LOCUS       NM_173761               3199 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus YTH N6-methyladenosine RNA binding protein 1 (Ythdf1),
            mRNA.
ACCESSION   NM_173761
VERSION     NM_173761.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3199)
  AUTHORS   Wang,Y., Zhang,S., Kang,N., Dong,L., Ni,H., Liu,S., Chong,S.,
            Ji,Z., Wan,Z., Chen,X., Wang,F., Lu,Y., Hou,B., Tong,P., Qi,H.,
            Xu,M.M. and Liu,W.
  TITLE     Progressive polyadenylation and m6A modification of Ighg1 mRNA
            maintain IgG1 antibody homeostasis in antibody-secreting cells
  JOURNAL   Immunity 57 (11), 2547-2564 (2024)
   PUBMED   39476842
REFERENCE   2  (bases 1 to 3199)
  AUTHORS   Zhao,W., Li,R., Zhong,X. and Huang,P.
  TITLE     Deletion of YTHDF1 (not YTHDF3) reduced brain and gut damage after
            traumatic brain injury
  JOURNAL   Neurol Res 46 (11), 1037-1045 (2024)
   PUBMED   39081030
  REMARK    GeneRIF: Deletion of YTHDF1 (not YTHDF3) reduced brain and gut
            damage after traumatic brain injury.
REFERENCE   3  (bases 1 to 3199)
  AUTHORS   Mao,Y., Meng,Y., Zou,K., Qin,N., Wang,Y., Yan,J., Chen,P.,
            Cheng,Y., Shi,W., Zhou,C., Chen,H., Sheng,J., Liu,X., Pan,J. and
            Huang,H.
  TITLE     Advanced paternal age exacerbates neuroinflammation in offspring
            via m6A modification-mediated intergenerational inheritance
  JOURNAL   J Neuroinflammation 21 (1), 249 (2024)
   PUBMED   39367406
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3199)
  AUTHORS   Ou,C., Zhang,K., Mu,Y., Huang,Z., Li,X., Huang,W., Wang,Y., Zeng,W.
            and Ouyang,H.
  TITLE     YTHDF1 in periaqueductal gray inhibitory neurons contributes to
            morphine withdrawal responses in mice
  JOURNAL   BMC Med 22 (1), 406 (2024)
   PUBMED   39304892
  REMARK    GeneRIF: YTHDF1 in periaqueductal gray inhibitory neurons
            contributes to morphine withdrawal responses in mice.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3199)
  AUTHORS   Wang,S., Zhang,W., Wang,Z., Liu,Z., Yi,X. and Wu,J.
  TITLE     Mettl3-m6A-YTHDF1 axis promotion of mitochondrial dysfunction in
            metabolic dysfunction-associated steatotic liver disease
  JOURNAL   Cell Signal 121, 111303 (2024)
   PUBMED   39019337
  REMARK    GeneRIF: Mettl3-m6A-YTHDF1 axis promotion of mitochondrial
            dysfunction in metabolic dysfunction-associated steatotic liver
            disease.
REFERENCE   6  (bases 1 to 3199)
  AUTHORS   Han,B., Yan,S., Wei,S., Xiang,J., Liu,K., Chen,Z., Bai,R.,
            Sheng,J., Xu,Z. and Gao,X.
  TITLE     YTHDF1-mediated translation amplifies Wnt-driven intestinal
            stemness
  JOURNAL   EMBO Rep 21 (4), e49229 (2020)
   PUBMED   32064749
REFERENCE   7  (bases 1 to 3199)
  AUTHORS   Zhuang,M., Li,X., Zhu,J., Zhang,J., Niu,F., Liang,F., Chen,M.,
            Li,D., Han,P. and Ji,S.J.
  TITLE     The m6A reader YTHDF1 regulates axon guidance through translational
            control of Robo3.1 expression
  JOURNAL   Nucleic Acids Res 47 (9), 4765-4777 (2019)
   PUBMED   30843071
  REMARK    GeneRIF: Our findings identify a mechanism that YTHDF1-mediated
            translation of m6A-modified Robo3.1 mRNA controls pre-crossing axon
            guidance in spinal cord
REFERENCE   8  (bases 1 to 3199)
  AUTHORS   Han,D., Liu,J., Chen,C., Dong,L., Liu,Y., Chang,R., Huang,X.,
            Liu,Y., Wang,J., Dougherty,U., Bissonnette,M.B., Shen,B.,
            Weichselbaum,R.R., Xu,M.M. and He,C.
  TITLE     Anti-tumour immunity controlled through mRNA m6A methylation and
            YTHDF1 in dendritic cells
  JOURNAL   Nature 566 (7743), 270-274 (2019)
   PUBMED   30728504
  REMARK    GeneRIF: Anti-tumour immunity controlled through mRNA m(6)A
            methylation and YTHDF1 in dendritic cells
            Erratum:[Nature. 2019 Apr;568(7751):E3. doi:
            10.1038/s41586-019-1046-1.. PMID: 30911170]
REFERENCE   9  (bases 1 to 3199)
  AUTHORS   Shi,H., Zhang,X., Weng,Y.L., Lu,Z., Liu,Y., Lu,Z., Li,J., Hao,P.,
            Zhang,Y., Zhang,F., Wu,Y., Delgado,J.Y., Su,Y., Patel,M.J., Cao,X.,
            Shen,B., Huang,X., Ming,G.L., Zhuang,X., Song,H., He,C. and Zhou,T.
  TITLE     m6A facilitates hippocampus-dependent learning and memory through
            YTHDF1
  JOURNAL   Nature 563 (7730), 249-253 (2018)
   PUBMED   30401835
  REMARK    GeneRIF: YTHDF1 facilitates translation of m(6)A-methylated
            neuronal mRNAs in response to neuronal stimulation, and this
            process contributes to learning and memory
REFERENCE   10 (bases 1 to 3199)
  AUTHORS   Weng,Y.L., Wang,X., An,R., Cassin,J., Vissers,C., Liu,Y., Liu,Y.,
            Xu,T., Wang,X., Wong,S.Z.H., Joseph,J., Dore,L.C., Dong,Q.,
            Zheng,W., Jin,P., Wu,H., Shen,B., Zhuang,X., He,C., Liu,K., Song,H.
            and Ming,G.L.
  TITLE     Epitranscriptomic m6A Regulation of Axon Regeneration in the Adult
            Mammalian Nervous System
  JOURNAL   Neuron 97 (2), 313-325 (2018)
   PUBMED   29346752
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC065050.1.
            
            On Jan 11, 2004 this sequence version replaced NM_173761.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC065050.1, BC061479.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164140, SAMN01164142
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3199
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 103.5 cM"
     gene            1..3199
                     /gene="Ythdf1"
                     /gene_synonym="2210410K23Rik; 8030473O16"
                     /note="YTH N6-methyladenosine RNA binding protein 1"
                     /db_xref="GeneID:228994"
                     /db_xref="MGI:MGI:1917431"
     exon            1..253
                     /gene="Ythdf1"
                     /gene_synonym="2210410K23Rik; 8030473O16"
                     /inference="alignment:Splign:2.1.0"
     CDS             227..1906
                     /gene="Ythdf1"
                     /gene_synonym="2210410K23Rik; 8030473O16"
                     /note="YTH domain family protein 1; DACA-1 homolog;
                     dermatomyositis associated with cancer putative
                     autoantigen 1 homolog; YTH domain family 1"
                     /codon_start=1
                     /product="YTH domain-containing family protein 1"
                     /protein_id="NP_776122.1"
                     /db_xref="CCDS:CCDS17188.1"
                     /db_xref="GeneID:228994"
                     /db_xref="MGI:MGI:1917431"
                     /translation="MSATSVDPQRTKGQDNKVQNGSLHQKDAVHDNDFEPYLSGQSNP
                     SNSYPSMSDPYLSSYYPPSIGFPYSLSEAPWSTAGDPPIPYLTTYGQLSNGDHHFMHD
                     AVFGQPGGLGNNIYQHRFNFFPENPAFSAWGTSGSQGQQTQSSAYGSSYTYPPSSLGG
                     TVVDGQTGFHSDSLNKAPGMNSLEQGMVGLKIGDVTTSAVKTVGSVVNSVALTGVLSG
                     NGGTNVNMPVSKPTSWAAIASKPAKPQPKMKTKSGPIVGGALPPPPIKHNMDIGTWDN
                     KGPAPKASAPQQTPSPQAAPQPQQVAQPLPVQPPPLVQPQYQSPQQPLQPRWVAPRNR
                     NAAFGQSGGANSDSNSVGNAQPTSAPSVESHPVLEKLKAAHSYNPKEFDWNLKSGRVF
                     IIKSYSEDDIHRSIKYSIWCSTEHGNKRLDGAFRSMSSKGPVYLLFSVNGSGHFCGVA
                     EMKSPVDYGTSAGVWSQDKWKGKFDVKWIFVKDVPNNQLRHIRLENNDNKPVTNSRDT
                     QEVPLEKAKQVLKIIASYKHTTSIFDDFSHYEKRQEEEEVVRKERQNRNKQ"
     exon            254..278
                     /gene="Ythdf1"
                     /gene_synonym="2210410K23Rik; 8030473O16"
                     /inference="alignment:Splign:2.1.0"
     exon            279..358
                     /gene="Ythdf1"
                     /gene_synonym="2210410K23Rik; 8030473O16"
                     /inference="alignment:Splign:2.1.0"
     exon            359..1879
                     /gene="Ythdf1"
                     /gene_synonym="2210410K23Rik; 8030473O16"
                     /inference="alignment:Splign:2.1.0"
     exon            1880..3171
                     /gene="Ythdf1"
                     /gene_synonym="2210410K23Rik; 8030473O16"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3152..3157
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ythdf1"
                     /gene_synonym="2210410K23Rik; 8030473O16"
                     /note="hexamer: AATAAA"
     polyA_site      3171
                     /gene="Ythdf1"
                     /gene_synonym="2210410K23Rik; 8030473O16"
                     /note="major polyA site"
ORIGIN      
        1 gtcccagccg ccgcggccgc cattggagtc ggcgccccct cagcctgtcc gctaccttcc
       61 gctgcttccc gctgttccgg cccgcgtgcc tacagctgcc gccgcgcccg gccgcacccg
      121 cggagttggc ggcggggcac ggggccgcgc gcggcgtgac aggcccggcc tcgtgggagg
      181 cccgagccgg cggcgcccgg gtcccgcgcc gcgctgttca tgaagcatgt cggccaccag
      241 cgtggacccc cagagaacaa aaggacaaga taataaagta caaaatggtt ctttgcatca
      301 gaaggatgca gttcatgaca atgactttga gccctacctt tctggacagt ccaatccgag
      361 taacagttac ccctcgatga gtgatcctta cctgtccagt tactatccac catccattgg
      421 atttccttac tccctcagcg aggcaccatg gtccactgca ggggaccctc ccatcccgta
      481 tctcactacc tatggacaac ttagtaatgg agaccatcac ttcatgcatg atgctgtttt
      541 tgggcagcct gggggtctgg ggaacaacat ttaccagcac aggtttaatt ttttccctga
      601 aaaccctgca ttctcagcat gggggacaag tggttctcag gggcagcaga ctcagagctc
      661 agcctatggg agcagttaca cttacccacc tagctccctt ggtggcacag ttgttgatgg
      721 gcagacaggt tttcacagtg actccctcaa caaggcccct gggatgaaca gtctggagca
      781 gggcatggtt ggcctgaaga ttggggatgt taccacctct gcagttaaga cggtgggttc
      841 agttgtcaac agtgtggcac tgactggtgt cctttctggc aatggtggga caaatgtaaa
      901 catgccagtt tcaaaaccaa cttcatgggc agccattgct agcaagcctg caaaaccaca
      961 gcctaagatg aaaacaaaga gtgggccgat agttgggggt gcactgcctc ctccccctat
     1021 caagcataac atggacattg gtacttggga taacaagggc cctgctccaa aggcctccgc
     1081 cccccagcag acaccatccc cccaggctgc cccacagccc cagcaggtag ctcaacctct
     1141 ccctgttcag cccccacctt tggtccagcc acagtatcag agccctcagc agccacttca
     1201 accccgctgg gtggctcctc gaaacagaaa tgcagcattt gggcagagtg gaggggccaa
     1261 cagtgacagt aactctgttg gaaatgccca acctacttct gccccgagtg tagaatccca
     1321 ccctgtcctg gagaaactga aagctgccca cagctataac cctaaagagt tcgactggaa
     1381 tcttaagagt gggcgggtgt tcatcatcaa gagctattct gaggacgaca tccaccgctc
     1441 catcaagtac tccatctggt gtagtactga acacggcaac aagcgcctgg acggcgcctt
     1501 ccgctccatg agcagcaagg ggcctgttta tctcctcttc agtgtcaatg ggagtggaca
     1561 tttctgtggg gtggcagaga tgaagtcccc tgtggactac ggcaccagcg ctggggtctg
     1621 gtctcaggac aagtggaagg gaaagtttga tgtgaagtgg atttttgtga aggatgtgcc
     1681 caacaaccag ctgcggcaca tcagactgga gaataacgac aacaaacctg tcacaaactc
     1741 ccgtgataca caggaggtgc ccttagaaaa agcaaaacaa gtgctgaaga ttatcgcttc
     1801 ctataagcac acaacctcta tctttgacga cttttctcat tatgagaagc gccaggagga
     1861 agaggaggtg gtgcgtaagg aaagacagaa tcgaaacaaa caataagaac aagccagttt
     1921 gtttttggtt aatggttgac tttgaaaaca gagttttaaa gctgtatgct tggtgctgtc
     1981 tccgagtcag ctccagtgtc gtcctcgtgc ggggttgatt gttgcatctt tatctttgta
     2041 gttcattttt gccagatgga tctgcattca tttgtatttt tctatgtatt ataatattgt
     2101 agaactcact aataaaggag tattttgttt gtcagcttat cagtcagatt gacctaatgc
     2161 aaaatataaa tattcttcaa aacaaaacac ctaatacatc ccaaagatat ttttattttg
     2221 gcagaaatta tgttcttatt cttatatcta gccatttaat atccctatag gatacttcat
     2281 atttcttgtc ctctcctgct ttacagcaaa caaaaagccc attcagcatg tgctgttgat
     2341 gtctcttcac agtactgaag tggcttgcca ttttactatc tgtggtatcc atcatattgc
     2401 tgacctgccc ttttgagttt cctactagac aaataacttt tagttttaag tgtgctcaca
     2461 gctgtctatg ggcaagctgt ccatagttta gtgcccacac agagcggtgc tccagttctc
     2521 cttgccaccg tctgccactg catgaggttt gggctctgtg gcaaggaact agaaggtgtt
     2581 ttaagtctgg ttcagctttg cgacattctt agttgttcgt agatcatttt tagttgtcct
     2641 ctttcttctc tagagaatcc tgatgctgtc ttaagttttt ataccagtaa cgctaagctt
     2701 taattgtagg aatctgatag tacaggcagt gtgatggatg ctgctgccga ctgtaaattt
     2761 cactgtgtgt ctattttttt tttctgttga atgggtgaaa aaagcaaaaa aacaaaaaat
     2821 cctttagaaa acaaatttgc tatcatgttt tgtggaatga ggagcctcgg aggagctcac
     2881 cgccatctgg agttggagtt tagcatgaaa gtggtgctca tgcccgacgc cctcgcatac
     2941 tgaatctgca cgcgcccact gtagaggatc tttactgtct tagagagcag ataccttccg
     3001 aaactattta ctccaaaaga ccctctgagt taacatttaa gctgtattat ttagacttgt
     3061 atttagaacg tgtcacttcc tcgagctgtt actgcctgta cggagtcgtg gacaacatcg
     3121 gatacctgtc ctctaggaga atacaagcct taataaacac ctgttgagca aaaaaaaaaa
     3181 aaaaaaaaaa aaaaaaaaa
//
