LOCUS       NM_001359907            3272 bp    mRNA    linear   ROD 19-NOV-2024
DEFINITION  Mus musculus YTH domain containing 1 (Ythdc1), transcript variant
            4, mRNA.
ACCESSION   NM_001359907 XM_006534864
VERSION     NM_001359907.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3272)
  AUTHORS   Ma,Z., Niu,H., Qi,H. and Li,Y.
  TITLE     Functional role of lncRNA MEG3 on pyroptosis through interacting
            with EZH2 and YTHDC1 in postoperative cognitive dysfunction
  JOURNAL   Brain Res Bull 217, 111060 (2024)
   PUBMED   39236791
  REMARK    GeneRIF: Functional role of lncRNA MEG3 on pyroptosis through
            interacting with EZH2 and YTHDC1 in postoperative cognitive
            dysfunction.
REFERENCE   2  (bases 1 to 3272)
  AUTHORS   Mao,Y., Meng,Y., Zou,K., Qin,N., Wang,Y., Yan,J., Chen,P.,
            Cheng,Y., Shi,W., Zhou,C., Chen,H., Sheng,J., Liu,X., Pan,J. and
            Huang,H.
  TITLE     Advanced paternal age exacerbates neuroinflammation in offspring
            via m6A modification-mediated intergenerational inheritance
  JOURNAL   J Neuroinflammation 21 (1), 249 (2024)
   PUBMED   39367406
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3272)
  AUTHORS   Deng,W., Zhong,L., Ye,S., Luo,J., Ren,G., Huang,J. and Zhuang,X.
  TITLE     Mir22hg facilitates ferritinophagy-mediated ferroptosis in sepsis
            by recruiting the m6A reader YTHDC1 and enhancing Angptl4 mRNA
            stability
  JOURNAL   J Bioenerg Biomembr 56 (4), 405-418 (2024)
   PUBMED   38842666
  REMARK    GeneRIF: Mir22hg facilitates ferritinophagy-mediated ferroptosis in
            sepsis by recruiting the m6A reader YTHDC1 and enhancing Angptl4
            mRNA stability.
REFERENCE   4  (bases 1 to 3272)
  AUTHORS   Zhang,M., Guan,J., Yu,S., Zhang,Y., Cheng,L. and Zhang,Y.
  TITLE     YTHDC1 inhibits osteoclast differentiation to alleviate
            osteoporosis by enhancing PTPN6 messenger RNA stability in an
            m6A-hUR-dependent manner
  JOURNAL   J Leukoc Biol 115 (6), 1154-1164 (2024)
   PUBMED   38289832
  REMARK    GeneRIF: YTHDC1 inhibits osteoclast differentiation to alleviate
            osteoporosis by enhancing PTPN6 messenger RNA stability in an
            m6A-hUR-dependent manner.
REFERENCE   5  (bases 1 to 3272)
  AUTHORS   Zhang,C., Chen,L., Xie,C., Wang,F., Wang,J., Zhou,H., Liu,Q.,
            Zeng,Z., Li,N., Huang,J., Zhao,Y. and Liu,H.
  TITLE     YTHDC1 delays cellular senescence and pulmonary fibrosis by
            activating ATR in an m6A-independent manner
  JOURNAL   EMBO J 43 (1), 61-86 (2024)
   PUBMED   38177310
  REMARK    GeneRIF: YTHDC1 delays cellular senescence and pulmonary fibrosis
            by activating ATR in an m6A-independent manner.
REFERENCE   6  (bases 1 to 3272)
  AUTHORS   Taniwaki,T., Haruna,K., Nakamura,H., Sekimoto,T., Oike,Y.,
            Imaizumi,T., Saito,F., Muta,M., Soejima,Y., Utoh,A., Nakagata,N.,
            Araki,M., Yamamura,K. and Araki,K.
  TITLE     Characterization of an exchangeable gene trap using pU-17 carrying
            a stop codon-beta geo cassette
  JOURNAL   Dev Growth Differ 47 (3), 163-172 (2005)
   PUBMED   15840001
REFERENCE   7  (bases 1 to 3272)
  AUTHORS   Okazaki,N., F-Kikuno,R., Ohara,R., Inamoto,S., Koseki,H.,
            Hiraoka,S., Saga,Y., Seino,S., Nishimura,M., Kaisho,T., Hoshino,K.,
            Kitamura,H., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: IV. The complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (3), 205-218 (2004)
   PUBMED   15368895
REFERENCE   8  (bases 1 to 3272)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (bases 1 to 3272)
  AUTHORS   Nelson,P.S., Pritchard,C., Abbott,D. and Clegg,N.
  TITLE     The human (PEDB) and mouse (mPEDB) Prostate Expression Databases
  JOURNAL   Nucleic Acids Res 30 (1), 218-220 (2002)
   PUBMED   11752298
REFERENCE   10 (bases 1 to 3272)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC102016.4.
            
            On Jan 19, 2018 this sequence version replaced XM_006534864.1.
            
            Transcript Variant: This variant (4) encodes the longest isoform
            (4).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660813.923.1,
                                           SRR1660819.104646.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-326               AC102016.4         42608-42933         c
            327-362             AC102016.4         37859-37894         c
            363-464             AC102016.4         31469-31570         c
            465-793             AC102016.4         30407-30735         c
            794-1220            AC102016.4         29866-30292         c
            1221-1310           AC102016.4         27024-27113         c
            1311-1364           AC102016.4         26513-26566         c
            1365-1459           AC102016.4         25853-25947         c
            1460-1568           AC102016.4         24495-24603         c
            1569-1686           AC102016.4         24291-24408         c
            1687-1771           AC102016.4         20388-20472         c
            1772-1938           AC102016.4         19078-19244         c
            1939-2021           AC102016.4         16563-16645         c
            2022-2058           AC102016.4         15499-15535         c
            2059-2098           AC102016.4         15363-15402         c
            2099-2161           AC102016.4         15189-15251         c
            2162-2296           AC102016.4         13557-13691         c
            2297-3272           AC102016.4         10540-11515         c
FEATURES             Location/Qualifiers
     source          1..3272
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 43.56 cM"
     gene            1..3272
                     /gene="Ythdc1"
                     /gene_synonym="A730098D12Rik; mKIAA1966"
                     /note="YTH domain containing 1"
                     /db_xref="GeneID:231386"
                     /db_xref="MGI:MGI:2443713"
     exon            1..326
                     /gene="Ythdc1"
                     /gene_synonym="A730098D12Rik; mKIAA1966"
                     /inference="alignment:Splign:2.1.0"
     exon            327..362
                     /gene="Ythdc1"
                     /gene_synonym="A730098D12Rik; mKIAA1966"
                     /inference="alignment:Splign:2.1.0"
     exon            363..464
                     /gene="Ythdc1"
                     /gene_synonym="A730098D12Rik; mKIAA1966"
                     /inference="alignment:Splign:2.1.0"
     exon            465..793
                     /gene="Ythdc1"
                     /gene_synonym="A730098D12Rik; mKIAA1966"
                     /inference="alignment:Splign:2.1.0"
     exon            794..1220
                     /gene="Ythdc1"
                     /gene_synonym="A730098D12Rik; mKIAA1966"
                     /inference="alignment:Splign:2.1.0"
     exon            1221..1310
                     /gene="Ythdc1"
                     /gene_synonym="A730098D12Rik; mKIAA1966"
                     /inference="alignment:Splign:2.1.0"
     exon            1311..1364
                     /gene="Ythdc1"
                     /gene_synonym="A730098D12Rik; mKIAA1966"
                     /inference="alignment:Splign:2.1.0"
     exon            1365..1459
                     /gene="Ythdc1"
                     /gene_synonym="A730098D12Rik; mKIAA1966"
                     /inference="alignment:Splign:2.1.0"
     exon            1460..1568
                     /gene="Ythdc1"
                     /gene_synonym="A730098D12Rik; mKIAA1966"
                     /inference="alignment:Splign:2.1.0"
     exon            1569..1686
                     /gene="Ythdc1"
                     /gene_synonym="A730098D12Rik; mKIAA1966"
                     /inference="alignment:Splign:2.1.0"
     exon            1687..1771
                     /gene="Ythdc1"
                     /gene_synonym="A730098D12Rik; mKIAA1966"
                     /inference="alignment:Splign:2.1.0"
     exon            1772..1938
                     /gene="Ythdc1"
                     /gene_synonym="A730098D12Rik; mKIAA1966"
                     /inference="alignment:Splign:2.1.0"
     exon            1939..2021
                     /gene="Ythdc1"
                     /gene_synonym="A730098D12Rik; mKIAA1966"
                     /inference="alignment:Splign:2.1.0"
     exon            2022..2058
                     /gene="Ythdc1"
                     /gene_synonym="A730098D12Rik; mKIAA1966"
                     /inference="alignment:Splign:2.1.0"
     exon            2059..2098
                     /gene="Ythdc1"
                     /gene_synonym="A730098D12Rik; mKIAA1966"
                     /inference="alignment:Splign:2.1.0"
     exon            2099..2161
                     /gene="Ythdc1"
                     /gene_synonym="A730098D12Rik; mKIAA1966"
                     /inference="alignment:Splign:2.1.0"
     exon            2162..2296
                     /gene="Ythdc1"
                     /gene_synonym="A730098D12Rik; mKIAA1966"
                     /inference="alignment:Splign:2.1.0"
     exon            2297..3272
                     /gene="Ythdc1"
                     /gene_synonym="A730098D12Rik; mKIAA1966"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3100..3105
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ythdc1"
                     /gene_synonym="A730098D12Rik; mKIAA1966"
                     /note="hexamer: AATAAA"
     polyA_site      3123
                     /gene="Ythdc1"
                     /gene_synonym="A730098D12Rik; mKIAA1966"
     regulatory      3255..3260
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ythdc1"
                     /gene_synonym="A730098D12Rik; mKIAA1966"
                     /note="hexamer: GATAAA"
     polyA_site      3272
                     /gene="Ythdc1"
                     /gene_synonym="A730098D12Rik; mKIAA1966"
                     /note="major polyA site"
ORIGIN      
        1 gcgccgcccg gcgtcgccat ctgtgtctct ctcctccccc ttgtctctgt ggtggccgaa
       61 ccccaacagg aaggctgaag cccgcgccga ccgaggccag agagccaggc gggaagagaa
      121 ccagagcacg ggaggaaggg ttgcgcgtag gaagctgagt ggagcaggtc aggtcgaagc
      181 gcgcggcccg ccggacggac tgacggacgg actcgtgcgc ctgcggccgc gtctgcggcg
      241 cccgcgcgac tcgcgtcccg gcggcggcgg tggcggcggc ggaagccgga gggcagccat
      301 ggcggccgac agccgggagg agaaagaaga ttgccaagac tgctccagct ggttgttttc
      361 agatggggaa cttaatgttt tggatgatat tttgactgaa gtaccagaac aggatgatga
      421 attgtataat ccagagagtg aacaagataa aaatgagaaa aaaggatcaa aaagaaaaag
      481 tgagagaatg gagtctactg acaccaagcg acaaaaacct tccatccatt caagacaatt
      541 gatttctaag ccactaagct catctgtaag caataataaa agaatagtta gtacaaaagg
      601 aaagtcggtt acagaatata aaaatgagga atatcaaaga tctgaaagga acaagcgtct
      661 agatgctgat cgaaaaattc gtctgtcaag cagttcctct agagaacctt acaagagtca
      721 accagaaaaa acttgtctac ggaaaaggga ttctgaaaga agggccaagt ctcctacacc
      781 agatggttct gagagaattg ggcttgaagt tgatagacgt gcaagcagat ccagccagtc
      841 ttcaaaggaa gaggtgaact ctgaagacta tggctctgac cacgagacag gaagcagtgg
      901 ttcttctgaa cagggcaaca acactgagaa tgaggaggaa ggaggggagg aagatgtaga
      961 ggaagatgaa gaggtagatg aagatgcaga agatgatgag gaagtggatg aagatgcaga
     1021 ggaggaggag gaagaggatg aagaggaaga agaggatgag gacgaggatg aagaggaaga
     1081 agaatatgaa caggatgaga gagatcagaa ggaagaaggg aatgattatg acacccgaag
     1141 tgaggccagt gattctggtt ccgagtctgt ttccttcaca gatggatctg tcagatctgg
     1201 gtcaggaaca gatggatcag atgagaaaaa gaaggaaagg aagagagctc gaggcatatc
     1261 acccattgtc tttgatagaa gtggcagttc tgcatcagag tcatatgcag gttcagaaaa
     1321 gaagcatgag aaattatcat cttccgttcg tgctgtccga aaagatcaaa ccagtaaact
     1381 caaatatgtc cttcaggatg caagattttt cctcataaag agtaataacc atgagaatgt
     1441 gtctcttgcc aaagcaaagg gtgtatggtc cacattgcct gtaaatgaga agaaattaaa
     1501 tcttgcattt agatctgcaa ggagtgttat attaatattt tctgtcagag aaagtggaaa
     1561 atttcaaggt tttgccagat tgtcttcaga atcacaccat ggcggatctc ctatacactg
     1621 ggtgcttcca gcaggaatga gtgctaaaat gcttggaggt gtttttaaaa tagactggat
     1681 ttgcaggcgt gaattaccct ttactaaatc agctcatctc accaatccct ggaatgaaca
     1741 taagccagta aagattggac gtgatggaca ggaaattgaa cttgaatgtg gaactcagct
     1801 ttgtcttctg tttccccctg atgaaagtat tgacttgtat cagctcattc ataaaatgcg
     1861 tcacaagaga agaatgcatt ctcagcctcg atcaagagga cgtccatccc gtcgagaacc
     1921 agtccgggat gtgggaaggc gtcgaccaga agattatgat attcataaca gcagaaagaa
     1981 accaaggatt gactatcccc ctgagtttca ccagagacca gggtatgtaa aggatccccg
     2041 ataccaggaa gtggacagac gattttcagg agttcgccga gatgtgtttt taaatgggtc
     2101 ctacaatgat tatgtgaggg aatttcataa catgggacca ccgcctcctt ggcaaggaat
     2161 gcctccttac ccgggaatag aacaacctcc acaccatcct tactaccagc accatgcccc
     2221 acctcctcaa gcccaccccc cttactcagg acaccatccg gtaccacatg aagcaagata
     2281 cagagataaa cgagtacatg actatgatat gagggtcgat gatttccttc gccgcacgca
     2341 agctgtggtc agtggtcgga gaagtagacc tcgagaaaga gatcgggagc gagagcgaga
     2401 ccgccccaga gataacagaa gagatagaga gcgagacaga ggtcgtgatc gagaaagaga
     2461 gagagaaaga atatgtgatc gggacagaga ccgaggggag agaggtcgtt atcgaagata
     2521 atgtgctttt ggaagcactg actgaagata aagaaaatat tgtatttttt ttgtgtgtgt
     2581 ttacaagtag taaatttatt ttcagctgtc gacttaaagc tcattgtgta gaaggattta
     2641 ttatcacctt tgttccaagc atgcagtaga ataagaactg gaaaactcag atccgccaaa
     2701 aaaatgcaca gttgacagtt gggttgactc ttttattggg gcagaatgga acagtccaag
     2761 aatgtagata ttgattcatt ctccataaat gttcttttta cagtgtattc atcctagagt
     2821 tattttgttt gtttgttctc cttttggacc ttggtcaata actgccatag aatttcgctt
     2881 tgtgtttcta taggtagctg ctcacggttc agtaaaaata ctgctgctat caagtatgca
     2941 aatatggaag tatgatggtt tgactatatg gcagtgttgt agcagcctct cggtttttcc
     3001 tctttcctcc ttttttttaa acctataaag tcacttttaa gtcttcaatg atgagagcaa
     3061 tattaagaag acgttgctat ctaattttta atctttttaa ataaaaagtt cctgtgttca
     3121 gtagcatggt taatgctatt gtttagcctc ccttttaaac tgtacactgg cttggaatgt
     3181 tcacagtttc gcgtgtgtgg cagcagaaga taaccccaca ttctacattg ctactgtttt
     3241 gtatgaaata aattgataaa gattgacact aa
//
