LOCUS       NM_011738               1806 bp    mRNA    linear   ROD 12-NOV-2024
DEFINITION  Mus musculus tyrosine 3-monooxygenase/tryptophan 5-monooxygenase
            activation protein, eta polypeptide (Ywhah), mRNA.
ACCESSION   NM_011738
VERSION     NM_011738.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1806)
  AUTHORS   Han,Z., Wang,R., Chi,P., Zhang,Z., Min,L., Jiao,H., Ou,G., Zhou,D.,
            Qin,D., Xu,C., Gao,Z., Qi,Q., Li,J., Lu,Y., Wang,X., Chen,J.,
            Yu,X., Hu,H., Li,L. and Deng,D.
  TITLE     The subcortical maternal complex modulates the cell cycle during
            early mammalian embryogenesis via 14-3-3
  JOURNAL   Nat Commun 15 (1), 8887 (2024)
   PUBMED   39406751
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1806)
  AUTHORS   Cui,Y., Zhang,Y., Dai,S., Wan,S., Guan,H., Wang,D., Jin,B., Xiao,W.
            and Liu,F.
  TITLE     The mechanism of 14-3-3eta in thyroxine induced mitophagy in
            cardiomyocytes
  JOURNAL   Mol Cell Endocrinol 590, 112271 (2024)
   PUBMED   38759835
  REMARK    GeneRIF: The mechanism of 14-3-3eta in thyroxine induced mitophagy
            in cardiomyocytes.
REFERENCE   3  (bases 1 to 1806)
  AUTHORS   Hu,T., Yu,W.P., Wang,X.Q., Wang,Z.Y., Xu,Z.Q., Hu,F.J., Liu,J.C.,
            Yu,F. and Wang,L.J.
  TITLE     Activation of PPAR-alpha attenuates myocardial ischemia/reperfusion
            injury by inhibiting ferroptosis and mitochondrial injury via
            upregulating 14-3-3eta
  JOURNAL   Sci Rep 14 (1), 15246 (2024)
   PUBMED   38956068
  REMARK    GeneRIF: Activation of PPAR-alpha attenuates myocardial
            ischemia/reperfusion injury by inhibiting ferroptosis and
            mitochondrial injury via upregulating 14-3-3eta.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1806)
  AUTHORS   Eisa,A., Dey,S., Ignatious,A., Nofal,W., Hess,R.A., Kurokawa,M.,
            Kline,D. and Vijayaraghavan,S.
  TITLE     The protein YWHAE (14-3-3 epsilon) in spermatozoa is essential for
            male fertility
  JOURNAL   Andrology 9 (1), 312-328 (2021)
   PUBMED   32657535
REFERENCE   5  (bases 1 to 1806)
  AUTHORS   Kwon,H.J., Kim,D.S., Kim,W., Jung,H.Y., Yu,Y.H., Ju,Y.I.,
            Park,D.K., Hwang,I.K., Kim,D.W. and Yoo,D.Y.
  TITLE     Tat-Cannabinoid Receptor Interacting Protein Reduces
            Ischemia-Induced Neuronal Damage and Its Possible Relationship with
            14-3-3eta
  JOURNAL   Cells 9 (8), 1827 (2020)
   PUBMED   32756411
  REMARK    GeneRIF: Tat-Cannabinoid Receptor Interacting Protein Reduces
            Ischemia-Induced Neuronal Damage and Its Possible Relationship with
            14-3-3eta.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1806)
  AUTHORS   Fanger,G.R., Widmann,C., Porter,A.C., Sather,S., Johnson,G.L. and
            Vaillancourt,R.R.
  TITLE     14-3-3 proteins interact with specific MEK kinases
  JOURNAL   J Biol Chem 273 (6), 3476-3483 (1998)
   PUBMED   9452471
REFERENCE   7  (bases 1 to 1806)
  AUTHORS   De Valck,D., Heyninck,K., Van Criekinge,W., Vandenabeele,P.,
            Fiers,W. and Beyaert,R.
  TITLE     A20 inhibits NF-kappaB activation independently of binding to
            14-3-3 proteins
  JOURNAL   Biochem Biophys Res Commun 238 (2), 590-594 (1997)
   PUBMED   9299557
REFERENCE   8  (bases 1 to 1806)
  AUTHORS   Sladeczek,F., Camonis,J.H., Burnol,A.F. and Le Bouffant,F.
  TITLE     The Cdk-like protein PCTAIRE-1 from mouse brain associates with p11
            and 14-3-3 proteins
  JOURNAL   Mol Gen Genet 254 (5), 571-577 (1997)
   PUBMED   9197417
REFERENCE   9  (bases 1 to 1806)
  AUTHORS   Papin,C., Denouel,A., Calothy,G. and Eychene,A.
  TITLE     Identification of signalling proteins interacting with B-Raf in the
            yeast two-hybrid system
  JOURNAL   Oncogene 12 (10), 2213-2221 (1996)
   PUBMED   8668348
REFERENCE   10 (bases 1 to 1806)
  AUTHORS   McConnell,J.E., Armstrong,J.F., Hodges,P.E. and Bard,J.B.
  TITLE     The mouse 14-3-3 epsilon isoform, a kinase regulator whose
            expression pattern is modulated in mesenchyme and neuronal
            differentiation
  JOURNAL   Dev Biol 169 (1), 218-228 (1995)
   PUBMED   7750640
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB183421.1, AK149224.1 and CD770463.1.
            
            On Dec 18, 2007 this sequence version replaced NM_011738.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC061497.1, AK149224.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-31                CB183421.1         1-31
            32-1758             AK149224.1         2-1728
            1759-1806           CD770463.1         382-429
FEATURES             Location/Qualifiers
     source          1..1806
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 17.42 cM"
     gene            1..1806
                     /gene="Ywhah"
                     /note="tyrosine 3-monooxygenase/tryptophan 5-monooxygenase
                     activation protein, eta polypeptide"
                     /db_xref="GeneID:22629"
                     /db_xref="MGI:MGI:109194"
     exon            1..339
                     /gene="Ywhah"
                     /inference="alignment:Splign:2.1.0"
     CDS             253..993
                     /gene="Ywhah"
                     /note="14-3-3 eta"
                     /codon_start=1
                     /product="14-3-3 protein eta"
                     /protein_id="NP_035868.1"
                     /db_xref="CCDS:CCDS19198.1"
                     /db_xref="GeneID:22629"
                     /db_xref="MGI:MGI:109194"
                     /translation="MGDREQLLQRARLAEQAERYDDMASAMKAVTELNEPLSNEDRNL
                     LSVAYKNVVGARRSSWRVISSIEQKTMADGNEKKLEKVKAYREKIEKELETVCNDVLA
                     LLDKFLIKNCNDFQYESKVFYLKMKGDYYRYLAEVASGEKKNSVVEASEAAYKEAFEI
                     SKEHMQPTHPIRLGLALNFSVFYYEIQNAPEQACLLAKQAFDDAIAELDTLNEDSYKD
                     STLIMQLLRDNLTLWTSDQQDEEAGEGN"
     exon            340..1764
                     /gene="Ywhah"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1740..1745
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ywhah"
                     /note="hexamer: AATAAA"
     polyA_site      1764
                     /gene="Ywhah"
                     /note="major polyA site"
ORIGIN      
        1 cccgcccgcc cgcccgcccg cggcgccccc tatcctctct cggcggctcc gcggcgctcg
       61 ccacagcgcg tgcagccagc cagcgagaag gcgcgagcgg cggcgcagcc tgcagcctcc
      121 cgccagccgg cgagccagtg cgcgtgcgcg gtagcggcct cggcggcgac cgggaagcgg
      181 acgggcgggc gagcgagcga gcgagtgagc aggcggtgtg ggcgtgcgag gcgaggccga
      241 gtcgcgagcg acatggggga tcgagagcag ctgctgcagc gggcgcgact ggcggagcag
      301 gcggagcgct acgacgatat ggcctccgcc atgaaggcgg tgacagagct gaatgaacca
      361 ctatctaacg aagatcgaaa tctcctctct gtggcctaca agaatgtagt tggtgccagg
      421 cgatcttctt ggagggttat tagtagcatt gagcagaaaa ccatggcaga tgggaatgag
      481 aagaagttgg agaaagttaa agcctaccgg gagaagattg aaaaggagct ggagacagtt
      541 tgcaatgatg tcttggctct gcttgacaag ttccttatca agaactgcaa tgattttcag
      601 tatgagagca aggtgttcta cctgaaaatg aagggcgatt actaccgcta cctggcagag
      661 gtggcttctg gggagaagaa aaacagtgtg gttgaagctt ctgaggccgc gtataaggaa
      721 gccttcgaaa tcagcaaaga gcacatgcag ccaacacacc ccatccggct tggcctggcc
      781 ctcaattttt ctgtgttcta ctatgagatc cagaatgcac cagagcaagc ctgcctctta
      841 gccaaacaag ccttcgatga tgctatagct gagctggaca cattaaacga ggattcctat
      901 aaggactcca ctctcatcat gcagttgctg cgagacaacc tcaccctctg gacgagcgac
      961 cagcaggatg aagaagcagg agaaggcaac tgaagaccct tcaggtccct ggctcttcct
     1021 tcacccacca cccccattat cactgattct tccttgccac aatcactata tctagtgcta
     1081 aacctatctg tattggcagc acagctattc agatctgccc tcctgtccct tgggaagcag
     1141 tttcagataa accttcatgg gcatttgctg gactgatggt tgctttgagt cacagggcgc
     1201 ttcctttttg aattgtgcag agaagtgtgt tctgaacaag gcattttatt atgtctgttg
     1261 atctctagca aatccaggtg atggtaattg agtgtagaaa ggagaattag ccaacacagg
     1321 ctatggctgc tatttaaaac aagctgatag tgttttgtta agcagtacat cttgtgcatg
     1381 caaaaatgaa tttgaccctc tcacccctcc cttcagctaa tggaaactga cacagcgaca
     1441 actcattcct tcaccatcag ctttataaac tgtttcttgt gagctttcag cagcccttgc
     1501 tgtgcctctt taaattatga tgtgcacaca ccttcctttc aatgcaatgc atcagaagtt
     1561 tttgatatgt gtaacttttt tttgattgtg attaagaatc atggatttat tttttgtaac
     1621 tctttggcta ttgttcttgt gtaccctgac agcatcatgt gtgtcaacct gtgtcaatta
     1681 tgatgggtgg ttatgaaatg ccagactgct aaaataaatg ttttggactt aaaagagtaa
     1741 ataaatgctg ctttagggat attaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     1801 aaaaaa
//
