LOCUS       NM_145393               4078 bp    mRNA    linear   ROD 11-FEB-2025
DEFINITION  Mus musculus YTH N6-methyladenosine RNA binding protein 2 (Ythdf2),
            mRNA.
ACCESSION   NM_145393
VERSION     NM_145393.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4078)
  AUTHORS   Chen,Z., Zeng,C., Yang,L., Che,Y., Chen,M., Sau,L., Wang,B.,
            Zhou,K., Chen,Y., Qing,Y., Shen,C., Zhang,T., Wunderlich,M., Wu,D.,
            Li,W., Wang,K., Leung,K., Sun,M., Tang,T., He,X., Zhang,L.,
            Swaminathan,S., Mulloy,J.C., Muschen,M., Huang,H., Weng,H.,
            Xiao,G., Deng,X. and Chen,J.
  TITLE     YTHDF2 promotes ATP synthesis and immune evasion in B cell
            malignancies
  JOURNAL   Cell 188 (2), 331-351 (2025)
   PUBMED   39694037
REFERENCE   2  (bases 1 to 4078)
  AUTHORS   Zhang,F., Fu,Y., Jimenez-Cyrus,D., Zhao,T., Shen,Y., Sun,Y.,
            Zhang,Z., Wang,Q., Kawaguchi,R., Geschwind,D.H., He,C., Ming,G.L.
            and Song,H.
  TITLE     m6A/YTHDF2-mediated mRNA decay targets TGF-beta signaling to
            suppress the quiescence acquisition of early postnatal mouse
            hippocampal NSCs
  JOURNAL   Cell Stem Cell 32 (1), 144-156 (2025)
   PUBMED   39476834
REFERENCE   3  (bases 1 to 4078)
  AUTHORS   Mao,Y., Meng,Y., Zou,K., Qin,N., Wang,Y., Yan,J., Chen,P.,
            Cheng,Y., Shi,W., Zhou,C., Chen,H., Sheng,J., Liu,X., Pan,J. and
            Huang,H.
  TITLE     Advanced paternal age exacerbates neuroinflammation in offspring
            via m6A modification-mediated intergenerational inheritance
  JOURNAL   J Neuroinflammation 21 (1), 249 (2024)
   PUBMED   39367406
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4078)
  AUTHORS   Wang,J., Shen,Y., Zhang,Y., Lin,D., Wang,Q., Sun,X., Wei,D.,
            Shen,B., Chen,J., Ji,Y., Fulton,D., Yu,Y., Chen,F. and Hu,L.
  TITLE     Smooth Muscle Ythdf2 Abrogation Ameliorates Pulmonary Vascular
            Remodeling by Regulating Myadm Transcript Stability
  JOURNAL   Hypertension 81 (8), 1785-1798 (2024)
   PUBMED   38832511
  REMARK    GeneRIF: Smooth Muscle Ythdf2 Abrogation Ameliorates Pulmonary
            Vascular Remodeling by Regulating Myadm Transcript Stability.
REFERENCE   5  (bases 1 to 4078)
  AUTHORS   Xiao,S., Ma,S., Sun,B., Pu,W., Duan,S., Han,J., Hong,Y., Zhang,J.,
            Peng,Y., He,C., Yi,P., Caligiuri,M.A. and Yu,J.
  TITLE     The tumor-intrinsic role of the m6A reader YTHDF2 in regulating
            immune evasion
  JOURNAL   Sci Immunol 9 (95), eadl2171 (2024)
   PUBMED   38820140
  REMARK    GeneRIF: The tumor-intrinsic role of the m[6]A reader YTHDF2 in
            regulating immune evasion.
REFERENCE   6  (bases 1 to 4078)
  AUTHORS   Zhang,F., Kang,Y., Wang,M., Li,Y., Xu,T., Yang,W., Song,H., Wu,H.,
            Shu,Q. and Jin,P.
  TITLE     Fragile X mental retardation protein modulates the stability of its
            m6A-marked messenger RNA targets
  JOURNAL   Hum Mol Genet 27 (22), 3936-3950 (2018)
   PUBMED   30107516
  REMARK    GeneRIF: These data together suggest that FMRP regulates the
            stability of its m6A-marked mRNA targets through YTHDF2, which
            could potentially contribute to the molecular pathogenesis of
            Fragile X syndrome.
REFERENCE   7  (bases 1 to 4078)
  AUTHORS   Li,Z., Qian,P., Shao,W., Shi,H., He,X.C., Gogol,M., Yu,Z., Wang,Y.,
            Qi,M., Zhu,Y., Perry,J.M., Zhang,K., Tao,F., Zhou,K., Hu,D.,
            Han,Y., Zhao,C., Alexander,R., Xu,H., Chen,S., Peak,A., Hall,K.,
            Peterson,M., Perera,A., Haug,J.S., Parmely,T., Li,H., Shen,B.,
            Zeitlinger,J., He,C. and Li,L.
  TITLE     Suppression of m6A reader Ythdf2 promotes hematopoietic stem cell
            expansion
  JOURNAL   Cell Res 28 (9), 904-917 (2018)
   PUBMED   30065315
  REMARK    GeneRIF: The study provides the first demonstration of the function
            of YTHDF2 in adult stem cell maintenance and identifies its
            important role in regulating HSC ex vivo expansion by regulating
            the stability of multiple mRNAs critical for HSC self-renewal, thus
            identifying potential for future clinical applications.
            Erratum:[Cell Res. 2018 Oct;28(10):1042. doi:
            10.1038/s41422-018-0083-x.. PMID: 30150672]
REFERENCE   8  (bases 1 to 4078)
  AUTHORS   Li,M., Zhao,X., Wang,W., Shi,H., Pan,Q., Lu,Z., Perez,S.P.,
            Suganthan,R., He,C., Bjoras,M. and Klungland,A.
  TITLE     Ythdf2-mediated m6A mRNA clearance modulates neural development in
            mice
  JOURNAL   Genome Biol 19 (1), 69 (2018)
   PUBMED   29855337
  REMARK    GeneRIF: Ythdf2 modulates neural development by promoting
            m(6)A-dependent degradation of neural development-related mRNA
            targets.
            Publication Status: Online-Only
REFERENCE   9  (bases 1 to 4078)
  AUTHORS   Ivanova,I., Much,C., Di Giacomo,M., Azzi,C., Morgan,M.,
            Moreira,P.N., Monahan,J., Carrieri,C., Enright,A.J. and
            O'Carroll,D.
  TITLE     The RNA m6A Reader YTHDF2 Is Essential for the Post-transcriptional
            Regulation of the Maternal Transcriptome and Oocyte Competence
  JOURNAL   Mol Cell 67 (6), 1059-1067 (2017)
   PUBMED   28867294
  REMARK    GeneRIF: The m(6)A-reader YTHDF2 is an intrinsic determinant of
            mammalian oocyte competence and early zygotic development.
REFERENCE   10 (bases 1 to 4078)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK034655.1, AK150669.1 and BX537301.12.
            
            On Mar 21, 2009 this sequence version replaced NM_145393.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK034655.1, AK150350.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164142 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-147               AK034655.1         2-148
            148-2937            AK150669.1         2-2791
            2938-4078           BX537301.12        10642-11782         c
FEATURES             Location/Qualifiers
     source          1..4078
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 64.92 cM"
     gene            1..4078
                     /gene="Ythdf2"
                     /gene_synonym="9430020E02Rik; HGRG8; NY-REN-2"
                     /note="YTH N6-methyladenosine RNA binding protein 2"
                     /db_xref="GeneID:213541"
                     /db_xref="MGI:MGI:2444233"
     exon            1..357
                     /gene="Ythdf2"
                     /gene_synonym="9430020E02Rik; HGRG8; NY-REN-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             331..2070
                     /gene="Ythdf2"
                     /gene_synonym="9430020E02Rik; HGRG8; NY-REN-2"
                     /note="YTH domain family 2"
                     /codon_start=1
                     /product="YTH domain-containing family protein 2"
                     /protein_id="NP_663368.3"
                     /db_xref="CCDS:CCDS18719.1"
                     /db_xref="GeneID:213541"
                     /db_xref="MGI:MGI:2444233"
                     /translation="MSASSLLEQRPKGQGNKVQNGSVHQKDGLNDDDFEPYLSPQARP
                     NNAYTAMSDSYLPSYYSPSIGFSYSLGEAAWSTGGDTAMPYLTSYGQLSNGEPHFLPD
                     AMFGQPGALGSTPFLGQHGFNFFPSGIDFSAWGNNSSQGQSTQSSGYSSNYAYAPSSL
                     GGAMIDGQSAFANETLNKAPGMNTIDQGMAALKLGSTEVASSVPKVVGSAVGSGSITS
                     NIVASSSLPPATIAPPKPASWADIASKPAKQQPKLKTKNGIAGSSLPPPPIKHNMDIG
                     TWDNKGPVAKAPSQALVQNIGQPTQGSPQPVGQQANNSPPVAQASVGQQTQPLPPPPP
                     QPAQLSVQQQAAQPTRWVAPRNRGSGFGHNGVDGNGVGQSQAGSGSTPSEPHPVLEKL
                     RSINNYNPKDFDWNLKHGRVFIIKSYSEDDIHRSIKYNIWCSTEHGNKRLDAAYRSMN
                     GKGPVYLLFSVNGSGHFCGVAEMKSAVDYNTCAGVWSQDKWKGRFDVRWIFVKDVPNS
                     QLRHIRLENNENKPVTNSRDTQEVPLEKAKQVLKIIASYKHTTSIFDDFSHYEKRQEE
                     EESVKKERQGRGK"
     exon            358..382
                     /gene="Ythdf2"
                     /gene_synonym="9430020E02Rik; HGRG8; NY-REN-2"
                     /inference="alignment:Splign:2.1.0"
     exon            383..462
                     /gene="Ythdf2"
                     /gene_synonym="9430020E02Rik; HGRG8; NY-REN-2"
                     /inference="alignment:Splign:2.1.0"
     exon            463..2046
                     /gene="Ythdf2"
                     /gene_synonym="9430020E02Rik; HGRG8; NY-REN-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2047..4078
                     /gene="Ythdf2"
                     /gene_synonym="9430020E02Rik; HGRG8; NY-REN-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2903..2908
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ythdf2"
                     /gene_synonym="9430020E02Rik; HGRG8; NY-REN-2"
                     /note="hexamer: AATAAA"
     polyA_site      2938
                     /gene="Ythdf2"
                     /gene_synonym="9430020E02Rik; HGRG8; NY-REN-2"
                     /note="major polyA site"
ORIGIN      
        1 tgggtcagcg actgtgagag tcagcgctcg cgccgcgcgc gccgcccgcc tctgccgctc
       61 ggcctccccc attcgggctg cgagggggcg ggcgcgcgct ccggagcata gagacgggcg
      121 ttgagctcgg cggcctagag cgtcgccgga tcggagccgg agcccgagtc gcgcgctgtg
      181 tctctgctgc gtccgccgag gcgaggctcc gagtgtcagg gacaaaagcc gccgccgcac
      241 cctctgctcc cgtcgtcggg gctcatccgc cgccgccgct gtcccgacga ggagtccgcc
      301 gccgtcgttc cccgtgagga tccgagagcc atgtcggcca gcagcctctt ggagcagaga
      361 ccaaaaggtc aaggaaacaa agtacaaaat ggttctgtgc atcaaaagga tggactaaat
      421 gatgatgatt tcgaacctta cttgagccca caggcaaggc cgaataatgc atatactgcc
      481 atgtcagact cctacttacc cagttactac agcccctcca ttggcttttc ctattctttg
      541 ggtgaagctg cttggtctac tggaggtgac acagccatgc cctatctaac ttcttatgga
      601 caactgagca acggagagcc ccactttcta ccagatgcaa tgtttgggca accaggagcc
      661 ctaggtagca ctccatttct tggtcagcat ggttttaatt tttttcccag tgggattgac
      721 ttctcagcat ggggaaataa cagttctcag ggacagtcta ctcaaagctc tggatatagt
      781 agcaattacg cttatgcacc cagctcctta ggtggagcca tgattgatgg acagtcagct
      841 tttgccaatg agaccctcaa taaagctcca ggcatgaata ctatagacca agggatggca
      901 gcactgaaac taggtagcac agaagttgca agcagtgttc caaaagttgt aggctctgct
      961 gttggtagtg ggtccatcac tagtaacatt gtggcttcta gcagtttgcc tccagctact
     1021 attgctcctc caaaaccagc atcttgggct gatattgcta gcaagcctgc aaaacaacag
     1081 cctaaactga agaccaagaa tggcattgca ggatcaagtc ttccaccacc cccaataaag
     1141 cataacatgg atattggaac ttgggataac aagggtcctg tggcaaaagc cccctcacag
     1201 gctttggttc aaaatatagg tcagccaacc cagggatctc ctcagcctgt tggacagcag
     1261 gccaataata gcccaccagt ggctcaggca tcagtagggc aacagacgca gccattgcct
     1321 ccacctccac cacagcctgc tcagctctca gtccagcaac aggcagctca gccaactcgc
     1381 tgggtagcac ctcggaaccg tggcagtggg ttcggtcata atggggtgga tggtaatgga
     1441 gtaggacagt ctcaggcggg ttctggatct actccttcag agcctcaccc ggtgttggag
     1501 aaacttcggt ccattaataa ctataaccct aaagatttcg actggaatct gaaacatggc
     1561 cgggttttca tcattaagag ctactctgag gacgatatcc accgttccat taagtataat
     1621 atctggtgca gcacagagca tggtaacaag agactggatg ccgcctatcg ttccatgaat
     1681 gggaagggtc ccgtgtactt acttttcagt gtcaacggca gtggacactt ctgtggagtt
     1741 gcagagatga aatctgctgt ggactacaac acatgtgcag gtgtgtggtc ccaggacaaa
     1801 tggaagggtc gtttcgatgt cagatggatt tttgtgaagg acgttcccaa tagccaactg
     1861 cgacacattc gtctagagaa caacgagaat aaaccagtga ccaactctag ggacactcag
     1921 gaagtgcctc tggaaaaagc taagcaggtg ttgaaaatca tagccagcta caagcacacc
     1981 acttccattt ttgatgactt ctcacactat gagaaacgcc aagaggaaga agaaagtgtt
     2041 aaaaaggaac gtcaaggtcg tgggaaatag aaagcggttc tgcatagact gcagcaacgg
     2101 ttgcatctcc ttatcctaag aggacacgat gacctgcaag aaaattagga ctttttttct
     2161 taatttcatt gacttcagag acaattgcaa acttgcagtt tatgtattgg aatttcacaa
     2221 aagacatagg acttaactgg aaaatggaaa aaaaaaagga aaaaaagaaa aagaaaaaac
     2281 ctaaacaaaa attccctcta ggtagtttag gtaaaaaaat gtccctttta ttttggcttt
     2341 ggttgtgatt cagagcataa tgctttggtt tttttttttg tttttttttt tttttttgtc
     2401 tttttactct atttttcgga tttttaagtc cgtaagtgca tacaattttc tcttaatttt
     2461 taaacccttt cctcccccat tttgacattt gcacttggag aacacttgag ttgcgcagat
     2521 tttgggtgtc caccccagaa agtgggaatt tgatttttcc cttccgaact ggaagaaaat
     2581 ttttatgaag aatttttgtc taggaaagtt taataacagt gttacccaag gttgtgtctg
     2641 taagggtggc tcattttctc tgaccctttg ttactcaaag taaagtacta ggagtcctaa
     2701 gaaatgttct gttcttgtgt attatactga ttaagtcagg attaatttga tttcaaagct
     2761 aagaacagtg ataaaaactt gttttcagaa atgcattttg gaagagaaaa cattgtaaaa
     2821 catgtagtga atgtttcttc agtttcttgt tcagccaatg aggaaagggc attgcctttc
     2881 tttttcccat taatcacttc tcaataaacg tgagagcctg tcgagcatca ctccagtacc
     2941 acttagtatt atttgagtct ctgtgtttgg ggagagattt tggagtctaa ggagttttga
     3001 gaggtgacct agtgactcac tttagacagt ttgtgttaat ggccctgcat ggtgttgcat
     3061 gcctgtaatc cttgcattta ggagacggga gcaggatgga tgaggtcaga ggttatcctc
     3121 aggccagttg ggctacatga gaccctgtca acaaaaaggt tgtattggaa ggacattgct
     3181 ttgtacccaa ggactagaaa cctgctgtga cgatattcat aatgcctgtt tctggttctt
     3241 tatatagaga aaacacagca ctgctaaacc attcagcagt atttgtgtgt atggtgccag
     3301 gtactgtgct aattccatag gaacctcacc ctgtaaaaag aggtggcacc cactatccca
     3361 gtatgtaagt gtctgatcca gtatatggct gatttagaca gtatgcccca gagatgtagg
     3421 tcccaaaaat gaaattctag tggaactcac agaggaattt gtttctttcc ctaaggctta
     3481 attaaaaggc ttttctgctt tagagagtct ttactcttaa gatgtcctaa ttctagaggg
     3541 ttaaatgttc aaaaactcta tactaagaga ttctggaaat aaagcttaat actgtggaca
     3601 gtgttacact ggaatgcagg gccgtgctca cacagccaga ctgctaagaa aggcagctca
     3661 gggatgctgg gatatcgctc agtcagccgg tgtgccctgc gccatcaagg aaaagcagtg
     3721 ttggtttcta gcattgtagc cagcaaaggc acggcaaagg cttgtgcata tttgtttctg
     3781 ccaagttttt ttttttttaa aggtttattt atgcatatga gcacgctctc ttcatgcaca
     3841 ccagaagaga gcatcagatc ccattacaga tagctagctg tgagccacct tgtggtttcg
     3901 gggaattgaa ctcagaatct ctggaagagc agtcagtgct cctgaccgct gagccactct
     3961 ccagccacct ctgccaaact ttttattata aaatatatct tcaatattgg agttctcagt
     4021 gtttttgtta gttggaatat acaaattttt tacatttaat taaaaaaaat gtatgtgc
//
