LOCUS       NM_009536               2078 bp    mRNA    linear   ROD 12-NOV-2024
DEFINITION  Mus musculus tyrosine 3-monooxygenase/tryptophan 5-monooxygenase
            activation protein, epsilon polypeptide (Ywhae), mRNA.
ACCESSION   NM_009536
VERSION     NM_009536.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2078)
  AUTHORS   Han,Z., Wang,R., Chi,P., Zhang,Z., Min,L., Jiao,H., Ou,G., Zhou,D.,
            Qin,D., Xu,C., Gao,Z., Qi,Q., Li,J., Lu,Y., Wang,X., Chen,J.,
            Yu,X., Hu,H., Li,L. and Deng,D.
  TITLE     The subcortical maternal complex modulates the cell cycle during
            early mammalian embryogenesis via 14-3-3
  JOURNAL   Nat Commun 15 (1), 8887 (2024)
   PUBMED   39406751
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2078)
  AUTHORS   Miao,D., Shi,J., Lv,Q., Tan,D., Zhao,C., Xiong,Z. and Zhang,X.
  TITLE     NAT10-mediated ac4C-modified ANKZF1 promotes tumor progression and
            lymphangiogenesis in clear-cell renal cell carcinoma by attenuating
            YWHAE-driven cytoplasmic retention of YAP1
  JOURNAL   Cancer Commun (Lond) 44 (3), 361-383 (2024)
   PUBMED   38407929
  REMARK    GeneRIF: NAT10-mediated ac[4]C-modified ANKZF1 promotes tumor
            progression and lymphangiogenesis in clear-cell renal cell
            carcinoma by attenuating YWHAE-driven cytoplasmic retention of
            YAP1.
REFERENCE   3  (bases 1 to 2078)
  AUTHORS   Denomme-Pichon,A.S., Collins,S.C., Bruel,A.L., Mikhaleva,A.,
            Wagner,C., Vancollie,V.E., Thomas,Q., Chevarin,M., Weber,M.,
            Prada,C.E., Overs,A., Palomares-Bralo,M., Santos-Simarro,F.,
            Pacio-Miguez,M., Busa,T., Legius,E., Bacino,C.A., Rosenfeld,J.A.,
            Le Guyader,G., Egloff,M., Le Guillou,X., Mencarelli,M.A.,
            Renieri,A., Grosso,S., Levy,J., Dozieres,B., Desguerre,I.,
            Vitobello,A., Duffourd,Y., Lelliott,C.J., Thauvin-Robinet,C.,
            Philippe,C., Faivre,L. and Yalcin,B.
  TITLE     YWHAE loss of function causes a rare neurodevelopmental disease
            with brain abnormalities in human and mouse
  JOURNAL   Genet Med 25 (7), 100835 (2023)
   PUBMED   36999555
  REMARK    GeneRIF: YWHAE loss of function causes a rare neurodevelopmental
            disease with brain abnormalities in human and mouse.
            Review article
REFERENCE   4  (bases 1 to 2078)
  AUTHORS   Karl-Scholler,F., Kunz,M., Kress,L., Held,M., Egenolf,N.,
            Wiesner,A., Dandekar,T., Sommer,C. and Uceyler,N.
  TITLE     A translational study: Involvement of miR-21-5p in development and
            maintenance of neuropathic pain via immune-related targets CCL5 and
            YWHAE
  JOURNAL   Exp Neurol 347, 113915 (2022)
   PUBMED   34758342
  REMARK    GeneRIF: A translational study: Involvement of miR-21-5p in
            development and maintenance of neuropathic pain via immune-related
            targets CCL5 and YWHAE.
REFERENCE   5  (bases 1 to 2078)
  AUTHORS   Fu,W., Hettinghouse,A., Chen,Y., Hu,W., Ding,X., Chen,M., Ding,Y.,
            Mundra,J., Song,W., Liu,R., Yi,Y.S., Attur,M., Samuels,J.,
            Strauss,E., Leucht,P., Schwarzkopf,R. and Liu,C.J.
  TITLE     14-3-3 epsilon is an intracellular component of TNFR2 receptor
            complex and its activation protects against osteoarthritis
  JOURNAL   Ann Rheum Dis 80 (12), 1615-1627 (2021)
   PUBMED   34226187
  REMARK    GeneRIF: 14-3-3 epsilon is an intracellular component of TNFR2
            receptor complex and its activation protects against
            osteoarthritis.
REFERENCE   6  (bases 1 to 2078)
  AUTHORS   Hamilton,B.A., Smith,D.J., Mueller,K.L., Kerrebrock,A.W.,
            Bronson,R.T., van Berkel,V., Daly,M.J., Kruglyak,L., Reeve,M.P.,
            Nemhauser,J.L., Hawkins,T.L., Rubin,E.M. and Lander,E.S.
  TITLE     The vibrator mutation causes neurodegeneration via reduced
            expression of PITP alpha: positional complementation cloning and
            extragenic suppression
  JOURNAL   Neuron 18 (5), 711-722 (1997)
   PUBMED   9182797
REFERENCE   7  (bases 1 to 2078)
  AUTHORS   Wang,W. and Shakes,D.C.
  TITLE     Molecular evolution of the 14-3-3 protein family
  JOURNAL   J Mol Evol 43 (4), 384-398 (1996)
   PUBMED   8798343
REFERENCE   8  (bases 1 to 2078)
  AUTHORS   Chong,S.S., Tanigami,A., Roschke,A.V. and Ledbetter,D.H.
  TITLE     14-3-3 epsilon has no homology to LIS1 and lies telomeric to it on
            chromosome 17p13.3 outside the Miller-Dieker syndrome chromosome
            region
  JOURNAL   Genome Res 6 (8), 735-741 (1996)
   PUBMED   8858348
REFERENCE   9  (bases 1 to 2078)
  AUTHORS   Jin,D.Y., Lyu,M.S., Kozak,C.A. and Jeang,K.T.
  TITLE     Function of 14-3-3 proteins
  JOURNAL   Nature 382 (6589), 308 (1996)
   PUBMED   8684458
REFERENCE   10 (bases 1 to 2078)
  AUTHORS   McConnell,J.E., Armstrong,J.F., Hodges,P.E. and Bard,J.B.
  TITLE     The mouse 14-3-3 epsilon isoform, a kinase regulator whose
            expression pattern is modulated in mesenchyme and neuronal
            differentiation
  JOURNAL   Dev Biol 169 (1), 218-228 (1995)
   PUBMED   7750640
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY293945.1, BC058686.1 and AK135831.1.
            
            On Apr 16, 2009 this sequence version replaced NM_009536.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK135831.1, SRR1660817.246990.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-41                BY293945.1         1-41
            42-1400             BC058686.1         1-1359
            1401-2078           AK135831.1         1328-2005
FEATURES             Location/Qualifiers
     source          1..2078
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 45.92 cM"
     gene            1..2078
                     /gene="Ywhae"
                     /note="tyrosine 3-monooxygenase/tryptophan 5-monooxygenase
                     activation protein, epsilon polypeptide"
                     /db_xref="GeneID:22627"
                     /db_xref="MGI:MGI:894689"
     exon            1..205
                     /gene="Ywhae"
                     /inference="alignment:Splign:2.1.0"
     CDS             142..909
                     /gene="Ywhae"
                     /note="14-3-3E; tyrosine 3-monooxygenase/tryptophan
                     5-monooxygenase activatioprotein, epsilon polypeptide;
                     14-3-3 epsilon"
                     /codon_start=1
                     /product="14-3-3 protein epsilon"
                     /protein_id="NP_033562.3"
                     /db_xref="CCDS:CCDS25056.1"
                     /db_xref="GeneID:22627"
                     /db_xref="MGI:MGI:894689"
                     /translation="MDDREDLVYQAKLAEQAERYDEMVESMKKVAGMDVELTVEERNL
                     LSVAYKNVIGARRASWRIISSIEQKEENKGGEDKLKMIREYRQMVETELKLICCDILD
                     VLDKHLIPAANTGESKVFYYKMKGDYHRYLAEFATGNDRKEAAENSLVAYKAASDIAM
                     TELPPTHPIRLGLALNFSVFYYEILNSPDRACRLAKAAFDDAIAELDTLSEESYKDST
                     LIMQLLRDNLTLWTSDMQGDGEEQNKEALQDVEDENQ"
     exon            206..405
                     /gene="Ywhae"
                     /inference="alignment:Splign:2.1.0"
     exon            406..512
                     /gene="Ywhae"
                     /inference="alignment:Splign:2.1.0"
     exon            513..719
                     /gene="Ywhae"
                     /inference="alignment:Splign:2.1.0"
     exon            720..856
                     /gene="Ywhae"
                     /inference="alignment:Splign:2.1.0"
     exon            857..2078
                     /gene="Ywhae"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1801..1806
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ywhae"
                     /note="hexamer: ATTAAA"
     polyA_site      1815
                     /gene="Ywhae"
                     /note="major polyA site"
     regulatory      1847..1852
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ywhae"
                     /note="hexamer: AATAAA"
     polyA_site      1866
                     /gene="Ywhae"
     regulatory      2056..2061
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ywhae"
                     /note="hexamer: ATTAAA"
     polyA_site      2078
                     /gene="Ywhae"
ORIGIN      
        1 agttgtccgc gtgcgcaggc ggaagtcccg gattgaggcg ccgccatttt tcctgctcgg
       61 acgcggagcg agaagctgag agagtcggag acgctatccg cttccatccg tcgcgcagac
      121 cctgccggag ccgctgccgc aatggatgat cgggaggatc tggtgtacca ggcgaagctg
      181 gcagagcagg ccgagcgata cgacgaaatg gtggaatcaa tgaagaaagt agcagggatg
      241 gacgtggagc tgacagttga agaacgaaac cttttatctg ttgcatataa aaatgtgatt
      301 ggagccagaa gagcatcctg gagaataatc agcagcattg aacagaagga agaaaacaag
      361 ggaggagagg acaaattaaa gatgattcgg gagtaccggc aaatggttga aactgagctc
      421 aagttaatct gttgtgacat tctggatgta ctggacaaac acctcattcc agcagctaac
      481 actggcgagt ccaaggtttt ctattataaa atgaaagggg actaccacag gtatctggct
      541 gagtttgcca caggaaatga caggaaggag gcagcagaga acagcctcgt ggcttacaaa
      601 gctgctagtg acattgcgat gacagaactt cctccaacgc accccattcg tttaggtctt
      661 gctctcaact tttccgtatt ctactatgaa attcttaatt cccccgaccg tgcctgcagg
      721 ttggcaaaag cagcttttga tgacgcaatt gcagaactgg acacgctgag tgaagaaagc
      781 tataaggact ctacgctcat catgcagctg ctacgtgata acctgacgct gtggacctca
      841 gacatgcagg gtgatggtga agagcagaat aaagaagcgc tgcaggatgt ggaagatgag
      901 aatcagtgag acgaaataaa agccaacaag agaaaccatc tctgactacc ccttcccccc
      961 ctccccttgg aagttcccca ttgtcactga gaaccaccaa atttgacttt cacatttggt
     1021 ctcagaattt aggttcctgc cctgttgttt ttctttcttt ttcttttttt tttttctccc
     1081 ctcccctttt ttaaaacaaa caaacaaaca aacagttttc agaagttctt aaggcaagag
     1141 tgaatttctg tggattttac tggtcccagc tttaggttct ttacgacact aacaggactg
     1201 catagaggct ttttcagcat tactgtattg tctccggcca cactggcaag atcatcatta
     1261 gaaatggaaa tgacatttga aagccattag acttctaggt gatgcatcta agaaagatta
     1321 atcacacaat agaggcatat gcgctgtcat ttttcctttt tttaattgtt aaattgaatt
     1381 ttataccaat gtttaaactt aaattgggtg ttagcttgag gtgttttggg ggagtttgtt
     1441 gtaatggttt tgctgtaaac tgtgtttgga actctgctga agtgttgctg aaaagcatgg
     1501 tgctggtaac agttcaacaa tccgtggctg ctcattcttg ccgactcctc cccctctgaa
     1561 gcaggttagc attgaaggtg gtatggaagc ctgcatgcgt gttcaactct gttcctcctc
     1621 cctcctcctc ggcctccctc ctcccctcct tcgctcgctc aacctctttt gttcagtacg
     1681 tgtaacttga agctaatttg tactactgga tatctgactg gagccgcagg tacagatctg
     1741 tattgttctt actgaaacac agcatggaat taacattaaa cttaaataaa acaaacctaa
     1801 attaaaaatg ccaaatatat catgcctcca tcctttatac ttctaaaata aaatctctag
     1861 tccagacata tttgacagta ttgtttgtct gaatgtgaaa tatcccccat tttatcccat
     1921 aaatcatttg ttttccaatg atgtgtattt ggggggaagg gaggattgct tgtaatctgg
     1981 tgttgaacaa ctaagtcagt aattgtcctg tctttcaaac cagttagcaa cacaatattt
     2041 atgtttaaat ttatcattaa agtacaacag tcatttaa
//
