LOCUS       NM_021394               1988 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Mus musculus Z-DNA binding protein 1 (Zbp1), transcript variant 1,
            mRNA.
ACCESSION   NM_021394
VERSION     NM_021394.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1988)
  AUTHORS   Jena,K.K., Mambu,J., Boehmer,D., Sposito,B., Millet,V., de Sousa
            Casal,J., Muendlein,H.I., Spreafico,R., Fenouil,R., Spinelli,L.,
            Wurbel,S., Riquier,C., Galland,F., Naquet,P., Chasson,L.,
            Elkins,M., Mitsialis,V., Ketelut-Carneiro,N., Bugda Gwilt,K.,
            Thiagarajah,J.R., Ruan,H.B., Lin,Z., Lien,E., Shao,F., Chou,J.,
            Poltorak,A., Ordovas-Montanes,J., Fitzgerald,K.A., Snapper,S.B.,
            Broggi,A. and Zanoni,I.
  TITLE     Type III interferons induce pyroptosis in gut epithelial cells and
            impair mucosal repair
  JOURNAL   Cell 187 (26), 7533-7550 (2024)
   PUBMED   39500322
REFERENCE   2  (bases 1 to 1988)
  AUTHORS   Gong,T., Fu,Y., Wang,Q., Loughran,P.A., Li,Y., Billiar,T.R.,
            Wen,Z., Liu,Y. and Fan,J.
  TITLE     Decoding the multiple functions of ZBP1 in the mechanism of
            sepsis-induced acute lung injury
  JOURNAL   Commun Biol 7 (1), 1361 (2024)
   PUBMED   39433574
  REMARK    GeneRIF: Decoding the multiple functions of ZBP1 in the mechanism
            of sepsis-induced acute lung injury.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1988)
  AUTHORS   Wang,J., Wang,R., Li,Y., Huang,J., Liu,Y., Wang,J., Xian,P.,
            Zhang,Y., Yang,Y., Zhang,H. and Li,J.
  TITLE     Lipolysis engages CD36 to promote ZBP1-mediated
            necroptosis-impairing lung regeneration in COPD
  JOURNAL   Cell Rep Med 5 (9), 101732 (2024)
   PUBMED   39255796
REFERENCE   4  (bases 1 to 1988)
  AUTHORS   Yu,F., Yang,L., Zhang,R., Hu,F., Yuan,Y., Wang,Z. and Yang,W.
  TITLE     Low levels of supercoiled mitochondrial DNA are involved in heart
            failure induced by transverse aortic constriction in mice via an
            inflammatory response mediated by ZBP1
  JOURNAL   Exp Cell Res 442 (1), 114187 (2024)
   PUBMED   39069152
  REMARK    GeneRIF: Low levels of supercoiled mitochondrial DNA are involved
            in heart failure induced by transverse aortic constriction in mice
            via an inflammatory response mediated by ZBP1.
REFERENCE   5  (bases 1 to 1988)
  AUTHORS   Sun,K., Lu,F., Hou,L., Zhang,X., Pan,C., Liu,H., Zheng,Z., Guo,Z.,
            Ruan,Z., Hou,Y., Zhang,J., Guo,F. and Zhu,W.
  TITLE     IRF1 regulation of ZBP1 links mitochondrial DNA and chondrocyte
            damage in osteoarthritis
  JOURNAL   Cell Commun Signal 22 (1), 366 (2024)
   PUBMED   39026271
  REMARK    GeneRIF: IRF1 regulation of ZBP1 links mitochondrial DNA and
            chondrocyte damage in osteoarthritis.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1988)
  AUTHORS   Wang,Z., Choi,M.K., Ban,T., Yanai,H., Negishi,H., Lu,Y., Tamura,T.,
            Takaoka,A., Nishikura,K. and Taniguchi,T.
  TITLE     Regulation of innate immune responses by DAI (DLM-1/ZBP1) and other
            DNA-sensing molecules
  JOURNAL   Proc Natl Acad Sci U S A 105 (14), 5477-5482 (2008)
   PUBMED   18375758
  REMARK    GeneRIF: mechanism of DAI activation and the complex regulatory
            mechanisms underlying DNA-mediated protective and pathologic immune
            responses.
REFERENCE   7  (bases 1 to 1988)
  AUTHORS   Ishii,K.J., Kawagoe,T., Koyama,S., Matsui,K., Kumar,H., Kawai,T.,
            Uematsu,S., Takeuchi,O., Takeshita,F., Coban,C. and Akira,S.
  TITLE     TANK-binding kinase-1 delineates innate and adaptive immune
            responses to DNA vaccines
  JOURNAL   Nature 451 (7179), 725-729 (2008)
   PUBMED   18256672
REFERENCE   8  (bases 1 to 1988)
  AUTHORS   Takaoka,A., Wang,Z., Choi,M.K., Yanai,H., Negishi,H., Ban,T.,
            Lu,Y., Miyagishi,M., Kodama,T., Honda,K., Ohba,Y. and Taniguchi,T.
  TITLE     DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of
            innate immune response
  JOURNAL   Nature 448 (7152), 501-505 (2007)
   PUBMED   17618271
  REMARK    GeneRIF: observations underscore an integral role of DAI
            (DLM-1/ZBP1) in the DNA-mediated activation of innate immune
            responses
REFERENCE   9  (bases 1 to 1988)
  AUTHORS   Schwartz,T., Behlke,J., Lowenhaupt,K., Heinemann,U. and Rich,A.
  TITLE     Structure of the DLM-1-Z-DNA complex reveals a conserved family of
            Z-DNA-binding proteins
  JOURNAL   Nat Struct Biol 8 (9), 761-765 (2001)
   PUBMED   11524677
  REMARK    GeneRIF: shares common structure-specific recognition core within
            the binding domain with an RNA editing enzyme but binds Z-DNA
REFERENCE   10 (bases 1 to 1988)
  AUTHORS   Fu,Y., Comella,N., Tognazzi,K., Brown,L.F., Dvorak,H.F. and
            Kocher,O.
  TITLE     Cloning of DLM-1, a novel gene that is up-regulated in activated
            macrophages, using RNA differential display
  JOURNAL   Gene 240 (1), 157-163 (1999)
   PUBMED   10564822
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY170802.1, AX775969.1, AL837509.11 and AI643886.1.
            
            On Nov 19, 2008 this sequence version replaced NM_021394.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because C57BL/6 strain transcript sequence
            from the C57BL/6 strain consistent with the reference genome
            assembly was not available for all regions of the RefSeq
            transcript. The extent of this transcript is supported by
            transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF136520.1, BC020033.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-46                BY170802.1         3-48
            47-756              AX775969.1         1-710
            757-757             AL837509.11        119100-119100       c
            758-1741            AX775969.1         712-1695
            1742-1988           AI643886.1         1-247               c
FEATURES             Location/Qualifiers
     source          1..1988
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 95.83 cM"
     gene            1..1988
                     /gene="Zbp1"
                     /gene_synonym="2010010H03Rik; Dai; Dlm1; mZaDLM"
                     /note="Z-DNA binding protein 1"
                     /db_xref="GeneID:58203"
                     /db_xref="MGI:MGI:1927449"
     exon            1..181
                     /gene="Zbp1"
                     /gene_synonym="2010010H03Rik; Dai; Dlm1; mZaDLM"
                     /inference="alignment:Splign:2.1.0"
     CDS             148..1383
                     /gene="Zbp1"
                     /gene_synonym="2010010H03Rik; Dai; Dlm1; mZaDLM"
                     /note="isoform 1 is encoded by transcript variant 1; tumor
                     stroma and activated macrophage protein DLM-1;
                     DNA-dependent activator of IFN-regulatory factors"
                     /codon_start=1
                     /product="Z-DNA-binding protein 1 isoform 1"
                     /protein_id="NP_067369.2"
                     /db_xref="CCDS:CCDS17142.1"
                     /db_xref="GeneID:58203"
                     /db_xref="MGI:MGI:1927449"
                     /translation="MAEAPVDLSTGDNLEQKILQVLSDDGGPVKIGQLVKKCQVPKKT
                     LNQVLYRLKKEDRVSSPEPATWSIGGAASGDGAPAIPENSSAQPSLDERILRFLEANG
                     PHRALHIAKALGMTTAKEVNPLLYSMRNKHLLSYDGQTWKIYHSRQEGQDIAHSGVTQ
                     ESPAIICQHNPVNMICQQGANSHISIANSNAIQIGHGNVIVREKACGEPGPRTSHPLP
                     LAWDASAQDMPPVAHGAQYIYMDKSLLQQVQLGHHNEMSLVGDAGKHPSYSFSDSPPE
                     VSTTTADPGASFNMQTSEPGPHPEGDTVQTVHIKSCFLEDATIGNGNKMTIHLRSKGE
                     VMESGDSEEPKKEDTGTSSEATPPRSCQHTPSDSMLPTSELRAMALGDSSPQTTEPVL
                     REHEVQDIESSQDTGLSKQ"
     exon            182..418
                     /gene="Zbp1"
                     /gene_synonym="2010010H03Rik; Dai; Dlm1; mZaDLM"
                     /inference="alignment:Splign:2.1.0"
     exon            419..607
                     /gene="Zbp1"
                     /gene_synonym="2010010H03Rik; Dai; Dlm1; mZaDLM"
                     /inference="alignment:Splign:2.1.0"
     exon            608..775
                     /gene="Zbp1"
                     /gene_synonym="2010010H03Rik; Dai; Dlm1; mZaDLM"
                     /inference="alignment:Splign:2.1.0"
     exon            776..973
                     /gene="Zbp1"
                     /gene_synonym="2010010H03Rik; Dai; Dlm1; mZaDLM"
                     /inference="alignment:Splign:2.1.0"
     exon            974..1195
                     /gene="Zbp1"
                     /gene_synonym="2010010H03Rik; Dai; Dlm1; mZaDLM"
                     /inference="alignment:Splign:2.1.0"
     exon            1196..1373
                     /gene="Zbp1"
                     /gene_synonym="2010010H03Rik; Dai; Dlm1; mZaDLM"
                     /inference="alignment:Splign:2.1.0"
     exon            1374..1988
                     /gene="Zbp1"
                     /gene_synonym="2010010H03Rik; Dai; Dlm1; mZaDLM"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1966..1971
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zbp1"
                     /gene_synonym="2010010H03Rik; Dai; Dlm1; mZaDLM"
                     /note="hexamer: TATAAA"
     polyA_site      1988
                     /gene="Zbp1"
                     /gene_synonym="2010010H03Rik; Dai; Dlm1; mZaDLM"
                     /note="major polyA site"
ORIGIN      
        1 gatgggtatt tgtttccggg atggtaacag ctggtgcctg caggtccaag cagccattct
       61 tgcctgtgga ttcagagccc caggcctgac cacagtgcca gaaactgcca ccccctgccc
      121 taaaggagcc ccaaggctgc tgtgagcatg gcagaagctc ctgttgactt gagcacagga
      181 gacaatctgg agcaaaagat cctgcaggtg ttgagcgatg acggcggccc tgtgaagatt
      241 ggccagctgg tgaagaaatg ccaagtgccc aagaaaaccc tcaatcaagt cctttaccgc
      301 ctgaagaagg aggacagagt gtcctcccca gagcctgcaa catggagcat aggcggggct
      361 gcttctggag atggggctcc tgcaatccct gagaactcca gtgcccagcc tagccttgat
      421 gaaagaatat taagattcct ggaagccaat gggcctcaca gggccctgca catcgccaag
      481 gctctgggaa tgacgacagc caaagaagtg aacccactcc tgtattccat gagaaataag
      541 caccttctga gctatgacgg acagacgtgg aagatctacc actcacgtca ggaaggccaa
      601 gacatagctc attctggagt cacacaagag tcccctgcga ttatttgtca gcacaatccg
      661 gtcaacatga tctgccaaca aggagccaac agccacatct ccattgccaa ttcaaacgcc
      721 atccagattg gtcacgggaa tgtcatagta agagagaaag cctgtggtga gccaggtccc
      781 aggacctctc accctctacc cttggcatgg gacgcctctg ctcaggacat gccccctgtt
      841 gcccacggag ctcagtacat ctacatggac aagtccttgc tccaacaagt gcagcttggc
      901 caccacaacg agatgagcct cgtgggggat gcagggaagc acccctctta tagcttttct
      961 gacagccccc cagaagtgtc aaccaccact gctgacccag gagcttcatt caacatgcaa
     1021 acatctgagc caggccctca ccctgaggga gacacagtcc agacagtcca catcaaatcc
     1081 tgctttctag aggacgccac cattggtaac ggcaacaaga tgaccatcca ccttaggtca
     1141 aagggtgaag tcatggagtc tggagacagt gaagagccga agaaggaaga cacaggtaca
     1201 agctctgaag ccactccacc cagaagctgc cagcacacgc ccagtgactc catgctgccc
     1261 acctctgagc tgagagctat ggctctggga gacagtagcc cccagaccac agaacctgtg
     1321 cttagagagc atgaagtcca ggacatagaa agctctcaag acacaggact gagcaagcaa
     1381 tgaagctgtg ggaccatagg ctgacccctc tgccactata agtcaaatca acctttcctg
     1441 cctcaagatc aatcaatcga tcaaccgcag gagccagttc taccactcct ggatgctcac
     1501 ccaaaggcaa aagtcaacac agagagatct ccgcatatcc atgtagattg ggacactgtt
     1561 cacagcagct aagaagtgga accgaccttg ctacccagca gtaaaagatg ggtgaattgg
     1621 agtatgcaca cagccatggg aaatactgag gctgtcattg gccagaagag gatgtgacca
     1681 gaggccacca tgttgaatga atgaaagcca tcttagaaag acaagggcca cattttctct
     1741 gttgtggctc ctagacttta gatagattta taaaatcata tacacagatg tgacatgaaa
     1801 gtacatgtaa caccaaccag gggatgagga tggtgcatgg ggaggagagg cgggggtcac
     1861 agcctggggg ggggtcacgg tctgggaggg tgtcaccacc taaagagatc acagctgggg
     1921 ggatcagggc cgggaggggg gacactgctg aatgcactgt acttttataa aaaggtgtac
     1981 ctctgaaa
//
