LOCUS       NM_011739               2110 bp    mRNA    linear   ROD 12-NOV-2024
DEFINITION  Mus musculus tyrosine 3-monooxygenase/tryptophan 5-monooxygenase
            activation protein theta (Ywhaq), mRNA.
ACCESSION   NM_011739
VERSION     NM_011739.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2110)
  AUTHORS   Han,Z., Wang,R., Chi,P., Zhang,Z., Min,L., Jiao,H., Ou,G., Zhou,D.,
            Qin,D., Xu,C., Gao,Z., Qi,Q., Li,J., Lu,Y., Wang,X., Chen,J.,
            Yu,X., Hu,H., Li,L. and Deng,D.
  TITLE     The subcortical maternal complex modulates the cell cycle during
            early mammalian embryogenesis via 14-3-3
  JOURNAL   Nat Commun 15 (1), 8887 (2024)
   PUBMED   39406751
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2110)
  AUTHORS   Ke,Y.D., van Hummel,A., Au,C., Chan,G., Lee,W.S., van der Hoven,J.,
            Przybyla,M., Deng,Y., Sabale,M., Morey,N., Bertz,J., Feiten,A.,
            Ippati,S., Stevens,C.H., Yang,S., Gladbach,A., Haass,N.K.,
            Kril,J.J., Blair,I.P., Delerue,F. and Ittner,L.M.
  TITLE     Targeting 14-3-3theta;-mediated TDP-43 pathology in amyotrophic
            lateral sclerosis and frontotemporal dementia mice
  JOURNAL   Neuron 112 (8), 1249-1264 (2024)
   PUBMED   38366598
  REMARK    GeneRIF: Targeting 14-3-3theta;-mediated TDP-43 pathology in
            amyotrophic lateral sclerosis and frontotemporal dementia mice.
REFERENCE   3  (bases 1 to 2110)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 2110)
  AUTHORS   Underwood,R., Gannon,M., Pathak,A., Kapa,N., Chandra,S., Klop,A.
            and Yacoubian,T.A.
  TITLE     14-3-3 mitigates alpha-synuclein aggregation and toxicity in the in
            vivo preformed fibril model
  JOURNAL   Acta Neuropathol Commun 9 (1), 13 (2021)
   PUBMED   33413679
  REMARK    GeneRIF: 14-3-3 mitigates alpha-synuclein aggregation and toxicity
            in the in vivo preformed fibril model.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2110)
  AUTHORS   Lee,J.H., Han,J.H., Kim,H., Park,S.M., Joe,E.H. and Jou,I.
  TITLE     Parkinson's disease-associated LRRK2-G2019S mutant acts through
            regulation of SERCA activity to control ER stress in astrocytes
  JOURNAL   Acta Neuropathol Commun 7 (1), 68 (2019)
   PUBMED   31046837
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2110)
  AUTHORS   Hatada,I., Nabetani,A., Morisaki,H., Xin,Z., Ohishi,S., Tonoki,H.,
            Niikawa,N., Inoue,M., Komoto,Y., Okada,A., Steichen,E., Ohashi,H.,
            Fukushima,Y., Nakayama,M. and Mukai,T.
  TITLE     New p57KIP2 mutations in Beckwith-Wiedemann syndrome
  JOURNAL   Hum Genet 100 (5-6), 681-683 (1997)
   PUBMED   9341892
REFERENCE   7  (bases 1 to 2110)
  AUTHORS   Perego,L. and Berruti,G.
  TITLE     Molecular cloning and tissue-specific expression of the mouse
            homologue of the rat brain 14-3-3 theta protein: characterization
            of its cellular and developmental pattern of expression in the male
            germ line
  JOURNAL   Mol Reprod Dev 47 (4), 370-379 (1997)
   PUBMED   9211421
REFERENCE   8  (bases 1 to 2110)
  AUTHORS   Sladeczek,F., Camonis,J.H., Burnol,A.F. and Le Bouffant,F.
  TITLE     The Cdk-like protein PCTAIRE-1 from mouse brain associates with p11
            and 14-3-3 proteins
  JOURNAL   Mol Gen Genet 254 (5), 571-577 (1997)
   PUBMED   9197417
REFERENCE   9  (bases 1 to 2110)
  AUTHORS   Zha,J., Harada,H., Yang,E., Jockel,J. and Korsmeyer,S.J.
  TITLE     Serine phosphorylation of death agonist BAD in response to survival
            factor results in binding to 14-3-3 not BCL-X(L)
  JOURNAL   Cell 87 (4), 619-628 (1996)
   PUBMED   8929531
REFERENCE   10 (bases 1 to 2110)
  AUTHORS   Papin,C., Denouel,A., Calothy,G. and Eychene,A.
  TITLE     Identification of signalling proteins interacting with B-Raf in the
            yeast two-hybrid system
  JOURNAL   Oncogene 12 (10), 2213-2221 (1996)
   PUBMED   8668348
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC140457.3.
            
            On Mar 21, 2007 this sequence version replaced NM_011739.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC090838.1, SRR9219382.185711.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN02415127, SAMN02415130
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-639               AC140457.3         128079-128717
            640-763             AC140457.3         147151-147274
            764-927             AC140457.3         149070-149233
            928-1023            AC140457.3         150455-150550
            1024-2110           AC140457.3         154100-155186
FEATURES             Location/Qualifiers
     source          1..2110
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 8.31 cM"
     gene            1..2110
                     /gene="Ywhaq"
                     /gene_synonym="2700028P07Rik"
                     /note="tyrosine 3-monooxygenase/tryptophan 5-monooxygenase
                     activation protein theta"
                     /db_xref="GeneID:22630"
                     /db_xref="MGI:MGI:891963"
     exon            1..639
                     /gene="Ywhaq"
                     /gene_synonym="2700028P07Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             346..1083
                     /gene="Ywhaq"
                     /gene_synonym="2700028P07Rik"
                     /note="14-3-3 protein tau; 14-3-3 theta; 14-3-3 tau;
                     14-3-3 protein T-cell; tyrosine 3-monooxygenase/tryptophan
                     5-monooxygenase activation protein, theta polypeptide"
                     /codon_start=1
                     /product="14-3-3 protein theta"
                     /protein_id="NP_035869.1"
                     /db_xref="CCDS:CCDS25837.1"
                     /db_xref="GeneID:22630"
                     /db_xref="MGI:MGI:891963"
                     /translation="MEKTELIQKAKLAEQAERYDDMATCMKAVTEQGAELSNEERNLL
                     SVAYKNVVGGRRSAWRVISSIEQKTDTSDKKLQLIKDYREKVESELRSICTTVLELLD
                     KYLIANATNPESKVFYLKMKGDYFRYLAEVACGDDRKQTIENSQGAYQEAFDISKKEM
                     QPTHPIRLGLALNFSVFYYEILNNPELACTLAKTAFDEAIAELDTLNEDSYKDSTLIM
                     QLLRDNLTLWTSDSAGEECDAAEGAEN"
     exon            640..763
                     /gene="Ywhaq"
                     /gene_synonym="2700028P07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            764..927
                     /gene="Ywhaq"
                     /gene_synonym="2700028P07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            928..1023
                     /gene="Ywhaq"
                     /gene_synonym="2700028P07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1024..2110
                     /gene="Ywhaq"
                     /gene_synonym="2700028P07Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2086..2091
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ywhaq"
                     /gene_synonym="2700028P07Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2110
                     /gene="Ywhaq"
                     /gene_synonym="2700028P07Rik"
                     /note="major polyA site"
ORIGIN      
        1 cggagcacgg tcctcatatc tgctaggcta ccgcgcgcct gaggttcggg ctgggacggg
       61 aaggtgcggc accaacggcc gcttccatct tgggccgggt ggggcccgcg ctccggcctt
      121 ggggaggcgc ggcgggcggg ccggagggcg cgggcggaag gcggcggccc cgtgagaggc
      181 cggaggacgc gccgcctcgt gcgctgagac aaagcgggcg tccggctgca ttgtctgacg
      241 cgctctctcc tcgctccttt ttgtcctcgc cggcgccgcc ccgccccgcc cctcgcggct
      301 ctcaggagga ctccggatcc ggctcggcgc tcgccctcgc tcgccatgga gaagaccgag
      361 ctgatccaga aggccaagct ggccgagcag gccgagcgct acgacgacat ggccacctgc
      421 atgaaagccg tgacggagca gggcgccgag ctgtccaacg aggagcgcaa cctgctgtcg
      481 gtggcctaca aaaacgtggt agggggccgc aggtccgcct ggagggtcat ctcgagcatt
      541 gagcagaaga ccgacacctc tgacaagaag ttgcagctga tcaaggacta tcgggagaaa
      601 gtggagtcgg agctgaggtc catctgcacc acggtcctgg aattgttgga taagtattta
      661 atagccaatg caactaatcc agagagtaag gtcttctatc tgaaaatgaa gggagattat
      721 ttccggtatc ttgctgaagt agcttgtggc gatgatcgaa aacaaacaat agaaaattcc
      781 caaggagcct accaagaggc gtttgatata agcaagaagg agatgcagcc tacgcatcca
      841 atccgcctgg ggctggctct taacttttct gtattttact atgagatcct taataatcca
      901 gagcttgcct gcacactggc taaaacggct tttgatgagg ccatcgcaga gcttgataca
      961 ctgaacgaag actcctacaa agacagcacc ctcatcatgc agttgcttag agacaactta
     1021 acattatgga catcagacag tgcaggagaa gaatgtgatg cagcagaggg ggccgaaaac
     1081 taaaggcatc cagggcacca acctccttcc cctcaagaaa acctttttac atctccattc
     1141 cttattccac ttggatttcc tctagcaagg aagcccattc gtgtgtatgg gatcaactgt
     1201 ttatatagtc ttttcacact gcagctttgg gaaaactcca tcccttggtt tgtgttatct
     1261 ccgccttcct ggtgtgcagt tactgctgta gaaaagtatc aatagcttca tttcatagaa
     1321 acacgagtaa cttccagaca cttgtgtaga ggagtgacag cacacttggt atttaagtaa
     1381 tctgaaccag ttctacaagt gactgtgttt tgtattactg cgaagatatg gaaaatgtag
     1441 tgcattacaa tttaaagtaa ttgtaataat aacgtcttga tttctacatt ccttttctga
     1501 accttcttgg aggtttcctt tcagaagcaa cttttccatg ctcttactac aaattccttt
     1561 ttagtaggaa tccagaagtg ttagattgaa tgggaaagcg cttaatgcat ccgggcttgg
     1621 ggtcacagat cgaaatgtct cctgtgtcac atattctgga ggttacatct ttctgtgaca
     1681 acagggagtt tccttatgca ttcttcattt gctgctgttt aagttgacaa cttccttccc
     1741 aataaaaatt cacttacacc tcctgccttc gtagctctgg tattcacttt accttgtgat
     1801 agaagtagca tgttgctgcc agaatacaag cattgcttcg ggcaaattaa aatgcatgtc
     1861 ctttcttaat acactaggaa ggagaaataa agtccacaag tccaagcctg cacttcaata
     1921 cttttccatg cagagttgtg cacatgggag agggtatccg gtttgtccag tgattgttct
     1981 ttagagagtt ggaccactat attgtgtgtt tgctaatcat tgactgtagt cccaaaaaag
     2041 cctcgtggaa atgttatgcc ctatgtaaca gcagagtaac ataaaaataa aactacattt
     2101 tataaaacca
//
