LOCUS       NM_011740               3801 bp    mRNA    linear   ROD 12-NOV-2024
DEFINITION  Mus musculus tyrosine 3-monooxygenase/tryptophan 5-monooxygenase
            activation protein, zeta polypeptide (Ywhaz), transcript variant 1,
            mRNA.
ACCESSION   NM_011740
VERSION     NM_011740.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3801)
  AUTHORS   Han,Z., Wang,R., Chi,P., Zhang,Z., Min,L., Jiao,H., Ou,G., Zhou,D.,
            Qin,D., Xu,C., Gao,Z., Qi,Q., Li,J., Lu,Y., Wang,X., Chen,J.,
            Yu,X., Hu,H., Li,L. and Deng,D.
  TITLE     The subcortical maternal complex modulates the cell cycle during
            early mammalian embryogenesis via 14-3-3
  JOURNAL   Nat Commun 15 (1), 8887 (2024)
   PUBMED   39406751
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3801)
  AUTHORS   Ayyasamy,R., Fan,S., Czernik,P., Lecka-Czernik,B., Chattopadhyay,S.
            and Chakravarti,R.
  TITLE     14-3-3zeta suppresses RANKL signaling by destabilizing TRAF6
  JOURNAL   J Biol Chem 300 (7), 107487 (2024)
   PUBMED   38908751
  REMARK    GeneRIF: 14-3-3zeta suppresses RANKL signaling by destabilizing
            TRAF6.
REFERENCE   3  (bases 1 to 3801)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 3801)
  AUTHORS   Yip,K.H., Chao,J., Coolen,C., Pant,H., Kral,A., Smith,W.,
            Schwarz,Q., Grimbaldeston,M.A., Pitson,S., Lopez,A.F., Woodcock,J.
            and Tumes,D.J.
  TITLE     IgE receptor of mast cells signals mediator release and
            inflammation via adaptor protein 14-3-3zeta
  JOURNAL   J Allergy Clin Immunol 152 (3), 725-735 (2023)
   PUBMED   37127225
  REMARK    GeneRIF: IgE receptor of mast cells signals mediator release and
            inflammation via adaptor protein 14-3-3zeta.
REFERENCE   5  (bases 1 to 3801)
  AUTHORS   Cao,F., Jiang,Y., Chang,L., Du,H., Chang,D., Pan,C., Huang,X.,
            Yu,D., Zhang,M., Fan,Y., Bian,X. and Li,K.
  TITLE     High-throughput functional screen identifies YWHAZ as a key
            regulator of pancreatic cancer metastasis
  JOURNAL   Cell Death Dis 14 (7), 431 (2023)
   PUBMED   37452033
  REMARK    GeneRIF: High-throughput functional screen identifies YWHAZ as a
            key regulator of pancreatic cancer metastasis.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3801)
  AUTHORS   Honda,R., Ohba,Y. and Yasuda,H.
  TITLE     14-3-3 zeta protein binds to the carboxyl half of mouse wee1 kinase
  JOURNAL   Biochem Biophys Res Commun 230 (2), 262-265 (1997)
   PUBMED   9016762
REFERENCE   7  (bases 1 to 3801)
  AUTHORS   Chambers,D.M. and Abbott,C.M.
  TITLE     Isolation and mapping of novel mouse brain cDNA clones containing
            trinucleotide repeats, and demonstration of novel alleles in
            recombinant inbred strains
  JOURNAL   Genome Res 6 (8), 715-723 (1996)
   PUBMED   8858346
REFERENCE   8  (bases 1 to 3801)
  AUTHORS   Papin,C., Denouel,A., Calothy,G. and Eychene,A.
  TITLE     Identification of signalling proteins interacting with B-Raf in the
            yeast two-hybrid system
  JOURNAL   Oncogene 12 (10), 2213-2221 (1996)
   PUBMED   8668348
REFERENCE   9  (bases 1 to 3801)
  AUTHORS   Kajiwara,K., Nagawawa,H., Shimizu-Nishikawa,S., Ookuri,T.,
            Kimura,M. and Sugaya,E.
  TITLE     Molecular characterization of seizure-related genes isolated by
            differential screening
  JOURNAL   Biochem Biophys Res Commun 219 (3), 795-799 (1996)
   PUBMED   8645260
REFERENCE   10 (bases 1 to 3801)
  AUTHORS   Suen,K.L., Bustelo,X.R. and Barbacid,M.
  TITLE     Lack of evidence for the activation of the Ras/Raf mitogenic
            pathway by 14-3-3 proteins in mammalian cells
  JOURNAL   Oncogene 11 (5), 825-831 (1995)
   PUBMED   7675443
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB652039.1, AK150381.1, AC138604.5 and BQ833188.1.
            
            On Dec 12, 2009 this sequence version replaced NM_011740.2.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1). Variants 1-3 and 5 encode the same isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC050891.1, SRR10662772.1581385.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-469               BB652039.1         1-469
            470-1280            AK150381.1         1-811
            1281-3741           AC138604.5         117591-120051       c
            3742-3801           BQ833188.1         1-60                c
FEATURES             Location/Qualifiers
     source          1..3801
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 14.56 cM"
     gene            1..3801
                     /gene="Ywhaz"
                     /gene_synonym="1110013I11Rik; 14-3-3zeta"
                     /note="tyrosine 3-monooxygenase/tryptophan 5-monooxygenase
                     activation protein, zeta polypeptide"
                     /db_xref="GeneID:22631"
                     /db_xref="MGI:MGI:109484"
     exon            1..394
                     /gene="Ywhaz"
                     /gene_synonym="1110013I11Rik; 14-3-3zeta"
                     /inference="alignment:Splign:2.1.0"
     exon            395..591
                     /gene="Ywhaz"
                     /gene_synonym="1110013I11Rik; 14-3-3zeta"
                     /inference="alignment:Splign:2.1.0"
     exon            592..896
                     /gene="Ywhaz"
                     /gene_synonym="1110013I11Rik; 14-3-3zeta"
                     /inference="alignment:Splign:2.1.0"
     CDS             603..1340
                     /gene="Ywhaz"
                     /gene_synonym="1110013I11Rik; 14-3-3zeta"
                     /note="isoform 1 is encoded by transcript variant 1;
                     14-3-3 protein zeta/delta; SEZ-2; KCIP-1; protein kinase C
                     inhibitor protein 1; 14-3-3 zeta"
                     /codon_start=1
                     /product="14-3-3 protein zeta/delta isoform 1"
                     /protein_id="NP_035870.1"
                     /db_xref="CCDS:CCDS27432.1"
                     /db_xref="GeneID:22631"
                     /db_xref="MGI:MGI:109484"
                     /translation="MDKNELVQKAKLAEQAERYDDMAACMKSVTEQGAELSNEERNLL
                     SVAYKNVVGARRSSWRVVSSIEQKTEGAEKKQQMAREYREKIETELRDICNDVLSLLE
                     KFLIPNASQPESKVFYLKMKGDYYRYLAEVAAGDDKKGIVDQSQQAYQEAFEISKKEM
                     QPTHPIRLGLALNFSVFYYEILNSPEKACSLAKTAFDEAIAELDTLSEESYKDSTLIM
                     QLLRDNLTLWTSDTQGDEAEAGEGGEN"
     exon            897..1020
                     /gene="Ywhaz"
                     /gene_synonym="1110013I11Rik; 14-3-3zeta"
                     /inference="alignment:Splign:2.1.0"
     exon            1021..1184
                     /gene="Ywhaz"
                     /gene_synonym="1110013I11Rik; 14-3-3zeta"
                     /inference="alignment:Splign:2.1.0"
     exon            1185..1280
                     /gene="Ywhaz"
                     /gene_synonym="1110013I11Rik; 14-3-3zeta"
                     /inference="alignment:Splign:2.1.0"
     exon            1281..3797
                     /gene="Ywhaz"
                     /gene_synonym="1110013I11Rik; 14-3-3zeta"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3269..3274
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ywhaz"
                     /gene_synonym="1110013I11Rik; 14-3-3zeta"
                     /note="hexamer: AATAAA"
     polyA_site      3288
                     /gene="Ywhaz"
                     /gene_synonym="1110013I11Rik; 14-3-3zeta"
                     /note="major polyA site"
     regulatory      3758..3763
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ywhaz"
                     /gene_synonym="1110013I11Rik; 14-3-3zeta"
                     /note="hexamer: AATAAA"
     polyA_site      3797
                     /gene="Ywhaz"
                     /gene_synonym="1110013I11Rik; 14-3-3zeta"
ORIGIN      
        1 ggaggagcct cgctcctcct ccagctagag ccctaggaac ggccacgctc cctaaccttg
       61 cttccaggac ctaaaagggt cggtcactct cttacaatgc gctaattagg aacaatgtgt
      121 ctcccaatga aagctctaca gagggtaaag tgcagcccac gacaacagtt cggtgtgttc
      181 tagcctgttt ccccgcctcg ccccacgtca ggcttctacg atcacgtcca acccgctagc
      241 ccaacccttt ccccgctcct cccagcgacc acccattgtc cccgcggctg tcacggtgtg
      301 gacgccgagc tcgcgactgg aaaggcaggg cgtcattcag cctcgcgctt ttcccagcct
      361 taaaaggtct aaggccgctt cctgcagcca gaagcgtttg acgtcatcgt gcgtgtggtg
      421 cccctgctgc cggggctagt gattggagga aaccccgtgt ctgcggagcg gctgtagcct
      481 gtgagcagcc agatcaggga cagagtctca gcctcgccgc caccgctgct gccgccgccg
      541 cccagagacc gccgagccgc gtccgtgtgc cgccacccac tccggacaca gaatatccag
      601 ttatggataa aaatgagctg gtgcagaagg ccaagctggc cgagcaggca gagcgatatg
      661 atgacatggc agcctgcatg aagtctgtca ctgagcaggg agctgagctg tcgaatgagg
      721 agagaaacct tctctctgtt gcttataaaa acgttgtagg agcccgtagg tcatcgtgga
      781 gggtcgtctc aagtattgag cagaagacgg aaggtgctga gaaaaagcag cagatggctc
      841 gagaatacag agagaagatc gagacggagc tgcgtgacat ctgcaacgat gtactgtctc
      901 ttttggaaaa gttcttgatc cccaatgctt cgcaaccaga aagcaaagtc ttctatttga
      961 aaatgaaggg tgactactac cgttacttgg ccgaggttgc tgctggtgat gacaagaaag
     1021 gaattgtgga ccagtcacag caagcatacc aagaagcatt tgaaatcagc aaaaaggaga
     1081 tgcagccgac acaccccatc agactgggtc tggccctcaa cttctctgtg ttctattacg
     1141 agatcctgaa ctccccagag aaagcctgct ctcttgcaaa aacagctttc gatgaagcca
     1201 ttgctgaact tgatacatta agtgaagagt cgtacaaaga cagcacgcta ataatgcagt
     1261 tactgagaga caacttaaca ttgtggacat cggataccca aggagatgaa gcagaagcag
     1321 gagaaggagg ggaaaattaa ccggccttcc aacctttgtc tgcctcattc taaaatttac
     1381 acagtagacc atttgtcatc catgctgtcc cacagatagt ttttttgttt acgatttatg
     1441 acaggtttat gttacttcta tttgaatttc tatatttccc atgtggtttt tatgttttaa
     1501 tattagggga gtagagccag ttaactttag ggagttactc attttcatct tgaggtggcc
     1561 aatatgggat gtggaatttt tacatgagtt acacatgttt ggcatagtac ttttggtaca
     1621 ttgtggcttc agaagggcca gtgttaaaac tgcttccatg tctaagcaaa gaaaactgcc
     1681 tacatattgg tgtgtgctgg cggggaataa tcaggataat gggttccagt catgagtgta
     1741 gtctttgtgg gtactgtaag gcctggagca cttgtgaggc tgtgacacaa acaccctgtg
     1801 gatgcacgct aggatcgtgt gtgtctgcgt gcacactctt gaccacagct ccagaagttg
     1861 tctctagaca aagtcgtgac ccaatttact ctggtaaggg cagaaacggt tcacattcca
     1921 ttatttgtaa agttacctgc tgtttgcttt cattattttt gctacacatt ttatttgtat
     1981 ttaaatgttt taggcaatct aagaacaaat gtaaaagtaa agatgcagta aaaacgagtt
     2041 gcttggtgtg cccggctcca tacgtatcaa gcacagcggt aaacaaaatc ccatgtattt
     2101 aactttttct ttcttttttt ttttttttaa agttttttgt tttgttttgt ttttgctttt
     2161 gtgatttttt ttttttcttt ttgatacttg cctaacatgc atgtgctgta aaaatagtta
     2221 acagggaaat aacttgagat gacggctagc tttgttttaa tgtcttaaga aattttcatg
     2281 aacaatccaa gcataattgt taagaacaca tgtattaaag ttcatgtaag tggaataaaa
     2341 gttttatgaa tggacttttc aactactttt ctctacagct tttcatgtaa attagtcttt
     2401 tggttttgag acttctccaa aggaaattgt ctccttattc cctcttggca gctaatgggc
     2461 ttttaccaat tttgaatgca gagtttatca taaaaaaaaa aaaaccgcta atgtagcttc
     2521 catcctcagc cacctcccac attttcccct tactcctcaa caattgaagt ggacttttat
     2581 ggggtggggg gtgattggca aaaggtaatg tgttccattt ataattttgg tctatggagt
     2641 tttctaactt aggaagccac aatgttcttg gcccatgtga ctgacactgg gcagcattaa
     2701 ctgttaagtt ctgtgcttcc aagtcgctgt tggttttaag aatttcctga tgctcttaca
     2761 gtctgcctgg gattctattc ctctatttcc atgttgggca caggctcact tcccttttac
     2821 tgtcttgtca ccaaccattc caacttggtg gccatgtatt tgggaaaagg gccgcatgat
     2881 ctttctggct ccactcagtg tctaagatac ccgcttcccc tgcttgcctc ccacagcctc
     2941 ccctcatcct ctctacagcc cagctcgcct cagttgagct tgtgtttatc tccctggaag
     3001 tcctgcccta aatggtctgt caccgtctcc ctttaaaatc cttcctcctc ctcttcctcc
     3061 tcctcctcct cctcacataa tgatggggct aagtcacacc caaagctcac accctaccga
     3121 gtatttcctc agtactttac agaaaacacc aaacaaaaat gccattttac aagaggtgta
     3181 tttttttttc ttttagaatg taagctcgtc tagagcaggg acaatgtttt ctgtatgttc
     3241 tattgtgcct agtacactgt aaatgctcaa taaatattga tgatgggagg catgagtctc
     3301 agtggtgagg gaggggagag aaatcccaag catgttttct ggcttgcttc atgatgatct
     3361 gaatctgaaa tcccactcct tttggacaga ttatcacaac tactgcattc aggtggggtg
     3421 gggtggggtg gggtgggggt gttttctgga gaaacgacat cacacacgtg gtgccatgac
     3481 ccatcttcct ttacaactca attccttgat tttgcctcag ctcccagact gaggaagatt
     3541 aagcaatgga cagcaggatg tcatctcatt tgagtaaatt acaaatgata cctggaacct
     3601 gtcacatttg cctaattggc ttattcacat gcattagaca ttgctaaact agtttgattt
     3661 tagttattga tgtggttttt tttttttttt atgaatagtg cccagtagat ggagaaagat
     3721 ttgcaacctc aaattttcca ccccctggaa tttgaataat aaatttgttt ttaacttact
     3781 tccctaattg tcccaaaaaa a
//
