LOCUS       NM_009547               3947 bp    mRNA    linear   ROD 12-FEB-2025
DEFINITION  Mus musculus zinc finger and BTB domain containing 14 (Zbtb14),
            transcript variant 1, mRNA.
ACCESSION   NM_009547
VERSION     NM_009547.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3947)
  AUTHORS   Medeiros de Araujo,J.A., Barao,S., Mateos-White,I., Espinosa,A.,
            Costa,M.R., Gil-Sanz,C. and Muller,U.
  TITLE     ZBTB20 is crucial for the specification of a subset of callosal
            projection neurons and astrocytes in the mammalian neocortex
  JOURNAL   Development 148 (16) (2021)
   PUBMED   34351428
REFERENCE   2  (bases 1 to 3947)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3947)
  AUTHORS   Kim,W., Zhao,F., Wu,R., Qin,S., Nowsheen,S., Huang,J., Zhou,Q.,
            Chen,Y., Deng,M., Guo,G., Luo,K., Lou,Z. and Yuan,J.
  TITLE     ZFP161 regulates replication fork stability and maintenance of
            genomic stability by recruiting the ATR/ATRIP complex
  JOURNAL   Nat Commun 10 (1), 5304 (2019)
   PUBMED   31757956
  REMARK    GeneRIF: ZFP161 acts as a scaffolding protein to facilitate the
            interaction between RPA and ATR/ATRIP. ZFP161 binds to RPA and
            ATR/ATRIP through distinct regions and stabilizes the RPA-ATR-ATRIP
            complex at stalled replication forks. This function of ZFP161 is
            important to the ATR signaling cascade and genome stability
            maintenance. ZFP161 knockout mice showed a defect in ATR activation
            and genomic instability.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3947)
  AUTHORS   San Agustin,J.T., Klena,N., Granath,K., Panigrahy,A., Stewart,E.,
            Devine,W., Strittmatter,L., Jonassen,J.A., Liu,X., Lo,C.W. and
            Pazour,G.J.
  TITLE     Genetic link between renal birth defects and congenital heart
            disease
  JOURNAL   Nat Commun 7, 11103 (2016)
   PUBMED   27002738
  REMARK    Erratum:[Nat Commun. 2016 Jun 08;7:11910. doi:
            10.1038/ncomms11910.. PMID: 27273704]
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3947)
  AUTHORS   Li,Y., Klena,N.T., Gabriel,G.C., Liu,X., Kim,A.J., Lemke,K.,
            Chen,Y., Chatterjee,B., Devine,W., Damerla,R.R., Chang,C., Yagi,H.,
            San Agustin,J.T., Thahir,M., Anderton,S., Lawhead,C., Vescovi,A.,
            Pratt,H., Morgan,J., Haynes,L., Smith,C.L., Eppig,J.T.,
            Reinholdt,L., Francis,R., Leatherbury,L., Ganapathiraju,M.K.,
            Tobita,K., Pazour,G.J. and Lo,C.W.
  TITLE     Global genetic analysis in mice unveils central role for cilia in
            congenital heart disease
  JOURNAL   Nature 521 (7553), 520-524 (2015)
   PUBMED   25807483
REFERENCE   6  (bases 1 to 3947)
  AUTHORS   Obata,T., Yanagidani,A., Yokoro,K., Numoto,M. and Yamamoto,S.
  TITLE     Analysis of the consensus binding sequence and the DNA-binding
            domain of ZF5
  JOURNAL   Biochem Biophys Res Commun 255 (2), 528-534 (1999)
   PUBMED   10049742
REFERENCE   7  (bases 1 to 3947)
  AUTHORS   Yokoro,K., Yanagidani,A., Obata,T., Yamamoto,S. and Numoto,M.
  TITLE     Genomic cloning and characterization of the mouse POZ/zinc-finger
            protein ZF5
  JOURNAL   Biochem Biophys Res Commun 246 (3), 668-674 (1998)
   PUBMED   9618270
REFERENCE   8  (bases 1 to 3947)
  AUTHORS   Sobek-Klocke,I., Disque-Kochem,C., Ronsiek,M., Klocke,R.,
            Jockusch,H., Breuning,A., Ponstingl,H., Rojas,K., Overhauser,J. and
            Eichenlaub-Ritter,U.
  TITLE     The human gene ZFP161 on 18p11.21-pter encodes a putative c-myc
            repressor and is homologous to murine Zfp161 (Chr 17) and
            Zfp161-rs1 (X Chr)
  JOURNAL   Genomics 43 (2), 156-164 (1997)
   PUBMED   9244432
  REMARK    Erratum:[Genomics 1997 Nov 1;45(3):633]
REFERENCE   9  (bases 1 to 3947)
  AUTHORS   Sugiura,K., Muro,Y., Nagai,Y., Kamimoto,T., Wakabayashi,T.,
            Ohashi,M. and Hagiwara,M.
  TITLE     Expression cloning and intracellular localization of a human ZF5
            homologue
  JOURNAL   Biochim Biophys Acta 1352 (1), 23-26 (1997)
   PUBMED   9177479
REFERENCE   10 (bases 1 to 3947)
  AUTHORS   Numoto,M., Niwa,O., Kaplan,J., Wong,K.K., Merrell,K., Kamiya,K.,
            Yanagihara,K. and Calame,K.
  TITLE     Transcriptional repressor ZF5 identifies a new conserved domain in
            zinc finger proteins
  JOURNAL   Nucleic Acids Res 21 (16), 3767-3775 (1993)
   PUBMED   8367294
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB247149.1, BC052017.1, AK082051.1 and AK136762.1.
            
            On Sep 28, 2017 this sequence version replaced NM_009547.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK082051.1, AK136762.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-174               CB247149.1         137-310
            175-3739            BC052017.1         1-3565
            3740-3945           AK082051.1         3708-3913
            3946-3947           AK136762.1         3868-3869
FEATURES             Location/Qualifiers
     source          1..3947
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 40.42 cM"
     gene            1..3947
                     /gene="Zbtb14"
                     /gene_synonym="b2b1982Clo; ZF5; Zfp161"
                     /note="zinc finger and BTB domain containing 14"
                     /db_xref="GeneID:22666"
                     /db_xref="MGI:MGI:1195345"
     exon            1..422
                     /gene="Zbtb14"
                     /gene_synonym="b2b1982Clo; ZF5; Zfp161"
                     /inference="alignment:Splign:2.1.0"
     exon            423..506
                     /gene="Zbtb14"
                     /gene_synonym="b2b1982Clo; ZF5; Zfp161"
                     /inference="alignment:Splign:2.1.0"
     CDS             504..1853
                     /gene="Zbtb14"
                     /gene_synonym="b2b1982Clo; ZF5; Zfp161"
                     /note="zfp-161; zinc finger protein 161; zinc finger
                     protein 5"
                     /codon_start=1
                     /product="zinc finger and BTB domain-containing protein
                     14"
                     /protein_id="NP_033573.1"
                     /db_xref="CCDS:CCDS37682.1"
                     /db_xref="GeneID:22666"
                     /db_xref="MGI:MGI:1195345"
                     /translation="MEFFISMSETIKYNDDDHKTLFLKTLNEQRLEGEFCDIAIVVED
                     VKFRAHRCVLAACSTYFKKLFKKLEVDSSSVIEIDFLRSDIFEEVLNYMYTAKISVKK
                     EDVNLMMSSGQILGIRFLDKLCSQKRDVSSPDESNGQSKSKYCLKLNRPIGDAADAQD
                     DDVEEIGDQDDSPSDDTVEGTPPSQEDGKSPTTTLRVQEAILKELGSEEVRKVNCYGQ
                     EVESMETPESKDLGSQTPQALTFNDGMSEVKDEQTPGWTTAASDMKFEYLLYGHHREQ
                     IACQACGKTFSDEGRLRKHEKLHTADRPFVCEMCTKGFTTQAHLKEHLKIHTGYKPYS
                     CEVCGKSFIRAPDLKKHERVHSNERPFACHMCDKAFKHKSHLKDHERRHRGEKPFVCG
                     SCTKAFAKASDLKRHENNMHSERKQVTPSAIQSETEQLQAAAMAAEAEQQLETIACS"
     exon            507..3947
                     /gene="Zbtb14"
                     /gene_synonym="b2b1982Clo; ZF5; Zfp161"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3367..3372
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zbtb14"
                     /gene_synonym="b2b1982Clo; ZF5; Zfp161"
                     /note="hexamer: ATTAAA"
     polyA_site      3389
                     /gene="Zbtb14"
                     /gene_synonym="b2b1982Clo; ZF5; Zfp161"
                     /note="major polyA site"
     regulatory      3719..3724
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zbtb14"
                     /gene_synonym="b2b1982Clo; ZF5; Zfp161"
                     /note="hexamer: TATAAA"
     polyA_site      3741
                     /gene="Zbtb14"
                     /gene_synonym="b2b1982Clo; ZF5; Zfp161"
     regulatory      3927..3932
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zbtb14"
                     /gene_synonym="b2b1982Clo; ZF5; Zfp161"
                     /note="hexamer: ATTACA"
     polyA_site      3947
                     /gene="Zbtb14"
                     /gene_synonym="b2b1982Clo; ZF5; Zfp161"
ORIGIN      
        1 ggggcgcgag ctcggggctc gcgggcggag cagggcgcgg cgcggcgcgg ggctgcggaa
       61 ccggccgcat gcccgctccc gagctcgtcg cgccgccggg gctgctgcgg gccaaggaag
      121 agagcctcgc gcccgcgccg cgacctggag aagtggagga tggtggaagg gaaggtggcc
      181 cgtcgctggc gggcacagct caggggagct tttgtttagg agagaatgct gagggctcgc
      241 tgcatccggc ggctcattgg ctgcgaaatg cgaatgtggg ctccccacgc gcggactgcg
      301 ccccatgtct ttcgcggggc cccggattcc ccactcccaa gttgtgcggt cgcaacaggg
      361 aagtggtgtg gccgccattg tcgcagctgc tccggaataa ggaggcggct gcggctgctt
      421 atatctggct tgcccctgat cagcctgagt ctgatctgaa gattttggtg tttaaggcat
      481 taagaacata gcctgaattg ttcatggagt ttttcatcag tatgtctgaa accataaaat
      541 ataatgatga tgatcataaa acgctgtttc tgaaaacact gaacgaacag cgcctggagg
      601 gagaattctg cgacatcgcc atcgtggttg aagatgtaaa gttccgagcc caccggtgtg
      661 tcctcgccgc ctgcagcacg tactttaaga agcttttcaa gaagctagaa gtagacagct
      721 cgtccgtcat agagatagat ttcctccgct ctgacatatt tgaagaggtg ctgaactaca
      781 tgtacaccgc caagatttcc gtgaaaaagg aggacgtcaa cttgatgatg tcgtccgggc
      841 agattctcgg tatccggttt ttggataaac tgtgttctca gaagcgcgat gtgtctagtc
      901 cggatgaaag taacggccag tcgaagagta agtattgcct caaactaaac cgccccatcg
      961 gagacgctgc tgatgctcag gacgatgatg tggaagaaat cggggaccaa gatgacagcc
     1021 cttctgatga cacggtagag ggcactcccc cgagtcaaga ggacggcaag tctcccacaa
     1081 ccactctcag ggttcaggaa gcaattttga aagagctggg gagtgaggaa gttcggaaag
     1141 tgaactgtta cggccaggaa gtggagtcca tggagactcc cgaatccaaa gatctgggct
     1201 ctcagacccc tcaggcctta acctttaatg atgggatgag cgaagtaaaa gatgaacaga
     1261 ctccgggctg gaccacggcg gccagcgaca tgaagttcga gtacttgctc tacggtcacc
     1321 atcgagagca gatcgcctgc caggcgtgtg ggaagacgtt ctccgatgaa ggccggctga
     1381 ggaaacatga gaagctccac accgctgaca ggccgtttgt ctgtgagatg tgcacaaaag
     1441 gtttcaccac ccaggcccac ctgaaagaac acctaaaaat ccatacaggg tacaaaccct
     1501 acagctgcga ggtgtgcgga aagtcattca tccgcgcccc agacctgaag aagcacgaga
     1561 gggttcacag caacgaaaga ccatttgcgt gtcacatgtg tgacaaagcc ttcaaacaca
     1621 agtctcacct caaggaccac gagagaagac acagagggga aaagcctttt gtgtgtggct
     1681 cctgcaccaa ggccttcgcc aaggcctcag acctgaagag gcatgagaac aatatgcaca
     1741 gtgagaggaa acaggtcacc cccagtgcca tccagagtga gacagaacag ttgcaggccg
     1801 cagccatggc cgctgaggct gagcagcagc tggagacaat tgcctgtagc tagaggtgat
     1861 gggttaggaa cactgggcct gggaggtgga tgctaagatt gcattggctg tagtcagtga
     1921 acacctttga ccgctttgtg gcaatttaca gcgttgtgct ggctggacct aagacagtgc
     1981 gcactccggt taggtgattc tcaaatttct caaggcagtt atgttcctac gttctgacca
     2041 aacagtttgc tttttttatc ttttggtttg tgtgtgcgtg tgcgtgtgcg tgtgtgtgtt
     2101 gtctagtatt catattccca gtaagctccc ctacccttct ttatggtttt aatttgaaat
     2161 ctcctttgtc tggtttaaaa tgagtggctt ctgtttcatt cttaattcct caactcttgc
     2221 caagctggtg agtgcactgc acagagtcat ggaataaatt gatttcctag tcccagtata
     2281 tgtgacttat gtcaaaacag cagttttaat aactggatac aagaccttta tatggatgca
     2341 gaaaatgttg gcacgcgctg acccagaaca ctgcagaagt acaaaaccaa atttggaaaa
     2401 atggaatggt tttagtttta tatttggttt gtgattttta aatctctctc tctatatata
     2461 tatatcattg tttctcactg ttccttggac aaataatggt tgctttgctg aagtgttcct
     2521 tcatccatta caatggcccc tgtacccacc ccaaatgctg caggtcatgt atacctcagg
     2581 atgagtgaga ccaccaggat gctggtggtg ttgggactca gtttcccttt cattcagtgt
     2641 ggccatgctg tctgtgtgtg tccgtgcaat ggaccagcat cgacaggaga agagtctgac
     2701 acaaggtttt cacagataca aaaaacccct aggtcttgaa atcgtgactg atttcagaaa
     2761 tggttttgta tttaagatca aaattaggac aagcagcagc aatgtttctt caaatgcgtt
     2821 tttgtagttt acagatggtc aggcctcggg gtctctgcat ctctgcagca ctcaatttcc
     2881 cttggagcag atgcttcctt aaatacgtct gaaacccttc acgtgtgtaa atagtattgt
     2941 tggtcttatg tatttcgaga aaagggacag ctgcattttt tttctttcct ttttattttt
     3001 tttatacagt ggattaaagt acctttcatt ggcaacacat atcagacccc tttaaccaat
     3061 attaaagact atcagaccaa atgtttatgt tttccaaata tgtcttatca ctggttgcag
     3121 ttttcaatag aagctgattg ccctgtcata gccataaatc ggaattatga actttgtttc
     3181 agattgggtg tactaaaacg ctcctttgac tatttcctta aggatatatt gaaatgccca
     3241 cagagtttga attatgttct gtaggaaagt gtagacagtt gttttaggat gtgtacagtt
     3301 gtagaaggtg ccaactttaa aagctcatgt ttggttctta aggttttctt tttaaaaaaa
     3361 aaatgcatta aagtaatttc gttacatggc ctgctgtact aacatctgtt attactgtcg
     3421 tgagaaaaat tttattttta aaaccggtgt ccatgttgtg ccagagattg taggatggag
     3481 gggaggctac ctttaaattt ttttctttat ttatcgttaa aatgtttcag cttaaattaa
     3541 tctttcctga gtgttttttt ttctgttttg aaggcaatcc catcagttcg tctgtgcagt
     3601 tagtaggagg ggccggactg gtgatcctag gctgtgttaa ccaaagcaaa tgtgaaatca
     3661 gctggcatcc tgttgataac tacttcaaca aaccatattt tgggcctttg tttttgtata
     3721 taaagataat gatacactcc tcttgttctt gatcattctt tataccactg ttgttaatgt
     3781 ccagatctat acgctaccat agtcatggtt tcatagaggg tcacactcct gatctaaaat
     3841 cagtccctat aaaaagcctt gtggacaggt aatcatgtca ttgtgtccca atctgagaaa
     3901 acaaagtaga attctgaata cttcgtatta catgtttagt gtttgaa
//
