LOCUS       NM_018871               3592 bp    mRNA    linear   ROD 12-NOV-2024
DEFINITION  Mus musculus tyrosine 3-monooxygenase/tryptophan 5-monooxygenase
            activation protein, gamma polypeptide (Ywhag), mRNA.
ACCESSION   NM_018871
VERSION     NM_018871.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3592)
  AUTHORS   Han,Z., Wang,R., Chi,P., Zhang,Z., Min,L., Jiao,H., Ou,G., Zhou,D.,
            Qin,D., Xu,C., Gao,Z., Qi,Q., Li,J., Lu,Y., Wang,X., Chen,J.,
            Yu,X., Hu,H., Li,L. and Deng,D.
  TITLE     The subcortical maternal complex modulates the cell cycle during
            early mammalian embryogenesis via 14-3-3
  JOURNAL   Nat Commun 15 (1), 8887 (2024)
   PUBMED   39406751
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3592)
  AUTHORS   Cho,E., Park,J., Hwang,E.M., Kim,H.W. and Park,J.Y.
  TITLE     14-3-3gamma haploinsufficiency leads to altered dopamine pathway
            and Parkinson's disease-like motor incoordination in mice
  JOURNAL   Mol Brain 16 (1), 2 (2023)
   PUBMED   36604743
  REMARK    GeneRIF: 14-3-3gamma haploinsufficiency leads to altered dopamine
            pathway and Parkinson's disease-like motor incoordination in mice.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3592)
  AUTHORS   Park,H., Lee,Y.B. and Chang,K.A.
  TITLE     miR-200c suppression increases tau hyperphosphorylation by
            targeting 14-3-3gamma in early stage of 5xFAD mouse model of
            Alzheimer's disease
  JOURNAL   Int J Biol Sci 18 (5), 2220-2234 (2022)
   PUBMED   35342350
  REMARK    GeneRIF: miR-200c suppression increases tau hyperphosphorylation by
            targeting 14-3-3gamma in early stage of 5xFAD mouse model of
            Alzheimer's disease.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3592)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3592)
  AUTHORS   Menzel,J., Kownatzki-Danger,D., Tokar,S., Ballone,A.,
            Unthan-Fechner,K., Kilisch,M., Lenz,C., Urlaub,H., Mori,M.,
            Ottmann,C., Shattock,M.J., Lehnart,S.E. and Schwappach,B.
  TITLE     14-3-3 binding creates a memory of kinase action by stabilizing the
            modified state of phospholamban
  JOURNAL   Sci Signal 13 (647) (2020)
   PUBMED   32873725
  REMARK    GeneRIF: 14-3-3 binding creates a memory of kinase action by
            stabilizing the modified state of phospholamban.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3592)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   7  (bases 1 to 3592)
  AUTHORS   Eilers,A.L., Sundwall,E., Lin,M., Sullivan,A.A. and Ayer,D.E.
  TITLE     A novel heterodimerization domain, CRM1, and 14-3-3 control
            subcellular localization of the MondoA-Mlx heterocomplex
  JOURNAL   Mol Cell Biol 22 (24), 8514-8526 (2002)
   PUBMED   12446771
REFERENCE   8  (bases 1 to 3592)
  AUTHORS   Chen,X.Q. and Yu,A.C.
  TITLE     The association of 14-3-3gamma and actin plays a role in cell
            division and apoptosis in astrocytes
  JOURNAL   Biochem Biophys Res Commun 296 (3), 657-663 (2002)
   PUBMED   12176032
  REMARK    GeneRIF: The association of 14-3-3gamma and actin plays a role in
            cell division and apoptosis in astrocytes
REFERENCE   9  (bases 1 to 3592)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
REFERENCE   10 (bases 1 to 3592)
  AUTHORS   Brady,K.P., Rowe,L.B., Her,H., Stevens,T.J., Eppig,J.,
            Sussman,D.J., Sikela,J. and Beier,D.R.
  TITLE     Genetic mapping of 262 loci derived from expressed sequences in a
            murine interspecific cross using single-strand conformational
            polymorphism analysis
  JOURNAL   Genome Res 7 (11), 1085-1093 (1997)
   PUBMED   9371744
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY244024.1, AK164356.1, AK153307.1 and BB419675.1.
            
            On May 7, 2009 this sequence version replaced NM_018871.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660813.95574.1,
                                           SRR1660815.52593.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-477               BY244024.1         16-492
            478-2630            AK164356.1         429-2581
            2631-2826           AK153307.1         2586-2781
            2827-3559           AK164356.1         2658-3390
            3560-3592           BB419675.1         256-288
FEATURES             Location/Qualifiers
     source          1..3592
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 75.53 cM"
     gene            1..3592
                     /gene="Ywhag"
                     /gene_synonym="14-3-3gamma; D7Bwg1348e"
                     /note="tyrosine 3-monooxygenase/tryptophan 5-monooxygenase
                     activation protein, gamma polypeptide"
                     /db_xref="GeneID:22628"
                     /db_xref="MGI:MGI:108109"
     exon            1..319
                     /gene="Ywhag"
                     /gene_synonym="14-3-3gamma; D7Bwg1348e"
                     /inference="alignment:Splign:2.1.0"
     exon            320..3592
                     /gene="Ywhag"
                     /gene_synonym="14-3-3gamma; D7Bwg1348e"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3544..3549
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ywhag"
                     /gene_synonym="14-3-3gamma; D7Bwg1348e"
                     /note="hexamer: AATAAA"
     polyA_site      3562
                     /gene="Ywhag"
                     /gene_synonym="14-3-3gamma; D7Bwg1348e"
                     /note="major polyA site"
ORIGIN      
        1 gggaccgcag ggggttgtcc gcccgcggca cgcattggag ccgcagcctc cttgcgccgg
       61 gtcccgcggt cgcagctcgt gccgcctcct tctcctcctc gtctcagtag cttgcttcgt
      121 gggtcggtcc ctccgacaca cgagctccaa gccgctcctc tcttttcctg aagcccttca
      181 aggcggtctt cggtttcctt ctttccagcc gatcctcttc agccctgtga agatggtgga
      241 ccgcgagcaa ctggtgcaga aagcccggct ggccgagcag gcggagcgct acgacgatat
      301 ggccgcggcc atgaagaacg tgaccgagct gaacgaacca ctgtccaatg aggaacggaa
      361 cctcctgtcg gtggcctaca agaacgtggt gggggctcgc cgctcctcct ggagggtcat
      421 cagcagcatc gagcagaaga cgtctgcgga cggcaacgag aagaagatcg agatggtccg
      481 agcctaccgg gagaagatcg agaaggagct ggaggccgtg tgccaggacg tgctgagcct
      541 gctggacaac tacctgatca agaactgcag cgagacccag tacgagagca aggtgttcta
      601 cctgaagatg aaaggggact attaccgtta cctggcagaa gtggccaccg gggagaagag
      661 ggcgaccgtg gtggagtcgt ctgagaaggc ctacagcgaa gcccacgaga tcagcaagga
      721 gcacatgcag cccacccacc ccatccggct gggcctggcg ctcaactact cggttttcta
      781 ctatgagatc cagaacgccc cggagcaagc gtgccacctg gccaagaccg ccttcgacga
      841 cgccatcgcc gagctcgaca ctctgaacga ggactcctac aaggactcca ctctgatcat
      901 gcagctgctc cgagacaacc tcacgctctg gacgagcgac cagcaagacg acgacggcgg
      961 tgaaggcaac aactaaggcc ccaggtggac tggcagcgcc cgctgatgct actactgcag
     1021 tctttatttt ttcccatgag ttgggggtcg ggtgggggag gggaaaggga ggggtgacct
     1081 tcccagggag aaacccacga ctgtcctgtc tttgattgcc tctttgacat ttttgccaaa
     1141 ataccactag tggaaagtca ggctagctat gctggtatgg gagtagcagc ctcacacaga
     1201 cgtccggact gttgtgcagg ctcggaacga gcaagcggag ctgtctgcct ttagtttaac
     1261 ttattgctag acggtagggt tctaagaaga aaaaccggag atggatggcc ctcattcagt
     1321 gcgttctgtg gttccagtaa ggattcttct gtccatgccc ttgtcctcag ttccgtggct
     1381 gttttctctc tttggctgtg ctttctctct ctctctctct ctctctctct ctctctctct
     1441 ctctctctct ctctctcttt tttccccctg gggtgtacac cagagaagtt atagtttaaa
     1501 ttacccaact cgacaggctt agagtggaag gcacaccttt tgttagtgag ttagacgtgg
     1561 ccctgtattt ggaagtctct gacgggttga cagtattaac actcaattgt agtttacagt
     1621 atttatacat gacagccata catgacgcca agccatgggt tctcagtttt cctttgtcag
     1681 gtcggctttc atccgcgtcc gggttggtct ggctcttcat catttcgtaa cgtggggaga
     1741 gtcagagctc cctgttccgt tttggttgat gggtgtttgg gagggggctg cgggggatac
     1801 tttttttttt agttcttctt tacccttaag gtcagcccat cacaaaaaca gaaaccgtta
     1861 aatacccccc acacagagaa aacggagaaa attcaggtct gtatgtcatt tatcagagac
     1921 tctgctctca gcagccaggg ctccgtctca gtgtcactgc ctgttgaatg ttcctcagca
     1981 cccaagtcta ctctgcacct tgtgctagca gcatgcaggt gccccgaggc gtaggactgg
     2041 agtgtagcgg gtgggggatt atcatccggt gccagcagct gagcctacag ggaacccact
     2101 aggaagaggc agttcacttg aggcagcctg gtccctaagc cagttgtccc tgcctccctc
     2161 cagccccggc actcctttcc caagtgctta gtggagggta gccgaggttc ggcaggaggc
     2221 catgctcacc ctgtttgacc taagctttcc tggtttcccc tttttgaatg aaatcgtagt
     2281 tgttgagatt ggcttctctc tcatgaggtc gctgcacatg tgacattgaa ggaagctctg
     2341 ctgctatgtc ctacatggtc cgtctcagcc ctaggtccct cattctcact gtggatagcc
     2401 ctttccataa acacgcccgg ttgcatgcag agtgtgcagt ttatgtcttc tggagaactc
     2461 atggtctcgt gggttcccaa gacgggcagc gccccaaact tgcttaactt gtcttcagag
     2521 gcccagcagc cactttgtcg cccacttgag ctggtgccgt ggctgcggaa ggatgacgcc
     2581 cctctgcaca gtcccagcat gccctttctc ggagcccctc cccatgctag tgtgccagca
     2641 ccccctaacc gagaccgcgc aaggccgcag cagaggaagc ttggccacca gagtggacag
     2701 aggggccgga gaggcttcgc ccgggggttt gtctccttgt ccgcagtgag cgtgtctgtg
     2761 tcccgcttgt actgtttgga aatgacctac tggaattgca aaacctagtt tctctttaca
     2821 tttcagcctt gacctttgct gtgttctaga acagtcatgt gagggtagaa ctgaagaggg
     2881 agagcgggag acctgccgtg agcttggttc cttctccttc ctttactgtt gagaagtgtg
     2941 cctgcctctg atgctgtccc cagtgccgcg cggctgctcc tccatcctat tgatacagta
     3001 ttgtgcatgc tggtgttgta tttctatacg gtagcttgac atttattacc ttacactgta
     3061 ggtgttatgt atcctatgac aaaaaaactt aagacttcaa tttttttttt aaacttcttt
     3121 tttttaattt aattttttcc tttcaggggt aaagtttgct ttaccaaata gtgattgtaa
     3181 cagattgatc tgttttggat gttgctatag tgacatgcag ttctatattt tgtttttcag
     3241 gggggagggg acaaaagaaa caccagtgtt agcttactct taataatgtc tggtgtttgt
     3301 catggtgaaa ctataactat cgcagtgcag gagaacgcgc ggacgttctc agaacgcgcc
     3361 tctgtgcttt cttgtcatgt tatgcagtga aaatattttt aaggtctaat caagtgattt
     3421 tttccccccc aactccgtgt ttcgctaagg aattatttcg cacacggacc attcttagca
     3481 gtttcctcag tgatggaata ttcatgaatg tgagtcatta tgtagccgtc gtacattgag
     3541 caaaataaac ttacagatct gatgtcggcg gtgcccagct tcatttaata gc
//
