LOCUS       NM_001098723            2867 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus Yy2 transcription factor (Yy2), mRNA.
ACCESSION   NM_001098723
VERSION     NM_001098723.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2867)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2867)
  AUTHORS   Dong,X. and Kwan,K.M.
  TITLE     Yin Yang 1 is critical for mid-hindbrain neuroepithelium
            development and involved in cerebellar agenesis
  JOURNAL   Mol Brain 13 (1), 104 (2020)
   PUBMED   32703236
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2867)
  AUTHORS   Wang,Z., Gan,X., Qiu,C., Yang,D., Sun,X. and Zeng,Z.
  TITLE     Role of polypyrimidine tract-binding protein 1/yin yang 2 signaling
            in regulating vascular smooth muscle cell proliferation and
            neointima hyperplasia
  JOURNAL   Toxicol Appl Pharmacol 383, 114747 (2019)
   PUBMED   31499192
  REMARK    GeneRIF: PTBP1 is a critical regulator of vascular smooth muscle
            cell proliferation and neointima hyperplasia via modulating the
            expression of YY2.
REFERENCE   4  (bases 1 to 2867)
  AUTHORS   Tahmasebi,S., Jafarnejad,S.M., Tam,I.S.,
            Gonatopoulos-Pournatzis,T., Matta-Camacho,E., Tsukumo,Y.,
            Yanagiya,A., Li,W., Atlasi,Y., Caron,M., Braunschweig,U., Pearl,D.,
            Khoutorsky,A., Gkogkas,C.G., Nadon,R., Bourque,G., Yang,X.J.,
            Tian,B., Stunnenberg,H.G., Yamanaka,Y., Blencowe,B.J., Giguere,V.
            and Sonenberg,N.
  TITLE     Control of embryonic stem cell self-renewal and differentiation via
            coordinated alternative splicing and translation of YY2
  JOURNAL   Proc Natl Acad Sci U S A 113 (44), 12360-12367 (2016)
   PUBMED   27791185
REFERENCE   5  (bases 1 to 2867)
  AUTHORS   Kakizaki,F., Sonoshita,M., Miyoshi,H., Itatani,Y., Ito,S.,
            Kawada,K., Sakai,Y. and Taketo,M.M.
  TITLE     Expression of metastasis suppressor gene AES driven by a Yin Yang
            (YY) element in a CpG island promoter and transcription factor YY2
  JOURNAL   Cancer Sci 107 (11), 1622-1631 (2016)
   PUBMED   27561171
  REMARK    GeneRIF: in a transplantation mouse model of liver metastases,
            expression of Yy2 (and therefore of Aes) is downregulated
REFERENCE   6  (bases 1 to 2867)
  AUTHORS   Klar,M., Fenske,P., Vega,F.R., Dame,C. and Brauer,A.U.
  TITLE     Transcription factor Yin-Yang 2 alters neuronal outgrowth in vitro
  JOURNAL   Cell Tissue Res 362 (2), 453-460 (2015)
   PUBMED   26350623
  REMARK    GeneRIF: both the up- and down-regulation of yy2 significantly
            impairs the outgrowth of the major neurite of primary hippocampal
            neurons and the numbers of neuronal processes in proximate
            extensions
REFERENCE   7  (bases 1 to 2867)
  AUTHORS   Garcia-Tunon,I., Guallar,D., Alonso-Martin,S., Benito,A.A.,
            Benitez-Lazaro,A., Perez-Palacios,R., Muniesa,P., Climent,M.,
            Sanchez,M., Vidal,M. and Schoorlemmer,J.
  TITLE     Association of Rex-1 to target genes supports its interaction with
            Polycomb function
  JOURNAL   Stem Cell Res 7 (1), 1-16 (2011)
   PUBMED   21530438
REFERENCE   8  (bases 1 to 2867)
  AUTHORS   Drews,D., Klar,M., Dame,C. and Brauer,A.U.
  TITLE     Developmental expression profile of the YY2 gene in mice
  JOURNAL   BMC Dev Biol 9, 45 (2009)
   PUBMED   19638226
  REMARK    GeneRIF: Yy2 expression in the heart and lung is constitutively
            expressed during embryogenesis and in adult mice. Developmental
            changes of yy2 transcription became obvious in various areas of the
            brain.
            Publication Status: Online-Only
REFERENCE   9  (bases 1 to 2867)
  AUTHORS   Kim,J.D., Faulk,C. and Kim,J.
  TITLE     Retroposition and evolution of the DNA-binding motifs of YY1, YY2
            and REX1
  JOURNAL   Nucleic Acids Res 35 (10), 3442-3452 (2007)
   PUBMED   17478514
REFERENCE   10 (bases 1 to 2867)
  AUTHORS   Klar,M. and Bode,J.
  TITLE     Enhanceosome formation over the beta interferon promoter underlies
            a remote-control mechanism mediated by YY1 and YY2
  JOURNAL   Mol Cell Biol 25 (22), 10159-10170 (2005)
   PUBMED   16260628
  REMARK    GeneRIF: the novel factor YY2 antagonizes the negative actions
            exerted by YY1
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK161451.1.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AK161451.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-97                AK161451.1         2-98
            98-2867             AK161451.1         100-2869
FEATURES             Location/Qualifiers
     source          1..2867
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 72.57 cM"
     gene            1..2867
                     /gene="Yy2"
                     /note="Yy2 transcription factor"
                     /db_xref="GeneID:100073351"
                     /db_xref="MGI:MGI:3837947"
     exon            1..2867
                     /gene="Yy2"
                     /inference="alignment:Splign:2.1.0"
     CDS             218..1354
                     /gene="Yy2"
                     /note="YY-2; yin and yang 2"
                     /codon_start=1
                     /product="transcription factor YY2"
                     /protein_id="NP_001092193.1"
                     /db_xref="CCDS:CCDS53233.1"
                     /db_xref="GeneID:100073351"
                     /db_xref="MGI:MGI:3837947"
                     /translation="MASETEKLLCLNTESAEIPADFVELLPPDNIGDIEAVSLETSVG
                     QTIEVYGDVGVDWAHGSQYHSPVIALQPLVGSSLSSRDHDKEMFVVQTREEEVVGYQD
                     SDNLLFSPEFGSQMVLPVNEDDYLQPTTASFTGFLAAENGQGELSPYEGNLCGLTTFI
                     EAGAEESVNADLGDKQWEQKQIDGLDGEFPFTMWDDVNEKEDPIAEEQAGESPPDYSE
                     YMTGKKFPPEGIPGIDLSDPKQLAEFTSMRPKKPKGDFPRPIACSHKGCEKMFKDNSA
                     MRKHLHIHGPRVHVCAECGKAFVESSKLKRHQLVHTGEKPYQCTFEGCGRRFSLDFNL
                     RTHVRIHTGDKPFVCPFDACNKKFAQSTNLKSHILTHVKNKNDQ"
     regulatory      2847..2852
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Yy2"
                     /note="putative"
     polyA_site      2867
                     /gene="Yy2"
                     /note="putative"
ORIGIN      
        1 agacgacggc ggcttttctc cgaagcgcac ggctttcgtc aggctctctc gggtttgttt
       61 ttttgttgta gttttgtcgt ttgggttttt tttttttctc gttttgtttt ggttttatcc
      121 agcacgccag cgcgtgcttt tcttccctga ttttttctct actccacagc tctctcccac
      181 ctgcttgcta cccaggaccg gtccgcgggt ctccgccatg gcctctgaga cagagaaact
      241 tctgtgtctt aacacagaaa gcgcagagat tcctgctgat tttgtggagc tgctgccacc
      301 ggataatatc ggtgatatcg aggcggtttc tctggaaacc agcgtaggcc aaaccatcga
      361 agtatatgga gatgtaggtg tcgattgggc gcatggtagc caataccact ctcctgttat
      421 tgctctgcag ccgcttgtgg gcagcagcct gagtagtaga gatcatgata aggaaatgtt
      481 tgtcgttcag acacgagagg aggaggtggt gggctaccaa gactcagaca acctactatt
      541 cagtcctgaa tttggaagcc agatggtttt gccagttaat gaagacgact atctccagcc
      601 gaccactgcc tcttttacgg gctttctggc ggcagagaat ggtcaaggtg agctcagccc
      661 ctatgaaggg aatctctgtg gtttgacgac ctttatagag gccggtgcag aagaaagcgt
      721 gaacgctgac ctgggtgaca aacagtggga gcagaagcag atcgatggtc ttgatggcga
      781 atttcccttc accatgtggg acgatgttaa tgaaaaagaa gatcccatag ctgaagaaca
      841 ggctggtgag tcaccccccg attattctga gtatatgaca ggaaagaaat ttcctcctga
      901 aggaatacct ggcattgatc tttctgatcc caaacaactg gcagaattta ctagcatgag
      961 acccaaaaag ccaaaaggag actttccaag acctatagca tgctctcata aaggctgcga
     1021 gaagatgttc aaagataatt ctgctatgag aaagcacttg cacatccatg ggccgagagt
     1081 gcatgtctgt gcagaatgtg gcaaagcttt tgttgagagt tccaagctga aacgtcatca
     1141 gcttgttcac actggagaga aaccctacca gtgtaccttt gaaggctgtg ggagacgctt
     1201 ttccctggat ttcaatttgc gcacacatgt gcgaatccat actggagaca aacctttcgt
     1261 gtgtccattt gatgcctgca acaagaagtt tgcacagtca acaaacctga aatcgcatat
     1321 cttaacccat gttaagaaca agaatgacca gtaaaaagaa gtgagagtcc ctttgaagcc
     1381 tgggaagtat tttacagtaa tgtgcctgag aataaatatg cccctagttt gaatagtttc
     1441 taggaaagtt attgcaaatg aattttgtac atatctgaag tttatgtttt gatagatcaa
     1501 aaagttaaaa gttttatgtt cttaagatgc tctattttat actgcagtgg tgttttgcaa
     1561 agtttggttt caacaggaga ctaattcaca aacctcatat tgttgctaaa gatggcctgc
     1621 attcttttta tgctgaagtg ttttgagata tttggttaac aagagacaaa actgtgaacc
     1681 tcatattcct aagataccct atcttctaca gtggtaattt tatgaaagtt gctttcaaca
     1741 agagactatt tcaagaacta gatatcccaa gatgacctgt tttattctgc agtggtattt
     1801 ttatgaaact tgctttcagc ggactaattc aaatggtctg tgctattttg cactgaagtt
     1861 ttttgagaag tttgatttca gtagactaaa ttacaaaccc tattgtcact aagatgtact
     1921 gtgttattct gtgagatgat ttttttgtga agtttggttt caacagggga ctaaatcaca
     1981 aacctcatat tgctcaggta tcctatcttc tgcaatggtg tttttttgaa gtttggtttc
     2041 accaagagac aatttcgtga acttcatatg ctaaaatgat ctgtattatt caacaaggtg
     2101 tttttatgaa acttgctttc aacaaacttc attttgctaa ggtgtcttgt attactctgc
     2161 aatagtgttg taaagttgat tttgacatga gaataactca tgaacctcaa aacataatgt
     2221 tgctaacatg tcctgtttgt ttagtggtgt tttttgaagt ttggtttcaa caggagactt
     2281 aattcatgag ccccatattt ttgttgagat gtcctgtcgt attttgcaat gttttttttt
     2341 ttttctgtga agtttggttt agacagggaa taatttatga aatccatgtc aaattacatt
     2401 tctttataca actttgtgaa ttgggattct cataaatatg aagtttactt atattttaaa
     2461 attgtgtgtt ataaatgttc atgtttatac ttttaggaat atgtctagta attgtatatc
     2521 tgatgtctgt ggagttgatg tttgtaaaga attgacagct ttatgcattc atattattct
     2581 gataaagaaa ctttaagttt gacagtattc cttgataacc aagacatttt gtacaagttt
     2641 cttttatctg tattatacag tatagaatat tatatgacat aattttatta gccagttctt
     2701 ttagtcactt tatcccatcc ccgaatatta tttagagtgc ttgagtgtaa tttctttgat
     2761 caattaagaa gtttgtgttg attgcataat atcttgtctt gacattgatt gcatgtttga
     2821 tggatatttt cgtgctatag aacaaaaata aaactgtttg aagaatt
//
