataaggagat gacacctatt
    19741 tacccagaac acatagtctg cagctcatct taaaagacgc ttaggaacaa aaggaagttc
    19801 ctgtgttaca gcaaacagat gcggtagtac ccaaagctta cctgtctctt ctctctcctc
    19861 tcttccgtct tactgccatg tcctctcaac gagacttaaa cttcatctca tgaatggcac
    19921 cagaagaact atttgactcc ttggcttctc tctttttcag taggctggta gctcattcaa
    19981 aattaaaacc aagcaaatac tattagtggc tagccccctg agggctgaac aatttcccaa
    20041 gtgtcttgat gatcccaata tcttgataat caactctgat aacttggaag ttttggctgg
    20101 ctcagacatc tgtcaacttt attttcattt tgtctccatt tccatttgaa tcttaagtga
    20161 gagtggaaag gtagaatcat gggaaagatt gtgaggctgc aattctaggg tagagtttgt
    20221 cagaagtttg tattatccca aatagaaatt tctatactta ctttcaattt aatgttaccc
    20281 tgaatataat ttctattaca tttattgtta tttttataaa aatagagttc aattactatg
    20341 tctagttgag tgctctcttt tctattttcc cacatggatg cagtaccaac ctgttaccta
    20401 aatatctttt tattatattg ttaatatgta attctactgt agaccaaaaa tataaaaaca
    20461 aatttgctca ttttaaacat atacagactc taatgagtaa agatgaggag aaaagaccag
    20521 agagcagtgg ttgactatgt tgttagaaat caaagagtag ccttacctat ttttaaccag
    20581 tgcttgccgt cacaccatag ttaggactat gttagcatgg cttcttcatg cttacgttct
    20641 gcaagccttg tctgtctgtt tcctttgatg tgttcgaggt tgcacaatga tgctattgtt
    20701 tttttctttt ggtaatgcct gattttatta taatgtactt tatcagtcat ttcctttaga
    20761 agaatgaggg ggaaagtttt atttcttctt ttaatttaaa ttttgtttaa tgcactggaa
    20821 ataaaattgg acacatttca ctgtttaaaa atcagaaacg aaacaaaaca aaaccccgaa
    20881 gaaaaaacca gcaaacaagt aagtaatagg atacacacac atacaaaaaa gctatgaaaa
    20941 atattctgtt catacaaaat ataggctata tctcacatga gagataaata ctgtcaagta
    21001 ataaaaagac attgtcaact acagtgctga aaactataag aggaacctag gtgtacagtg
    21061 tgtggggaaa actacgaatc ctttctgagg cgagatcttt ccattgttcc aataaaaacc
    21121 taagcaagtt gaatgtggaa gtcggtaagt agggagcacc ccgccttctt tacaccagcg
    21181 gacctctggg ttactttcta ccatgggtct cagccacata cacatacaca cgcacgcact
    21241 catgtgcaca cactcaatac ttgagaagga tttgtgaaaa tgtacatacc cagtacacag
    21301 atgtacacag tgctctgaca gccctcaagc tcttctgagg cttagcagtg atgggtccac
    21361 aacatggaat actgaaaggg attcactgag atctacgtgt gctaataaag tgcttgaagc
    21421 cagcctggtc tcttccccag catcccctag tccaaggcca gctgccacac acacatggac
    21481 agagaaaggc gagacaccgg ttacttctcc tagccaactg gctcattatt atttgctgaa
    21541 tatttgctgg atttttctgg ttttgttctg ttttagaatg gggtgggagt ggatgttatg
    21601 tcacaatcct aatacagtaa agttttgcat cttccatatc ttatgcaaaa acagacattt
    21661 aaatcaataa atagttgtgc cctagactga aagttaatgt ttaggagagg gaaaaattgt
    21721 tggaattttt tctacatttt tttgtgaaga atcttttttg gaaaggaagg atacatattt
    21781 ttgttgtgta atattttcta tttttgaatg cattttattg gtacaagact gtttttttgg
    21841 tgaagacatt atttaaaaaa agaaaaaaag aaaaaaacta atcgaaaagt ttgcccttaa
    21901 ggatatgctg cagttttgag attaaaaaat aataactgat tcaagatgcg tgttaaaagt
    21961 tgggattata ttgttgtttt tgtaattgtt acaagaagaa gtttgtaccc actgctgttt
    22021 attttgtttc agatgagtaa gtaaagggat tgttcttgtt ttattctttt tttagagaaa
    22081 aaagctattt atgaaatgtc aaaaacactg gactgtgagt ttaagtgtgg aagcatttta
    22141 ccaccctgtg tcttcaacca attatgggaa accttttctc tccccccctg ccttagcctt
    22201 gccaaatgag gaaaacgtaa cagctctcag atgacggaag tcaccgaagc cctgctttaa
    22261 tttttatggt ctgaaaaagt cggaaaacca aagttaaatt tgtttctgaa atcccgctgt
    22321 ctatagcccc ttttttgtac aacacagccg gctggctctg cctctctatc ttggatcatt
    22381 gccttcttag gaacgtgggg ccagctctgc caagaggcgt gaaggtggcg aggtcacagg
    22441 aagtgaggtg tgagggggac ccctagggcc ccggagcttc tccatccaga ggcgaggctg
    22501 ccaagagcac acacagctaa cagtgcctgg cggggtcgcc cctgtccccc tcaccttctg
    22561 cttcgaagac cctccagtta ccgtggctct gcctttctca gcagcccacg ttccgtggat
    22621 gggagggggt gggatccaag cagaaaacac ggctgtgggc gctgcgaagg ccccggccct
    22681 caggaggtaa agcaagggac cactcagcac aagggctctt gctgcccgcc tcctctttga
    22741 ctctgtggat cgtccatcca tctgctcact gtgaagatgg agaggcagtg cgccctgagg
    22801 ctgttcaata gcttttccat attttttcaa cattgaaaaa ataattttta aaaactgtga
    22861 tatttaaaaa aaaaaaaatc atttggctgg agggaaggga aaagggaaac accaaaagct
    22921 gtaacatgat taactggaga tatttataac tggggcactt tccagaccaa gacaaatgaa
    22981 ttgttttctg gacccgaaag cagccaaatt ttaagactgt cagtgacaaa aagctgaaga
    23041 gaggcctcca tttctcctcc tttcttcttt ctgtcccaaa ttctctcatt ttctcttcta
    23101 gcttctcttg gtaactgtcc aatggacttc atacttcatg caaaatcccg cgcatgcacg
    23161 cgagcgcgca cgcatgcgcg tgtacacaca cacacacaca cacacacaca cacacacaca
    23221 cacacaagca aaaaaaaaaa ctatttttct taaggattgt gggactaaat ttaaagtcat
    23281 gtgccttcat ttttttccct tttatagtta aatgaacctc ttcctttttt acaatgtgtt
    23341 gggttttgtt ttgtttttag tagaagggga aggttaaagt gtttgtggaa gagaggattt
    23401 ttaggcatca actgggagat ttttttagca tattccccca ctaaatatta aacacaaaca
    23461 tctcaatccc tccacgtgtc actgtgcaca cttagagcat caaggaatca gaatccgaca
    23521 gcctaatcca cttgatttta gagaagttcc tgaaatttct atttcctaga cttttttatt
    23581 gttcttattt tatcacagtg aggtgagcaa ggcaagttgc ctcgttctcc caactcggtg
    23641 cttctgcttg tggggtgggg gtggggcggt atagacaagg gtgcactcct aaagctctct
    23701 ggtgctgaag ggcctcaagg ttgagtttct ttcagaaaat gtgtatggca cactctcaag
    23761 tgcacacgtg aacggtgtca tgcgcactat ttttaaagga caagggaagg ggctctgaag
    23821 tgggttttgc tttctctcat gacatttgat ttccctggtg ccttattcct attctatgct
    23881 ggcactcaca tgcccacagg aacacacgct gatgtcagcc ccaggagtga ggacctctag
    23941 gtgacagttg agcatgtggg gaccatcgga tattggggtc agttggtagg ggaggaacta
    24001 gatggctgaa aatacacagg gactgcacaa gcccatcaca gtcaagatta gtaatgctca
    24061 tatgtgagta tgtgcaatac atgcacacac aaacacacac acagacacac acagagatgc
    24121 acacacaaac accaaataca ctcttcttcc tctgaacatt gcttccttct tcatttcctg
    24181 tctttgcctt ctcataaagg tgctgcttgc tgctgctgct gaggtgcccg gagtccagaa
    24241 tgcccagtaa tcactcaggc acaagcctgg cactgccacg ttcagtcctt ggcaagacca
    24301 aaccctggtt tctcttgcct ggggctgaaa accgtcagat ttttctcatc aaaaaaaaaa
    24361 aaaaaaagtt atccaaggaa tcagtggatt atagttactc tgcattaaaa atgcacttta
    24421 aaaataaata aaagctccag actgtttaaa acacacagag ggaacaggag aaagataaac
    24481 gtgctagtgt ctgaacccag ttcagcatat ctccagttga aacagtatac actatattat
    24541 gtataaatgt atacacactt ctatatatgt ccacatatat gcggtgtgtg tattatacag
    24601 gtataggtgt gtgtgcacgc acacaggtgc acatagcata tcaagtgttc attacaaatc
    24661 cagatgctca tttcacaaac agcagcagag gaaacaaggt tggactcttg cagcagatca
    24721 caaaacaata aaaacagcca cttgcggtga cgctggtcac tgctgtgtgt tcataaggaa
    24781 tggattgtaa caaaggaaaa caaggagcag tgttagcaat tgaggaaaac tgggacagac
    24841 catcttgatc caatgggaat gcagtaatgt tctctaccat ttcatccgtt ctttctgtta
    24901 gtcgtgacga tttgattttc atttttgcct attaaaaatg gtttagattc aagtgaccac
    24961 atccaagtga acaaaacaac cacagtgaaa gtccttttca gtaggaagat gtcagaaaac
    25021 tcaaaaccct tggcctggct cagaactacc atgtgcaaac cagaactctc tcaacgtttg
    25081 aaataaaaac tttaaaactc tttttgaagc accttaacgt ggccatccat ttgacaagtg
    25141 ggtgccacct ttttctttga gcaccttatt gacgtatttt gctatctgct gtcttctgtt
    25201 actgttggct gaatagctag ctgttaacac acacacatgt gcacagacca gacatctgag
    25261 catgcgtgtt ctcaatgacg tttaccgtgg tgactgctgg aaggtgaact cattttctga
    25321 tttgcccacc acagtgttgt gataagactc gaagaaaccc tgccctgcac ggaaaaatgt
    25381 cccttatcac gttgtatatt agggtgggaa ggaatatggt cccctttttg caattgctac
    25441 tgtgtataca tacacatgca cacacacaca cacacacaca cacacacaca cacacacaca
    25501 cacacacact gtatattcag acatgatgta cacacacaaa cataactcat ttgtccaagt
    25561 gatatttcag atgtttctgt gggtgtcaca caccatgtgc agttttccac ttcccagaga
    25621 attttgagtg gagggtaact tttcagactg atgaacgggg cactgaggaa gagtttgaag
    25681 tgggaggcaa gaaaggagag agcattaagt caaaagaata atttcccaag agaagctgga
    25741 ggaatggctg tccttgcagg tgggtgtgga acactgctgt ctcagtctgc actgtagaaa
    25801 tccatgcaca catcaacaca cacacacaca cacacacaca cacacataca cacatccccc
    25861 cacaggggcg tggtctggga tgagcaggtc aatagttttg agagggagtt tgttcctttt
    25921 ttttctctca ttatactctt gtcagttatt aaacaaacaa acagaaaaaa attgttttga
    25981 aaaaccttgc gtacgccttt tctatcaagt gctttaaaat atagactaaa tacacacatc
    26041 ctgccagttt ttcttacagt gacagtaccc ttacctgcca tttaatatta gcctcgtatt
    26101 tttctcacgt atatttacct gtgacttgta tttgttattt aaacaggaaa aaatttcaaa
    26161 aaaaagaaaa attaactgta gcgcttcatt atactattat attattatta ttgtgacatt
    26221 ttggaatact gtgaagtttt atctcttgca tatactttat acagaagtat tacgccttaa
    26281 aaatacgaaa ataaatttta caaggtttct gttttgtgtg gaagagtaat tgatgttgct
    26341 aagaatgatg tttgtttttt ggggtttttg ttgttttttt ttttaaatgt taccagcact
    26401 ttttttgtaa gtttcacttt ctgaggtatt gtacaagttc acactgtttg tgaagtttga
    26461 atatgaagga ataattaaaa aaaaaaaaaa aa
//
