LOCUS       NM_001139519             781 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Mus musculus Z-DNA binding protein 1 (Zbp1), transcript variant 2,
            mRNA.
ACCESSION   NM_001139519
VERSION     NM_001139519.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 781)
  AUTHORS   Jena,K.K., Mambu,J., Boehmer,D., Sposito,B., Millet,V., de Sousa
            Casal,J., Muendlein,H.I., Spreafico,R., Fenouil,R., Spinelli,L.,
            Wurbel,S., Riquier,C., Galland,F., Naquet,P., Chasson,L.,
            Elkins,M., Mitsialis,V., Ketelut-Carneiro,N., Bugda Gwilt,K.,
            Thiagarajah,J.R., Ruan,H.B., Lin,Z., Lien,E., Shao,F., Chou,J.,
            Poltorak,A., Ordovas-Montanes,J., Fitzgerald,K.A., Snapper,S.B.,
            Broggi,A. and Zanoni,I.
  TITLE     Type III interferons induce pyroptosis in gut epithelial cells and
            impair mucosal repair
  JOURNAL   Cell 187 (26), 7533-7550 (2024)
   PUBMED   39500322
REFERENCE   2  (bases 1 to 781)
  AUTHORS   Gong,T., Fu,Y., Wang,Q., Loughran,P.A., Li,Y., Billiar,T.R.,
            Wen,Z., Liu,Y. and Fan,J.
  TITLE     Decoding the multiple functions of ZBP1 in the mechanism of
            sepsis-induced acute lung injury
  JOURNAL   Commun Biol 7 (1), 1361 (2024)
   PUBMED   39433574
  REMARK    GeneRIF: Decoding the multiple functions of ZBP1 in the mechanism
            of sepsis-induced acute lung injury.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 781)
  AUTHORS   Wang,J., Wang,R., Li,Y., Huang,J., Liu,Y., Wang,J., Xian,P.,
            Zhang,Y., Yang,Y., Zhang,H. and Li,J.
  TITLE     Lipolysis engages CD36 to promote ZBP1-mediated
            necroptosis-impairing lung regeneration in COPD
  JOURNAL   Cell Rep Med 5 (9), 101732 (2024)
   PUBMED   39255796
REFERENCE   4  (bases 1 to 781)
  AUTHORS   Yu,F., Yang,L., Zhang,R., Hu,F., Yuan,Y., Wang,Z. and Yang,W.
  TITLE     Low levels of supercoiled mitochondrial DNA are involved in heart
            failure induced by transverse aortic constriction in mice via an
            inflammatory response mediated by ZBP1
  JOURNAL   Exp Cell Res 442 (1), 114187 (2024)
   PUBMED   39069152
  REMARK    GeneRIF: Low levels of supercoiled mitochondrial DNA are involved
            in heart failure induced by transverse aortic constriction in mice
            via an inflammatory response mediated by ZBP1.
REFERENCE   5  (bases 1 to 781)
  AUTHORS   Sun,K., Lu,F., Hou,L., Zhang,X., Pan,C., Liu,H., Zheng,Z., Guo,Z.,
            Ruan,Z., Hou,Y., Zhang,J., Guo,F. and Zhu,W.
  TITLE     IRF1 regulation of ZBP1 links mitochondrial DNA and chondrocyte
            damage in osteoarthritis
  JOURNAL   Cell Commun Signal 22 (1), 366 (2024)
   PUBMED   39026271
  REMARK    GeneRIF: IRF1 regulation of ZBP1 links mitochondrial DNA and
            chondrocyte damage in osteoarthritis.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 781)
  AUTHORS   Wang,Z., Choi,M.K., Ban,T., Yanai,H., Negishi,H., Lu,Y., Tamura,T.,
            Takaoka,A., Nishikura,K. and Taniguchi,T.
  TITLE     Regulation of innate immune responses by DAI (DLM-1/ZBP1) and other
            DNA-sensing molecules
  JOURNAL   Proc Natl Acad Sci U S A 105 (14), 5477-5482 (2008)
   PUBMED   18375758
  REMARK    GeneRIF: mechanism of DAI activation and the complex regulatory
            mechanisms underlying DNA-mediated protective and pathologic immune
            responses.
REFERENCE   7  (bases 1 to 781)
  AUTHORS   Ishii,K.J., Kawagoe,T., Koyama,S., Matsui,K., Kumar,H., Kawai,T.,
            Uematsu,S., Takeuchi,O., Takeshita,F., Coban,C. and Akira,S.
  TITLE     TANK-binding kinase-1 delineates innate and adaptive immune
            responses to DNA vaccines
  JOURNAL   Nature 451 (7179), 725-729 (2008)
   PUBMED   18256672
REFERENCE   8  (bases 1 to 781)
  AUTHORS   Takaoka,A., Wang,Z., Choi,M.K., Yanai,H., Negishi,H., Ban,T.,
            Lu,Y., Miyagishi,M., Kodama,T., Honda,K., Ohba,Y. and Taniguchi,T.
  TITLE     DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of
            innate immune response
  JOURNAL   Nature 448 (7152), 501-505 (2007)
   PUBMED   17618271
  REMARK    GeneRIF: observations underscore an integral role of DAI
            (DLM-1/ZBP1) in the DNA-mediated activation of innate immune
            responses
REFERENCE   9  (bases 1 to 781)
  AUTHORS   Schwartz,T., Behlke,J., Lowenhaupt,K., Heinemann,U. and Rich,A.
  TITLE     Structure of the DLM-1-Z-DNA complex reveals a conserved family of
            Z-DNA-binding proteins
  JOURNAL   Nat Struct Biol 8 (9), 761-765 (2001)
   PUBMED   11524677
  REMARK    GeneRIF: shares common structure-specific recognition core within
            the binding domain with an RNA editing enzyme but binds Z-DNA
REFERENCE   10 (bases 1 to 781)
  AUTHORS   Fu,Y., Comella,N., Tognazzi,K., Brown,L.F., Dvorak,H.F. and
            Kocher,O.
  TITLE     Cloning of DLM-1, a novel gene that is up-regulated in activated
            macrophages, using RNA differential display
  JOURNAL   Gene 240 (1), 157-163 (1999)
   PUBMED   10564822
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY170802.1 and AK008179.1.
            
            Transcript Variant: This variant (2) differs in the 3' UTR and has
            multiple differences in the 3' coding region, compared to variant
            1. The resulting isoform (2) has a shorter and distinct C-terminus,
            compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK008179.1, BI685388.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-56                BY170802.1         3-58
            57-781              AK008179.1         2-726
FEATURES             Location/Qualifiers
     source          1..781
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 95.83 cM"
     gene            1..781
                     /gene="Zbp1"
                     /gene_synonym="2010010H03Rik; Dai; Dlm1; mZaDLM"
                     /note="Z-DNA binding protein 1"
                     /db_xref="GeneID:58203"
                     /db_xref="MGI:MGI:1927449"
     exon            1..181
                     /gene="Zbp1"
                     /gene_synonym="2010010H03Rik; Dai; Dlm1; mZaDLM"
                     /inference="alignment:Splign:2.1.0"
     CDS             148..711
                     /gene="Zbp1"
                     /gene_synonym="2010010H03Rik; Dai; Dlm1; mZaDLM"
                     /note="isoform 2 is encoded by transcript variant 2; tumor
                     stroma and activated macrophage protein DLM-1;
                     DNA-dependent activator of IFN-regulatory factors"
                     /codon_start=1
                     /product="Z-DNA-binding protein 1 isoform 2"
                     /protein_id="NP_001132991.1"
                     /db_xref="CCDS:CCDS50813.1"
                     /db_xref="GeneID:58203"
                     /db_xref="MGI:MGI:1927449"
                     /translation="MAEAPVDLSTGDNLEQKILQVLSDDGGPVKIGQLVKKCQVPKKT
                     LNQVLYRLKKEDRVSSPEPATWSIGGAASGDGAPAIPENSSAQPSLDERILRFLEANG
                     PHRALHIAKALGMTTAKEVNPLLYSMRNKHLLSYDGQTWKIYHSRQEGQDIVLPCSPG
                     CPRTHHVDQAGLEPTEIFLLLPIKFWD"
     exon            182..418
                     /gene="Zbp1"
                     /gene_synonym="2010010H03Rik; Dai; Dlm1; mZaDLM"
                     /inference="alignment:Splign:2.1.0"
     exon            419..607
                     /gene="Zbp1"
                     /gene_synonym="2010010H03Rik; Dai; Dlm1; mZaDLM"
                     /inference="alignment:Splign:2.1.0"
     exon            608..781
                     /gene="Zbp1"
                     /gene_synonym="2010010H03Rik; Dai; Dlm1; mZaDLM"
                     /inference="alignment:Splign:2.1.0"
     regulatory      753..758
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zbp1"
                     /gene_synonym="2010010H03Rik; Dai; Dlm1; mZaDLM"
                     /note="putative"
     polyA_site      781
                     /gene="Zbp1"
                     /gene_synonym="2010010H03Rik; Dai; Dlm1; mZaDLM"
                     /note="putative"
ORIGIN      
        1 gatgggtatt tgtttccggg atggtaacag ctggtgcctg caggtccaag cagccattct
       61 tgcctgtgga ttcagagccc caggcctgac cacagtgcca gaaactgcca ccccctgccc
      121 taaaggagcc ccaaggctgc tgtgagcatg gcagaagctc ctgttgactt gagcacagga
      181 gacaatctgg agcaaaagat cctgcaggtg ttgagcgatg acggcggccc tgtgaagatt
      241 ggccagctgg tgaagaaatg ccaagtgccc aagaaaaccc tcaatcaagt cctttaccgc
      301 ctgaagaagg aggacagagt gtcctcccca gagcctgcaa catggagcat aggcggggct
      361 gcttctggag atggggctcc tgcaatccct gagaactcca gtgcccagcc tagccttgat
      421 gaaagaatat taagattcct ggaagccaat gggcctcaca gggccctgca catcgccaag
      481 gctctgggaa tgacgacagc caaagaagtg aacccactcc tgtattccat gagaaataag
      541 caccttctga gctatgacgg acagacgtgg aagatctacc actcacgtca ggaaggccaa
      601 gacatagtct tgccatgtag ccctggatgt cctagaactc accatgtaga ccaagctggt
      661 cttgaaccca cagagatctt cttgcttctg cctattaaat tctgggatta aagcaccact
      721 acacctggaa aaatatcttt taaagccagt aaaataaatg aacaattaaa gaatgcatct
      781 c
//
