LOCUS       NM_001145919            5175 bp    mRNA    linear   ROD 11-FEB-2025
DEFINITION  Mus musculus YTH N6-methyladenosine RNA binding protein 3 (Ythdf3),
            transcript variant 2, mRNA.
ACCESSION   NM_001145919
VERSION     NM_001145919.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5175)
  AUTHORS   Zhao,W., Li,R., Zhong,X. and Huang,P.
  TITLE     Deletion of YTHDF1 (not YTHDF3) reduced brain and gut damage after
            traumatic brain injury
  JOURNAL   Neurol Res 46 (11), 1037-1045 (2024)
   PUBMED   39081030
  REMARK    GeneRIF: Deletion of YTHDF1 (not YTHDF3) reduced brain and gut
            damage after traumatic brain injury.
REFERENCE   2  (bases 1 to 5175)
  AUTHORS   Mao,Y., Meng,Y., Zou,K., Qin,N., Wang,Y., Yan,J., Chen,P.,
            Cheng,Y., Shi,W., Zhou,C., Chen,H., Sheng,J., Liu,X., Pan,J. and
            Huang,H.
  TITLE     Advanced paternal age exacerbates neuroinflammation in offspring
            via m6A modification-mediated intergenerational inheritance
  JOURNAL   J Neuroinflammation 21 (1), 249 (2024)
   PUBMED   39367406
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5175)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 5175)
  AUTHORS   Feng,Z.W., Peng,B., Wang,S.H., Zhao,D.C., Wang,Y.B., Yang,A.,
            Zhan,H.W., Sheng,X.Y., Xu,L.H., Ren,X.J., Yang,F., Geng,B. and
            Xia,Y.Y.
  TITLE     METTL3-mediated m6A modification of SOX4 regulates osteoblast
            proliferation and differentiation via YTHDF3 recognition
  JOURNAL   Cell Signal 115, 111038 (2024)
   PUBMED   38195035
  REMARK    GeneRIF: METTL3-mediated m[6]A modification of SOX4 regulates
            osteoblast proliferation and differentiation via YTHDF3
            recognition.
REFERENCE   5  (bases 1 to 5175)
  AUTHORS   Li,L., Sun,Y., Davis,A.E., Shah,S.H., Hamed,L.K., Wu,M.R.,
            Lin,C.H., Ding,J.B. and Wang,S.
  TITLE     Mettl14-mediated m6A modification ensures the cell-cycle
            progression of late-born retinal progenitor cells
  JOURNAL   Cell Rep 42 (6), 112596 (2023)
   PUBMED   37269288
REFERENCE   6  (bases 1 to 5175)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 5175)
  AUTHORS   Lasman,L., Krupalnik,V., Viukov,S., Mor,N., Aguilera-Castrejon,A.,
            Schneir,D., Bayerl,J., Mizrahi,O., Peles,S., Tawil,S., Sathe,S.,
            Nachshon,A., Shani,T., Zerbib,M., Kilimnik,I., Aigner,S.,
            Shankar,A., Mueller,J.R., Schwartz,S., Stern-Ginossar,N., Yeo,G.W.,
            Geula,S., Novershtern,N. and Hanna,J.H.
  TITLE     Context-dependent functional compensation between Ythdf m6A reader
            proteins
  JOURNAL   Genes Dev 34 (19-20), 1373-1391 (2020)
   PUBMED   32943573
REFERENCE   8  (bases 1 to 5175)
  AUTHORS   Winkler,R., Gillis,E., Lasman,L., Safra,M., Geula,S., Soyris,C.,
            Nachshon,A., Tai-Schmiedel,J., Friedman,N., Le-Trilling,V.T.K.,
            Trilling,M., Mandelboim,M., Hanna,J.H., Schwartz,S. and
            Stern-Ginossar,N.
  TITLE     m6A modification controls the innate immune response to infection
            by targeting type I interferons
  JOURNAL   Nat Immunol 20 (2), 173-182 (2019)
   PUBMED   30559377
  REMARK    Erratum:[Nat Immunol. 2019 Feb;20(2):243. doi:
            10.1038/s41590-019-0314-4.. PMID: 30635652]
REFERENCE   9  (bases 1 to 5175)
  AUTHORS   Zhang,Y., Wang,X., Zhang,X., Wang,J., Ma,Y., Zhang,L. and Cao,X.
  TITLE     RNA-binding protein YTHDF3 suppresses interferon-dependent
            antiviral responses by promoting FOXO3 translation
  JOURNAL   Proc Natl Acad Sci U S A 116 (3), 976-981 (2019)
   PUBMED   30591559
  REMARK    GeneRIF: findings uncover the role of YTHDF3 as a negative
            regulator of antiviral immunity through the translational promotion
            of FOXO3 mRNA under homeostatic conditions, adding insight into the
            networks of RNA-binding protein-RNA interactions in homeostatically
            maintaining host antiviral immune function and preventing
            inflammatory response.
REFERENCE   10 (bases 1 to 5175)
  AUTHORS   Dominissini,D., Moshitch-Moshkovitz,S., Schwartz,S.,
            Salmon-Divon,M., Ungar,L., Osenberg,S., Cesarkas,K.,
            Jacob-Hirsch,J., Amariglio,N., Kupiec,M., Sorek,R. and Rechavi,G.
  TITLE     Topology of the human and mouse m6A RNA methylomes revealed by
            m6A-seq
  JOURNAL   Nature 485 (7397), 201-206 (2012)
   PUBMED   22575960
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ066078.1 and BC067040.1.
            
            On Nov 16, 2017 this sequence version replaced NM_001145919.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC067040.1, SRR1660815.97064.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-47                CJ066078.1         1-47
            48-5175             BC067040.1         1-5128
FEATURES             Location/Qualifiers
     source          1..5175
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 4.04 cM"
     gene            1..5175
                     /gene="Ythdf3"
                     /gene_synonym="9130022A11Rik"
                     /note="YTH N6-methyladenosine RNA binding protein 3"
                     /db_xref="GeneID:229096"
                     /db_xref="MGI:MGI:1918850"
     exon            1..356
                     /gene="Ythdf3"
                     /gene_synonym="9130022A11Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             333..2090
                     /gene="Ythdf3"
                     /gene_synonym="9130022A11Rik"
                     /note="isoform 2 is encoded by transcript variant 2; YTH
                     domain-containing family protein 3; YTH domain family 3"
                     /codon_start=1
                     /product="YTH domain-containing family protein 3 isoform
                     2"
                     /protein_id="NP_001139391.1"
                     /db_xref="CCDS:CCDS50869.1"
                     /db_xref="GeneID:229096"
                     /db_xref="MGI:MGI:1918850"
                     /translation="MSATSVDQRPKGQGNKVSVQNGSIHQKDAVNDDDFEPYLSSQTN
                     QNNSYPPMSDPYMPSYYAPSIGFPYSLGEAAWSTAGDQPMPYLTTYGQMSNGEHHYIP
                     DGVFSQPGALGNTPPFLGQHGFNFFPGNADFSTWGTSGSQGQSTQNSAYSSSYGYPPS
                     SLGRAITDGQAGFGNDTLSKVPGISSIEQGMTGLKIGGDLTAAVTKTVGTALSSSGMT
                     SIATNNVPPVSSAAPKPTSWAAIARKPAKPQPKLKPKGNVGIGGSAVPPPPIKHNMNI
                     GTWDEKGSVVKAPPTQPVLPPQTIIQQPQPLIQPPPLVQSQLPQQQPQPPQPQQQQGP
                     QPQAQPHQVQSQQPQLQNRWVAPRNRGTGFNQNNGTGSENFGLGVVPVSASPSSVEVH
                     PVLEKLKAINNYNPKDFDWNLKNGRVFIIKSYSEDDIHRSIKYSIWCSTEHGNKRLDA
                     AYRSLNGKGPLYLLFSVNGSGHFCGVAEMKSVVDYNAYAGVWSQDKWKGKFEVKWIFV
                     KDVPNNQLRHIRLENNDNKPVTNSRDTQEVPLEKAKQVLKIIATFKHTTSIFDDFAHY
                     EKRQEEEEAMRRERNRNKQ"
     exon            357..381
                     /gene="Ythdf3"
                     /gene_synonym="9130022A11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            382..467
                     /gene="Ythdf3"
                     /gene_synonym="9130022A11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            468..2066
                     /gene="Ythdf3"
                     /gene_synonym="9130022A11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2067..5149
                     /gene="Ythdf3"
                     /gene_synonym="9130022A11Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5129..5134
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ythdf3"
                     /gene_synonym="9130022A11Rik"
                     /note="hexamer: AATAAA"
     polyA_site      5149
                     /gene="Ythdf3"
                     /gene_synonym="9130022A11Rik"
                     /note="major polyA site"
ORIGIN      
        1 gagtggggga ggaactgcga ggtgtgcgtg gacgtcagac tggatagcgg aaggtcagga
       61 cggcccggag cggaagtggg gctgaggcgc ctgtccgcca ttgtgggccc gaggatcgga
      121 ggacgagcgg ggacgagcag tgtgcaggcg gcgagctcgg gccccttccg cgactcccga
      181 gcgtgagccc tctccctgga gcctgcgaga gcggcggcgg cggaggccgg agcagagctt
      241 cgcgagggcg gtagtcgact gctgtgagtg ctctcggcga ggcccaggca gcggcggcgg
      301 cggcggcggt tcctctcggg ttacggtgaa gaatgtcagc cactagcgtg gatcagagac
      361 ctaaagggca aggaaataaa gtttcagtac aaaatggttc gattcatcaa aaagatgctg
      421 taaatgatga tgattttgag ccatacttaa gtagccagac aaatcagaat aacagctatc
      481 caccaatgtc agatccatat atgcctagtt actatgctcc gtccattgga tttccatatt
      541 ctcttgggga agcagcatgg tccacggctg gagatcagcc tatgccatat ctgacaacct
      601 atggacaaat gagtaatgga gaacatcatt atataccaga tggtgttttt agtcaaccag
      661 gggcattagg aaatacccct ccatttcttg gtcaacatgg atttaacttt tttcctggta
      721 atgctgattt ctctacatgg ggaacaagtg gatctcaggg acaatcaaca caaaattctg
      781 cttatagtag cagttacggc tatccaccta gttctcttgg gagagctatt actgatggac
      841 aggccggatt tggcaatgat actttgagta aggtgcctgg cattagtagt attgagcaag
      901 gcatgactgg actgaaaatt ggtggtgacc tgacagctgc ggtgacgaaa actgtaggta
      961 cagccttgag cagcagtggt atgactagca ttgcaaccaa taatgtgccc cctgttagca
     1021 gtgcagcacc taaaccaact tcttgggctg ctattgccag aaagcctgca aaacctcagc
     1081 cgaaacttaa acccaagggc aatgtgggaa ttgggggttc tgctgtgcca ccacctccta
     1141 taaaacacaa catgaatatt ggaacttggg atgaaaaggg gtcagtggta aaggctccac
     1201 caacccaacc agttctgcct cctcaaacta taatccagca gcctcagcca ttaattcaac
     1261 caccaccatt ggtgcaaagc caactgcctc aacagcagcc tcagccacca caaccacagc
     1321 agcaacaagg acctcagcca caggcccagc ctcaccaagt gcagtctcaa cagccacagt
     1381 tgcagaatcg ttgggtagct cctcggaata ggggaaccgg cttcaaccag aacaatggaa
     1441 caggcagtga aaactttggt ttaggtgttg tgcctgttag tgcttcacct tctagtgtag
     1501 aggtgcatcc agtgctggaa aaactaaagg ccataaacaa ttataatccc aaagactttg
     1561 attggaacct gaagaatgga cgtgtgttta taattaagag ctattctgag gatgatatac
     1621 atcgttccat caagtactct atctggtgta gtactgagca tggtaataag cgtttggatg
     1681 cagcttatcg ttccctgaat gggaaaggcc cactctattt actcttcagt gtgaatggca
     1741 gtggacattt ttgtggagtg gctgaaatga agtctgttgt agactataat gcttatgctg
     1801 gtgtctggtc tcaggataag tggaagggca aatttgaagt taaatggatc tttgtcaaag
     1861 atgttcccaa taaccaatta cgacatattc gcttagaaaa taatgacaac aaaccagtaa
     1921 ccaattcaag ggacactcaa gaagtacccc tagaaaaagc aaagcaagtg cttaaaataa
     1981 tcgctacttt caagcatacc acctcaatct ttgatgactt tgcacattat gaaaagcgtc
     2041 aagaggagga ggaagccatg cgaagggaga gaaatagaaa caagcaataa ccaccgtgtg
     2101 gagatgtcct attaaaatga caacactaat gatgtagact ctggaaatgc ctaataagtc
     2161 aaagaagatg ttattaaagc tttttgtttt ctgcttaagg tgacatcttt gaacccttta
     2221 acatgaaatt gattcttctt gtaatggttt tcatcagcgc atctgccctt attctctcac
     2281 caaacacact tgagaactgt aacttcatga agcactttgt gtcctgaagc ttttaccagt
     2341 acctgctgtc ttttgtaatt atgcatccta gctaaggcac agaagactga atgaattgca
     2401 aggattcatt aactcttgga atttgttaag tactaacagt tatccattag aagtggttca
     2461 atgatgtaag agtctcactg cttcaatctt ttcattgtcg tagtttttaa attgtcaatt
     2521 tttagctatt tgacagatta aaagcaaaat aatcatgcca tatttagtct ggagttcaag
     2581 tctgaatgtt tatgtgaaaa attattgtag caaactttta atatggcaaa gcaaccttat
     2641 gctctatttt agccaaacag tacataatct aaaattatat attagaacat ttcccttgtc
     2701 ttcaaactat ttgatgtaac aaatatgcag cctggtgggc ttcaccaatt aatgcacatc
     2761 ccctcctctc cagttacatg tacactgaga atatgcgttg gtttgaggga ttattttgtt
     2821 tctaccactt aatgaatctc aacattttga gtaaatgtac ctcagtctaa tcagactttt
     2881 tatgaccttt ataactacat ttaaaaccct taaattctat ttctgggtgt ttgcgagcct
     2941 gattgctatc atgaagtaaa aatttattac tctaggtatt cactagataa atatagttct
     3001 tgtttagtaa gcatatactg tttctcaact cttctccagc ttttgcagtg tactggcatc
     3061 cttaaaatac tttgaaaata tggccttgat ccatgaatta aatcagtatc taagtgaatg
     3121 tgttgatgtt ttattgatga gatctatata catgggaata cagtatatat ctgggtattc
     3181 ttatagataa tctttttaac atcctatttt tttcattaat tacatatcaa cattaatttt
     3241 gtatcttgaa acaaattgat tttgtataat tgaatgtgtt gtgcatctgt atttgatttg
     3301 atggtataag gttatgaaaa taatgtcctg ccccttatat tactgttttg aaaggagaaa
     3361 gctatgtaga atgatatgtt aagggtgaaa atagcaatac agtagatttg aatgtctttt
     3421 tgatctgcat tagttcattt atgtttacat cgtagttaga gatcttttca tttgctcttg
     3481 tctttgctca cttcaatttg aaagcctcat gacacatatt tctttgaaac tttgatttat
     3541 ataattttta taaaatattt taggatgtac aaatattgta tttttttatt aaaatacagt
     3601 atttgtaaat gaccatagct acttcacagt tacttgttag tcccagtgta gttatatcag
     3661 tgtttactga agggaacaca aaaatattaa tggtatatta cagaatgaaa actttcttaa
     3721 aggaaaattg cacctatttt acatttttga gactaagcca tgaaatcttg taatatgtct
     3781 cttaactatt tataatgaaa gttggcattt gggtatagtc agcacagcaa tgttctgtat
     3841 ccttaggatt gtataagtag gacattttaa agatgactca tgtcattctg gagctcctac
     3901 tagagaaaac tgtaaaaagg gtgaccttgt aggaaggagc tgaggcctcc ctctgagggt
     3961 ctctttttct tggtgcttta ttagcaactc tggatatttt tataaaacta gatacattag
     4021 aaactaattc agtcttgttt aatttacatt aggttttatg taagaaatgt catcaaaata
     4081 cccaatgagc aggctgattg cagtagactc agacagggcc agtgaatctc agctgagagt
     4141 ctattcgtgg tgaagagaac atcccagtgc ctttaacctg aatttctaat cttatgtgaa
     4201 atgggtgcag cattcctttg gacaaaagct tccacttggt aatttttgtg tttttctcac
     4261 tttaagtatt ccccaaagca ccaacttctc ttccttcttg gtcagtcagt atattgtaag
     4321 attattttcc attaaatgac atcattaccg gttgtctcta aagtacaacc aacagaatgt
     4381 ttcttaactg cggggaccaa aagggagaga ctctgagctc tacaagagta tatatataat
     4441 aaaatgtttg aataatatta aattaagaca ttattggtcc tgtgatttct tgctcagtgt
     4501 ttttccaatt tgtcatttga atgattctta ctaaagttat tttatgtggg tattttattt
     4561 ttaatggtat tatagtttgt atatttaaca gtaaggggga aagtaaccaa aattagtatt
     4621 ctttcactat acatattggt acttgaaact tcctttaaaa aaaatcaaca aaaaactcaa
     4681 acttttagtg cttaattcct cattttaacc tgtgatcttt ctaattgaaa agctgtgtta
     4741 tttttgacta ccatgcatgt ggggttaagc tgatgttgaa acagtttgca gttaaaaaaa
     4801 aatcttaatc agcttaagtc attcaatcat ttcaagtgag ttctgcatcc tttaaaagta
     4861 agtttgtgag attttaagag aattgtgttt tcattaaatt ttgtgtattt tttgttatgc
     4921 catgtaaatt ccctttttcc tatgattaaa ggaagggtat gatgaaatga ttagttcatt
     4981 tacatttcac gtgtagcagt tacatgagaa tttaaatttt gtcgtgtttg ggtttgttca
     5041 ttcctgtgaa tgatggtaca gtaggtgaga ttttttttgt tatggtaccg aactcatctt
     5101 ttggtcctct ttaatctttg agggtttcaa taaaaattgt tcactctaaa aaaaaaaaaa
     5161 aaaaaaaaaa aaaaa
//
