LOCUS       NM_001285805            3209 bp    mRNA    linear   ROD 08-MAR-2025
DEFINITION  Mus musculus zinc finger and BTB domain containing 20 (Zbtb20),
            transcript variant 3, mRNA.
ACCESSION   NM_001285805
VERSION     NM_001285805.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3209)
  AUTHORS   Kim,T.A., Cruz,G., Syty,M.D., Wang,F., Wang,X., Duan,A.,
            Halterman,M., Xiong,Q., Palop,J.J. and Ge,S.
  TITLE     Neural circuit mechanisms underlying aberrantly prolonged
            functional hyperemia in young Alzheimer's disease mice
  JOURNAL   Mol Psychiatry 30 (2), 367-378 (2025)
   PUBMED   39043843
REFERENCE   2  (bases 1 to 3209)
  AUTHORS   Lin,Y.Y., Chang,W.H., Hsieh,S.L. and Cheng,I.H.
  TITLE     The deficient CLEC5A ameliorates the behavioral and pathological
            deficits via the microglial Abeta clearance in Alzheimer's disease
            mouse model
  JOURNAL   J Neuroinflammation 21 (1), 273 (2024)
   PUBMED   39443966
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3209)
  AUTHORS   Rentsch,P., Ganesan,K., Langdon,A., Konen,L.M. and Vissel,B.
  TITLE     Toward the development of a sporadic model of Alzheimer's disease:
            comparing pathologies between humanized APP and the familial J20
            mouse models
  JOURNAL   Front Aging Neurosci 16, 1421900 (2024)
   PUBMED   39040546
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3209)
  AUTHORS   Milham,L.T., Morris,G.P., Konen,L.M., Rentsch,P., Avgan,N. and
            Vissel,B.
  TITLE     Quantification of AMPA receptor subunits and RNA editing-related
            proteins in the J20 mouse model of Alzheimer's disease by capillary
            western blotting
  JOURNAL   Front Mol Neurosci 16, 1338065 (2024)
   PUBMED   38299128
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3209)
  AUTHORS   L'Esperance,O.J., McGhee,J., Davidson,G., Niraula,S., Smith,A.S.,
            Sosunov,A.A., Yan,S.S. and Subramanian,J.
  TITLE     Functional Connectivity Favors Aberrant Visual Network c-Fos
            Expression Accompanied by Cortical Synapse Loss in a Mouse Model of
            Alzheimer's Disease
  JOURNAL   J Alzheimers Dis 101 (1), 111-131 (2024)
   PUBMED   39121131
REFERENCE   6  (bases 1 to 3209)
  AUTHORS   Wyss-Coray,T., Yan,F., Lin,A.H., Lambris,J.D., Alexander,J.J.,
            Quigg,R.J. and Masliah,E.
  TITLE     Prominent neurodegeneration and increased plaque formation in
            complement-inhibited Alzheimer's mice
  JOURNAL   Proc Natl Acad Sci U S A 99 (16), 10837-10842 (2002)
   PUBMED   12119423
REFERENCE   7  (bases 1 to 3209)
  AUTHORS   Mitchelmore,C., Kjaerulff,K.M., Pedersen,H.C., Nielsen,J.V.,
            Rasmussen,T.E., Fisker,M.F., Finsen,B., Pedersen,K.M. and
            Jensen,N.A.
  TITLE     Characterization of two novel nuclear BTB/POZ domain zinc finger
            isoforms. Association with differentiation of hippocampal neurons,
            cerebellar granule cells, and macroglia
  JOURNAL   J Biol Chem 277 (9), 7598-7609 (2002)
   PUBMED   11744704
REFERENCE   8  (bases 1 to 3209)
  AUTHORS   Yu,H., Saura,C.A., Choi,S.Y., Sun,L.D., Yang,X., Handler,M.,
            Kawarabayashi,T., Younkin,L., Fedeles,B., Wilson,M.A., Younkin,S.,
            Kandel,E.R., Kirkwood,A. and Shen,J.
  TITLE     APP processing and synaptic plasticity in presenilin-1 conditional
            knockout mice
  JOURNAL   Neuron 31 (5), 713-726 (2001)
   PUBMED   11567612
REFERENCE   9  (bases 1 to 3209)
  AUTHORS   Mucke,L., Masliah,E., Yu,G.Q., Mallory,M., Rockenstein,E.M.,
            Tatsuno,G., Hu,K., Kholodenko,D., Johnson-Wood,K. and McConlogue,L.
  TITLE     High-level neuronal expression of abeta 1-42 in wild-type human
            amyloid protein precursor transgenic mice: synaptotoxicity without
            plaque formation
  JOURNAL   J Neurosci 20 (11), 4050-4058 (2000)
   PUBMED   10818140
REFERENCE   10 (bases 1 to 3209)
  AUTHORS   Ko,M.S., Threat,T.A., Wang,X., Horton,J.H., Cui,Y., Wang,X.,
            Pryor,E., Paris,J., Wells-Smith,J., Kitchen,J.R., Rowe,L.B.,
            Eppig,J., Satoh,T., Brant,L., Fujiwara,H., Yotsumoto,S. and
            Nakashima,H.
  TITLE     Genome-wide mapping of unselected transcripts from extraembryonic
            tissue of 7.5-day mouse embryos reveals enrichment in the t-complex
            and under-representation on the X chromosome
  JOURNAL   Hum Mol Genet 7 (12), 1967-1978 (1998)
   PUBMED   9811942
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BI659024.1 and BC056446.1.
            
            Transcript Variant: This variant (3) differs in the 5' UTR compared
            to variant 1. Variant 1 and 3 encode the same isoform (L).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC056446.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164133, SAMN01164136
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-28                BI659024.1         1-28
            29-3209             BC056446.1         1-3181
FEATURES             Location/Qualifiers
     source          1..3209
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="NMRI"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 28.44 cM"
     gene            1..3209
                     /gene="Zbtb20"
                     /gene_synonym="1300017A20Rik; 7330412A13Rik;
                     A930017C21Rik; D16Wsu73e; DPZF; HOF; J20; ODA-8S; Oda8;
                     Tg(PDGFB-APPSwInd)20Lms; Zfp288"
                     /note="zinc finger and BTB domain containing 20"
                     /db_xref="GeneID:56490"
                     /db_xref="MGI:MGI:1929213"
     exon            1..77
                     /gene="Zbtb20"
                     /gene_synonym="1300017A20Rik; 7330412A13Rik;
                     A930017C21Rik; D16Wsu73e; DPZF; HOF; J20; ODA-8S; Oda8;
                     Tg(PDGFB-APPSwInd)20Lms; Zfp288"
                     /inference="alignment:Splign:2.1.0"
     exon            78..127
                     /gene="Zbtb20"
                     /gene_synonym="1300017A20Rik; 7330412A13Rik;
                     A930017C21Rik; D16Wsu73e; DPZF; HOF; J20; ODA-8S; Oda8;
                     Tg(PDGFB-APPSwInd)20Lms; Zfp288"
                     /inference="alignment:Splign:2.1.0"
     exon            128..189
                     /gene="Zbtb20"
                     /gene_synonym="1300017A20Rik; 7330412A13Rik;
                     A930017C21Rik; D16Wsu73e; DPZF; HOF; J20; ODA-8S; Oda8;
                     Tg(PDGFB-APPSwInd)20Lms; Zfp288"
                     /inference="alignment:Splign:2.1.0"
     exon            190..236
                     /gene="Zbtb20"
                     /gene_synonym="1300017A20Rik; 7330412A13Rik;
                     A930017C21Rik; D16Wsu73e; DPZF; HOF; J20; ODA-8S; Oda8;
                     Tg(PDGFB-APPSwInd)20Lms; Zfp288"
                     /inference="alignment:Splign:2.1.0"
     exon            237..276
                     /gene="Zbtb20"
                     /gene_synonym="1300017A20Rik; 7330412A13Rik;
                     A930017C21Rik; D16Wsu73e; DPZF; HOF; J20; ODA-8S; Oda8;
                     Tg(PDGFB-APPSwInd)20Lms; Zfp288"
                     /inference="alignment:Splign:2.1.0"
     exon            277..377
                     /gene="Zbtb20"
                     /gene_synonym="1300017A20Rik; 7330412A13Rik;
                     A930017C21Rik; D16Wsu73e; DPZF; HOF; J20; ODA-8S; Oda8;
                     Tg(PDGFB-APPSwInd)20Lms; Zfp288"
                     /inference="alignment:Splign:2.1.0"
     exon            378..435
                     /gene="Zbtb20"
                     /gene_synonym="1300017A20Rik; 7330412A13Rik;
                     A930017C21Rik; D16Wsu73e; DPZF; HOF; J20; ODA-8S; Oda8;
                     Tg(PDGFB-APPSwInd)20Lms; Zfp288"
                     /inference="alignment:Splign:2.1.0"
     exon            436..599
                     /gene="Zbtb20"
                     /gene_synonym="1300017A20Rik; 7330412A13Rik;
                     A930017C21Rik; D16Wsu73e; DPZF; HOF; J20; ODA-8S; Oda8;
                     Tg(PDGFB-APPSwInd)20Lms; Zfp288"
                     /inference="alignment:Splign:2.1.0"
     CDS             589..2814
                     /gene="Zbtb20"
                     /gene_synonym="1300017A20Rik; 7330412A13Rik;
                     A930017C21Rik; D16Wsu73e; DPZF; HOF; J20; ODA-8S; Oda8;
                     Tg(PDGFB-APPSwInd)20Lms; Zfp288"
                     /note="isoform L is encoded by transcript variant 3; zinc
                     finger protein 288; zinc finger and BTB domain-containing
                     protein 20; BTB/POZ domain zinc finger factor HOF;
                     POZ/zinc finger transcription factor ODA-8; PDGF-APPSwInd;
                     PDGF-hAPP695,751,770V171F, KM670/671NL; APP Tg"
                     /codon_start=1
                     /product="zinc finger and BTB domain-containing protein 20
                     isoform L"
                     /protein_id="NP_001272734.1"
                     /db_xref="CCDS:CCDS28178.1"
                     /db_xref="GeneID:56490"
                     /db_xref="MGI:MGI:1929213"
                     /translation="MLERKKPKTAENQKASEENEITQPGGSSAKPALPCLNFEAVLSP
                     APALIHSTHSLTNSHAHTGSSDCDISCKGMTERIHSINLHNFSNSVLETLNEQRNRGH
                     FCDVTVRIHGSMLRAHRCVLAAGSPFFQDKLLLGYSDIEIPSVVSVQSVQKLIDFMYS
                     GVLRVSQSEALQILTAASILQIKTVIDECTRIVSQNVGDVFPGIQDSGQDTPRGTPES
                     GTSGQSSDTESGYLQSHPQHSVDRIYSALYACSMQNGSGERSFYSGAVVSHHETALGL
                     PRDHHMEDPSWITRIHERSQQMERYLSTTPETTHCRKQPRPVRIQTLVGNIHIKQEME
                     DDYDYYGQQRVQILERNESEECTEDTDQAEGTESEPKGESFDSGVSSSIGTEPDSVEQ
                     QFGAAAPRDGQAEPAQPEQAAEAPAESSAQPNQLEPGASSPERSNESEMDNTVITVSN
                     SSDKGVLQQPSVNTSIGQPLPSTQLYLRQTETLTSNLRMPLTLTSNTQVIGTAGNTYL
                     PALFTTQPAGSGPKPFLFSLPQPLTGQQTQFVTVSQPGLSTFTAQLPAPQPLASSAGH
                     STASGQGDKKPYECTLCNKTFTAKQNYVKHMFVHTGEKPHQCSICWRSFSLKDYLIKH
                     MVTHTGVRAYQCSICNKRFTQKSSLNVHMRLHRGEKSYECYICKKKFSHKTLLERHVA
                     LHSASNGTPPAGTPPGARAGPPGVVACTEGTTYVCSVCPAKFDQIEQFNDHMRMHVSD
                     G"
     exon            600..787
                     /gene="Zbtb20"
                     /gene_synonym="1300017A20Rik; 7330412A13Rik;
                     A930017C21Rik; D16Wsu73e; DPZF; HOF; J20; ODA-8S; Oda8;
                     Tg(PDGFB-APPSwInd)20Lms; Zfp288"
                     /inference="alignment:Splign:2.1.0"
     exon            788..2392
                     /gene="Zbtb20"
                     /gene_synonym="1300017A20Rik; 7330412A13Rik;
                     A930017C21Rik; D16Wsu73e; DPZF; HOF; J20; ODA-8S; Oda8;
                     Tg(PDGFB-APPSwInd)20Lms; Zfp288"
                     /inference="alignment:Splign:2.1.0"
     exon            2393..3198
                     /gene="Zbtb20"
                     /gene_synonym="1300017A20Rik; 7330412A13Rik;
                     A930017C21Rik; D16Wsu73e; DPZF; HOF; J20; ODA-8S; Oda8;
                     Tg(PDGFB-APPSwInd)20Lms; Zfp288"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2845..2850
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zbtb20"
                     /gene_synonym="1300017A20Rik; 7330412A13Rik;
                     A930017C21Rik; D16Wsu73e; DPZF; HOF; J20; ODA-8S; Oda8;
                     Tg(PDGFB-APPSwInd)20Lms; Zfp288"
                     /note="hexamer: AACAAA"
     polyA_site      2862
                     /gene="Zbtb20"
                     /gene_synonym="1300017A20Rik; 7330412A13Rik;
                     A930017C21Rik; D16Wsu73e; DPZF; HOF; J20; ODA-8S; Oda8;
                     Tg(PDGFB-APPSwInd)20Lms; Zfp288"
     regulatory      2865..2870
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zbtb20"
                     /gene_synonym="1300017A20Rik; 7330412A13Rik;
                     A930017C21Rik; D16Wsu73e; DPZF; HOF; J20; ODA-8S; Oda8;
                     Tg(PDGFB-APPSwInd)20Lms; Zfp288"
                     /note="hexamer: AATAAA"
     regulatory      2877..2882
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zbtb20"
                     /gene_synonym="1300017A20Rik; 7330412A13Rik;
                     A930017C21Rik; D16Wsu73e; DPZF; HOF; J20; ODA-8S; Oda8;
                     Tg(PDGFB-APPSwInd)20Lms; Zfp288"
                     /note="hexamer: AACAAA"
     polyA_site      2886
                     /gene="Zbtb20"
                     /gene_synonym="1300017A20Rik; 7330412A13Rik;
                     A930017C21Rik; D16Wsu73e; DPZF; HOF; J20; ODA-8S; Oda8;
                     Tg(PDGFB-APPSwInd)20Lms; Zfp288"
                     /note="major polyA site"
     polyA_site      2912
                     /gene="Zbtb20"
                     /gene_synonym="1300017A20Rik; 7330412A13Rik;
                     A930017C21Rik; D16Wsu73e; DPZF; HOF; J20; ODA-8S; Oda8;
                     Tg(PDGFB-APPSwInd)20Lms; Zfp288"
                     /note="major polyA site"
ORIGIN      
        1 ggcagtcatt accactcaca ctgtacttcc agggagacac cgattatgag aagagaaact
       61 cagcgctggg gaagaagata actgaatgga gtgtttgaat tgcgctttgc gactctgaag
      121 gctgaaggtg tttccttata ataacaactt cagccatatt ataaacatct tcgaaagaaa
      181 acttccaaga ctcttttatc atcagcaatt gaatatttca cacaacttgc tggctgtccc
      241 ttgaccacca gtctgttgcc tgttgctgct cttcatatgc agccactctc tgtcccctgc
      301 cccaatgaac atctgcacta ggcccaagcc ttggagtgat ttacctgaag agtgacacca
      361 attatctgga aactactaaa gtataattga gaggaacagg gtgaaggaaa tgcaaatgcg
      421 aaagggaagc agtagatgag gaaactgaag cccagagaag tgaagtgagg tgcccaaagc
      481 cacacagcaa gttgcaggca cagctagttc cgtagctcaa gtctcctgac tcccagtcca
      541 gtgttcttcc cattactcca cgggtcctgt ctctaagctt cctgacaaat gctagaacgg
      601 aagaaaccca agacagctga aaaccagaag gcatctgagg agaatgagat tactcagccg
      661 ggcggatcca gcgccaagcc ggcccttccc tgcctgaact ttgaagctgt tttgtctcca
      721 gccccagccc tcatccactc gacacattca ctgacaaact ctcacgctca caccgggtca
      781 tctgattgtg acatcagttg caaggggatg accgagcgca ttcacagcat caaccttcac
      841 aacttcagca attccgtgct cgagaccctc aacgagcagc gcaaccgtgg ccacttctgt
      901 gacgtgacgg ttcgcatcca cgggagcatg ctgcgcgcac atcgctgcgt gctggcagcc
      961 ggcagcccct tcttccaaga caagctgctg ctgggctaca gcgacatcga aatcccgtcg
     1021 gtggtgtccg tacaatcggt gcaaaagctc attgacttca tgtacagcgg tgtgctgaga
     1081 gtctcacagt cggaagctct gcagatcctc acagccgcca gcatcctgca gatcaaaaca
     1141 gtcatagatg agtgcactcg catcgtgtca cagaacgtgg gcgatgtgtt cccaggcatc
     1201 caggattctg gccaggacac accaagaggc acaccagagt caggcacatc tggccagagc
     1261 agtgacacgg aatcaggcta cctgcagagc cacccacagc atagtgtgga ccgaatctac
     1321 tccgcactct acgcctgctc catgcagaat ggcagcggcg agcgctcctt ctacagtggt
     1381 gcagtggtca gccaccacga aacagctctc ggcctgcccc gtgaccacca catggaagac
     1441 cctagctgga tcacacgcat tcatgagcgc tcccagcaaa tggagcgcta cctgtccacc
     1501 acccctgaga ccacgcactg ccggaagcag ccccggcctg tgcgtatcca gaccctggtg
     1561 ggtaacatcc acatcaagca ggaaatggaa gatgactatg actactatgg gcagcaaagg
     1621 gtgcagatcc tagaacgcaa tgaatccgag gagtgcacag aagacactga ccaagcagag
     1681 ggcactgaga gcgagcccaa aggtgaaagc tttgattctg gggtcagctc ctccatcggc
     1741 accgaacctg actcagtgga gcaacagttt ggggcagcag ccccaaggga cggtcaggca
     1801 gaacccgccc aacctgagca ggcagcagaa gccccagctg agagcagtgc ccagccaaac
     1861 cagctagaac caggtgcctc ctctcctgag agaagcaacg agtcagagat ggacaacaca
     1921 gtcatcactg tcagtaacag ctccgataag ggcgtcctac agcagccttc agtcaacaca
     1981 tccatcgggc agccattgcc aagtacccag ctctatttac gccagacaga aaccctcacc
     2041 agcaacctga ggatgcctct gaccttgacc agcaacacac aggtcattgg caccgctggc
     2101 aacacctatc tgccagccct cttcactacc caacccgcgg gcagtggccc caagcctttt
     2161 ctcttcagcc tgccgcagcc cctgacaggc cagcagaccc agtttgtgac agtgtcccag
     2221 cccggtctgt ccacctttac tgcacagctg ccagcgccac agcccctggc ctcatctgca
     2281 ggccacagca cagccagtgg gcaaggcgac aaaaagcctt atgagtgcac tctctgcaac
     2341 aagactttca cagccaaaca gaactacgtc aagcacatgt tcgtacatac aggtgagaag
     2401 ccccaccagt gcagcatctg ctggcgctcc ttctccttga aggattacct tatcaagcac
     2461 atggtgacgc acaccggcgt gagagcgtac cagtgtagca tctgcaacaa gcgcttcacc
     2521 cagaagagtt ccctcaacgt gcacatgcgc ctgcaccgcg gggagaagtc ctatgagtgc
     2581 tacatctgca aaaagaagtt ctcccacaag accctgctgg agcgacacgt ggccctgcac
     2641 agtgccagca acgggacccc tccggcaggc acgcccccag gtgcccgcgc gggtccgcca
     2701 ggcgtggtgg cctgcacaga ggggaccact tacgtctgct ccgtctgccc agcaaagttt
     2761 gaccaaatcg agcagttcaa cgaccacatg aggatgcatg tgtctgacgg ataagtagta
     2821 cctttctctc tttcttacga accaaacaaa acgacaacaa aagaaataaa caagcaaaca
     2881 aacagacaaa aagctatggc actagaattt aagaaatgtt ttggtttcct ttttactttc
     2941 tgtttttgtt tctgttccgt ttcattttgt actacatgaa gaactgtttt ttgcctgctg
     3001 gtacattaca tttccggggg cttgggtgga taatactttt cccagtcccc cttggatggt
     3061 ggccttaagg cctggtagtg cttcaggagg tccactggtt ggatctctag ctactggcct
     3121 ctaaatacaa cccttcttta caaaaacaaa aaacaaacaa acaaaaaaaa agacaaaaac
     3181 aaaaacaaaa caaaaaaaaa aaaaaaaaa
//
