LOCUS       NM_001395904           10284 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus zinc finger, BED type containing 6 (Zbed6), transcript
            variant 2, mRNA.
ACCESSION   NM_001395904
VERSION     NM_001395904.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 10284)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 10284)
  AUTHORS   Wang,X., Younis,S., Cen,J., Wang,Y., Krizhanovskii,C., Andersson,L.
            and Welsh,N.
  TITLE     ZBED6 counteracts high-fat diet-induced glucose intolerance by
            maintaining beta cell area and reducing excess mitochondrial
            activation
  JOURNAL   Diabetologia 64 (10), 2292-2305 (2021)
   PUBMED   34296320
  REMARK    GeneRIF: ZBED6 counteracts high-fat diet-induced glucose
            intolerance by maintaining beta cell area and reducing excess
            mitochondrial activation.
REFERENCE   3  (bases 1 to 10284)
  AUTHORS   Wang,D., Pu,Y., Li,Y., Pan,D., Wang,S., Tian,W., Ma,Y. and Jiang,L.
  TITLE     Comprehensive analysis of lncRNAs involved in skeletal muscle
            development in ZBED6-knockout Bama pigs
  JOURNAL   BMC Genomics 22 (1), 593 (2021)
   PUBMED   34348644
  REMARK    GeneRIF: Comprehensive analysis of lncRNAs involved in skeletal
            muscle development in ZBED6-knockout Bama pigs.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 10284)
  AUTHORS   Younis,S., Naboulsi,R., Wang,X., Cao,X., Larsson,M., Sargsyan,E.,
            Bergsten,P., Welsh,N. and Andersson,L.
  TITLE     The importance of the ZBED6-IGF2 axis for metabolic regulation in
            mouse myoblast cells
  JOURNAL   FASEB J 34 (8), 10250-10266 (2020)
   PUBMED   32557799
  REMARK    GeneRIF: The importance of the ZBED6-IGF2 axis for metabolic
            regulation in mouse myoblast cells.
REFERENCE   5  (bases 1 to 10284)
  AUTHORS   Younis,S., Schonke,M., Massart,J., Hjortebjerg,R., Sundstrom,E.,
            Gustafson,U., Bjornholm,M., Krook,A., Frystyk,J., Zierath,J.R. and
            Andersson,L.
  TITLE     The ZBED6-IGF2 axis has a major effect on growth of skeletal muscle
            and internal organs in placental mammals
  JOURNAL   Proc Natl Acad Sci U S A 115 (9), E2048-E2057 (2018)
   PUBMED   29440408
  REMARK    GeneRIF: the effect of ZBED6 on growth of muscle and internal
            organs is mediated through the binding site in the Igf2 gene
REFERENCE   6  (bases 1 to 10284)
  AUTHORS   Jiang,L., Wallerman,O., Younis,S., Rubin,C.J., Gilbert,E.R.,
            Sundstrom,E., Ghazal,A., Zhang,X., Wang,L., Mikkelsen,T.S.,
            Andersson,G. and Andersson,L.
  TITLE     ZBED6 modulates the transcription of myogenic genes in mouse
            myoblast cells
  JOURNAL   PLoS One 9 (4), e94187 (2014)
   PUBMED   24714595
  REMARK    GeneRIF: We propose that ZBED6 preferentially binds to active
            promoters and modulates transcriptional activity without recruiting
            repressive histone modifications.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 10284)
  AUTHORS   Huang,Y.Z., Zhang,L.Z., Lai,X.S., Li,M.X., Sun,Y.J., Li,C.J.,
            Lan,X.Y., Lei,C.Z., Zhang,C.L., Zhao,X. and Chen,H.
  TITLE     Transcription factor ZBED6 mediates IGF2 gene expression by
            regulating promoter activity and DNA methylation in myoblasts
  JOURNAL   Sci Rep 4, 4570 (2014)
   PUBMED   24691566
  REMARK    GeneRIF: ZBED6 inhibits IGF2 activity.
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 10284)
  AUTHORS   Wang,X., Jiang,L., Wallerman,O., Engstrom,U., Ameur,A., Gupta,R.K.,
            Qi,Y., Andersson,L. and Welsh,N.
  TITLE     Transcription factor ZBED6 affects gene expression, proliferation,
            and cell death in pancreatic beta cells
  JOURNAL   Proc Natl Acad Sci U S A 110 (40), 15997-16002 (2013)
   PUBMED   24043816
  REMARK    GeneRIF: Transcription factor ZBED6 affects gene expression,
            proliferation, and cell death in pancreatic beta cells.
REFERENCE   9  (bases 1 to 10284)
  AUTHORS   Butter,F., Kappei,D., Buchholz,F., Vermeulen,M. and Mann,M.
  TITLE     A domesticated transposon mediates the effects of a
            single-nucleotide polymorphism responsible for enhanced muscle
            growth
  JOURNAL   EMBO Rep 11 (4), 305-311 (2010)
   PUBMED   20134481
  REMARK    GeneRIF: muscle growth regulator (MGR) is a repressor of Igf2
REFERENCE   10 (bases 1 to 10284)
  AUTHORS   Markljung,E., Jiang,L., Jaffe,J.D., Mikkelsen,T.S., Wallerman,O.,
            Larhammar,M., Zhang,X., Wang,L., Saenz-Vash,V., Gnirke,A.,
            Lindroth,A.M., Barres,R., Yan,J., Stromberg,S., De,S., Ponten,F.,
            Lander,E.S., Carr,S.A., Zierath,J.R., Kullander,K., Wadelius,C.,
            Lindblad-Toh,K., Andersson,G., Hjalm,G. and Andersson,L.
  TITLE     ZBED6, a novel transcription factor derived from a domesticated DNA
            transposon regulates IGF2 expression and muscle growth
  JOURNAL   PLoS Biol 7 (12), e1000256 (2009)
   PUBMED   20016685
  REMARK    GeneRIF: Silencing of Zbed6 in mouse C2C12 myoblasts affected Igf2
            expression, cell proliferation, wound healing, and myotube
            formation.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC124338.11.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FR682664.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            NMD candidate          :: translation inferred from conservation
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-6030              AC124338.11        57668-63697
            6031-6090           AC124338.11        65010-65069
            6091-6284           AC124338.11        71513-71706
            6285-6404           AC124338.11        73196-73315
            6405-6528           AC124338.11        78307-78430
            6529-6732           AC124338.11        79799-80002
            6733-6849           AC124338.11        80093-80209
            6850-6930           AC124338.11        80429-80509
            6931-7041           AC124338.11        81583-81693
            7042-7101           AC124338.11        82986-83045
            7102-7200           AC124338.11        85182-85280
            7201-7704           AC124338.11        91772-92275
            7705-7787           AC124338.11        93112-93194
            7788-8115           AC124338.11        94232-94559
            8116-8282           AC124338.11        95892-96058
            8283-8350           AC124338.11        96858-96925
            8351-10284          AC124338.11        97241-99174
FEATURES             Location/Qualifiers
     source          1..10284
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1"
     gene            1..10284
                     /gene="Zbed6"
                     /gene_synonym="667118; Gm38394; Gm8466; MGR"
                     /note="zinc finger, BED type containing 6"
                     /db_xref="GeneID:667118"
                     /db_xref="MGI:MGI:3828086"
     exon            1..6030
                     /gene="Zbed6"
                     /gene_synonym="667118; Gm38394; Gm8466; MGR"
                     /inference="alignment:Splign:2.1.0"
     CDS             1778..4720
                     /gene="Zbed6"
                     /gene_synonym="667118; Gm38394; Gm8466; MGR"
                     /note="muscle growth regulator; zinc finger, BED domain
                     containing 6"
                     /codon_start=1
                     /product="zinc finger BED domain-containing protein 6"
                     /protein_id="NP_001382833.1"
                     /db_xref="GeneID:667118"
                     /db_xref="MGI:MGI:3828086"
                     /translation="MSVCTLSVPVSSISPGRRCSTFGDAGILGCVSINSNTDEDDVVE
                     GKMVAEGANKETKLPAKKKRKKGLRIKGKRRRKKLILAKKFSKDLGSGRPVADAPASL
                     ASGAPEQDEESLFEGNIEKQIYLPSTRAKTSIVWHFFHVDPQYTWRAICNLCEKSVSR
                     GKPGSHLGTSTLQRHLQARHSPHWTRANKFGVTNGEEDFTLDLSLSPPSPGSNGSFEY
                     IPTDSVDENRMGKKRDKSASDALRAKRGRFLIKSNIVKHALIPGTRAKTSAVWNFFYT
                     DPQHISRAVCNICKRSVSRGRPGSHLGTSTLQRHLQATHPIHWAVANKDSGAIGNGLD
                     ETETESSDLLNDTMPGEKSSGSQDLTAEDLSDSDTDEPPCLEVENRSESPIPVADQDN
                     PVHAQERETTTHCENAAANQISQAVIQMIVEDLHPYNYFSTPAFQRFLQIVAPDYRLP
                     SETYFFTKAVPQLYDSVREKIFLTLENVQSQKIHLTADIWTHDPSTDYFIVTVHWVSL
                     ETASSPSNGGTPNFRKWAVLCVTGLAKDCLITNILQELNDQIGLWLSPNFLTPSFIVS
                     DNSSNVVHAIKGGGFTHVPCFLHCLNIVIQDFFCEHKSIENMLVAARKTCHHFSHSVK
                     ARQILQEFQNDHQLPWKNLKQDETGHWISTFYMLKWLLEHCYSVHHSLGRASGVVLTS
                     LQWTLMTYVCDILKPFEEATQRVSVKTTGLNQVLPLIHHLLFSLQRLREDFQVRGITQ
                     ALNLVDSLSLKLESDALLSAMLKSKHCILATLLDPCFKNSLEDFFPQGADLETYKQIL
                     AEEVCNYMESSPGACQISSSETSGPLVRLGTDSFTSIKEGTSSAGSLDSSAAGSVAVG
                     SKSSLLPAAVAVVDEYFKEKYSELSGGDDPLVYWQRKVSIWPALTQVAIQYLSCPMCS
                     WQSECMFTTNSHFHPKQIMNMDFDNIEQLIFLKMNLENVNYDYSTLILSWDPENKAVQ
                     SNEKEILP"
     exon            6031..6090
                     /gene="Zbed6"
                     /gene_synonym="667118; Gm38394; Gm8466; MGR"
                     /inference="alignment:Splign:2.1.0"
     exon            6091..6284
                     /gene="Zbed6"
                     /gene_synonym="667118; Gm38394; Gm8466; MGR"
                     /inference="alignment:Splign:2.1.0"
     exon            6285..6404
                     /gene="Zbed6"
                     /gene_synonym="667118; Gm38394; Gm8466; MGR"
                     /inference="alignment:Splign:2.1.0"
     exon            6405..6528
                     /gene="Zbed6"
                     /gene_synonym="667118; Gm38394; Gm8466; MGR"
                     /inference="alignment:Splign:2.1.0"
     exon            6529..6732
                     /gene="Zbed6"
                     /gene_synonym="667118; Gm38394; Gm8466; MGR"
                     /inference="alignment:Splign:2.1.0"
     exon            6733..6849
                     /gene="Zbed6"
                     /gene_synonym="667118; Gm38394; Gm8466; MGR"
                     /inference="alignment:Splign:2.1.0"
     exon            6850..6930
                     /gene="Zbed6"
                     /gene_synonym="667118; Gm38394; Gm8466; MGR"
                     /inference="alignment:Splign:2.1.0"
     exon            6931..7041
                     /gene="Zbed6"
                     /gene_synonym="667118; Gm38394; Gm8466; MGR"
                     /inference="alignment:Splign:2.1.0"
     exon            7042..7101
                     /gene="Zbed6"
                     /gene_synonym="667118; Gm38394; Gm8466; MGR"
                     /inference="alignment:Splign:2.1.0"
     exon            7102..7200
                     /gene="Zbed6"
                     /gene_synonym="667118; Gm38394; Gm8466; MGR"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      7195
                     /gene="Zbed6"
                     /gene_synonym="667118; Gm38394; Gm8466; MGR"
     exon            7201..7704
                     /gene="Zbed6"
                     /gene_synonym="667118; Gm38394; Gm8466; MGR"
                     /inference="alignment:Splign:2.1.0"
     exon            7705..7787
                     /gene="Zbed6"
                     /gene_synonym="667118; Gm38394; Gm8466; MGR"
                     /inference="alignment:Splign:2.1.0"
     exon            7788..8115
                     /gene="Zbed6"
                     /gene_synonym="667118; Gm38394; Gm8466; MGR"
                     /inference="alignment:Splign:2.1.0"
     exon            8116..8282
                     /gene="Zbed6"
                     /gene_synonym="667118; Gm38394; Gm8466; MGR"
                     /inference="alignment:Splign:2.1.0"
     exon            8283..8350
                     /gene="Zbed6"
                     /gene_synonym="667118; Gm38394; Gm8466; MGR"
                     /inference="alignment:Splign:2.1.0"
     exon            8351..10284
                     /gene="Zbed6"
                     /gene_synonym="667118; Gm38394; Gm8466; MGR"
                     /inference="alignment:Splign:2.1.0"
     regulatory      10265..10270
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zbed6"
                     /gene_synonym="667118; Gm38394; Gm8466; MGR"
                     /note="hexamer: AATAAA"
     polyA_site      10284
                     /gene="Zbed6"
                     /gene_synonym="667118; Gm38394; Gm8466; MGR"
                     /note="major polyA site"
ORIGIN      
        1 gacgctggca gtcctgggtt tctgcttgtt cggctgctgt gaggacggcg ggcgaccgca
       61 gctaagaaaa gagaaagacg tggcagcacg cgggagtcgg agacattgtc atcggttcgg
      121 taaagtttct gttctctggt aactagaccc attttttgat tcccgggtga cttggggcct
      181 gggagggaga agagggcgag gggagtggca gcggcctccc ctcgcccgac tttcggccta
      241 gcccgggaag tctgaaccgg gcccatcagc acggcagcta cccggactcc cgccggcggc
      301 cccggcctgc tgggctccta ggcagacttc agctcacttt cccaccctcc ctgcccccac
      361 ccgctccgcc ccacccccac ggcgcctgct cccttactta ccaacctctt ccccctcccc
      421 ccacatccgg tgttcccgaa ccgggattcc cgggtagccc cggaaaagcg actgtttcgg
      481 acccccggag ggggaactga cactaggttg ctctcttccg ggaatcagtt tctttagtta
      541 gctggccctc cctcccgaga tcagatcaag tgcctggacc cgactttacc tcctcgcctt
      601 cctctctagg gtcccactac tttggaggtt ttctaatatt ccacatacag agtcgaattc
      661 tggtatccta ttcccattcc ctaccctgat tactctcccg cccaagcctt catcctcgaa
      721 gtcaagagct acagggactc ttcgttcttg taggattggt gagatcgtac gaagaacacc
      781 ccttagacgc ccataatcgg tgcggatccc catggggaag gctcgttttg ttgacatcta
      841 ccaggctttg gttctgaacc cagagaaggc ggctgtgcag ctagtggtag ccatgctttc
      901 gtagggtaaa cgtgttggta ttgaggggag gggagggggc ccacggaaaa ggaatggaag
      961 tggtttaaag cttattttag tttggctgct catagaatgt caatttatga gttatttaca
     1021 ggttgtatgt aatgttgctt cagtctaaaa atatgaactc ttgatagaaa ccgtaaatga
     1081 agaatatagc ttgttacctt gttttgaaat tttatttcca gttaattttt cttcagccac
     1141 ctatagtttt caaaatatca gaacagaaag ggcacagcta gcgcttactg ctaatgccta
     1201 gtatgtggaa tctgatttag ctggccggaa ttgacttttt aggttgtatt ggcaagtcag
     1261 tcttaaatga tgactgttga gtggtgcact aagcttaagt gaaatttcct gaaaatattc
     1321 ccgaagttaa gggaaagcca gtgttgttgt cgtgtggatt cactaaaagt acatatttta
     1381 agaactgaag gcatttccag cagatgaagt tcttgattcg gcagcaagaa cgtgaacctg
     1441 caatttggaa gacttaacct ttagctgctc cagatcccat gacggtggga aaatgggcct
     1501 cggttctctt ttctataaca taaggacact ggacgatttg aatttgaaag ttacaagaac
     1561 tcctaaagcc ctgcaagaca gagtttggga atgttctcca ttgctgtcat ttttcctcca
     1621 aaaataacct ggcttggaaa tcatcagttg aaagggaatt tgactcccca tagaaactgg
     1681 aggaaaggta atacaagtgg agagggtcag ctgtatttct gccagagtaa taaacccact
     1741 gagaggttct ggtccgcatt gtggagacat aaagagaatg agtgtatgta ctctaagtgt
     1801 accagtttcc tcaatctctc ctggcagaag atgcagtact tttggtgatg ctgggattct
     1861 ggggtgcgtt tccattaatt caaacacaga cgaagacgat gtggtagagg gaaagatggt
     1921 ggcagaagga gcgaataaag agacaaaatt gcctgctaaa aagaaaagaa agaagggttt
     1981 gcgaattaag gggaaaagac gccgaaaaaa attgattctt gccaaaaagt ttagtaagga
     2041 tttggggtct gggagacctg ttgctgatgc ccctgcttcg ttagcttccg gtgcccctga
     2101 gcaagatgaa gaaagtcttt ttgagggcaa catagaaaag caaatctatc tgcctagtac
     2161 cagagccaaa acctccattg tgtggcactt ctttcatgtt gacccccaat atacctggag
     2221 agcaatttgt aacctgtgtg aaaaaagtgt cagcaggggt aagccaggca gccatcttgg
     2281 tacatctact cttcaaagac atcttcaggc aaggcattct cctcactgga ccagggccaa
     2341 caagtttgga gtcactaatg gggaggagga ctttaccttg gatttatcgt tgtctcctcc
     2401 ttctcctgga agcaatggaa gctttgagta tattcctact gattctgtag atgaaaacag
     2461 aatgggtaag aagcgcgata agtcagcatc tgatgccctg agggcaaaaa gagggcgctt
     2521 tctcatcaaa agcaacattg tcaagcatgc cttaattcca ggaacgagag ccaagacatc
     2581 tgcagtttgg aatttttttt atactgaccc tcagcacatc tcaagagctg tgtgtaacat
     2641 atgtaaaaga agtgtgagcc ggggtaggcc aggttcccac ttaggaactt caacacttca
     2701 acgacatctt caggccacgc atcccatcca ttgggctgtt gccaacaaag acagtggtgc
     2761 tattggaaac ggattagatg agactgaaac agagagcagt gatctcctga atgatacgat
     2821 gcctggagag aagtcatcag gcagccaaga tttaacagct gaggacctca gtgactctga
     2881 tacagatgaa cccccttgtt tagaggttga aaatagatct gagagtccta ttcctgttgc
     2941 agaccaagat aatccggtgc acgcacaaga gagagaaacg acgacacatt gtgaaaatgc
     3001 agccgcaaat caaataagtc aggcagttat tcagatgatt gtggaggatc tgcatccgta
     3061 caactatttc tcaaccccag cctttcaaag gtttctacag attgtcgctc ctgactatag
     3121 attgccatca gagacttact ttttcaccaa agctgtacct cagttatatg attctgttag
     3181 agaaaaaatt ttcttaactt tagagaatgt tcaaagccaa aagatccacc tgactgctga
     3241 catatggact catgaccctt ccactgacta tttcattgtg actgtacact gggtctcttt
     3301 ggaaactgca tcttctccca gtaatggtgg gactcccaat tttagaaagt gggcagtact
     3361 ttgtgttaca ggtttagcca aagactgttt gataactaac attttacaag aattaaatga
     3421 ccagattggt ctgtggcttt ctcctaattt ccttacccct agcttcattg tttctgacaa
     3481 ttcttctaat gtggtacatg caatcaaagg tggtggcttt acccatgtgc catgcttcct
     3541 gcattgtcta aatatagtga ttcaggactt tttctgtgag cacaaaagta ttgagaatat
     3601 gttagtggct gctaggaaaa cctgccatca ttttagccat tctgtcaaag cccgccagat
     3661 actacaagaa ttccaaaatg atcaccagct tccatggaag aatctgaagc aggatgaaac
     3721 tggccactgg atttctacct tttacatgtt aaaatggctt ttagaacatt gctactctgt
     3781 tcaccatagt ctgggcagag ccagtggagt tgtacttacc tcccttcagt ggactctaat
     3841 gacatacgtt tgtgatattc ttaagccatt tgaggaggcc acccagagag tgagtgtgaa
     3901 gacaacagga ttgaatcagg tgctacccct aatccaccat ctcctctttt ccctgcagag
     3961 actcagagaa gattttcaag tcagaggtat tactcaggcc ctcaatctgg tggacagttt
     4021 atctttgaaa cttgaaagtg atgccttact aagtgccatg ctcaaatcca agcattgtat
     4081 cttggctact ttgttagatc cttgttttaa gaacagtttg gaggactttt ttcctcaagg
     4141 tgctgattta gaaacttaca aacagatcct tgcagaagag gtttgtaatt atatggaatc
     4201 ttcgccaggg gcctgccaga tttcaagttc tgaaacatct ggccctttag ttaggttagg
     4261 aactgattcg tttacttcta taaaagaagg cacctccagt gcaggttctc tggatagctc
     4321 agccgcaggc agtgttgctg ttgggagcaa aagctccttg ctccccgctg cggtagcagt
     4381 agtagatgag tacttcaaag agaagtattc agagctctca ggaggtgatg accctttggt
     4441 ttactggcag aggaaggtga gcatatggcc agctttgacc caagttgcca ttcagtatct
     4501 gagttgcccc atgtgtagtt ggcaatctga atgcatgttt accacaaata gccactttca
     4561 tccaaagcag atcatgaaca tggactttga taatatagaa cagctcatat ttctgaaaat
     4621 gaacttggag aatgttaact atgactattc tacattgatt ctgagctggg accctgaaaa
     4681 taaggctgtt cagagcaatg aaaaagaaat actaccttaa tttccttttc cttgtcctac
     4741 ttaaaatggg cagctttcgc tatattacta tatcttattg ctgttgttac tatatgtagt
     4801 cgtactattt atccttttaa aaaaatggct gggtgtgttc acagtgcctg tagtcctggc
     4861 tatttgagac actgaggctg gattatgact ttagcacatg agtttgagac cagcccaggc
     4921 aacatgttaa gatcctgcct tacaaaaatg aaaaacctga ggaaatccga aattacagaa
     4981 agactgaaaa ctccacagag gcagtgtaac gatgacaaaa tgaaggttaa ctttgaaaat
     5041 ttcacagttg taactcagtg taactaacat ctatcaaagt gtcatttgta tcacttgaga
     5101 gagagggcag tgttaatgag aaacacagtg aagcgttgaa ggacttaggt atttctggtt
     5161 ggtagattga gctagtcatt gattagagta aaaacttctt ccactgtgga agattgggtt
     5221 tcagttatta tttatataaa tacagtgatt caggacttct atgagcacaa aggtgtttag
     5281 aatgtgttag tgactgcatt aacatagtct ttccctcccc tgttttttaa tttctttaaa
     5341 acccctgaca cagcttgaca gaatgaaaac ccacaaaatt gtttcatttt tagaaattat
     5401 agttgcctca ccctggtcag tttataatgt caggttactg ggtatgatag aattatcttt
     5461 tatatttagg attgggtcta tataaaaggg aacattacaa aacaattaga aaatgacttt
     5521 ttggtctttg atttgctttt tataatatag taccaaaaac agggattata taggtgcctt
     5581 taaaataacc cattagtaaa aaacattaga tgtttgtaaa atcaaaaaac aagcaagcct
     5641 cgtgaacgtg cagaccccat gtgagtttcc cagagaatat ttctagagct tgttcatttt
     5701 tttcaagggt gctcctggtc catagcatga tgttcctaac tgcagtttgg aactgtattt
     5761 ttaactgaga taagcagttg aaactttact gtgttaggca tcattgctga aatgagtgaa
     5821 ctgtctcagt ggccctgcag gtgccttccc actcggagag tctgtttctg tgactgagtg
     5881 ggaggccaca gagagctgac ttttagtaag tctattagat gtttcagatt gaataactaa
     5941 tgtaagatcc caatttttcc ttttttttca ttttagattt ggggatattc cctgcccaaa
     6001 aaattcctgg aaaattgact agtattaagt gcgtaatagc ttggaactga gtgaagacac
     6061 agatgttcct gttgagagca accagctaat ggttacattt taaagacgat ttctgtggct
     6121 gagtggtcat tggaagagta agtccttttc aagagtcctc ggagctggtc tcacctcgga
     6181 agcagtggct tgttccagga agccggtttt ggcctgagaa tttacccagt atgcctaatc
     6241 agggagaaga ctgctatttt tatttctatt ctacatgcgc caaaggtgac agctgcccat
     6301 tccgtcactg tgaagctgca ctaggaaatg aaactgtttg cacactatgg caagaaggtc
     6361 gttgttttcg acaggtgtgc agatttcgtc acatggaaat tgacaaaaaa cgaagtgaaa
     6421 ttccttgtta ttgggaaaat cagccagtgg gatgtcaaaa actaaactgc gctttccatc
     6481 acaccagaag ccgctatgtt gatggactct tcctacctcc aagcaaaact gtgttaccca
     6541 ctgtgcctga gtcacaagaa gaagaagtaa agactagcca gctcacagtt caacagagca
     6601 aattgtctgt tcagtctaac ccctcccctc agctgcggag tgtaatgaaa gtagagagct
     6661 cagaaaacgt tcccagcccc acacatccgc ctgttgtaat caacgctgca gatgatgatg
     6721 aagatgacga tgatcagttt tctgaggagg gtgatgaaag caagacacct gccctgcagc
     6781 catctcctga cgtccataat ggattacgag tggcttctgc ccgcaaacct ggagtcagtt
     6841 taaagcaagg tgaatgtttg aattttggaa taaagactct tgaggaaatt aaatcaaaga
     6901 aaatgaagga aaaatccaag aagcaaggtg aaggctcctc gggagtttcc agtgttttac
     6961 agcagcctca gcccaatcca ggccctgaga aggagaatgt tcggactgtg gtgaggatgg
     7021 tgactctatc cagcaaacca gaagagccct tggttagact gagtctttct gagagactgg
     7081 ggaaacgaaa actttcagtg ggtggtgata gtgaccctcc attaaagcga agccttgcac
     7141 agaggctggg aaaaaaagtg gaatcgccag aaactaacat tgataaagca ccaaagaaag
     7201 agcgaggtca taaagctggg gagatccatg tgaagacact ggaagaaatt cttcttgaaa
     7261 gagccagtca gaaacgtgga gaattgcaaa ccaaactgaa ggcagaagaa ccttcaggag
     7321 ccgatgattc tccatcaggg acaaaaagtt cttcttcagt gcggatcaaa accttctctg
     7381 aggtcctggc tgaaaagaaa caccggcagc aggaaatgga aagacagaaa tccaaaaagg
     7441 atacaagttg cctcacgcta acagacgaca ctgaaatgaa aaagacagtg agtctgccca
     7501 ctgttgctgt tagcaaagga caaccagagg agcctgcagg aagagccagg tctatgcagg
     7561 aggtgcatat taagacacta gaggaaatta agctggagaa ggccctgagg gtgcagcaaa
     7621 gctctgagag tagtggcaac tcccgacctc aagctgaggc tgccccaggg acaaagaggc
     7681 tgctccgcat caccaagaga gcaggtgtaa aagaagagaa aaaatgtggc cttgaagaca
     7741 gtggtgaccc tcctcagagc agtgtgacta agatggaggc taatgagact tcagatgaga
     7801 ccataagtga tcccacaaaa cttgcagtca acagatgtga cactgtcaaa gagaaacaca
     7861 cacagagact gcaggagaga ggagcatcac aaaaggagaa agcagccttg tcatctgtgc
     7921 gaggagatga ggcttcttct tatacccgag tggcggggaa gccggtgctc actgctgtat
     7981 caggcgtcac tcggcatctg gcaaaacggc tccccgtgga gtcatcccag aaaggggagg
     8041 tagaaacctc cggaatcggg gactcaatac tgaatgtgaa atgcgcagca cagactttgg
     8101 agaagaggag taaagtcaaa cccaaagtaa atgtgaagcc atctgtggtc aaggttgtct
     8161 cagctcccaa attggctccc aaacgcaagg ctgtggagat gcactctgcc gtcatcgcag
     8221 ccgtgaagcc gctcagctcc agcagtgtcc tgcaggaaag ccccaccaag aaagcagctg
     8281 tggctgttgt cccactcctc tctgaggata aacccgtcac catgtctgag acagaaaacc
     8341 caaaagacag ttctgtgctg tcttcagccc aagctgcttc ggaacccttg ctcccggaag
     8401 gctctggccc ttcctcatcc cagacggcaa caaaaccgcg ccggctgagc tccgcctcca
     8461 cgggaaagcc tccactctct gtggaagatg attttgagaa actaatatgg gaaatttcag
     8521 ggggcaaatt ggaagctgag atcgacttgg atcctgggaa ggatgaagat gaccttctgc
     8581 ttgagctctc agagatgatt gacagctgaa acccaagggg ataatgagga cacttaaaaa
     8641 aaaaaaaaaa aaaaaaaccc tcaccaaaaa ctggacttag tttcatctat ttacctgagg
     8701 tgataatttc ttttaagtct caaattttgc ccaaatcaaa agtatacctc tgaagtacct
     8761 gtgtgtcctg gactccctgg ggtcggatct tttacatccc ttgataaata actgttttgt
     8821 ccacttgctg ccattgttga gcatctttga gaagaaagtt ctgtaatgcc cttctctcca
     8881 cctgagactg agctccaaat gaaacggtgc acgagaactc agtggtcctc gaggtgtttg
     8941 ttagtgtggg ctagcttccc tgctctattt atttatgtat tgtcttaatt ttatcagagt
     9001 ttaaaaatga agacagctgc taaccattgt ggaccaaatg tcatgctacc actaaacaaa
     9061 agacccactc agtctgtgtt aaattgtatg tcttgtattt ggaaattcgt ctaagcttta
     9121 aagagggccg ggcagctcga gaacctgaga tacggaccta actctggacc tggtcctgtt
     9181 gtgttagctg ttccgtgagc ctctgaagag caatagctaa tttattatta ctgtaatttt
     9241 ttaaaggctt taaagtgcct caggggtccc ctgaaactaa ttttctattt ctgggattcc
     9301 ctggattctt tataagagat ggtgacatga ctagggaaat tcttttttta gtatgaaaat
     9361 tgtcccttca atacctttct cttactggca ttgaattatc acagagacag aaaattggta
     9421 aattttttta atttctaact ctcccaggaa actccttgcc tagtatttat ttgatatgct
     9481 ttaaccatgg gggggtggac ctcaagctgc cagtattgat ctacagactg tagcagtaca
     9541 ctgggctgta ctgtcaggga tggcaagatg ctctggggtg tattggatac ctccagtttc
     9601 ttcacttctg gattgagttt tcttttctta atgttggtcc tcttcacatc acctcaaggt
     9661 ttagacttgt gaaggaacaa gtctgatgag gataatagtc ttgaaaggag acactgtaca
     9721 gaattggaag aaggaaagaa aagacttgtt cattgtgata ctttctgtag gtggccagtt
     9781 tgtttctcat agggaaatcc tggaccacct gtcatgttgg ctcctaagga actgctgttg
     9841 taagcggctc atcaagagtt gaagttcatg tagccttgtt gggaatatgg aaaaggaaga
     9901 aagccacagg actgccagtt cagtctggga agatctggat gattctgcac atgcaaaaat
     9961 gacttgaagt ttctgtatag acgcttgtac cgatccatct tcagctgact gaatgttgta
    10021 tgatagccct tctccaaagc agaggtggaa ggttctggtt tcaccacaca ttttataaac
    10081 acatctcctg ttttgaattg gcctataggt tgtaggcctc ttttgtatat aacctctatt
    10141 attttgcttt aaaaaaaaaa aaaggtctgt tcatatttaa tgccctgtat tagtcaatga
    10201 tttgtgttca acattatttg aaccatttgc cattaacgaa agagaaatac ttatttgtgt
    10261 tttaaataaa actgatatag gaaa
//
