LOCUS       NM_178691               6126 bp    mRNA    linear   ROD 08-FEB-2025
DEFINITION  Mus musculus YOD1 deubiquitinase (Yod1), mRNA.
ACCESSION   NM_178691
VERSION     NM_178691.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6126)
  AUTHORS   Liu,C., Fan,C., Liu,J., Zhang,S., Tang,H., Liu,Y., Zhang,S., Wu,Q.,
            Zhang,J., Qi,Z. and Shen,Y.
  TITLE     YOD1 protects against MRSA sepsis-induced DIC through Lys33-linked
            deubiquitination of NLRP3
  JOURNAL   Cell Death Dis 15 (5), 360 (2024)
   PUBMED   38789414
  REMARK    GeneRIF: YOD1 protects against MRSA sepsis-induced DIC through
            Lys33-linked deubiquitination of NLRP3.
            Erratum:[Cell Death Dis. 2024 Sep 4;15(9):651. doi:
            10.1038/s41419-024-06991-1.. PMID: 39231970]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6126)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 6126)
  AUTHORS   Park,J.H., Kim,S.Y., Cho,H.J., Lee,S.Y. and Baek,K.H.
  TITLE     YOD1 Deubiquitinates NEDD4 Involved in the Hippo Signaling Pathway
  JOURNAL   Cell Physiol Biochem 54 (1), 1-14 (2020)
   PUBMED   31916733
  REMARK    GeneRIF: YOD1 binds to and deubiquitinates neural precursor cell
            expressed developmentally down-regulated protein 4. YOD1 suppresses
            NEDD4-induced cell proliferation.
REFERENCE   4  (bases 1 to 6126)
  AUTHORS   Liu,C., Huang,S., Wang,X., Wen,M., Zheng,J., Wang,W., Fu,Y.,
            Tian,S., Li,L., Li,Z. and Wang,X.
  TITLE     The Otubain YOD1 Suppresses Aggregation and Activation of the
            Signaling Adaptor MAVS through Lys63-Linked Deubiquitination
  JOURNAL   J Immunol 202 (10), 2957-2970 (2019)
   PUBMED   30952814
  REMARK    GeneRIF: findings thus provided novel insights into the regulatory
            cascade of the cellular antiviral response through YOD1-mediated
            K63-linked deubiquitination and aggregation of MAVS.
REFERENCE   5  (bases 1 to 6126)
  AUTHORS   Tanji,K., Mori,F., Miki,Y., Utsumi,J., Sasaki,H., Kakita,A.,
            Takahashi,H. and Wakabayashi,K.
  TITLE     YOD1 attenuates neurogenic proteotoxicity through its
            deubiquitinating activity
  JOURNAL   Neurobiol Dis 112, 14-23 (2018)
   PUBMED   29330040
  REMARK    GeneRIF: YOD1 levels significantly increase in cells and tissues in
            response to various pathophysiological conditions.
REFERENCE   6  (bases 1 to 6126)
  AUTHORS   Kim,Y., Kim,W., Song,Y., Kim,J.R., Cho,K., Moon,H., Ro,S.W.,
            Seo,E., Ryu,Y.M., Myung,S.J. and Jho,E.H.
  TITLE     Deubiquitinase YOD1 potentiates YAP/TAZ activities through
            enhancing ITCH stability
  JOURNAL   Proc Natl Acad Sci U S A 114 (18), 4691-4696 (2017)
   PUBMED   28416659
REFERENCE   7  (bases 1 to 6126)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   8  (bases 1 to 6126)
  AUTHORS   Sehrawat,S., Koenig,P.A., Kirak,O., Schlieker,C., Fankhauser,M. and
            Ploegh,H.L.
  TITLE     A catalytically inactive mutant of the deubiquitylase YOD-1
            enhances antigen cross-presentation
  JOURNAL   Blood 121 (7), 1145-1156 (2013)
   PUBMED   23243279
  REMARK    GeneRIF: Antigen presenting cells (APCs) that express a
            catalytically inactive version of the deubiquitylase YOD1
            (YOD1-C160S) present exogenous antigens more efficiently to CD8(+)
            T cells, both in vitro and in vivo.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC139231.11.
            
            On Oct 19, 2022 this sequence version replaced NM_178691.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK036991.1, AK036938.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-485               AC139231.11        130478-130962       c
            486-6126            AC139231.11        123933-129573       c
FEATURES             Location/Qualifiers
     source          1..6126
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 56.89 cM"
     gene            1..6126
                     /gene="Yod1"
                     /gene_synonym="6330564D18Rik; 9930028C20Rik; Hshin7"
                     /note="YOD1 deubiquitinase"
                     /db_xref="GeneID:226418"
                     /db_xref="MGI:MGI:2442596"
     exon            1..485
                     /gene="Yod1"
                     /gene_synonym="6330564D18Rik; 9930028C20Rik; Hshin7"
                     /inference="alignment:Splign:2.1.0"
     CDS             158..1189
                     /gene="Yod1"
                     /gene_synonym="6330564D18Rik; 9930028C20Rik; Hshin7"
                     /EC_number="3.4.19.12"
                     /note="HIV-induced protein-7-like protease; YOD1 OTU
                     deubiquitinating enzyme 1 homologue"
                     /codon_start=1
                     /product="ubiquitin thioesterase OTU1"
                     /protein_id="NP_848806.2"
                     /db_xref="CCDS:CCDS48351.1"
                     /db_xref="GeneID:226418"
                     /db_xref="MGI:MGI:2442596"
                     /translation="MFGGAKGGHFGVPPAGYSGAVPQSEAGTKAGPAGGRPADTMWRV
                     RCKAKGGTHLLQGLSSRTRLRELQGQIAAITGIAPGSQRILVGYPPECLDLSDRDITL
                     GDLPIQSGDMLIVEEDQTRPKASPAFSKYGAPSYVREALPVLTRTAVPADNSCLFTSV
                     YYVVEGGVLNPACAPEMRRLIAQIVASDPVLYSEAILGKTNEDYCDWIRRDDTWGGAI
                     EISILSKFYQCEICVVDTQTVRIDRFGEDAGYTKRVLLIYDGIHYDPLQRNFPDPDTP
                     PLTIFSSNDDIVLVQALELADEARRKRQFTDVNRFTLRCMICQKGLTGQAEARDHARE
                     TGHTNFGEV"
     exon            486..6126
                     /gene="Yod1"
                     /gene_synonym="6330564D18Rik; 9930028C20Rik; Hshin7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1343..1348
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Yod1"
                     /gene_synonym="6330564D18Rik; 9930028C20Rik; Hshin7"
                     /note="hexamer: ATTAAA"
     polyA_site      1365
                     /gene="Yod1"
                     /gene_synonym="6330564D18Rik; 9930028C20Rik; Hshin7"
                     /note="major polyA site"
     regulatory      6108..6113
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Yod1"
                     /gene_synonym="6330564D18Rik; 9930028C20Rik; Hshin7"
                     /note="hexamer: AATAAA"
     polyA_site      6126
                     /gene="Yod1"
                     /gene_synonym="6330564D18Rik; 9930028C20Rik; Hshin7"
                     /note="major polyA site"
ORIGIN      
        1 accggagcgc tcgggagagc cggccgaccc ccaaccctca cccgcggccg cccttgccac
       61 tttaagagcc cgcgccgttt ttggaaggac cgaggccgag tcccccccac cccccaccga
      121 ggtgtcgcga gaagcgcccc agcggccacc tctcgcgatg tttggaggcg ccaaaggcgg
      181 ccattttggg gtcccccccg ctggttactc cggcgctgtc ccccagtctg aggctgggac
      241 caaggctggc cccgcaggag gccggccggc cgacactatg tggcgggtcc gctgcaaggc
      301 caagggtggc acccaccttt tgcagggtct ttccagccgg acccgcttac gggagctgca
      361 gggccaaatc gccgctatca ccggcatcgc tcccggcagt cagcgaatcc tcgttggcta
      421 cccgcccgag tgcctggatc tcagcgaccg ggacatcact cttggggacc tgcccatcca
      481 gtcaggtgac atgctgattg ttgaagaaga ccaaaccaga ccaaaagctt cacctgcgtt
      541 ttcaaaatat ggtgctccta gttatgtcag ggaagctctg cctgtgctta ccagaaccgc
      601 agtcccagca gacaactctt gcctctttac cagtgtgtac tatgtcgtgg aaggaggagt
      661 cttgaatcca gcttgtgccc ctgagatgag acgcctcata gcacaaattg tagcaagtga
      721 tccagtcttg tatagtgagg cgatactggg aaagacaaac gaagactact gtgattggat
      781 cagaagggat gatacgtggg ggggggcaat cgagatctca atcctgtcta agttttacca
      841 atgtgaaata tgtgtagtag atacacagac agtcagaatt gatcgttttg gggaagatgc
      901 aggatatacc aaaagagttc tgcttatcta cgatggcatt cactacgatc cgcttcagcg
      961 taacttccct gatccagata cccctcctct gaccattttc tcctcaaatg atgatattgt
     1021 tcttgtacaa gcactggaat tagctgatga agctagaaga aagagacagt tcactgatgt
     1081 aaaccgcttc accctgagat gcatgatctg tcagaagggc ctaaccggac aagcagaagc
     1141 aagggaccat gccagggaga caggccatac caactttgga gaggtgtgat ctattcataa
     1201 gagtgggagc ctactacctc acagatccag aaggctctgg gttttccaat aagctattca
     1261 taaccctaca gaatagaaca caatgcttgg accatccttt tatcctaaac tagtatgact
     1321 gacactgaaa ttccttgtta agattaaaat cagtgtgcaa gtttacagat gtgtgtctac
     1381 actagtggca tgccctcttt ctactggggg tcggaataag gtggttttgg ccacttggga
     1441 tgctaacccg aagactggat tatattataa accagcacct agtggcttta gcttatagaa
     1501 gaaaacatca tattttaggt aatgtggaaa gccttgtgga gggccactgg acatatacca
     1561 caatgtctcc agtagttgat tccttttaat aactttgaat gagttagtag tttctaaatt
     1621 ctgaattgat ccatcaaatg aagatactca gaattgtcaa aactttttat attgcaattt
     1681 ggtagacttt ataagtgtat ctaactactt acaagtatat tgaaagcaat tttacgggga
     1741 gaagtatgtc ccttgagaat gttatctaaa acagggatta atatggccct gttgcgattt
     1801 ctagtgtata aaagtagaat gtataagggg aaaaggtgcc tgaagcagct tcctgaagct
     1861 ttaaaagact gttggcctct tgttttaatg caattcatgt attgttattt gtcacattag
     1921 gtaatttttt ttttcagtga agcagggtat gcctttttaa ttgctaattt agtttaaaat
     1981 tcaagaagta tcttgaaaat ttgagtgttt agttcttttg tttttttttt ttttacatac
     2041 atataaattt ttctgaaggg atttgatttc ctcagctctt cagctcaaag cacttcttac
     2101 taacaagtct tcctctaaag tgtcaatgga atgctttggt ttcctgaaac tcttttccgt
     2161 agagaacagt attcatagat ccactatgat cttttggata tttcacagtt ctgcaagtta
     2221 gtactttgtt catctgtgat ctttgacttt cagtttttaa ataattgatt tggtttgttt
     2281 cacttagaaa atatacaaag ttttaaaatc cttgccttat acagctctct cagaatattg
     2341 ctacctagtg ttaggtatgt agccatttgc ttgatggatt gatcctcaag gcacttgctc
     2401 tcaaaactta gcttcactat agaatcttcc aggtaaagtt ttctacctct taattcttct
     2461 aaagatcagg gatgctaagt tataatttgt tgtatatctg tcatacagtg tatagaggca
     2521 taatgttgtg aagttttgtt atcttgatct catttattaa atatctcaga gaaccattta
     2581 caccaatgtg ctttaaagca cttaacatct ttccatgatt cttcttagca aatgttttaa
     2641 aatcaaagtc aacccttagc cttttacatg gtaatggtga ccatgtcaaa ttaaggaata
     2701 ttaaagtgaa caatttagaa agttccttta aggacaattg aacaattcac aaagtatgct
     2761 tcaatcatcc aatgagattc tcttttgtgt tgagacaaag tctccctgtg tgtttcttgt
     2821 cggcctggaa tttgttatat agaccaggct cctccaactc aaagtgatcc ttctgcctct
     2881 gccttctgag tgttgagatt acaagtaggg gccaccgtac ctggccagat gacttttctt
     2941 gaatgccctt tgtgcacata gccagtcagg caatggcatt attatagtca tataagttga
     3001 aaatgttttt cttttttgaa ctgagcctta aagatagttc tagtgagctt aggatgccgg
     3061 acacttggag gtcatgacat gtaatgactg tcacaaaagt ctcttcagac ctgtcctctg
     3121 ggttagattt tttaaatctc ttttgttttc tctgtaaaat atttaattta aagctgtaca
     3181 ttaaaactgt aaaattgggt tatgcaccgt atttatagag cttaccttta ccacttgagc
     3241 atccaaattc aatatttcta aaaatttgga tccaagtttg ttcatgcaac aagtatttat
     3301 tgaataactt ataatgtgtc aggcatgttc tattttttga aaataaattc ctgtcacttt
     3361 aaaattgagt ctatataatg tacagaggat ttgtttagta aacgtaaaga aatagaatga
     3421 gcactggtat cttaaaaatc aagtctttgt tctaagtgtt atttgtatgt cttgtttagt
     3481 atttatttag gggattgttt cttattctat ttttatcttt tgcttggttt gtcaggtaga
     3541 cacttgatag taaaatggct ttcaaaaaga cattttaatc atttgctgat atgagaactg
     3601 gtttgagagt agtgtttttg ttgtgaaaca ttccaggtga agcattatat gcaaattatt
     3661 taattattaa tttctgttca ttccaaatac aagctgttaa gcctcataga atttaaaaga
     3721 tttgtttcat attttttcct gtatttatta agctcttgaa attgtgagga aactcatttt
     3781 tagaattttg aaaaaaaaat ctgtgaattt agttgcagca acgctaaaaa aaaaaaaaaa
     3841 aacaccaaaa acaaaaagaa aacctatgtc ctaatgaaac ccattctgtc cagtttttgc
     3901 ctgtcctaca ataattattt ttaattaaaa tgagtcaatt tacattagtg gtagaataaa
     3961 aattatgctt tgaccccatt tccccagtac cccccactct tttagattaa agattcggtg
     4021 tgtttttata aagataccct agtcacagca gtagtccaaa ttaatgtccc tgggaatttt
     4081 gtgatatgac accacatgaa ggcatctaga tgctaccaca tcttttgcta gcgattcatg
     4141 gttgatttct taaagctctc catgaatgaa gtcataggca aggggttact ggccaaccta
     4201 accttgttgt taggaactga taccattaat accatttgaa tactctattg agttcaagtc
     4261 ccagaaaaat cagaatccca aattaacatt atttccctgc ccgggtgtgc gcctaactgc
     4321 tcctgcctaa cttacttgtc taacttactt gtctgcctag cttcttccct tcaagctgcc
     4381 ctaggtgaat tttctatctt tgtggaaaaa ttacagtagg atgtatatga aattaagcag
     4441 caatgatcca tacacacaca cacacacgtt atatatttaa aaatcaggtg gccttctgaa
     4501 atttacatat taaaatttac atttttcatg tgttggaaca tcatttgcag catttttttc
     4561 tttttttctt ttcctttttt tttttttttt tttttttttt tttttgagac agggtttctc
     4621 tgtgtagctc tggctgtcct ggaactctgt agaccaggct ggcctcgaac tcagaaatct
     4681 gcctgcctct gcctcctgag tgctaggatt aaaggcgtgt gccaccacgt ctggctcatt
     4741 tgcagcactt taaaaattag agaataaaag tttacatagc tctctagaag acctcgaggg
     4801 cagtaatgat acaaccccaa gccagctgct agccagcagc tctcatacgc tattgccatc
     4861 agtatttatg tatcttatga tacagtctaa tttcactcac tgttaggacc agggtctatg
     4921 tcctaacgta aggaataata cttctgtaat gtgattgttc tgtaatgtga tctctaaaga
     4981 gtcgattcat caaacctttc attcatttta agcaaactta ttttggaaga aattgatttt
     5041 tgagtaagat atgcaagcag tatttgcaaa tctaaaggaa cactttattt gaataagcta
     5101 gtttgttact catgctaagc atcgaaccag ggctttttgc tgcaagggta agtgcttagc
     5161 gatcagcatt ccaccccgga tggtttctta gtgcctattg taatgtgcag cacatccaac
     5221 tcaatgaata caaggctgcc ttggttgtgg gaaaggtttg ggtttttgtt gttttttgtt
     5281 tttcttcaaa aattagctaa cattttgttt acagtgcttt gactatttta tttggaaaac
     5341 aaagtattat gtttactgaa ttatgaagtg tttgtgtcta cattcatttg atttaaggca
     5401 gggtgttagc cttcccatgg cattttcaag tgaaaaggat gggtactact gaaaagatgt
     5461 atacggccgt gaacacaagc tttgaaacac atgaacctgt aattagtaat ttaagtatag
     5521 tgaatgaatg acgtggttta gttataggta aggaggctga ggatttctac cgagctgatg
     5581 tggcttggct ccagaatgca tatagaatgt ttagttgagt gtaacccatc agttacttaa
     5641 aggacaaggg ttgcctgttc acatttgtgc cattcaaggt gccacaggaa atgcatttgt
     5701 accaaattat ttgttttctt taagaatgcc ttgtcaaagg ttcagaatga aaaatagtct
     5761 tattgtggct gtactagcac agtggaagca gagctcctta aataagaaaa tcatcaataa
     5821 agcctgaaat acagagctca gagcataatt tcaaaagtat aaaagggggc caaacagaaa
     5881 gaattctttt cctggcatat gaaaatgtgt tcttagtgct gcttccagaa tgttctttgt
     5941 cgtttgccag caagtttcca aggtcaatgc actgctgctc tctgggagat gtctgacttc
     6001 attttataca actcatgatt ttgcctttgt tattaagatg cattcatttt atttatgaca
     6061 tgtgactttt tcaatatctg aatgtatgaa gtgacttgtt ttaaaggaat aaatgaagtg
     6121 aaaaca
//
