LOCUS       NM_001355098            4123 bp    mRNA    linear   ROD 18-APR-2023
DEFINITION  Mus musculus zinc finger and BTB domain containing 18 (Zbtb18),
            transcript variant 3, mRNA.
ACCESSION   NM_001355098
VERSION     NM_001355098.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4123)
  AUTHORS   Wang R, Bhatt AB, Minden-Birkenmaier BA, Travis OK, Tiwari S, Jia
            H, Rosikiewicz W, Martinot O, Childs E, Loesch R, Tossou G,
            Jamieson S, Finkelstein D, Xu B and Labelle M.
  TITLE     ZBTB18 restricts chromatin accessibility and prevents
            transcriptional adaptations that drive metastasis
  JOURNAL   Sci Adv 9 (1), eabq3951 (2023)
   PUBMED   36608120
  REMARK    GeneRIF: ZBTB18 restricts chromatin accessibility and prevents
            transcriptional adaptations that drive metastasis.
REFERENCE   2  (bases 1 to 4123)
  AUTHORS   Jin Y, Gao X, Lu M, Chen G, Yang X, Ren N, Song Y, Hou C, Li J, Liu
            Q and Gao J.
  TITLE     Loss of BAF (mSWI/SNF) chromatin-remodeling ATPase Brg1 causes
            multiple malformations of cortical development in mice
  JOURNAL   Hum Mol Genet 31 (20), 3504-3520 (2022)
   PUBMED   35666215
REFERENCE   3  (bases 1 to 4123)
  AUTHORS   Medeiros de Araujo JA, Barao S, Mateos-White I, Espinosa A, Costa
            MR, Gil-Sanz C and Muller U.
  TITLE     ZBTB20 is crucial for the specification of a subset of callosal
            projection neurons and astrocytes in the mammalian neocortex
  JOURNAL   Development 148 (16) (2021)
   PUBMED   34351428
REFERENCE   4  (bases 1 to 4123)
  AUTHORS   Xiang C, Frietze KK, Bi Y, Li Y, Dal Pozzo V, Pal S, Alexander N,
            Baubet V, D'Acunto V, Mason CE, Davuluri RV and Dahmane N.
  TITLE     RP58 Represses Transcriptional Programs Linked to Nonneuronal Cell
            Identity and Glioblastoma Subtypes in Developing Neurons
  JOURNAL   Mol Cell Biol 41 (7), e0052620 (2021)
   PUBMED   33903225
  REMARK    GeneRIF: RP58 Represses Transcriptional Programs Linked to
            Nonneuronal Cell Identity and Glioblastoma Subtypes in Developing
            Neurons.
REFERENCE   5  (bases 1 to 4123)
  AUTHORS   Cargnin F, Kwon JS, Katzman S, Chen B, Lee JW and Lee SK.
  TITLE     FOXG1 Orchestrates Neocortical Organization and Cortico-Cortical
            Connections
  JOURNAL   Neuron 100 (5), 1083-1096 (2018)
   PUBMED   30392794
REFERENCE   6  (bases 1 to 4123)
  AUTHORS   Takahashi A, Hirai S, Ohtaka-Maruyama C, Miwa A, Hata Y, Okabe S
            and Okado H.
  TITLE     Co-localization of a novel transcriptional repressor simiRP58 with
            RP58
  JOURNAL   Biochem Biophys Res Commun 368 (3), 637-642 (2008)
   PUBMED   18262495
  REMARK    GeneRIF: Interestingly, co-transfection with simiRP58 and RP58
            induced changes in the localization patterns of both proteins.
REFERENCE   7  (bases 1 to 4123)
  AUTHORS   Boland E, Clayton-Smith J, Woo VG, McKee S, Manson FD, Medne L,
            Zackai E, Swanson EA, Fitzpatrick D, Millen KJ, Sherr EH, Dobyns WB
            and Black GC.
  TITLE     Mapping of deletion and translocation breakpoints in 1q44
            implicates the serine/threonine kinase AKT3 in postnatal
            microcephaly and agenesis of the corpus callosum
  JOURNAL   Am J Hum Genet 81 (2), 292-303 (2007)
   PUBMED   17668379
REFERENCE   8  (bases 1 to 4123)
  AUTHORS   Ohtaka-Maruyama C, Miwa A, Kawano H, Kasai M and Okado H.
  TITLE     Spatial and temporal expression of RP58, a novel zinc finger
            transcriptional repressor, in mouse brain
  JOURNAL   J Comp Neurol 502 (6), 1098-1108 (2007)
   PUBMED   17447250
  REMARK    GeneRIF: These results suggest that RP58 plays a crucial role in
            neuronal proliferation, migration, and differentiation in the
            developing cerebral cortex.
REFERENCE   9  (bases 1 to 4123)
  AUTHORS   Kuninger D, Kuzmickas R, Peng B, Pintar JE and Rotwein P.
  TITLE     Gene discovery by microarray: identification of novel genes induced
            during growth factor-mediated muscle cell survival and
            differentiation
  JOURNAL   Genomics 84 (5), 876-889 (2004)
   PUBMED   15475267
REFERENCE   10 (bases 1 to 4123)
  AUTHORS   Meng G, Inazawa J, Ishida R, Tokura K, Nakahara K, Aoki K and Kasai
            M.
  TITLE     Structural analysis of the gene encoding RP58, a sequence-specific
            transrepressor associated with heterochromatin
  JOURNAL   Gene 242 (1-2), 59-64 (2000)
   PUBMED   10721697
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC120370.9.
            
            [WARNING] On May 19, 2023 this sequence was replaced by
            NM_001355098.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11927932.2910450.1, BQ770530.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849383, SAMN00849384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-245               AC120370.9         38159-38403         c
            246-363             AC120370.9         37413-37530         c
            364-447             AC120370.9         35932-36015         c
            448-4123            AC120370.9         29990-33665         c
FEATURES             Location/Qualifiers
     source          1..4123
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1"
     gene            1..4123
                     /gene="Zbtb18"
                     /gene_synonym="RP58; zfp-238; Zfp238; Znf238."
                     /note="zinc finger and BTB domain containing 18"
                     /db_xref="GeneID:30928"
                     /db_xref="MGI:MGI:1353609"
     exon            1..245
                     /gene="Zbtb18"
                     /gene_synonym="RP58; zfp-238; Zfp238; Znf238."
                     /inference="alignment:Splign:2.1.0"
     exon            246..363
                     /gene="Zbtb18"
                     /gene_synonym="RP58; zfp-238; Zfp238; Znf238."
                     /inference="alignment:Splign:2.1.0"
     exon            364..447
                     /gene="Zbtb18"
                     /gene_synonym="RP58; zfp-238; Zfp238; Znf238."
                     /inference="alignment:Splign:2.1.0"
     CDS             435..2030
                     /gene="Zbtb18"
                     /gene_synonym="RP58; zfp-238; Zfp238; Znf238."
                     /note="isoform 1 is encoded by transcript variant 3; 58
                     kDa repressor protein; transcriptional repressor RP58;
                     zinc finger protein 238; zinc finger and BTB
                     domain-containing protein 18"
                     /codon_start=1
                     /product="zinc finger and BTB domain-containing protein 18
                     isoform 1"
                     /protein_id="NP_001342027.1"
                     /db_xref="CCDS:CCDS35800.1"
                     /db_xref="GeneID:30928"
                     /db_xref="MGI:MGI:1353609"
                     /translation="MCPKGYEDSMEFPDHSRHLLQCLSEQRHQGFLCDCTVLVGDAQF
                     RAHRAVLASCSMYFHLFYKDQLDKRDIVHLNSDIVTAPAFALLLEFMYEGKLQFKDLP
                     IEDVLAAASYLHMYDIVKVCKKKLKEKATTEADSTKKEEDASSCSDKVESLSDGSSHM
                     AGDLPSDEDEGEDDKLNILPSKRDLAAEPGNMWMRLPSDSAGIPQAGGEAEPHATAAG
                     KTVASPCSSTESLSQRSVTSVRDSADVDCVLDLSVKSSLSGVENLNSSYFSSQDVLRS
                     NLVQVKVEKEASCDESDVGTNDYDMEHSTVKESVSTNNRVQYEPAHLAPLREDSVLRE
                     LDREDKASDDEMMTPESERVQVEGGMENSLLPYVSNILSPAGQIFMCPLCNKVFPSPH
                     ILQIHLSTHFREQDGIRSKPAADVNVPTCSLCGKTFSCMYTLKRHERTHSGEKPYTCT
                     QCGKSFQYSHNLSRHAVVHTREKPHACKWCERRFTQSGDLYRHIRKFHCELVNSLSVK
                     SEALSLPTVRDWTLEDSSQELWK"
     exon            448..4123
                     /gene="Zbtb18"
                     /gene_synonym="RP58; zfp-238; Zfp238; Znf238."
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aggctgcggc cgccgctggg ctgctgccat ggggagccgt tgaaagagtg gggccctgtg
       61 gctcggccgc gcgcctcagg ctgccagcgc gggcgggggg cggcgggggc gcgcggggcc
      121 cgggccgggg ccggcgggcg ggcgggggcc ggcggaggac gcccacaagt ccagcggcgg
      181 cggcggcggc agaggaggag gaggaggagg acgcggcggg gacgcggcga ctcgggccgc
      241 tccgtaacct ccgagggtcc gcggtagcgg tggacgggtc gatccgtgga gtggatgtct
      301 tcgggccatt gcggtgcttg ggactcatta aactgtcact cacccccacc accaccccac
      361 tggtctgctt tttttccacc gatgtaacag acctgcagcc agcaagactc cgagggaagg
      421 acttaatcaa gtttatgtgt cctaaaggtt atgaagacag tatggagttt ccagaccaca
      481 gcagacattt gctgcagtgt ctgagcgagc agaggcacca gggctttctt tgtgactgca
      541 ctgttctggt gggagatgcc cagttccggg cacaccgagc tgttctggct tcatgcagca
      601 tgtatttcca cctcttttac aaggaccagc tggacaaaag agacattgtt catctgaaca
      661 gcgacattgt gacagccccc gctttcgctc tcctgcttga attcatgtac gaagggaaac
      721 tccagttcaa agacttgccc attgaggacg tgctagcagc tgccagttat ctccacatgt
      781 atgacattgt caaagtctgc aaaaagaagc tgaaagagaa agctaccaca gaggcggaca
      841 gcaccaaaaa agaagaagat gcttcaagtt gttcggataa agtcgagagc ctctcagacg
      901 gcagcagcca catggcaggt gacctgccca gtgatgaaga tgaaggcgaa gatgacaaat
      961 tgaacattct acccagcaaa agggacttgg cagctgagcc tgggaacatg tggatgcgat
     1021 tgccctcaga ctcagcaggc atcccccagg ctggcggaga ggccgagcca cacgccacag
     1081 cagctggaaa aacagtagcc agcccctgca gctcaacaga gtctttgtcc cagaggtctg
     1141 tcacctccgt gagggattcg gcagatgttg actgtgtgct ggacctgtct gtcaagtcca
     1201 gcctttcagg agttgaaaat ctgaacagct cttatttctc ttcacaggac gtgctgagaa
     1261 gcaacctggt gcaggtgaag gtggagaaag aggcgtcctg tgatgagagt gatgttggca
     1321 ctaatgacta tgacatggaa catagcactg tgaaagagag tgtgagcact aacaacaggg
     1381 tacagtatga gccagcccac ctggctcctc tgagggagga ctcggtctta agggaactgg
     1441 atcgggagga caaagccagc gatgatgaga tgatgacccc agagagcgag cgggtccagg
     1501 tggaaggggg catggagaac agtctgcttc cctacgtctc caatatcctg agccccgcag
     1561 gccagatctt catgtgcccc ctgtgcaaca aagtcttccc cagcccccac atcctgcaga
     1621 tccacctgag cacgcacttc cgagagcagg atggcatccg tagcaagcct gccgccgatg
     1681 tcaatgtgcc cacgtgctcc ctgtgtggga agactttctc ctgcatgtac accctcaagc
     1741 gccacgagag gactcactcg ggggagaagc cctacacgtg cacccaatgc ggcaagagtt
     1801 tccagtactc gcacaacctg agccgtcatg ccgtggtgca cacccgcgag aagccccatg
     1861 cctgcaagtg gtgcgagcgc aggttcacgc agtccggaga cctgtacaga cacatccgca
     1921 agttccactg tgagttggtg aactccttgt cggtcaaaag tgaagcgctg agcttgccca
     1981 ctgtcagaga ctggacctta gaagatagct ctcaagaact ttggaaataa ttttatatat
     2041 atatatatat aaataatata tatatatata tatacatata tatacataga tctctatata
     2101 gttgtggtac ggtctaaaag cagtcttgtt tcctggaact gaaaagttgg gatcttaact
     2161 tgtttttgca ctttagaata atagcatgag aatctcacta atttagcatt ctgataaaag
     2221 aaactagagc aagtcacaag tagagagctg tctttctttt gagggttagg ccaagttagc
     2281 caataaaacc ttctcaacaa atggttctgt cacaaacgct ttcacatggc ttacttttgt
     2341 acacactgca ttgtcttgag cgctttccct gtgctccaca ctgttttgtt ttgttttgtt
     2401 ttcagagtag aaatcccctc cagtttatta gcctctttat atgtctcaaa ttgcatgaat
     2461 attttctggc tgttggaaac ctgaatgctt ttagacccaa atggaaaatt tctgaaatgc
     2521 tggattatct atttttaaac aagcagttga cttaaaactt tgtgtggcaa cttctggttt
     2581 tctgatggtc cccagtgaga gaaatctgac agtacactgg gtcactggga ctgtctctgt
     2641 gaaggtttgc ttgagatgaa aaaggatatt gcagcttcag cagtgttgaa ctgtgtgttt
     2701 aaaatgtgaa ttactgttct tgtatactgt aattgattac acgggctggg gggggtgtca
     2761 aagaacttga caggttgtgt tgatgctctt agttgagtct tgaaaagtaa atattaacgc
     2821 tacagaaatg catgagtttc aatatatttt ttgtctttgt ttgcattgta taactttaac
     2881 gagtgagttt aaaattattt aatttcctta gaaaaatagc accatttggg aaaaaaactg
     2941 gtgttacgaa gaacataaat gcactgtctt tatttttatt tttattttat ataatttaaa
     3001 ttgacttttc ccacgtcttt aagtttgaaa ctgttaagct gaataaaaac ttaagctgca
     3061 aattgataac ttcgctacat tacaaggaac atataaatgt ttacaaacgg cttaaagaat
     3121 tgcatgtgca gtgtgcattc ataccacact tgtaattgca cagaacccat gccagctcag
     3181 agtttaggtg tacacacgta cccagccgag tgtttttaga ataactactg cacaaattga
     3241 caataggtca taggtcattc tctctctccc tcctttttgc ttcccctttc tttttctccc
     3301 ctatttcctt tccttccccc taccccctaa ctcatgaaaa gattctatgg actgaaaaag
     3361 ccccaggctg aaaggactga accgccttga ttgacatggg gaggggggtt agtagactgt
     3421 gtatcggcag cagaggctgc agcccgatgt gtggttctga tggccagcgc ggggcagaag
     3481 cgttttgcac actgtttgtt ttcctgtctt gcacttacaa ataaggtcta tgggagtagc
     3541 atgggaaaca gtggttgttt ttcccttttt cttttttaat tgcttttgtt taaaatttga
     3601 tcgccttaac tactgtaaac atagcctatt tttgtgctta agatactgaa tggaaaactc
     3661 cattgtgtgt tgctggactg ttttggaaat atttggtcaa atgtatgtta atttggctgt
     3721 aatggcattt aaagcaaaca aacaaacaaa caaacaaagc tgtgaaaatg gccttggagc
     3781 attatcttta gttacttgaa gagtttctag tttttttttt tttaatacag tttatgttaa
     3841 aataatcttt attaatctag aggagacaat caatgtctgt ggaagaacgg acttttttgg
     3901 attttctttt ttaatggtca ttgtgagtga ttgctctttc ttttacttag tttcacattc
     3961 ttcctttgtt ctaaatctta gactgacatc tagctttgac aatcatagta tgttttattt
     4021 cctgaggggg aataacttat aatgctgttt agttttgtac tattggtgtg ttggtgaatt
     4081 tttaaactgt gtgctaactg caataaatta tatgaactga gaa
//
