LOCUS       NM_178744               3733 bp    mRNA    linear   ROD 06-JUN-2024
DEFINITION  Mus musculus zinc finger and BTB domain containing 1 (Zbtb1),
            transcript variant 1, mRNA.
ACCESSION   NM_178744 XM_915720 XM_923896 XM_923900
VERSION     NM_178744.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3733)
  AUTHORS   Medeiros de Araujo,J.A., Barao,S., Mateos-White,I., Espinosa,A.,
            Costa,M.R., Gil-Sanz,C. and Muller,U.
  TITLE     ZBTB20 is crucial for the specification of a subset of callosal
            projection neurons and astrocytes in the mammalian neocortex
  JOURNAL   Development 148 (16) (2021)
   PUBMED   34351428
REFERENCE   2  (bases 1 to 3733)
  AUTHORS   Wang,J.H., Shi,C.W., Lu,Y.Y., Zeng,Y., Cheng,M.Y., Wang,R.Y.,
            Sun,Y., Jiang,Y.L., Yang,W.T., Zhao,D.D., Huang,H.B., Ye,L.P.,
            Cao,X., Yang,G.L. and Wang,C.F.
  TITLE     MicroRNA and circRNA Expression Analysis in a Zbtb1 Gene Knockout
            Monoclonal EL4 Cell Line
  JOURNAL   Front Cell Infect Microbiol 11, 706919 (2021)
   PUBMED   34290994
  REMARK    GeneRIF: MicroRNA and circRNA Expression Analysis in a Zbtb1 Gene
            Knockout Monoclonal EL4 Cell Line.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3733)
  AUTHORS   Zhang,X., Lu,Y., Cao,X., Zhen,T. and Kovalovsky,D.
  TITLE     Zbtb1 prevents default myeloid differentiation of lymphoid-primed
            multipotent progenitors
  JOURNAL   Oncotarget 7 (37), 58768-58778 (2016)
   PUBMED   27542215
  REMARK    GeneRIF: these results show that Zbtb1 expression prevents
            activation of a default myeloid program in LMPP cells, ensuring the
            generation of lymphoid cells
REFERENCE   4  (bases 1 to 3733)
  AUTHORS   Cao,X., Lu,Y., Zhang,X. and Kovalovsky,D.
  TITLE     Zbtb1 Safeguards Genome Integrity and Prevents p53-Mediated
            Apoptosis in Proliferating Lymphoid Progenitors
  JOURNAL   J Immunol 197 (4), 1199-1211 (2016)
   PUBMED   27402700
  REMARK    GeneRIF: these results indicate that Zbtb1 prevents DNA damage in
            replicating immune progenitors, allowing the generation of B cells,
            T cells, and myeloid cells.
REFERENCE   5  (bases 1 to 3733)
  AUTHORS   Wiese,C.B., Ireland,S., Fleming,N.L., Yu,J., Valerius,M.T.,
            Georgas,K., Chiu,H.S., Brennan,J., Armstrong,J., Little,M.H.,
            McMahon,A.P. and Southard-Smith,E.M.
  TITLE     A genome-wide screen to identify transcription factors expressed in
            pelvic Ganglia of the lower urinary tract
  JOURNAL   Front Neurosci 6, 130 (2012)
   PUBMED   22988430
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3733)
  AUTHORS   Oeschger,F.M., Wang,W.Z., Lee,S., Garcia-Moreno,F., Goffinet,A.M.,
            Arbones,M.L., Rakic,S. and Molnar,Z.
  TITLE     Gene expression analysis of the embryonic subplate
  JOURNAL   Cereb Cortex 22 (6), 1343-1359 (2012)
   PUBMED   21862448
REFERENCE   7  (bases 1 to 3733)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   8  (bases 1 to 3733)
  AUTHORS   Zhang,D., Harry,G.J., Blackshear,P.J. and Zeldin,D.C.
  TITLE     G-protein pathway suppressor 2 (GPS2) interacts with the regulatory
            factor X4 variant 3 (RFX4_v3) and functions as a transcriptional
            co-activator
  JOURNAL   J Biol Chem 283 (13), 8580-8590 (2008)
   PUBMED   18218630
REFERENCE   9  (bases 1 to 3733)
  AUTHORS   Millien,G., Beane,J., Lenburg,M., Tsao,P.N., Lu,J., Spira,A. and
            Ramirez,M.I.
  TITLE     Characterization of the mid-foregut transcriptome identifies genes
            regulated during lung bud induction
  JOURNAL   Gene Expr Patterns 8 (2), 124-139 (2008)
   PUBMED   18023262
REFERENCE   10 (bases 1 to 3733)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC124453.3 and BQ032048.1.
            
            On Jun 14, 2018 this sequence version replaced NM_178744.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK029762.1, BC012239.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-211               AC124453.3         92336-92546
            212-3533            AC124453.3         107042-110363
            3534-3733           BQ032048.1         15-214              c
FEATURES             Location/Qualifiers
     source          1..3733
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 33.73 cM"
     gene            1..3733
                     /gene="Zbtb1"
                     /gene_synonym="9430077A12; Bsg2; C430003J21Rik"
                     /note="zinc finger and BTB domain containing 1"
                     /db_xref="GeneID:268564"
                     /db_xref="MGI:MGI:2442326"
     exon            1..211
                     /gene="Zbtb1"
                     /gene_synonym="9430077A12; Bsg2; C430003J21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            212..3733
                     /gene="Zbtb1"
                     /gene_synonym="9430077A12; Bsg2; C430003J21Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             228..2369
                     /gene="Zbtb1"
                     /gene_synonym="9430077A12; Bsg2; C430003J21Rik"
                     /note="isoform 1 is encoded by transcript variant 1; zinc
                     finger and BTB domain-containing protein 1; brain specific
                     protein 2"
                     /codon_start=1
                     /product="zinc finger and BTB domain-containing protein 1
                     isoform 1"
                     /protein_id="NP_848859.1"
                     /db_xref="CCDS:CCDS25992.1"
                     /db_xref="GeneID:268564"
                     /db_xref="MGI:MGI:2442326"
                     /translation="MAKPSHSSYVLQQLNNQREWGFLCDCCIAIDDIYFQAHKAVLAA
                     CSSYFRMFFMNHQHSTAQLNLSNMKISAECFDLILQFMYLGKIMTAPSSFEQFKVAMN
                     YLQLYNVPDCLEDIQDADCSSSKCSSSASSRQSSKMIFGVRMYEDTVARNGNEANRWC
                     AEPSSTVNTPHHREPEEESLQLANFPEPLFDVCKKSSVSKLSTPKERVSRRFGRSFTC
                     DSCGFGFSCEKLLDEHVLTCTNRHSYQNTTRAYHRIVDIRDGKDSNIKAELAEKDSSK
                     TFSAQPDKYREDANQAPDDSASTTGSRKSTVEAGIAGEEKSRATETKRIIIKMEPEDI
                     PADDMKDFNIIKVTEKDCNESTDNDELEDEPEEPFYRYYVEEDVGIKKSGRKTLKPRM
                     SISVDERGGLENMRPPNNTSPIQEDAENASCELCGLTITEEDLSSHYLAKHIENICAC
                     GKCGQILVKGRQLQEHAQRCGEPQDLTMNGLGNADEKMDMEENPDEQSEIRDMFVEML
                     DDFRDNHYQINSIQKKQLFKHSACPFRCPNCGQRFETENLVVEHMSSCLDQDMFKGAI
                     MEENERDHRRKHFCNLCGKGFYQRCHLREHYTVHTKEKQFVCQTCGKQFLRERQLRLH
                     NDMHKGMARYVCSICDQGNFRKHDHVRHMISHLSGGETICQVCFQIFPNNEQLEQHMD
                     VHLYTCGICGAKFNLRKDMRSHYNAKHLKRT"
     regulatory      3425..3430
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zbtb1"
                     /gene_synonym="9430077A12; Bsg2; C430003J21Rik"
                     /note="hexamer: AAGAAA"
     polyA_site      3441
                     /gene="Zbtb1"
                     /gene_synonym="9430077A12; Bsg2; C430003J21Rik"
                     /note="major polyA site"
     regulatory      3710..3715
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zbtb1"
                     /gene_synonym="9430077A12; Bsg2; C430003J21Rik"
                     /note="hexamer: AATAAA"
     polyA_site      3733
                     /gene="Zbtb1"
                     /gene_synonym="9430077A12; Bsg2; C430003J21Rik"
                     /note="major polyA site"
ORIGIN      
        1 agtgcggtgc ggcaggcgcg gctgtgcggc agcggaagtc ctttgttgca gcgcagtccc
       61 tggcagagcc cggagtgtct cggcgcagcc cagccgagcg ccgcgcgccg tcaactgcag
      121 cccgcagccc ctcgcctccg cccgccttcc cagcggctcc gctgccctca actccataaa
      181 acctccgcag ccgcgcgtcc caccgcgccc ggtcgagtca gcagaagatg gcaaagccca
      241 gccacagcag ctatgtcctg cagcagctca acaaccaaag agagtggggc tttctctgtg
      301 actgctgtat cgctatcgac gacatctact tccaagcaca caaagccgtc ctggctgcct
      361 gtagctccta ctttaggatg tttttcatga accatcagca cagtactgca caactgaacc
      421 tcagcaacat gaagataagt gctgagtgct ttgatctcat tttgcagttc atgtatttag
      481 gaaagatcat gaccgctcct tccagtttcg agcagttcaa agtggcaatg aactacctcc
      541 agctgtacaa tgttcctgac tgcttggaag acatacagga cgcagactgt tctagttcaa
      601 agtgttcgtc ttctgcctcc agcaggcaga gcagcaagat gatttttggg gtgagaatgt
      661 atgaagacac ggtggctaga aatggcaatg aagccaacag gtggtgtgcg gagcccagtt
      721 caacggtgaa tacgccgcat cacagagaac ctgaggaaga gtctttgcag ttggccaact
      781 tccccgagcc gctgtttgat gtgtgtaaaa aaagttctgt gtccaaatta tctactccaa
      841 aagaacgtgt gtctcgacgc tttggacgga gctttacctg tgatagttgt ggatttggct
      901 tcagctgtga aaagttacta gacgaacatg tgctgacctg taccaacaga cactcatacc
      961 aaaacacgac aagagcttac caccgaatag tagatattag agatggaaaa gatagtaaca
     1021 tcaaagctga acttgctgaa aaggattctt ctaaaacatt ttctgcacag ccggacaaat
     1081 acagagaaga cgccaaccag gcgcctgatg attcagcctc gaccactgga agcaggaaaa
     1141 gcaccgtgga ggctgggata gctggtgagg agaaaagcag agctactgag acaaaacgaa
     1201 ttatcatcaa gatggagcca gaagatatcc ctgcagatga catgaaagac ttcaacatta
     1261 ttaaagttac tgagaaagac tgcaacgagt ccaccgacaa tgatgaatta gaagatgaac
     1321 ccgaggagcc attttataga tactatgttg aggaagatgt cggcattaaa aaaagtggta
     1381 ggaaaaccct aaaacctcgt atgtccatca gcgtggatga gagaggtggc ttagagaaca
     1441 tgagaccccc gaataacacc agccccatac aagaggatgc agagaatgca tcttgtgagc
     1501 tgtgtggact cacaataact gaggaggacc tgtcgtctca ttacttggcc aagcacattg
     1561 aaaatatctg tgcatgtggt aaatgtggac agatacttgt caagggcaga cagcttcagg
     1621 aacatgctca gaggtgcgga gaaccccagg atctgacaat gaatgggcta gggaacgctg
     1681 acgagaaaat ggacatggaa gagaaccccg acgagcagtc tgagataaga gacatgtttg
     1741 ttgaaatgct ggatgatttc agagacaatc attaccaaat aaatagtatc cagaaaaagc
     1801 agttatttaa acattctgcc tgtcctttcc gatgtcctaa ttgtggccag cgttttgaaa
     1861 ctgaaaattt agtggtcgaa catatgtcta gctgcctaga ccaagatatg ttcaagggtg
     1921 ccatcatgga agaaaatgaa agagatcaca gaagaaaaca tttttgtaat ctgtgtggaa
     1981 aaggatttta tcagcgctgt catttgagag agcactatac tgtgcacact aaagaaaagc
     2041 agtttgtttg tcagacatgt ggaaagcagt ttttaagaga gcgccagttg cgtctacaca
     2101 atgatatgca caaaggcatg gccaggtatg tctgttccat ttgtgatcaa ggaaacttcc
     2161 gaaaacatga ccatgtacgg catatgatct cgcacctgtc tggtggggag actatatgcc
     2221 aggtctgctt tcagatattc ccaaataatg aacaactgga gcagcatatg gatgtccatc
     2281 tgtacacgtg tggaatatgt ggagcaaagt ttaatttgag gaaggatatg agatcgcatt
     2341 ataatgccaa gcatttgaaa agaacctgat gggtttctac tgtacagatg tttagttggt
     2401 aggcagaaca ccaaagcaaa aaggctatga gctatttaga actgatttta taacaagtgt
     2461 gggggaaatt ttcaaggccc ttttactttg aacgtttttg tttaggatct taagtctatt
     2521 ttaggcatta aatgtttatc atttttgttg ctttgagagc attctttgtt cctagttttc
     2581 ttaattacca ttaaaattac ttttcgttgt agactgtaag tggctattat cccttcaata
     2641 actattaaaa cagtttttgg gtttttttgt ttttgttttt ttaaaataag ataatgactt
     2701 tgctgtttct atgtactttc attttaaggt tatcctatga aattttaaac ccaagattat
     2761 tgaccactcc tgcttaaatt tttaaagaat tttaaaatag ttatttaaaa ctatcctatt
     2821 catttttaac ttttttgttt ttttgctttt tgggattttt ttgttgttgg ttttgttttg
     2881 ggggtgcttt ttgtcagttg tatagtgggg tggctactat tctcccttat aaatgaaatc
     2941 tatattctta aattgacaaa cttattaggc aagtgaggtg cactgaatct aacctttaag
     3001 gttgacatgg gctcaatctt ggcctgagat tgatggacct aaggaaactc ctataaatga
     3061 acatttccta taattgataa atgttatcat ttaataatca catttaaaac ttatattaag
     3121 tgtaaatccc aatgactttc cctcacttga gaaattagtg gggataagcc attttgtttt
     3181 gtgataatga atttaactat gatagttaat taaaaaagac atcttgtatt cattaaaata
     3241 ttttaattta aaaatattct gatttctaaa gtgtgttagt ttatcaatta ttttgtttat
     3301 aaatagactt taatagctct ttaggaatat gacatctaaa gaaaaatgat ttttcatctt
     3361 taaaattact ttggaactga gatttgaaaa agctgccatg tatattgata aacttaataa
     3421 aataaagaaa tcaattataa atctggttgt tctataaaag tagagtgcac aaaagtgtgt
     3481 tgtgttacac taagatttgg agaaaatgtg tgtggcaaat tacagtttat tactatgctt
     3541 tctatatcat tttctgtaaa agaaacaaga tttgaggact ataaaataat gacagcatat
     3601 gaacggacac agcttctact tttcaggtaa agtaatcata ttgttagttg ctgacagggt
     3661 ctatctctat caattacatg tgaactaaaa cactggcaaa taacccacca ataaacacat
     3721 ctatggaata gaa
//
