LOCUS       NM_009537               5854 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus YY1 transcription factor (Yy1), mRNA.
ACCESSION   NM_009537
VERSION     NM_009537.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5854)
  AUTHORS   Banerjee,S., Sanyal,S., Hodawadekar,S., Naiyer,S., Bano,N.,
            Banerjee,A., Rhoades,J., Dong,D., Allman,D. and Atchison,M.L.
  TITLE     YY1 knockout in pro-B cells impairs lineage commitment, enabling
            unusual hematopoietic lineage plasticity
  JOURNAL   Genes Dev 38 (17-20), 887-914 (2024)
   PUBMED   39362773
  REMARK    GeneRIF: YY1 knockout in pro-B cells impairs lineage commitment,
            enabling unusual hematopoietic lineage plasticity.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5854)
  AUTHORS   Lam,J.C., Aboreden,N.G., Midla,S.C., Wang,S., Huang,A.,
            Keller,C.A., Giardine,B., Henderson,K.A., Hardison,R.C., Zhang,H.
            and Blobel,G.A.
  TITLE     YY1-controlled regulatory connectivity and transcription are
            influenced by the cell cycle
  JOURNAL   Nat Genet 56 (9), 1938-1952 (2024)
   PUBMED   39210046
  REMARK    GeneRIF: YY1-controlled regulatory connectivity and transcription
            are influenced by the cell cycle.
REFERENCE   3  (bases 1 to 5854)
  AUTHORS   Phongbunchoo,Y., Braikia,F.Z., Pessoa-Rodrigues,C., Ramamoorthy,S.,
            Ramachandran,H., Grosschedl,A., Ma,F., Cauchy,P., Akhtar,A.,
            Sen,R., Mittler,G. and Grosschedl,R.
  TITLE     YY1-mediated enhancer-promoter communication in the immunoglobulin
            mu locus is regulated by MSL/MOF recruitment
  JOURNAL   Cell Rep 43 (7), 114456 (2024)
   PUBMED   38990722
  REMARK    GeneRIF: YY1-mediated enhancer-promoter communication in the
            immunoglobulin mu locus is regulated by MSL/MOF recruitment.
REFERENCE   4  (bases 1 to 5854)
  AUTHORS   Pereira,A., Diwakar,J., Masserdotti,G., Beskardes,S., Simon,T.,
            So,Y., Martin-Loarte,L., Bergemann,F., Vasan,L., Schauer,T.,
            Danese,A., Bocchi,R., Colome-Tatche,M., Schuurmans,C., Philpott,A.,
            Straub,T., Bonev,B. and Gotz,M.
  TITLE     Direct neuronal reprogramming of mouse astrocytes is associated
            with multiscale epigenome remodeling and requires Yy1
  JOURNAL   Nat Neurosci 27 (7), 1260-1273 (2024)
   PUBMED   38956165
  REMARK    GeneRIF: Direct neuronal reprogramming of mouse astrocytes is
            associated with multiscale epigenome remodeling and requires Yy1.
REFERENCE   5  (bases 1 to 5854)
  AUTHORS   Bowness,J.S., Almeida,M., Nesterova,T.B. and Brockdorff,N.
  TITLE     YY1 binding is a gene-intrinsic barrier to Xist-mediated gene
            silencing
  JOURNAL   EMBO Rep 25 (5), 2258-2277 (2024)
   PUBMED   38654121
  REMARK    GeneRIF: YY1 binding is a gene-intrinsic barrier to Xist-mediated
            gene silencing.
REFERENCE   6  (bases 1 to 5854)
  AUTHORS   Nieuwenhuizen,A.G., Karlsson,S., Fridolf,T. and Ahren,B.
  TITLE     Mechanisms underlying the insulinostatic effect of peptide YY in
            mouse pancreatic islets
  JOURNAL   Diabetologia 37 (9), 871-878 (1994)
   PUBMED   7806016
REFERENCE   7  (bases 1 to 5854)
  AUTHORS   Groner,B., Altiok,S. and Meier,V.
  TITLE     Hormonal regulation of transcription factor activity in mammary
            epithelial cells
  JOURNAL   Mol Cell Endocrinol 100 (1-2), 109-114 (1994)
   PUBMED   8056143
  REMARK    Review article
REFERENCE   8  (bases 1 to 5854)
  AUTHORS   Zhu,W., Lossie,A.C., Camper,S.A. and Gumucio,D.L.
  TITLE     Chromosomal localization of the transcription factor YY1 in the
            mouse and human
  JOURNAL   Mamm Genome 5 (4), 234-236 (1994)
   PUBMED   7912122
REFERENCE   9  (bases 1 to 5854)
  AUTHORS   Flanagan,J.R., Becker,K.G., Ennist,D.L., Gleason,S.L.,
            Driggers,P.H., Levi,B.Z., Appella,E. and Ozato,K.
  TITLE     Cloning of a negative transcription factor that binds to the
            upstream conserved region of Moloney murine leukemia virus
  JOURNAL   Mol Cell Biol 12 (1), 38-44 (1992)
   PUBMED   1309593
REFERENCE   10 (bases 1 to 5854)
  AUTHORS   Hariharan,N., Kelley,D.E. and Perry,R.P.
  TITLE     Delta, a transcription factor that binds to downstream elements in
            several polymerase II promoters, is a functionally versatile zinc
            finger protein
  JOURNAL   Proc Natl Acad Sci U S A 88 (21), 9799-9803 (1991)
   PUBMED   1946404
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC152061.6, CX633032.1, M74590.1 and AA137984.1.
            
            On Feb 8, 2019 this sequence version replaced NM_009537.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC055899.1, M73963.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-22                AC152061.6         132294-132315
            23-88               CX633032.1         2-67
            89-771              M74590.1           15-697
            772-772             AC152061.6         133065-133065
            773-1238            M74590.1           699-1164
            1239-1239           AC152061.6         154530-154530
            1240-1730           M74590.1           1166-1656
            1731-1731           AC152061.6         155022-155022
            1732-1959           M74590.1           1657-1884
            1960-5580           AC152061.6         155251-158871
            5581-5854           AA137984.1         1-274
FEATURES             Location/Qualifiers
     source          1..5854
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 59.58 cM"
     gene            1..5854
                     /gene="Yy1"
                     /gene_synonym="NF-E1; YY-1"
                     /note="YY1 transcription factor"
                     /db_xref="GeneID:22632"
                     /db_xref="MGI:MGI:99150"
     exon            1..795
                     /gene="Yy1"
                     /gene_synonym="NF-E1; YY-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             117..1361
                     /gene="Yy1"
                     /gene_synonym="NF-E1; YY-1"
                     /note="yin and yang 1; UCR-motif DNA-binding protein;
                     UCRBP transcription factor; delta transcription factor;
                     Yin Yang 1"
                     /codon_start=1
                     /product="transcriptional repressor protein YY1"
                     /protein_id="NP_033563.2"
                     /db_xref="CCDS:CCDS26163.1"
                     /db_xref="GeneID:22632"
                     /db_xref="MGI:MGI:99150"
                     /translation="MASGDTLYIATDGSEMPAEIVELHEIEVETIPVETIETTVVGEE
                     EEEDDDDEDGGGGDHGGGGGGHGHAGHHHHHHHHHHHHPPMIALQPLVTDDPTQVHHH
                     QEVILVQTREEVVGGDDSDGLRAEDGFEDQILIPVPAPAGGDDDYIEQTLVTVAAAGK
                     SGGGASSGGGRVKKGGGKKSGKKSYLGGGAGAAGGGGADPGNKKWEQKQVQIKTLEGE
                     FSVTMWSSDEKKDIDHETVVEEQIIGENSPPDYSEYMTGKKLPPGGIPGIDLSDPKQL
                     AEFARMKPRKIKEDDAPRTIACPHKGCTKMFRDNSAMRKHLHTHGPRVHVCAECGKAF
                     VESSKLKRHQLVHTGEKPFQCTFEGCGKRFSLDFNLRTHVRIHTGDRPYVCPFDGCNK
                     KFAQSTNLKSHILTHAKAKNNQ"
     exon            796..958
                     /gene="Yy1"
                     /gene_synonym="NF-E1; YY-1"
                     /inference="alignment:Splign:2.1.0"
     exon            959..1019
                     /gene="Yy1"
                     /gene_synonym="NF-E1; YY-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1020..1178
                     /gene="Yy1"
                     /gene_synonym="NF-E1; YY-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1179..5854
                     /gene="Yy1"
                     /gene_synonym="NF-E1; YY-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2197..2202
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Yy1"
                     /gene_synonym="NF-E1; YY-1"
                     /note="hexamer: AATAAA"
     polyA_site      2220
                     /gene="Yy1"
                     /gene_synonym="NF-E1; YY-1"
                     /note="major polyA site"
     regulatory      2314..2319
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Yy1"
                     /gene_synonym="NF-E1; YY-1"
                     /note="hexamer: AATAAA"
     polyA_site      2338
                     /gene="Yy1"
                     /gene_synonym="NF-E1; YY-1"
     polyA_site      2922
                     /gene="Yy1"
                     /gene_synonym="NF-E1; YY-1"
     regulatory      5825..5830
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Yy1"
                     /gene_synonym="NF-E1; YY-1"
                     /note="hexamer: AATAAA"
     polyA_site      5854
                     /gene="Yy1"
                     /gene_synonym="NF-E1; YY-1"
ORIGIN      
        1 ctccctctgc cttccttccc cacggccggc cgcctcctcg cccgcccgcc ctccctcccg
       61 cagcccagga gccgaggccg cctgccgcgg cggccgtggc ggcggagccc tcagccatgg
      121 cctcgggcga caccctctac atcgccacgg acggctcgga gatgccggcc gagatcgtgg
      181 agctgcatga gatcgaggtg gagaccatcc cggtggagac catcgagacc acggtggtgg
      241 gcgaggagga ggaggaggac gacgacgacg aggacggcgg cggcggcgac cacggcggcg
      301 gcgggggcgg ccacgggcac gccggccacc accatcacca ccaccaccac caccaccacc
      361 acccgcccat gatcgcgctg cagccgctgg tgacggacga cccgacccaa gtgcaccacc
      421 accaggaggt gatcctggtg cagacgcgcg aggaggtggt cggcggggac gactcggacg
      481 ggctgcgcgc cgaggacggc ttcgaggacc agatcctcat cccggtgccc gcgccggccg
      541 gcggcgacga cgactacata gagcagacgc tggtcaccgt ggcggcggcc ggcaagagcg
      601 gcggcggggc ctcgtcgggc ggcggtcgcg tgaagaaggg cggcggcaag aagagcggca
      661 agaagagtta cctgggcggc ggggccggcg cggcgggcgg cggcggcgcc gacccgggga
      721 ataagaagtg ggagcagaag caggtgcaga tcaagaccct ggagggcgag ttctcggtca
      781 ccatgtggtc ctcggatgaa aaaaaagata ttgaccatga aacagtggtt gaagagcaga
      841 tcattggaga gaactcacct cctgattatt ctgaatatat gacaggcaag aaactccctc
      901 ctggagggat acctggcatt gacctctcag accctaagca actggcagaa tttgccagaa
      961 tgaagccaag aaaaattaaa gaagatgatg ctccaagaac aatagcttgc cctcataaag
     1021 gctgcacaaa gatgttcagg gataactctg ctatgagaaa gcatctgcac acccacggtc
     1081 ccagagtcca cgtctgtgca gagtgtggca aagcgttcgt tgagagctca aagctaaaac
     1141 gacaccagct ggttcatact ggagaaaagc cctttcagtg cacattcgaa ggctgcggga
     1201 agcgcttttc actggacttc aatttgcgca cacatgtgcg aatccatacc ggagacaggc
     1261 cctatgtgtg ccccttcgac ggttgtaata agaagtttgc tcagtcaact aacctgaaat
     1321 ctcacatctt aacacacgct aaagccaaaa acaaccagtg aaaagaagag agaagacctt
     1381 ctcgacccgg gaagcctctt caggagtgtg attgggaata aatatgcctc tcctttgtat
     1441 attatttcta ggaagaattt taaaaatgaa tcctacacac ttaagggaca tgttttgata
     1501 aagtagtaaa aatttaaaaa atactttaat aagatgacat tgctaagatg ctatatcttg
     1561 ctctgtaatc tcgtttcaaa aacaaggtgt ttttgtaaag tgtggtccca acaggaggac
     1621 aattcatgaa cttcgcatca aaagacaatt ctttatacaa cagtgctaaa aatgggactt
     1681 cttttcacat tcttataaat atgaagctca cctgttgctt acaatttttt taattttgta
     1741 ttttccaagt gtgcatattg tacacttttt ggggatatgc ttagtaatgc tgtgtgattt
     1801 tctggaggtt gataactttg cttgcggtag attttcttta aaagaatggg cagttacatg
     1861 catacttcaa aagtattttt cctgtacaaa aaaaaagtta tataggtttt gtttgctatc
     1921 ttaattttgg ttgtattctt tgatgttaac acattttgta taattgtatc gtatagctgt
     1981 attgaatcat gtagaatcaa atattagatg tgatttaata gtgttaatca atttaaaccc
     2041 attttagtca cttttttttc cccaaaaaat actgccagat gctgatgttc agtgtaattt
     2101 ctttgcctgt tcagttacag aaagtggtgc tcagttgtag aatgtattgt accttttaac
     2161 atctgatgtg tacatccgtg taacagaaag ggcaacaata aaatagcgat cctaaagaaa
     2221 gattacggca gaaagagctc tgtaagcaca gccttatttt cttctgttgt ccagaatact
     2281 tagaattctt gagcctccca gaaattggaa gcaaataaag caacttgagt ttcctttatt
     2341 ttgcactcag tgacagtgac tgtgatgagg tccgtgcatg gacactagca tttcctacgt
     2401 gccctgaatc ccgagagcag gcaggaggca ccccgagcta gggaactacc tcagagtaca
     2461 cagacgaccc atggctggca ggattgccct tgatatcccg gtgcgtgtgg gagtgagacg
     2521 tttgcatggg cctgatgctt tctgaaggga aggcactgac tggcagtggg tgcgccaagg
     2581 gaggatgggc ctgccttctt tctcatcatc actcaggctg ccttcaacgg cggtggctcc
     2641 atgggttgtc caacaggaaa tctcagtgca gtccttatta gatgctgtca gatgtagcaa
     2701 ttgagtgcca gtagctgttt gcttgtagac acacttaagt gcagagcggc aaggcgatga
     2761 gattattaga aagttgtact cagtgagtac ttgacttgtc atgtgtgacc tcttcaatgt
     2821 ataatttttg aacttttact tacctagggt caaataccag acttgttaac tattttataa
     2881 actgccgtga tacatcaaaa tctcatttat tcaaaatgca aacctaactg tctgtctttc
     2941 tgtgctgaat gcttgactcc aaggtaaaat gacaaacaag taccaggttc agtcacaaag
     3001 aggccgggag agcagccgct cgaacactta gcccaatttc ttatggcctc gccaggagga
     3061 ctggtgacct ggaaacagtg gccccgtggc tctggaattt tgaagtgcct tctgaaccat
     3121 acatggaagt tgtaacttgg gacatttgtt ttattcgtcc agaatctgat ccagtgagca
     3181 gttgatggga ctgagctcag cagcagaccc agctgtgtgc tggagggcag gctttgctgt
     3241 gcctggcagt caggaggggg taagactaaa ggggccccat cagagccaag tacccatgtg
     3301 tctcccccag gccttcgctc cctaccatca ggttaagctt tcccaaatgc cctgcagtcg
     3361 gaggccagag ccatgttgcc ctccctcgcc caatattgtg ctaccttcaa gcctggccct
     3421 ggcacctcaa gacccttgcc cacggctcca cagcagagca gaagtgtgct gtggaaaagc
     3481 ctgccagcca ccctgagagt caggcccacg tatagagcga ggcctcaccc atcctctgtg
     3541 ccttgattcc ttgggagatg cttggccatc tcttctgtcc ctttctgtct gagtggagca
     3601 gcggtcatca tcttcaccct ttctgtgttg gcattgtctt ctcagtgtgc agttaacttc
     3661 tgttgggagt tcaaagacag catggtgtgc gggtcctcac ttaggacagc agtgtaggga
     3721 cctgtcacgt cagtggccag aagaaagctg cttctcattg gctttggctt aaacccattt
     3781 tgcttgttag aatttatagt tttgttatag atgtaattta ctaatttgaa atgatgttct
     3841 aacagtgagt cccttgtcta gacacttaaa atctgatttg taagtaatac tgatagacat
     3901 attttcttac atctgagcag aaataaatgc atgtttttag caaatgtaat gtaaaaactc
     3961 cagaggataa gtttacaccc aataagatat tattttctat ttttaaattt gatatttgcc
     4021 cctctttggt agtgaggttg ggggcatagt atctatacag agctgtcgct ccagagtgac
     4081 atttatttcc cgcagagatg ctgagctcac gctgtgctgg gcctgtgcga tgtgtgtact
     4141 ttgccagagg agctgaggaa aaccaagact tttcccccat cccccatttg gtttccacac
     4201 acaggttctt ctgaatgctg cttggtttgc taagttggtg ggcatgtaag acctcttgaa
     4261 gagatggtgt gtgcaaagac ggcccatgtt tctaggcagt tttagcttgt gtcttcacat
     4321 agatgagagc caactgtcgg tgaagtgtgt ggtgctccag ggatatggtg ctggcatggc
     4381 ttggcaccca ccccaccttt ccactcggca ggactcacct gtggtacagc cctcaaatca
     4441 ctgactagag tgtatgtcta tggcccagga agtcttgccc cctaagttta cccactcccc
     4501 acaatagaca gggatttgac tactacttcc tttcctctgt gctccgaatt gacatgattt
     4561 agccagtctg cggtgcggtg ggtttttatt ctcttgactt ctagcctaca ggaagaacag
     4621 ggacttcagg atcagaacag agatgagcag agttgccagt agatagatgc catccgtgac
     4681 taactactca gaggcattgc cctagcagcc ctactggctg cagaagctag ctccttttct
     4741 agcacagact gtttgaatct ctggccataa gaggccgcat ctgactttgc agccctttgt
     4801 tgttaatgtg acctcttcta gagcccaggc ccaggacctg gcagatacac tctagctgag
     4861 gacagggaag ggactcagaa ctccaaagca gatgtgcttg cttgcaacat ttaactctga
     4921 tcagaacaaa agctactcca tgcttcaaat cacgtgccag cagcattgac caggtaggtt
     4981 aggtctccaa aacagcgagc tttccccaca gcttgttaac tcctctcagg gtaagctcag
     5041 gtgcctcaga tggcttaata caggcccttc aggtgagtaa gttgcactga gcaggagagg
     5101 gtagctgtgt ggctaacagg ctacccggca tctttgggca tagttggtca gtaccgtgcc
     5161 aggaaggtca ttccccagct gggacagcat gtagacttca taggaaaggg tgggtggcag
     5221 atgtgagcag cttaaggcat tggtcattga gtgtcggcag taggtcacag gcggggtgca
     5281 ccttccaagg tgtgcctagc cagcactctg gagaccatca agggggggct agtgagcagc
     5341 actgtgctcc gcatttcaga gtggcagatt tgatgactaa agacactcag gcaccccgag
     5401 gaacagtact ggggatgtgc agctgtgctg gttggtccgc ctccctgccc ggagccacgt
     5461 ggtgtctaca tccatagcat gagggagcaa agaaggtatc gttaccggag tcacctcttc
     5521 tttataatgc cagcaactgt taaaaccctt gatgtctaca aatggcaaga aaagttgtgt
     5581 tttcattttc tgggaactcc cataggccct ggctcaagga ctctgcattg tgtgtcatgt
     5641 acatctctta agtgttcttt gctgttctgg aattgtcctt ggtttttcct tagctcatag
     5701 atcatagaca cagaaatatt atagtattta aagcatccgc atcaagcatc agatggcttc
     5761 gcatccagaa aaacataact cagtttgaag caccaagcat gtgtaacatg gctctataca
     5821 atacaataaa aagcgctaat gttaagctct ttaa
//
