LOCUS       NM_174877               1284 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus zygote arrest 1 (Zar1), transcript variant 1, mRNA.
ACCESSION   NM_174877
VERSION     NM_174877.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1284)
  AUTHORS   Wan,Y., Yang,S., Li,T., Cai,Y., Wu,X., Zhang,M., Muhammad,T.,
            Huang,T., Lv,Y., Chan,W.Y., Lu,G., Li,J., Sha,Q.Q., Chen,Z.J. and
            Liu,H.
  TITLE     LSM14B is essential for oocyte meiotic maturation by regulating
            maternal mRNA storage and clearance
  JOURNAL   Nucleic Acids Res 51 (21), 11652-11667 (2023)
   PUBMED   37889087
REFERENCE   2  (bases 1 to 1284)
  AUTHORS   Cheng,S., Altmeppen,G., So,C., Welp,L.M., Penir,S., Ruhwedel,T.,
            Menelaou,K., Harasimov,K., Stutzer,A., Blayney,M., Elder,K.,
            Mobius,W., Urlaub,H. and Schuh,M.
  TITLE     Mammalian oocytes store mRNAs in a mitochondria-associated
            membraneless compartment
  JOURNAL   Science 378 (6617), eabq4835 (2022)
   PUBMED   36264786
REFERENCE   3  (bases 1 to 1284)
  AUTHORS   Rong,Y., Zhu,Y.Z., Yu,J.L., Wu,Y.W., Ji,S.Y., Zhou,Y., Jiang,Y.,
            Jin,J., Fan,H.Y., Shen,L. and Sha,Q.Q.
  TITLE     USP16-mediated histone H2A lysine-119 deubiquitination during
            oocyte maturation is a prerequisite for zygotic genome activation
  JOURNAL   Nucleic Acids Res 50 (10), 5599-5616 (2022)
   PUBMED   35640597
REFERENCE   4  (bases 1 to 1284)
  AUTHORS   He,Y., Chen,Q., Dai,J., Cui,Y., Zhang,C., Wen,X., Li,J., Xiao,Y.,
            Peng,X., Liu,M., Shen,B., Sha,J., Hu,Z., Li,J. and Shu,W.
  TITLE     Single-cell RNA-Seq reveals a highly coordinated transcriptional
            program in mouse germ cells during primordial follicle formation
  JOURNAL   Aging Cell 20 (7), e13424 (2021)
   PUBMED   34174788
REFERENCE   5  (bases 1 to 1284)
  AUTHORS   Bai,D., Sun,J., Jia,Y., Yin,J., Zhang,Y., Li,Y., Gao,R., Du,X.,
            Li,K., Lin,J., Tu,Z., Wang,Y., Pan,J., Liang,S., Guo,Y., Ruan,J.,
            Kou,X., Zhao,Y., Wang,H., Jiang,C., Wang,F., Teng,X., Liu,W. and
            Gao,S.
  TITLE     Genome transfer for the prevention of female infertility caused by
            maternal gene mutation
  JOURNAL   J Genet Genomics 47 (6), 311-319 (2020)
   PUBMED   32893179
  REMARK    GeneRIF: Genome transfer for the prevention of female infertility
            caused by maternal gene mutation.
REFERENCE   6  (bases 1 to 1284)
  AUTHORS   Evsikov,A.V., Graber,J.H., Brockman,J.M., Hampl,A., Holbrook,A.E.,
            Singh,P., Eppig,J.J., Solter,D. and Knowles,B.B.
  TITLE     Cracking the egg: molecular dynamics and evolutionary aspects of
            the transition from the fully grown oocyte to embryo
  JOURNAL   Genes Dev 20 (19), 2713-2727 (2006)
   PUBMED   17015433
REFERENCE   7  (bases 1 to 1284)
  AUTHORS   Pangas,S.A., Choi,Y., Ballow,D.J., Zhao,Y., Westphal,H.,
            Matzuk,M.M. and Rajkovic,A.
  TITLE     Oogenesis requires germ cell-specific transcriptional regulators
            Sohlh1 and Lhx8
  JOURNAL   Proc Natl Acad Sci U S A 103 (21), 8090-8095 (2006)
   PUBMED   16690745
REFERENCE   8  (bases 1 to 1284)
  AUTHORS   Rajkovic,A., Pangas,S.A., Ballow,D., Suzumori,N. and Matzuk,M.M.
  TITLE     NOBOX deficiency disrupts early folliculogenesis and
            oocyte-specific gene expression
  JOURNAL   Science 305 (5687), 1157-1159 (2004)
   PUBMED   15326356
REFERENCE   9  (bases 1 to 1284)
  AUTHORS   Wu,X., Wang,P., Brown,C.A., Zilinski,C.A. and Matzuk,M.M.
  TITLE     Zygote arrest 1 (Zar1) is an evolutionarily conserved gene
            expressed in vertebrate ovaries
  JOURNAL   Biol Reprod 69 (3), 861-867 (2003)
   PUBMED   12773403
  REMARK    GeneRIF: The carboxyl-termini of these ZAR1 proteins contain an
            important functional domain that is conserved through vertebrate
            evolution and that may be necessary for normal female reproduction
            in the transition from oocyte to embryonic life.
REFERENCE   10 (bases 1 to 1284)
  AUTHORS   Wu,X., Viveiros,M.M., Eppig,J.J., Bai,Y., Fitzpatrick,S.L. and
            Matzuk,M.M.
  TITLE     Zygote arrest 1 (Zar1) is a novel maternal-effect gene critical for
            the oocyte-to-embryo transition
  JOURNAL   Nat Genet 33 (2), 187-191 (2003)
   PUBMED   12539046
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DV647930.1 and BC099399.1.
            
            On May 7, 2009 this sequence version replaced NM_174877.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY191415.1, DV655517.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-333               DV647930.1         4-336
            334-1284            BC099399.1         328-1278
FEATURES             Location/Qualifiers
     source          1..1284
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 38.44 cM"
     gene            1..1284
                     /gene="Zar1"
                     /note="zygote arrest 1"
                     /db_xref="GeneID:317755"
                     /db_xref="MGI:MGI:2180337"
     exon            1..801
                     /gene="Zar1"
                     /inference="alignment:Splign:2.1.0"
     CDS             28..1113
                     /gene="Zar1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     zygote arrest protein 1; oocyte-specific maternal effect
                     factor"
                     /codon_start=1
                     /product="zygote arrest protein 1 isoform 1"
                     /protein_id="NP_777366.1"
                     /db_xref="CCDS:CCDS19331.1"
                     /db_xref="GeneID:317755"
                     /db_xref="MGI:MGI:2180337"
                     /translation="MFPASTFHPCPHPYPQATKAGDGWRFGARGCRPAPPSFLPGYRQ
                     LMAAEYVDSHQRAQLMALLSRMGPRSVSSRDAAVQVNPRRDASVQCSLGRRTLQPAGC
                     RASPDARSGSCQPRGHAGAGRSPRSWQTVAPFSSVTFCGLSSSLEVAGGRQTPTKGEG
                     SPASSGTREPEPREVAARKAVPQPRSEEGDVQAAGQAGWEQQPPPEDRNSVAAMQSEP
                     GSEEPCPAAEMAQDPGDSDAPRDQASPQSTEQDKERLRFQFLEQKYGYYHCKDCKIRW
                     ESAYVWCVQGTSKVYFKQFCRVCEKSYNPYRVEDITCQSCKRTRCACPVRLRHVDPKR
                     PHRQDLCGRCKDKRLSCDSTFSFKYII"
     exon            802..894
                     /gene="Zar1"
                     /inference="alignment:Splign:2.1.0"
     exon            895..969
                     /gene="Zar1"
                     /inference="alignment:Splign:2.1.0"
     exon            970..1259
                     /gene="Zar1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1239..1244
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Zar1"
                     /note="hexamer: AATAAA"
     polyA_site      1259
                     /gene="Zar1"
                     /note="major polyA site"
ORIGIN      
        1 tgggcgggcg aggcgcggga cgcacccatg ttcccggcga gcacgttcca cccctgcccg
       61 catccttatc cgcaggccac caaagccggg gatggctgga ggttcggagc caggggctgc
      121 cgacccgcgc ccccctcctt cctccccggc tacagacagc tcatggccgc ggagtacgtc
      181 gacagccacc agcgggcaca gctcatggcc ctgctgtcgc ggatgggtcc ccggtcggtc
      241 agcagccgtg acgctgcggt gcaggtgaac ccgcgccgcg acgcctcggt gcagtgttca
      301 ctcgggcgcc gcacgctgca gcctgcaggg tgccgagcca gccccgacgc ccgatcgggt
      361 tcctgtcaac cccgtggcca cgccggcgcc gggagatccc cgcgatcctg gcagaccgta
      421 gccccgttct cgtccgtgac cttctgtggc ctctcctcct cactggaggt tgcgggaggc
      481 aggcagacac ccacgaaggg agaggggagc ccggcatcct cggggacccg ggaaccggag
      541 ccgagagagg tggccgcgag gaaagcggtc ccccagccgc gaagcgagga gggcgatgtt
      601 caggctgcag ggcaggccgg gtgggagcag cagccaccac cggaggaccg gaacagtgtg
      661 gcggcgatgc agtctgagcc tgggagcgag gagccatgtc ctgccgcaga gatggctcag
      721 gaccccggtg attcggatgc ccctcgagac caggcctccc cgcaaagcac ggagcaggac
      781 aaggagcgcc tgcgtttcca gttcttagag cagaagtacg gctactatca ctgcaaggac
      841 tgcaaaatcc ggtgggagag cgcctatgtg tggtgtgtgc agggcaccag taaggtgtac
      901 ttcaaacagt tctgccgagt gtgtgagaaa tcctacaacc cttacagagt ggaggacatc
      961 acctgtcaaa gttgtaaaag aactagatgt gcctgcccag tcagacttcg ccacgtggac
     1021 cctaaacgcc cccatcggca agacttgtgt gggagatgca aggacaaacg cctgtcctgc
     1081 gacagcacct tcagcttcaa atacatcatt tagtgagagt cgaaaacgtt tctgctagat
     1141 ggggctaatg gaatggacaa gtgagctttc tcccctcttc acctcttccc tttccaaatt
     1201 cttcatgaca gacagtgtac ttggatataa agcctgtgaa taaaaggtat tgcaaacaaa
     1261 aaaaaaaaaa aaaaaaaaaa aaaa
//
