LOCUS       NM_013771               4571 bp    mRNA    linear   ROD 20-SEP-2024
DEFINITION  Mus musculus YME1-like 1 (S. cerevisiae) (Yme1l1), mRNA.
ACCESSION   NM_013771
VERSION     NM_013771.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4571)
  AUTHORS   Xia,Y., He,C., Hu,Z., Wu,Z., Hui,Y., Liu,Y.Y., Mu,C. and Zha,J.
  TITLE     The mitochondrial protein YME1 Like 1 is important for non-small
            cell lung cancer cell growth
  JOURNAL   Int J Biol Sci 19 (6), 1778-1790 (2023)
   PUBMED   37063426
  REMARK    GeneRIF: The mitochondrial protein YME1 Like 1 is important for
            non-small cell lung cancer cell growth.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4571)
  AUTHORS   Park,E.J., Kim,H.S., Lee,D.H., Kim,S.M., Yoon,J.S., Lee,J.M.,
            Im,S.J., Lee,H., Lee,M.W. and Lee,C.W.
  TITLE     Ssu72 phosphatase is essential for thermogenic adaptation by
            regulating cytosolic translation
  JOURNAL   Nat Commun 14 (1), 1097 (2023)
   PUBMED   36841836
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4571)
  AUTHORS   Jian,Y., Yang,Y., Cheng,L., Yang,X., Liu,H., Li,W., Wan,Y. and
            Yang,D.
  TITLE     Sirt3 mitigates LPS-induced mitochondrial damage in renal tubular
            epithelial cells by deacetylating YME1L1
  JOURNAL   Cell Prolif 56 (2), e13362 (2023)
   PUBMED   36433732
  REMARK    GeneRIF: Sirt3 mitigates LPS-induced mitochondrial damage in renal
            tubular epithelial cells by deacetylating YME1L1.
REFERENCE   4  (bases 1 to 4571)
  AUTHORS   Wani,G.A., Sprenger,H.G., Ndoci,K., Chandragiri,S., Acton,R.J.,
            Schatton,D., Kochan,S.M.V., Sakthivelu,V., Jevtic,M., Seeger,J.M.,
            Muller,S., Giavalisco,P., Rugarli,E.I., Motori,E., Langer,T. and
            Bergami,M.
  TITLE     Metabolic control of adult neural stem cell self-renewal by the
            mitochondrial protease YME1L
  JOURNAL   Cell Rep 38 (7), 110370 (2022)
   PUBMED   35172139
  REMARK    GeneRIF: Metabolic control of adult neural stem cell self-renewal
            by the mitochondrial protease YME1L.
REFERENCE   5  (bases 1 to 4571)
  AUTHORS   Wang,R., Mishra,P., Garbis,S.D., Moradian,A., Sweredoski,M.J. and
            Chan,D.C.
  TITLE     Identification of new OPA1 cleavage site reveals that short
            isoforms regulate mitochondrial fusion
  JOURNAL   Mol Biol Cell 32 (2), 157-168 (2021)
   PUBMED   33237841
REFERENCE   6  (bases 1 to 4571)
  AUTHORS   Wai,T., Garcia-Prieto,J., Baker,M.J., Merkwirth,C., Benit,P.,
            Rustin,P., Ruperez,F.J., Barbas,C., Ibanez,B. and Langer,T.
  TITLE     Imbalanced OPA1 processing and mitochondrial fragmentation cause
            heart failure in mice
  JOURNAL   Science 350 (6265), aad0116 (2015)
   PUBMED   26785494
REFERENCE   7  (bases 1 to 4571)
  AUTHORS   Baburamani,A.A., Hurling,C., Stolp,H., Sobotka,K., Gressens,P.,
            Hagberg,H. and Thornton,C.
  TITLE     Mitochondrial Optic Atrophy (OPA) 1 Processing Is Altered in
            Response to Neonatal Hypoxic-Ischemic Brain Injury
  JOURNAL   Int J Mol Sci 16 (9), 22509-22526 (2015)
   PUBMED   26393574
  REMARK    GeneRIF: Data suggest that in a mouse model of neonatal
            hypoxic-ischemic brain injury, the expression of mitochondrial
            shaping proteins, such as OPA1 and Yme1L, are altered; in vitro and
            in vivo, OPA1 is cleaved to shorter forms and Yme1L expression is
            reduced.
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 4571)
  AUTHORS   Mishra,P., Carelli,V., Manfredi,G. and Chan,D.C.
  TITLE     Proteolytic cleavage of Opa1 stimulates mitochondrial inner
            membrane fusion and couples fusion to oxidative phosphorylation
  JOURNAL   Cell Metab 19 (4), 630-641 (2014)
   PUBMED   24703695
  REMARK    Erratum:[Cell Metab. 2014 May 6;19(5):891]
REFERENCE   9  (bases 1 to 4571)
  AUTHORS   Anand,R., Wai,T., Baker,M.J., Kladt,N., Schauss,A.C., Rugarli,E.
            and Langer,T.
  TITLE     The i-AAA protease YME1L and OMA1 cleave OPA1 to balance
            mitochondrial fusion and fission
  JOURNAL   J Cell Biol 204 (6), 919-929 (2014)
   PUBMED   24616225
  REMARK    GeneRIF: Constitutive OPA1 cleavage by YME1L and OMA1 at two
            distinct sites leads to the accumulation of both long and short
            forms of OPA1 and maintains mitochondrial fusion.
REFERENCE   10 (bases 1 to 4571)
  AUTHORS   Coppola,M., Pizzigoni,A., Banfi,S., Bassi,M.T., Casari,G. and
            Incerti,B.
  TITLE     Identification and characterization of YME1L1, a novel
            paraplegin-related gene
  JOURNAL   Genomics 66 (1), 48-54 (2000)
   PUBMED   10843804
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB624412.1, AF090430.1 and AL928706.6.
            
            On Mar 26, 2011 this sequence version replaced NM_013771.4.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK079175.1, BC007128.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-31                BB624412.1         1-31
            32-2668             AF090430.1         10-2646
            2669-4571           AL928706.6         13466-15368
FEATURES             Location/Qualifiers
     source          1..4571
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 15.24 cM"
     gene            1..4571
                     /gene="Yme1l1"
                     /gene_synonym="Ftsh; FtsH1"
                     /note="YME1-like 1 (S. cerevisiae)"
                     /db_xref="GeneID:27377"
                     /db_xref="MGI:MGI:1351651"
     exon            1..227
                     /gene="Yme1l1"
                     /gene_synonym="Ftsh; FtsH1"
                     /inference="alignment:Splign:2.1.0"
     CDS             195..2342
                     /gene="Yme1l1"
                     /gene_synonym="Ftsh; FtsH1"
                     /note="ATP-dependent metalloprotease FtsH1; YME1-like
                     protein 1"
                     /codon_start=1
                     /product="ATP-dependent zinc metalloprotease YME1L1"
                     /protein_id="NP_038799.1"
                     /db_xref="CCDS:CCDS15728.1"
                     /db_xref="GeneID:27377"
                     /db_xref="MGI:MGI:1351651"
                     /translation="MFSLSSTVQPQVTIPLSHLINAFHSPKNISVSVNTPVSQKQHRD
                     TVPEHEAPSSEPVLNLRDLGLSELKIGQIDKMVENLLPGFYKDKRVSSCWHTSHISAQ
                     SFFENKYGHLDMFSTLRSSSLYRQHPKTLRSICSDLQYFPVFIQSRGFKTLKSRTRRL
                     QSTSERLVEAQNIAPSFVKGFLLRDRGTDLESLDKLMKTKNIPEAHQDAFKTGFAEGF
                     LKAQALTQKTNDSLRRTRLILFVLLLFGIYGLLKNPFLSVRFRTTTGLDSAVDPVQMK
                     NVTFEHVKGVEEAKQELQEVVEFLKNPQKFTVLGGKLPKGILLVGPPGTGKTLLARAV
                     AGEADVPFYYASGSEFDEMFVGVGASRIRNLFREAKANAPCVIFIDELDSVGGKRIES
                     PMHPYSRQTINQLLAEMDGFKPNEGVIIIGATNFPEALDNALIRPGRFDMQVTVPRPD
                     VKGRTEILKWYLNKIKFDKSVDPEIIARGTVGFSGAELENLVNQAALKAAVDGKEMVT
                     MKELEFSKDKILMGPERRSVEIDNKNKTITAYHESGHAIIAYYTKDAMPINKATIMPR
                     GPTLGHVSLLPENDRWNETRAQLLAQMDVSMGGRVAEELIFGTDHITTGASSDFDNAT
                     KIAKRMVTKFGMSEKLGVMTYSDTGKLSPETQSAIEQEIRILLRESYERAKHILKTHA
                     KEHKNLAEALLTYETLDAKEIQIVLEGKKLEVR"
     exon            228..359
                     /gene="Yme1l1"
                     /gene_synonym="Ftsh; FtsH1"
                     /inference="alignment:Splign:2.1.0"
     exon            360..522
                     /gene="Yme1l1"
                     /gene_synonym="Ftsh; FtsH1"
                     /inference="alignment:Splign:2.1.0"
     exon            523..621
                     /gene="Yme1l1"
                     /gene_synonym="Ftsh; FtsH1"
                     /inference="alignment:Splign:2.1.0"
     exon            622..731
                     /gene="Yme1l1"
                     /gene_synonym="Ftsh; FtsH1"
                     /inference="alignment:Splign:2.1.0"
     exon            732..882
                     /gene="Yme1l1"
                     /gene_synonym="Ftsh; FtsH1"
                     /inference="alignment:Splign:2.1.0"
     exon            883..966
                     /gene="Yme1l1"
                     /gene_synonym="Ftsh; FtsH1"
                     /inference="alignment:Splign:2.1.0"
     exon            967..1049
                     /gene="Yme1l1"
                     /gene_synonym="Ftsh; FtsH1"
                     /inference="alignment:Splign:2.1.0"
     exon            1050..1140
                     /gene="Yme1l1"
                     /gene_synonym="Ftsh; FtsH1"
                     /inference="alignment:Splign:2.1.0"
     exon            1141..1293
                     /gene="Yme1l1"
                     /gene_synonym="Ftsh; FtsH1"
                     /inference="alignment:Splign:2.1.0"
     exon            1294..1426
                     /gene="Yme1l1"
                     /gene_synonym="Ftsh; FtsH1"
                     /inference="alignment:Splign:2.1.0"
     exon            1427..1489
                     /gene="Yme1l1"
                     /gene_synonym="Ftsh; FtsH1"
                     /inference="alignment:Splign:2.1.0"
     exon            1490..1602
                     /gene="Yme1l1"
                     /gene_synonym="Ftsh; FtsH1"
                     /inference="alignment:Splign:2.1.0"
     exon            1603..1758
                     /gene="Yme1l1"
                     /gene_synonym="Ftsh; FtsH1"
                     /inference="alignment:Splign:2.1.0"
     exon            1759..1910
                     /gene="Yme1l1"
                     /gene_synonym="Ftsh; FtsH1"
                     /inference="alignment:Splign:2.1.0"
     exon            1911..2037
                     /gene="Yme1l1"
                     /gene_synonym="Ftsh; FtsH1"
                     /inference="alignment:Splign:2.1.0"
     exon            2038..2111
                     /gene="Yme1l1"
                     /gene_synonym="Ftsh; FtsH1"
                     /inference="alignment:Splign:2.1.0"
     exon            2112..2198
                     /gene="Yme1l1"
                     /gene_synonym="Ftsh; FtsH1"
                     /inference="alignment:Splign:2.1.0"
     exon            2199..4571
                     /gene="Yme1l1"
                     /gene_synonym="Ftsh; FtsH1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3017..3022
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Yme1l1"
                     /gene_synonym="Ftsh; FtsH1"
                     /note="hexamer: ATTATA"
     polyA_site      3029
                     /gene="Yme1l1"
                     /gene_synonym="Ftsh; FtsH1"
                     /note="major polyA site"
     regulatory      3789..3794
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Yme1l1"
                     /gene_synonym="Ftsh; FtsH1"
                     /note="hexamer: CATAAA"
     polyA_site      3821
                     /gene="Yme1l1"
                     /gene_synonym="Ftsh; FtsH1"
     regulatory      3837..3842
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Yme1l1"
                     /gene_synonym="Ftsh; FtsH1"
                     /note="hexamer: AGTAAA"
     polyA_site      3863
                     /gene="Yme1l1"
                     /gene_synonym="Ftsh; FtsH1"
                     /note="major polyA site"
     regulatory      4541..4546
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Yme1l1"
                     /gene_synonym="Ftsh; FtsH1"
                     /note="hexamer: AATAAA"
     polyA_site      4562
                     /gene="Yme1l1"
                     /gene_synonym="Ftsh; FtsH1"
ORIGIN      
        1 ggtcttccgg ggcagatgtc gtcgtagcag ctgtcgggag gggaagccat tttttcgttt
       61 ctgggaggag taagggagaa actgggagaa aagcaaagag aaataaagag aaaataaaag
      121 ggctcagccc ctttcctcgg agctgaagct aagaagcagt ttcggctggc cggtaagatc
      181 tcgagggccc ggagatgttc tccctgtcga gcactgtgca gcctcaggtt acaattcctc
      241 tcagtcatct catcaatgct ttccattcac caaaaaatat atctgtttct gtcaatacac
      301 ctgtttctca aaaacagcat cgagatacag ttcctgagca tgaagctccc agtagtgagc
      361 ctgtgcttaa tttaagggac cttggattat ctgaattgaa aattggacag attgataaaa
      421 tggtagaaaa tttacttcct ggattttata aagacaaaag agtttcttcc tgttggcata
      481 catctcatat ttcggcacag tccttttttg aaaataaata tggtcactta gatatgttca
      541 gtacattacg ttcctctagc ttgtacaggc aacatccaaa aactcttcga agcatttgtt
      601 cagatcttca gtattttcca gttttcatac agtctcgggg tttcaaaacg ttgaaatcaa
      661 ggacacgacg tttgcagtct acctctgaaa gattagtaga agcacagaat atagcaccat
      721 catttgtgaa ggggtttctt ttgcgggaca gaggaacaga tcttgagagt ttggacaaac
      781 ttatgaaaac taaaaacata cctgaagctc accaagatgc atttaaaact ggttttgcag
      841 agggttttct caaagctcaa gctcttacac agaagaccaa tgattcctta aggcgaactc
      901 gtctgatcct ctttgttttg ctcctgtttg gcatttatgg actcttaaaa aatccgtttt
      961 tatctgtgcg ctttcggaca actacaggac ttgattctgc ggtagaccct gtccagatga
     1021 aaaatgtcac ttttgaacat gttaaagggg tggaggaagc caaacaagag ttacaggaag
     1081 tggttgaatt cttgaaaaat ccacagaagt ttactgtgct tggaggtaaa cttcccaaag
     1141 gaattctttt agttgggcca ccaggaacag ggaagacgct tcttgcccga gctgtggcag
     1201 gagaagctga cgtccctttt tattatgctt ctggatcaga gtttgatgag atgtttgtgg
     1261 gcgtaggagc cagcaggatc agaaatcttt ttagagaagc aaaagcaaat gctccttgtg
     1321 ttatattcat cgatgaatta gattctgttg gtggaaagag aattgaatct ccaatgcacc
     1381 cgtattcaag gcagacgatc aatcagcttc ttgctgaaat ggatggtttc aaacccaatg
     1441 aaggagtaat cattataggt gccacaaatt tcccagaggc attagataat gccttaatac
     1501 gtcctggtcg ttttgatatg caagttacag ttccaaggcc agatgtgaag ggtcgaactg
     1561 aaattttgaa atggtatctc aacaagataa agtttgataa atctgttgat ccagaaatca
     1621 tagctcgagg gactgttggg ttctctggag cagagttgga gaatcttgtg aaccaagctg
     1681 cactaaaggc agcagttgat ggaaaagaaa tggttaccat gaaggaacta gagttttcca
     1741 aggataaaat tctaatggga ccagaaagaa gaagtgtgga aattgataac aaaaacaaaa
     1801 ctataacagc ctatcatgaa tctggtcatg ctattattgc atattacaca aaggatgcaa
     1861 tgccaattaa taaagctaca atcatgcctc gagggccaac acttgggcat gtatcactgt
     1921 tgcctgagaa tgacagatgg aatgaaactc gagcccagct gcttgcacag atggatgtta
     1981 gcatgggagg aagagtggca gaggaactca tatttggaac tgatcatatt acaactggtg
     2041 cttctagtga ttttgataat gcaacaaaaa ttgctaagag gatggttacc aaatttggaa
     2101 tgagtgaaaa gcttggagtt atgacctaca gtgatacagg aaaactaagt cctgaaactc
     2161 aatcagccat tgaacaagaa ataagaatcc ttctacggga gtcatatgaa cgagcaaaac
     2221 atatcttgaa aacacatgcg aaagaacata agaacctggc agaagcattg ctgacctatg
     2281 agactttgga tgccaaagag attcaaattg ttcttgaggg aaagaaattg gaagtgagat
     2341 gataactctg ttgatattgc tggttttatt acaagaatat acttagtcct gcagtctcct
     2401 ttgcaacatt tttcaacccc cactcctgac ttggtatata attcaaggat gtgaaacact
     2461 ttgtcaatct tctgtcccat tatttgattt tggttattcc tgtgatgata ccattggaga
     2521 ttagtaactc atagcaaata cgtgaaagga taaataaaga actgtcagga ttaaagaaag
     2581 acattgaaaa atgtcaatca atcatgttga aagcaagcaa tcattttgtg ggtaattact
     2641 ccaagtgagt aaaaattgtg cctttatcta ttggtaaggt tttttttttt tttttttttt
     2701 tttggaaggt aaatttgaaa agctaccatc tcctgatagt aacatttctc tgtggggaaa
     2761 acaatgctgt ggataaatca tttctactta cattagtaga aatgccattg agatgtactt
     2821 aattatgttc ttgattgacc ttgtaaaatg gcctttaaaa gaaactattt gaattgtaaa
     2881 tatgacgata tactcagaat ttaaatgatt gtaatggatt aaaaatgcag catgtatgcc
     2941 cattttttca aatattacta tctcactgac aagatttgtt tcagaacaac aatattttat
     3001 gaagtaaaca agtaacatta tattctgaat atctgtataa ttacattgaa tctcaaaatc
     3061 aaaatgaaac caaaaactca attcctttca aaaatgatct ttctctgtcg ccttgtcaga
     3121 attggaaggc ttgttccatc tgcacattat agggtttaca aggtaatttc atattcagat
     3181 cagtagacca tagtgtgagt gcattttatt ggtgttacaa ccaagttaca ttcttgaagg
     3241 aactattaaa attacattgt tttcttattg aggatgttca tggtccttat taaagaagat
     3301 agatataatt aaagggacct tgttacatga tattttgacc ttttttaatg ttaaattttt
     3361 gatacacaca aatttcacaa tttcaaagtg aaaaatgttg atagagctcc attatattga
     3421 ttaagaccaa caggttttaa ttttcactgc tttttgctgt ctccattgtc actcatgttc
     3481 atgtgtttgt tctttctctc ttgtgccctc attctctaca tattcatgca tacacatatg
     3541 gaaaaacatc ggtgttttat ctaacctgac ttcagacatt tttacagtcc catagagctg
     3601 taattttcat gttataaaac atatccattg taaatataga taccaaagac ccccccaccc
     3661 cctttttaaa attgtgtaat tacctcaatt aggttttagg acaatttttt tcaagccttc
     3721 aaaattcaaa gtgactacac agttttgtat cttgtattat gtaaagtttc agcttcatca
     3781 ctattcaaca taaaagtgct gtttcactat cgacatccaa attgaatccc agtctcagta
     3841 aattatatag caagtttact gtggcttttg agtttagttg gttttattgc ttctactttg
     3901 tgtgtatgca aagactttaa taaccaagtg tagatataat tagctggaga attttctgct
     3961 ctgtatgtct ggtaaaccta ggatatttca tgaagtgatt atcaacgtcc tctgggtttc
     4021 tcatatcaca gaaagatcac actgattgta tcttgcagag tagccaacag ttttaggcta
     4081 gtaagcggct gatcattgcg atccgattta gtcagtacta catcaaggca gctgagttct
     4141 ctggtgaaat gaggataagc cttttttata tttttcttgg ggtgggttct tttgttgttt
     4201 gcttgttttt tgttgtttgt ttagtttgga gtcctttcca gaaagttctg ttttgtagcc
     4261 taggctagcc tccaactgac atccttccac ctgagcctct gggtgcatca ttcttggcac
     4321 acatatctta tttacagggt ctttcttcac cctggtttga acttgggact aggagctgcc
     4381 ctgagttggc aggaccacca aagaatcatg ttctgggtta aatttagtga ttttcatgaa
     4441 gaaacaagtc atactttttt gtaggtctct tgttaattcc tggagtcata gaatggttgg
     4501 ttgttttggt ttcgttgagg tttgtagttg actcttttca aataaaaatg aatttatcct
     4561 gatatatttt a
//
