LOCUS       NM_001418430            2878 bp    mRNA    linear   ROD 12-NOV-2024
DEFINITION  Mus musculus tyrosine 3-monooxygenase/tryptophan 5-monooxygenase
            activation protein, beta polypeptide (Ywhab), transcript variant 2,
            mRNA.
ACCESSION   NM_001418430
VERSION     NM_001418430.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2878)
  AUTHORS   Han,Z., Wang,R., Chi,P., Zhang,Z., Min,L., Jiao,H., Ou,G., Zhou,D.,
            Qin,D., Xu,C., Gao,Z., Qi,Q., Li,J., Lu,Y., Wang,X., Chen,J.,
            Yu,X., Hu,H., Li,L. and Deng,D.
  TITLE     The subcortical maternal complex modulates the cell cycle during
            early mammalian embryogenesis via 14-3-3
  JOURNAL   Nat Commun 15 (1), 8887 (2024)
   PUBMED   39406751
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2878)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2878)
  AUTHORS   Ferguson,C.J., Urso,O., Bodrug,T., Gassaway,B.M., Watson,E.R.,
            Prabu,J.R., Lara-Gonzalez,P., Martinez-Chacin,R.C., Wu,D.Y.,
            Brigatti,K.W., Puffenberger,E.G., Taylor,C.M., Haas-Givler,B.,
            Jinks,R.N., Strauss,K.A., Desai,A., Gabel,H.W., Gygi,S.P.,
            Schulman,B.A., Brown,N.G. and Bonni,A.
  TITLE     APC7 mediates ubiquitin signaling in constitutive heterochromatin
            in the developing mammalian brain
  JOURNAL   Mol Cell 82 (1), 90-105 (2022)
   PUBMED   34942119
REFERENCE   4  (bases 1 to 2878)
  AUTHORS   Frontini-Lopez,Y.R., Gojanovich,A.D., Del Veliz,S., Uhart,M. and
            Bustos,D.M.
  TITLE     14-3-3beta isoform is specifically acetylated at Lys51 during
            differentiation to the osteogenic lineage
  JOURNAL   J Cell Biochem 122 (12), 1767-1780 (2021)
   PUBMED   34379822
  REMARK    GeneRIF: 14-3-3beta isoform is specifically acetylated at Lys51
            during differentiation to the osteogenic lineage.
REFERENCE   5  (bases 1 to 2878)
  AUTHORS   Ji,L., Wang,Q., Liu,M., Zhu,C., Xiao,Y., Han,J., Fang,Y., Ye,J.,
            Yin,J. and Wei,L.
  TITLE     The 14-3-3 protein YWHAB inhibits glucagon-induced hepatic
            gluconeogenesis through interacting with the glucagon receptor and
            FOXO1
  JOURNAL   FEBS Lett 595 (9), 1275-1288 (2021)
   PUBMED   33641163
  REMARK    GeneRIF: The 14-3-3 protein YWHAB inhibits glucagon-induced hepatic
            gluconeogenesis through interacting with the glucagon receptor and
            FOXO1.
REFERENCE   6  (bases 1 to 2878)
  AUTHORS   Cavet,M.E., Lehoux,S. and Berk,B.C.
  TITLE     14-3-3beta is a p90 ribosomal S6 kinase (RSK) isoform 1-binding
            protein that negatively regulates RSK kinase activity
  JOURNAL   J Biol Chem 278 (20), 18376-18383 (2003)
   PUBMED   12618428
  REMARK    GeneRIF: 14-3-3beta is a p90 ribosomal S6 kinase (RSK) isoform
            1-binding protein that negatively regulates RSK kinase activity
REFERENCE   7  (bases 1 to 2878)
  AUTHORS   Kovacina,K.S., Park,G.Y., Bae,S.S., Guzzetta,A.W., Schaefer,E.,
            Birnbaum,M.J. and Roth,R.A.
  TITLE     Identification of a proline-rich Akt substrate as a 14-3-3 binding
            partner
  JOURNAL   J Biol Chem 278 (12), 10189-10194 (2003)
   PUBMED   12524439
  REMARK    GeneRIF: PRAS40 is a novel substrate of Akt, the phosphorylation of
            which leads to the binding of this protein to 14-3-3.
REFERENCE   8  (bases 1 to 2878)
  AUTHORS   Eilers,A.L., Sundwall,E., Lin,M., Sullivan,A.A. and Ayer,D.E.
  TITLE     A novel heterodimerization domain, CRM1, and 14-3-3 control
            subcellular localization of the MondoA-Mlx heterocomplex
  JOURNAL   Mol Cell Biol 22 (24), 8514-8526 (2002)
   PUBMED   12446771
REFERENCE   9  (bases 1 to 2878)
  AUTHORS   Toyooka,K., Muratake,T., Watanabe,H., Hayashi,S., Ichikawa,T.,
            Usui,H., Washiyama,K., Kumanishi,T. and Takahashi,Y.
  TITLE     Isolation and structure of the mouse 14-3-3 eta chain gene and the
            distribution of 14-3-3 eta mRNA in the mouse brain
  JOURNAL   Brain Res Mol Brain Res 100 (1-2), 13-20 (2002)
   PUBMED   12008017
  REMARK    GeneRIF: The transcription start site was identified and the
            polyadenylation signals (AATAAA) were found in exon 2 of the mouse
            gene. In the 5'-upstream sequence, we found three cis elements
            including a CRE sequence, a TATA box-like sequence, and a C/EBP
            element.
REFERENCE   10 (bases 1 to 2878)
  AUTHORS   Xiang,X., Yuan,M., Song,Y., Ruderman,N., Wen,R. and Luo,Z.
  TITLE     14-3-3 facilitates insulin-stimulated intracellular trafficking of
            insulin receptor substrate 1
  JOURNAL   Mol Endocrinol 16 (3), 552-562 (2002)
   PUBMED   11875115
  REMARK    GeneRIF: 14-3-3 participates in the intracellular trafficking of
            IRS-1
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL591542.20.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13422598.1369021.1,
                                           SRR13422603.503478.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849386, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-204               AL591542.20        120877-121080
            205-271             AL591542.20        123236-123302
            272-574             AL591542.20        137317-137619
            575-698             AL591542.20        139721-139844
            699-862             AL591542.20        140946-141109
            863-958             AL591542.20        141818-141913
            959-2878            AL591542.20        142384-144303
FEATURES             Location/Qualifiers
     source          1..2878
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 84.59 cM"
     gene            1..2878
                     /gene="Ywhab"
                     /gene_synonym="1300003C17Rik; 14-3-3b"
                     /note="tyrosine 3-monooxygenase/tryptophan 5-monooxygenase
                     activation protein, beta polypeptide"
                     /db_xref="GeneID:54401"
                     /db_xref="MGI:MGI:1891917"
     exon            1..204
                     /gene="Ywhab"
                     /gene_synonym="1300003C17Rik; 14-3-3b"
                     /inference="alignment:Splign:2.1.0"
     exon            205..271
                     /gene="Ywhab"
                     /gene_synonym="1300003C17Rik; 14-3-3b"
                     /inference="alignment:Splign:2.1.0"
     exon            272..574
                     /gene="Ywhab"
                     /gene_synonym="1300003C17Rik; 14-3-3b"
                     /inference="alignment:Splign:2.1.0"
     CDS             275..1015
                     /gene="Ywhab"
                     /gene_synonym="1300003C17Rik; 14-3-3b"
                     /note="14-3-3 protein beta; tyrosine 3/tryptophan 5
                     -monooxygenase activation protein, beta polypeptide;
                     KCIP-1; protein kinase C inhibitor protein 1"
                     /codon_start=1
                     /product="14-3-3 protein beta/alpha"
                     /protein_id="NP_001405359.1"
                     /db_xref="GeneID:54401"
                     /db_xref="MGI:MGI:1891917"
                     /translation="MTMDKSELVQKAKLAEQAERYDDMAAAMKAVTEQGHELSNEERN
                     LLSVAYKNVVGARRSSWRVISSIEQKTERNEKKQQMGKEYREKIEAELQDICNDVLEL
                     LDKYLILNATQAESKVFYLKMKGDYFRYLSEVASGENKQTTVSNSQQAYQEAFEISKK
                     EMQPTHPIRLGLALNFSVFYYEILNSPEKACSLAKTAFDEAIAELDTLNEESYKDSTL
                     IMQLLRDNLTLWTSENQGDEGDAGEGEN"
     exon            575..698
                     /gene="Ywhab"
                     /gene_synonym="1300003C17Rik; 14-3-3b"
                     /inference="alignment:Splign:2.1.0"
     exon            699..862
                     /gene="Ywhab"
                     /gene_synonym="1300003C17Rik; 14-3-3b"
                     /inference="alignment:Splign:2.1.0"
     exon            863..958
                     /gene="Ywhab"
                     /gene_synonym="1300003C17Rik; 14-3-3b"
                     /inference="alignment:Splign:2.1.0"
     exon            959..2878
                     /gene="Ywhab"
                     /gene_synonym="1300003C17Rik; 14-3-3b"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2858..2863
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ywhab"
                     /gene_synonym="1300003C17Rik; 14-3-3b"
                     /note="hexamer: AATAAA"
     polyA_site      2878
                     /gene="Ywhab"
                     /gene_synonym="1300003C17Rik; 14-3-3b"
                     /note="major polyA site"
ORIGIN      
        1 agagcggaag tgcagctgcc gccgccgcca ccgccgccgc cgattccgga gccgggtagc
       61 cgccgccgcc accgccgcca ctgcccctac ggtcgctgcc accgccgctg ccgccagccc
      121 cgcctgagga gtgagcccgg gaaggacgca gtcgctgccc tctgatcttc ccggaagcgc
      181 ctttgctccc tccagtcctc cgcgcccagc ctaggctcag actcactgcc ccagtcttct
      241 cccttctgcc tcttggatgc tgaacttaca gaaaatgacc atggataaga gtgagctggt
      301 acagaaagcc aaactggctg agcaggctga gcgctatgat gacatggctg cagctatgaa
      361 ggccgtaaca gagcagggac acgaactctc caatgaagag aggaatctac tctctgttgc
      421 ctacaagaac gtggtaggtg cccgccgctc ttcctggcgt gtcatctcca gcatcgaaca
      481 gaaaaccgag aggaatgaga agaagcagca gatgggcaaa gagtaccgtg agaagatcga
      541 ggcggagctg caggacatct gcaacgatgt gctggagctg ttggacaaat atctcattct
      601 caatgccacc caggcagaaa gcaaagtgtt ctacttaaaa atgaaaggag actactttag
      661 gtatctttct gaagttgcat ccggagaaaa taaacaaacc acggtgtcca actcccagca
      721 ggcttaccaa gaagcatttg aaatcagcaa gaaagaaatg cagcctacac acccgattcg
      781 cctcggcctg gcgctgaatt tctcagtctt ttactatgag attctaaact ctcctgaaaa
      841 ggcctgcagc ctggccaaaa cggcatttga tgaggcgatt gctgagttgg acaccctgaa
      901 tgaagagtct tacaaagaca gcaccctgat catgcagctg ctcagggaca atctcaccct
      961 gtggacgtca gaaaaccagg gggatgaagg agatgctgga gagggagaga actaatgtct
     1021 gttgtgctct gtgatctgtt tgtgtcactt tgtatcctcc acattatgtc cctttgtgcg
     1081 ataaacaaaa acaaaaaatc gaatgtggac tttcgatttt tcacagccta agccttgcaa
     1141 agatggtccc tgggatgaac agctggtatt tgtatctaaa gctcagactg gtcccttaat
     1201 accatggtat tgtgaagtct tgattttgat caacattgac aaggattact gtgtgtttaa
     1261 tttttacaaa ctgaacactg tgatcatggg gttttataac ttagcagaac tctttctggt
     1321 aggaaaaata gacctgaatt atgtgtaact tcttggaaag tttaatctga tatcaaaatg
     1381 gtcactgaaa tacaattctg ttgtaaagct gtacagaaag ttctagagat tctgtggtga
     1441 tgctgggact tggtgagatg ctgaccaccg gcatcctgag tttggtaact cacagtaatt
     1501 ctgcctgtgg ttgagggctt accaaccctt gatcattcag ggctgttgcc actcaaaagt
     1561 tcatgaccac aaatatctgc agtgtcttct gaggaaactc aaaacctgaa agtgaacttc
     1621 tttggccgat aattgggctg tgtcaccaca ataaaaaaag gtcccgtgct cataccacct
     1681 gtgtgactaa accctttact atagcagtgt gttcctgatt agcagcgtgt gaaaacaggg
     1741 ctgttacccc ctagctaaag gagaggggga aggaagagag aaagcagtgt atcttacaaa
     1801 tggccagacc agttttctgg atgattcttt aagaataatg tgttgaggcg gcctctcgcc
     1861 tgaggagcac tcatagtctt ggggttcttc tagcttggag ggtggaagct ttgaaattta
     1921 acgttctttc cgccctgtcc ttctgactgt tgactttttt ccctctttaa atttacagct
     1981 ttctgcttcc ttgggtggtt ttctttggaa gcctgtatta gtcaggactg tatggacagg
     2041 gcggggtgtt gagcacaggg tgagcaagct ttgctttaag gtgttgagaa agaagacctt
     2101 ccagtgccac caccctgcct tcctccagtt ctcagcacag ttgttcttca tagtgtgact
     2161 catccaaaac aaacaaacaa acaaacaaaa gtattttgaa gtctccatga tttcccccta
     2221 ttgcactcag ccctgacaat cttgttagtg cctgtcacca gaccctccag tgtactcatc
     2281 tagcttcgtg ctcagacacg tctcaacaag accttagaac acagggaagt tgcatggaca
     2341 ctacagtcga gacaaccaag aacagccagg ccttcagtct cacagtctca cccctctacc
     2401 ttgacattcc atgtagccgt agacatagtc catctgtttg tccatctgct gaaatatgaa
     2461 aagaattcat gcactgattt aaaccaaaaa aaaaaaaaaa aaaaacccac aaaaaaaatc
     2521 tcttctttct agctgaacaa aaaaaaatgt gcagttaata cttggcgctt gacaacgcag
     2581 tagtgagtgt ggaaccaagc ctgtctgtat atctggtagc tctttgctct ggttttttgt
     2641 ttgtttgttt gttttgtttt ttcccttacc agtattctgc ctaatgtttg cttctgtggt
     2701 ggttctattt gcctagcaag cacacccgtg attgtgaaaa tagtgtagca aaaaagaaaa
     2761 gaaaccccag ttactgatgt gctagatccg tgtatgtcta aacattctag tttcacctta
     2821 cacagagtaa tcaggaaaat gtaaaaactt aaagtgaaat aaaacatttt atcagtta
//
