LOCUS       NM_023249               2879 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus yippee like 1 (Ypel1), transcript variant 2, mRNA.
ACCESSION   NM_023249 NM_023769 NM_023782 XM_359233
VERSION     NM_023249.6
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2879)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2879)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   3  (bases 1 to 2879)
  AUTHORS   Hosono,K., Noda,S., Shimizu,A., Nakanishi,N., Ohtsubo,M.,
            Shimizu,N. and Minoshima,S.
  TITLE     YPEL5 protein of the YPEL gene family is involved in the cell cycle
            progression by interacting with two distinct proteins RanBPM and
            RanBP10
  JOURNAL   Genomics 96 (2), 102-111 (2010)
   PUBMED   20580816
REFERENCE   4  (bases 1 to 2879)
  AUTHORS   Cotter,L., Ozcelik,M., Jacob,C., Pereira,J.A., Locher,V.,
            Baumann,R., Relvas,J.B., Suter,U. and Tricaud,N.
  TITLE     Dlg1-PTEN interaction regulates myelin thickness to prevent
            damaging peripheral nerve overmyelination
  JOURNAL   Science 328 (5984), 1415-1418 (2010)
   PUBMED   20448149
REFERENCE   5  (bases 1 to 2879)
  AUTHORS   Hosono,K., Sasaki,T., Minoshima,S. and Shimizu,N.
  TITLE     Identification and characterization of a novel gene family YPEL in
            a wide spectrum of eukaryotic species
  JOURNAL   Gene 340 (1), 31-43 (2004)
   PUBMED   15556292
REFERENCE   6  (bases 1 to 2879)
  AUTHORS   Chiellini,C., Costa,M., Novelli,S.E., Amri,E.Z., Benzi,L.,
            Bertacca,A., Cohen,P., Del Prato,S., Friedman,J.M. and Maffei,M.
  TITLE     Identification of cathepsin K as a novel marker of adiposity in
            white adipose tissue
  JOURNAL   J Cell Physiol 195 (2), 309-321 (2003)
   PUBMED   12652657
REFERENCE   7  (bases 1 to 2879)
  AUTHORS   Farlie,P., Reid,C., Wilcox,S., Peeters,J., Reed,G. and Newgreen,D.
  TITLE     Ypel1: a novel nuclear protein that induces an epithelial-like
            morphology in fibroblasts
  JOURNAL   Genes Cells 6 (7), 619-629 (2001)
   PUBMED   11473580
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB649357.1, AK006505.1, AK139453.1 and AK014931.1.
            
            On Mar 23, 2014 this sequence version replaced NM_023249.5.
            
            Transcript Variant: This variant (2) lacks an alternate in-frame
            exon in the 5' coding region and uses a downstream start codon
            compared to variant 1. It encodes isoform 2 which has a shorter
            N-terminus compared to isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK139453.1, SRR1660817.3548.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-191               BB649357.1         1-191
            192-996             AK006505.1         3-807
            997-1182            AK139453.1         905-1090
            1183-1183           AK014931.1         1008-1008
            1184-2879           AK139453.1         1092-2787
FEATURES             Location/Qualifiers
     source          1..2879
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 10.58 cM"
     gene            1..2879
                     /gene="Ypel1"
                     /gene_synonym="0610009L05Rik; 1700016N17Rik;
                     1700019O22Rik; 4921520K19Rik; 4930511F14Rik; DGL-1; Dgl1;
                     mdgl-1; Ppil2"
                     /note="yippee like 1"
                     /db_xref="GeneID:106369"
                     /db_xref="MGI:MGI:1913303"
     exon            1..225
                     /gene="Ypel1"
                     /gene_synonym="0610009L05Rik; 1700016N17Rik;
                     1700019O22Rik; 4921520K19Rik; 4930511F14Rik; DGL-1; Dgl1;
                     mdgl-1; Ppil2"
                     /inference="alignment:Splign:2.1.0"
     exon            226..505
                     /gene="Ypel1"
                     /gene_synonym="0610009L05Rik; 1700016N17Rik;
                     1700019O22Rik; 4921520K19Rik; 4930511F14Rik; DGL-1; Dgl1;
                     mdgl-1; Ppil2"
                     /inference="alignment:Splign:2.1.0"
     CDS             389..745
                     /gene="Ypel1"
                     /gene_synonym="0610009L05Rik; 1700016N17Rik;
                     1700019O22Rik; 4921520K19Rik; 4930511F14Rik; DGL-1; Dgl1;
                     mdgl-1; Ppil2"
                     /note="isoform 2 is encoded by transcript variant 2;
                     cardiac Abnormality/abnormal facies (CATCH22),
                     microdeletion syndrome; protein yippee-like 1"
                     /codon_start=1
                     /product="protein yippee-like 1 isoform 2"
                     /protein_id="NP_075738.1"
                     /db_xref="CCDS:CCDS37268.1"
                     /db_xref="GeneID:106369"
                     /db_xref="MGI:MGI:1913303"
                     /translation="MVKMTKSKTFQAYLPHCHRTYSCIHCRAHLANHDELISKSFQGS
                     QGRAYLFNSVVNVGCGPAEERVLLTGLHAVADIYCENCKTTLGWKYEHAFESSQKYKE
                     GKFIIELAHMIKDNGW"
     exon            506..549
                     /gene="Ypel1"
                     /gene_synonym="0610009L05Rik; 1700016N17Rik;
                     1700019O22Rik; 4921520K19Rik; 4930511F14Rik; DGL-1; Dgl1;
                     mdgl-1; Ppil2"
                     /inference="alignment:Splign:2.1.0"
     exon            550..658
                     /gene="Ypel1"
                     /gene_synonym="0610009L05Rik; 1700016N17Rik;
                     1700019O22Rik; 4921520K19Rik; 4930511F14Rik; DGL-1; Dgl1;
                     mdgl-1; Ppil2"
                     /inference="alignment:Splign:2.1.0"
     exon            659..2879
                     /gene="Ypel1"
                     /gene_synonym="0610009L05Rik; 1700016N17Rik;
                     1700019O22Rik; 4921520K19Rik; 4930511F14Rik; DGL-1; Dgl1;
                     mdgl-1; Ppil2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2464..2469
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ypel1"
                     /gene_synonym="0610009L05Rik; 1700016N17Rik;
                     1700019O22Rik; 4921520K19Rik; 4930511F14Rik; DGL-1; Dgl1;
                     mdgl-1; Ppil2"
                     /note="hexamer: AACAAA"
     polyA_site      2484
                     /gene="Ypel1"
                     /gene_synonym="0610009L05Rik; 1700016N17Rik;
                     1700019O22Rik; 4921520K19Rik; 4930511F14Rik; DGL-1; Dgl1;
                     mdgl-1; Ppil2"
                     /note="major polyA site"
     regulatory      2516..2521
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ypel1"
                     /gene_synonym="0610009L05Rik; 1700016N17Rik;
                     1700019O22Rik; 4921520K19Rik; 4930511F14Rik; DGL-1; Dgl1;
                     mdgl-1; Ppil2"
                     /note="hexamer: TATAAA"
     polyA_site      2540
                     /gene="Ypel1"
                     /gene_synonym="0610009L05Rik; 1700016N17Rik;
                     1700019O22Rik; 4921520K19Rik; 4930511F14Rik; DGL-1; Dgl1;
                     mdgl-1; Ppil2"
     polyA_site      2835
                     /gene="Ypel1"
                     /gene_synonym="0610009L05Rik; 1700016N17Rik;
                     1700019O22Rik; 4921520K19Rik; 4930511F14Rik; DGL-1; Dgl1;
                     mdgl-1; Ppil2"
ORIGIN      
        1 tgattgggca tcgccacgtt ccgaggccgt ttatggcggc tgggctgggc tacgggtcca
       61 aaacaaaggg caggcggccc gcgaggcggc ggcaggagga tgcctcgcgc ccggagtggg
      121 cgccaacggc cggagcgcgt cccgggtcac accgggaccg cctgaaaacc gagctcgcgc
      181 cgaccgagcc tgggccggat gggcgcagcg gaccgcggag cggccgttgc actggcgttc
      241 ccttgcccca gtgtgtggac agcaccacac gccctccaga ccagcaacgg ctcttgcata
      301 tactttccag tgtttttgtc agagagtccg acagagccct agctcctcca gagctggccc
      361 agaaccgagt gacgagagcc cagcagacat ggtgaaaatg accaagtcca aaactttcca
      421 agcttatctg ccacactgtc accgaactta cagctgcatc cactgcagag cccatctggc
      481 caatcacgat gagcttatct ccaagtcctt tcagggaagc caggggcgag cctacctctt
      541 caactctgtg gtgaatgtgg gctgtggccc cgctgaggag agagtccttc taaccgggct
      601 gcatgcagtg gccgacatct actgtgagaa ctgcaagacc acactcgggt ggaaatacga
      661 acatgccttt gagagcagtc agaaatacaa ggaaggaaaa tttattattg aacttgccca
      721 catgatcaaa gacaacggct ggtaaagtga agcggtccac tcctgtttga atcctatttt
      781 atgaaagctg agtgtacaga agacctagct tcttggtgac aatgcttctt gaacttaacc
      841 tcacaggcca gcccagtctc aacacttgaa ggtgtctctc taggctatcc acttggtaag
      901 gtgcccattt gaatccctgt cgtgtacaat gcgtttttgg aagtctgagt tctttttcta
      961 acatcttaag ttctagagaa agaattgacc agctggtgac tcacctgcct agtgaatact
     1021 ttcttttacc ctacgcctgc aatgcctggc tgtgttctca ccaagcccaa gtccctaaaa
     1081 gcagagaagc aaggtctcct cacaagcaaa ggcatagtta ccagaagtaa agcatgtctc
     1141 caaaaactga aaccagccac tggtaacatg gaagagaagc taggaagcaa gcattcagtg
     1201 tacatcttaa gcaaataggg aggttcctga tgtagaaggc gagtgactta ctggtggctg
     1261 aacgctctgt cccagggcta cccaagtctg ccactgagct gactcccttg gtgctgcggc
     1321 agcacagcgg ctcagaatgt agggctggtc cctgccacag agcaacaggc tgggtttcac
     1381 tttataccct ggatgtactt gaaatagtta tgcatacaga ggccagagcc agtacgggaa
     1441 actgcaaaac atgagagttt tccaaggtaa aggaagagtt agcttagtat gggagctacc
     1501 ttttctgcct ggaatcacct catgacctga caagggagga tctgggccat cccccaagcc
     1561 caggctctca gattttaagt cacaacacat catactctat aaggagtggc caatttgcag
     1621 agaggatgga ggccagaacc attcccagat aagtttcatt gttttgtacc ctccccaggg
     1681 cagaagggca ggcagtaggc ctgtgaaggc tgagagccct tgagctgcaa aggcagcatt
     1741 acaggaaagc gcttagcacc ggctgctcta gagctgcctg ggtgtggtag tcaaaaagca
     1801 gtttctatct agacctttgg gctccagccc cagacctgct aaacccacat cctctggcca
     1861 gcacaggcac tcgctactcc tcttcacttc aaaacctaca ttttggtgcc atttctttgc
     1921 ccaagattgg aaggctggta atacaggaaa tgcctgcgca atgctggtcc tagcccaagc
     1981 tgctttttcc ccagctactt ccagtttccc tctagactaa ggctggcaaa gcaaagtgac
     2041 tctaccagta aggtaagtgc tgaaactcag cacaagcagc cgtgtgacct tggcaaggct
     2101 cagggccatc cttatctagg aatgaacact ggtcaacagt ctgctcaaac tggacatgcc
     2161 cgcctggcta gtttttaata cttttcagag tgggaacttg gtggctgagg catgggcggc
     2221 tttccccagt gggaaggcgg caagggagac agacccgagt acgtccttat agatgcctca
     2281 gtaaagctga agagtcttgg agaagtcttc tgtatatact aagattatat ttagacttta
     2341 tgctctgggc atgctatctg cccctcaact gagcactctg tattatcttt tgtgagagct
     2401 ctgactggaa cgtttttgct agtactctat atgacttacc tgtattgggg agtaatggat
     2461 ataaacaaac catttatcaa ggtttttttg gattttgcgt tggccttctg tgaaatataa
     2521 accaaaagaa ctgaccatga gctggcttca gggtaagtga tgcaagacca caaccaggca
     2581 tgctggtaaa ccactgaatg tctcacctcc ttacatttgt aaacagcacc attctgtgac
     2641 tattttaaag aggtttcctc agaacagtgg gaggtgatac caggtcatga acgccacttt
     2701 gctttagaaa tgtggtttat ttccttgttg tcttgttact gtatacatag tatttttata
     2761 ccttaatgct tattcttgat ggcatctgtc aggtatttga agagatcaga aatgagattt
     2821 tttttcccct caaaagtcct ttattttctg atgagctcat caggcagttt tcaaaatcc
//
