LOCUS       NM_178363              11052 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Mus musculus YLP motif containing 1 (Ylpm1), transcript variant 1,
            mRNA.
ACCESSION   NM_178363
VERSION     NM_178363.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 11052)
  AUTHORS   Qin,D., Wang,C., Yan,R., Qin,Y., Ying,Z., Kong,H., Zhao,W.,
            Zhang,L. and Song,H.
  TITLE     ZAP facilitates NLRP3 inflammasome activation via promoting the
            oligomerization of NLRP3
  JOURNAL   Int Immunopharmacol 133, 112123 (2024)
   PUBMED   38663314
  REMARK    GeneRIF: ZAP facilitates NLRP3 inflammasome activation via
            promoting the oligomerization of NLRP3.
REFERENCE   2  (bases 1 to 11052)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 11052)
  AUTHORS   Chen,E.Q., Dai,J., Bai,L. and Tang,H.
  TITLE     The efficacy of zinc finger antiviral protein against hepatitis B
            virus transcription and replication in tansgenic mouse model
  JOURNAL   Virol J 12, 25 (2015)
   PUBMED   25889209
  REMARK    GeneRIF: ZAP inhibited hepatitis B virus replication in vivo.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 11052)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   5  (bases 1 to 11052)
  AUTHORS   Armstrong,L., Lako,M., van Herpe,I., Evans,J., Saretzki,G. and
            Hole,N.
  TITLE     A role for nucleoprotein Zap3 in the reduction of telomerase
            activity during embryonic stem cell differentiation
  JOURNAL   Mech Dev 121 (12), 1509-1522 (2004)
   PUBMED   15511642
  REMARK    GeneRIF: Overexpression in murine embryonic stem cells results in
            reduction in telomerase activity and reduced cell division.
REFERENCE   6  (bases 1 to 11052)
  AUTHORS   Peeraully,M.R., Jenkins,J.R. and Trayhurn,P.
  TITLE     NGF gene expression and secretion in white adipose tissue:
            regulation in 3T3-L1 adipocytes by hormones and inflammatory
            cytokines
  JOURNAL   Am J Physiol Endocrinol Metab 287 (2), E331-E339 (2004)
   PUBMED   15100092
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK044440.1, CR974585.16, AC155811.2, CF742131.1, CF747026.1,
            CV561380.1, AW537032.1 and AC127582.4.
            
            On Nov 26, 2016 this sequence version replaced NM_178363.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. There are no full-length transcripts
            supporting this RefSeq in mouse; it is predicted based on partial
            mouse transcript alignments and on full-length transcript
            alignments from the human ortholog, GeneID:56252.
            
            CCDS Note: This CCDS representation lacks full-length transcript
            support in mouse. It is supported by partial mouse transcript
            alignments, and by full-length transcript alignments from the human
            ortholog, as represented in CCDS45135.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11927932.1656705.1,
                                           SRR9219380.882.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1492              AK044440.1         2-1493
            1493-2277           CR974585.16        176998-177782
            2278-2436           AC155811.2         113144-113302
            2437-4554           AC155811.2         126479-128596
            4555-4672           AC155811.2         131626-131743
            4673-5093           AC155811.2         138282-138702
            5094-5548           CF742131.1         257-711
            5549-5828           CF747026.1         421-700
            5829-6484           CV561380.1         161-816
            6485-7009           AW537032.1         1-525               c
            7010-11052          AC127582.4         124686-128728       c
FEATURES             Location/Qualifiers
     source          1..11052
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 39.5 cM"
     gene            1..11052
                     /gene="Ylpm1"
                     /gene_synonym="A930013E17Rik; ZAP; Zap3"
                     /note="YLP motif containing 1"
                     /db_xref="GeneID:56531"
                     /db_xref="MGI:MGI:1926195"
     exon            1..1036
                     /gene="Ylpm1"
                     /gene_synonym="A930013E17Rik; ZAP; Zap3"
                     /inference="alignment:Splign:2.1.0"
     CDS             170..6589
                     /gene="Ylpm1"
                     /gene_synonym="A930013E17Rik; ZAP; Zap3"
                     /note="isoform 1 is encoded by transcript variant 1;
                     nuclear protein ZAP; YLP motif-containing protein 1;
                     nuclear protein ZAP3"
                     /codon_start=1
                     /product="YLP motif-containing protein 1 isoform 1"
                     /protein_id="NP_848140.3"
                     /db_xref="CCDS:CCDS49114.1"
                     /db_xref="GeneID:56531"
                     /db_xref="MGI:MGI:1926195"
                     /translation="MYPNWGRYGGSSHYPPPPVPPPPPPVALPEASPGPGYSSSTAPA
                     APSSSGFMSFREQHLAQLQQLQQMHQKQMQCVLQPHHLPPPPLPPPPVMPGGGYGDWQ
                     PPPPPMPPPPGPALSYQKQQQYKHQMIHHQRDGPPGLVPMELESPPESPPVPPGSYMP
                     PSQSYMPPPQPPPSYYPPSSAQPYLPPAQPSPSQSPPSQSYLAPTPSYSSSSSSQSYL
                     SHSQPYLPPSQASPSRSSQGPSKPQLPPPPSIPSGNKTAIQQEPLESGAKNKTAEQKQ
                     AAPEPDPSTMTPQEQQQYWYRQHLLSLQQRTKVHLPGHKKGLVTAKDVPEPIKEEAPG
                     PAASQVAEPLAAEKPPLPPPNEEAPPPLSPEEPQSEDSEDSEDSEEDARFKQLKAIAA
                     HWQAAAAHWQQQQQQRVGFQYQGIMQRHTQLQQILQQYQQVIQHSPHIQTMSLDVQLR
                     HYEMQQQQFQHLFQDWEREFQLWEEQLHSYPHKDQLQEYEKQWKTWQGHMKATQTYLQ
                     EKVNSFQTVKSQYLGNMAMPPPFVPYSQMPPPLPTMPPPVLPPSLPPPVMPPALPTSI
                     PPPGMPPPVMPPSLPTSVPPPGMPPSLSSGPPPVLPPPALSSAGSPPVLPPPALPGGP
                     PILPLPPLSSATPPPGIPPPGAPQGMPPQLTAPLPPASGSQNSQIPEKPRQALLPTPV
                     SFGSTPPSPYHPPPQSEQVNSKPLNKVFSSEQGLGESSALSQSIIAAKDTPVKSGGLL
                     ADPPKGSFLEGPRGPRFDGPRRFEDLGSRCEGPRPKGPRFEGNRPDGPRPRYESHPAE
                     GTKSKWGTIPRGPASQFYITPNTSLSPRQSGPQWKGPKATVGQQHQQQPKQQPKSQAE
                     PLSGNKEPLADTSNNQQKNLKIQSAAFSISADVKDTKAAQSNENLSDSQQEPTKSQVS
                     EGPVEPSNWNQNSQSMETEMDKAEGVTQPVSLANKPVPTQSTFPSKVGSMEGGAAAAA
                     LTADDFKPLGVGLSHSENHQEKDLPQPDSRENRLEGNKGSSSSYRGPGQNRVEESRDK
                     GLVNRGRGQIINRGPGLVKQEDFHDKMMGRREDSREKMNRGEGNRDRVFVRPGSSRDK
                     IPGGLQDSQDSRANSRERGPPRRAGSQERGPPRRAGSRERVPPQRAGSRERVPPRGPG
                     SRERGLGRPDFGHDRVPFRSELGDGGDKVYPYHRDEPSRASWNHGEERGHEEFPVDGR
                     NAPIERERLDDWDRKRYWRECERDYQDDTLDSYSREDRFSAPPSRSHDGDRRGPWWDD
                     WERDQDMDEGYGREMDRDLDRDVDRIRRPLDIYDRNVDNEWDRDYGRPLDEQESQFRE
                     RDIPSLPPLPPLPPLPPLDRYRDDRWREERNRDHGYDRDFRDRGELRIREYPERGDTW
                     REKRDYVPDRMDWERERLSDRWYPSDVDRHSPMAEHMPSSHHSSEMMGSDANLDSDQG
                     LGGVMVLSQRQHEIILKAAQELKMLREQKEQLQKLKDFGSEPQMADHLPPPDSRLQNP
                     SRPGMYPPPGSYRPPPPMGKPPGSIVRPSAPPARSSIPMTRPPVPIPPPPPPPPPPPP
                     PPPVIKSKTSSVKQERWDEDSFFGLWDTNDDQGLNSEFKRDTATIPSAPVLPPPPVHS
                     SIPPPGPMPMGMPPMSKPPPVQHTVDYGHGRDMPTNKVEQIPYGERITLRPDPLPERS
                     TFDADHAGQRDRYDRDRDREPYFDRPSNITDHRDFKRDRETHRDRDRDRVLDYERDRF
                     DRERRPRDDRNQSYRDKKDHSSSRRGGFDRPSYDRKSDRPPYEGPPMFGGERRTYPEE
                     RMPLPAPALGHQPPPVPRVEKKPESKNVDDILKPPGRESRPERIVVIMRGLPGSGKTH
                     VAKLIRDKEVEFGGPAPRVLSLDDYFIAEVEKEEKDPDSGKKVKKKVMEYEYEADMEE
                     TYRTSMFKTFKKTLDDGFFPFIILDAINDRVRHFDQFWSAAKTKGFEVYLAEMSADNQ
                     TCGKRNIHGRKLKEINKMAEHWEVAPRHMMRLDIRSLLQDAAIEEVEMEDFDANIEDQ
                     KEEKKDAEEEESELGYIPKSKWEMDTSEAKLDKLDGLRTGTKRKRDWEAIASRMEDYL
                     QLPDDYETRASEPGKKRVRWADLEEKKDADRKRAIGFVVGQTDWEKITDESGHLAERA
                     LNRTKYI"
     exon            1037..1273
                     /gene="Ylpm1"
                     /gene_synonym="A930013E17Rik; ZAP; Zap3"
                     /inference="alignment:Splign:2.1.0"
     exon            1274..1492
                     /gene="Ylpm1"
                     /gene_synonym="A930013E17Rik; ZAP; Zap3"
                     /inference="alignment:Splign:2.1.0"
     exon            1493..2436
                     /gene="Ylpm1"
                     /gene_synonym="A930013E17Rik; ZAP; Zap3"
                     /inference="alignment:Splign:2.1.0"
     exon            2437..4554
                     /gene="Ylpm1"
                     /gene_synonym="A930013E17Rik; ZAP; Zap3"
                     /inference="alignment:Splign:2.1.0"
     exon            4555..4672
                     /gene="Ylpm1"
                     /gene_synonym="A930013E17Rik; ZAP; Zap3"
                     /inference="alignment:Splign:2.1.0"
     exon            4673..5093
                     /gene="Ylpm1"
                     /gene_synonym="A930013E17Rik; ZAP; Zap3"
                     /inference="alignment:Splign:2.1.0"
     exon            5094..5186
                     /gene="Ylpm1"
                     /gene_synonym="A930013E17Rik; ZAP; Zap3"
                     /inference="alignment:Splign:2.1.0"
     exon            5187..5376
                     /gene="Ylpm1"
                     /gene_synonym="A930013E17Rik; ZAP; Zap3"
                     /inference="alignment:Splign:2.1.0"
     exon            5377..5495
                     /gene="Ylpm1"
                     /gene_synonym="A930013E17Rik; ZAP; Zap3"
                     /inference="alignment:Splign:2.1.0"
     exon            5496..5650
                     /gene="Ylpm1"
                     /gene_synonym="A930013E17Rik; ZAP; Zap3"
                     /inference="alignment:Splign:2.1.0"
     exon            5651..5713
                     /gene="Ylpm1"
                     /gene_synonym="A930013E17Rik; ZAP; Zap3"
                     /inference="alignment:Splign:2.1.0"
     exon            5714..5833
                     /gene="Ylpm1"
                     /gene_synonym="A930013E17Rik; ZAP; Zap3"
                     /inference="alignment:Splign:2.1.0"
     exon            5834..6010
                     /gene="Ylpm1"
                     /gene_synonym="A930013E17Rik; ZAP; Zap3"
                     /inference="alignment:Splign:2.1.0"
     exon            6011..6094
                     /gene="Ylpm1"
                     /gene_synonym="A930013E17Rik; ZAP; Zap3"
                     /inference="alignment:Splign:2.1.0"
     exon            6095..6178
                     /gene="Ylpm1"
                     /gene_synonym="A930013E17Rik; ZAP; Zap3"
                     /inference="alignment:Splign:2.1.0"
     exon            6179..6259
                     /gene="Ylpm1"
                     /gene_synonym="A930013E17Rik; ZAP; Zap3"
                     /inference="alignment:Splign:2.1.0"
     exon            6260..6311
                     /gene="Ylpm1"
                     /gene_synonym="A930013E17Rik; ZAP; Zap3"
                     /inference="alignment:Splign:2.1.0"
     exon            6312..6442
                     /gene="Ylpm1"
                     /gene_synonym="A930013E17Rik; ZAP; Zap3"
                     /inference="alignment:Splign:2.1.0"
     exon            6443..6623
                     /gene="Ylpm1"
                     /gene_synonym="A930013E17Rik; ZAP; Zap3"
                     /inference="alignment:Splign:2.1.0"
     exon            6624..11052
                     /gene="Ylpm1"
                     /gene_synonym="A930013E17Rik; ZAP; Zap3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6988..6993
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ylpm1"
                     /gene_synonym="A930013E17Rik; ZAP; Zap3"
                     /note="hexamer: AATAAA"
     polyA_site      7011
                     /gene="Ylpm1"
                     /gene_synonym="A930013E17Rik; ZAP; Zap3"
                     /note="major polyA site"
     regulatory      11032..11037
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ylpm1"
                     /gene_synonym="A930013E17Rik; ZAP; Zap3"
                     /note="hexamer: AATAAA"
     polyA_site      11052
                     /gene="Ylpm1"
                     /gene_synonym="A930013E17Rik; ZAP; Zap3"
ORIGIN      
        1 gaccgcgggc ccagctccgt agcgccggcg cactggcgcg ctccgttcac acgctccgcg
       61 gcctgtaagg caccgcgagt tccggctgtc gccgtcaccg ccgcggctcc tggaggtcgg
      121 ttgcgacgag taacggcgcc gggacgagcc ccgcgccttc gtttcctata tgtatccgaa
      181 ttggggccgg tatggcggga gcagccacta tccgccgccg ccggtgccgc cgccgccgcc
      241 accggtggcg cttcccgagg cctcgccggg gcccgggtac tccagttcga cggctcccgc
      301 ggccccttcc tcttcaggct tcatgagctt ccgagagcaa cacttggcgc agctccagca
      361 gctgcagcag atgcaccaga agcaaatgca gtgcgtgctc caaccccacc atcttcctcc
      421 gcccccgctg ccacccccgc cggtgatgcc cgggggcggc tacggagact ggcagccgcc
      481 tccgccaccg atgcccccgc cacctggacc agccctcagt tatcagaagc agcagcagta
      541 caaacaccag atgatccacc accaacgaga tgggcctccg ggtttggttc caatggagct
      601 ggagtcccct cctgaatctc cccctgtacc tccaggatcc tacatgcccc catcccagtc
      661 gtacatgcct ccacctcagc caccaccctc gtactatccc ccttcctccg ctcagcccta
      721 cctgcctcct gctcagccat ccccttcaca gtctccacct tcccagtcct atctggcgcc
      781 cactccttct tattcttcct cgtcctcctc acaatcatat ttgagccatt cccagcccta
      841 cttaccccct tctcaggcct ctccttcccg ctcctcccag ggcccttcta aaccccagct
      901 accaccacca ccgtccatcc cttctgggaa taaaacagct atccagcaag agcctttgga
      961 gagtggggcc aagaacaaga ctgctgaaca gaagcaagct gctcctgaac cagatccctc
     1021 tacaatgact ccacaggagc aacaacaata ttggtatcga cagcatctac ttagtttgca
     1081 gcagaggaca aaggtgcatt tgccgggaca taaaaagggt cttgtcacag caaaggatgt
     1141 accagaaccc atcaaagaag aagctccggg gccagctgcc agtcaggtag cagaacctct
     1201 tgcagctgag aagcccccat tgccacctcc caatgaagaa gcaccacctc cgctctcacc
     1261 tgaggaaccc cagtcagaag actcagaaga ctcggaagac tctgaggagg atgctagatt
     1321 taaacagttg aaggctatag cagcacattg gcaggctgca gcagcacatt ggcaacagca
     1381 gcagcagcag cgagtcggct tccagtatca aggaataatg cagaggcaca cacagttaca
     1441 gcagatcctg cagcagtacc agcaagttat ccagcactca ccacacatac agaccatgtc
     1501 tctggatgtg cagctgcgac attatgagat gcagcagcaa cagtttcaac atctctttca
     1561 agactgggag cgagagtttc agctgtggga ggagcagctc cattcctatc ctcataaaga
     1621 tcagcttcag gagtatgaga agcagtggaa gacatggcag ggacatatga aagccactca
     1681 gacctatctc caggagaaag tcaactcgtt ccagactgtg aagagccagt acctggggaa
     1741 catggcaatg ccacctccgt ttgttccgta ttctcagatg cctccacctc tgccaacaat
     1801 gccacctcca gtattacctc catccttgcc accaccagtg atgccccctg ccctgcctac
     1861 ctccatccca ccacctggca tgcctccgcc tgtgatgcca ccttctctgc caacctctgt
     1921 ccccccacca ggaatgcctc catctctttc ttcagggcca cctccagttc tccctccacc
     1981 tgccctctct tcagcagggt caccaccagt ccttccccca ccggctctac ctgggggacc
     2041 acccatccta cccctcccac cattatcttc agccacacct cccccaggaa tacctccccc
     2101 tggagctcca caagggatgc ctcctcagtt aacagcccca cttccaccag cttctggttc
     2161 tcagaactca cagatcccag agaaacctag acaagcactg cttcccacac ctgtgtcttt
     2221 tggatcgacc ccaccttcac catatcaccc tccacctcag tcagaacaag tgaattccaa
     2281 acctctgaac aaggtgttct catctgagca aggactgggc gagtcttctg ctctatctca
     2341 gtccatcatt gcagctaagg acacgccagt gaagtcaggt ggactgcttg cagaccctcc
     2401 taagggcagt ttcttggaag gtccgagagg tccaagattt gatggtcctc gaagatttga
     2461 ggatttaggg tcaaggtgtg aaggaccgag acccaaaggg cctcgttttg aaggaaatcg
     2521 ccccgatggg ccaagaccca gatatgaaag tcacccagca gagggcacta aaagcaaatg
     2581 gggaacgatc cctcggggcc cagcatctca attttatata actcccaata catccctaag
     2641 tcctcgacag agtggaccac agtggaaagg ccccaaagca actgttggac agcagcatca
     2701 gcagcagcct aagcagcaac ctaagtcaca agcagaacct ctttcaggaa acaaagagcc
     2761 attagcagat acaagtaata accaacagaa gaatttaaaa attcagtcag ctgcgttttc
     2821 catttccgca gatgtcaagg ataccaaggc agctcagtca aatgagaatc taagtgactc
     2881 tcaacaagag ccaaccaaaa gccaagtctc ggaagggccc gtagagccct ctaattggaa
     2941 ccagaattct caaagtatgg agactgaaat ggacaaagca gaaggtgtta ctcagcctgt
     3001 atcccttgca aacaaacctg tacctactca atctactttc ccctcaaaag tagggagcat
     3061 ggagggagga gccgcagcag cagcactgac tgcagacgat ttcaaacctt tgggtgttgg
     3121 tttgtcccac tcagaaaacc accaagaaaa agatcttcct cagccagaca gcagagaaaa
     3181 tagattagaa ggcaataaag gcagcagctc atcatataga ggtcctgggc agaacagagt
     3241 ggaagagtca cgggataaag gactagtaaa cagaggtcgt ggccagataa ttaaccgtgg
     3301 tccaggtctg gtcaagcaag aagatttcca tgataaaatg atgggtagaa gagaagacag
     3361 tcgtgagaaa atgaacagag gagaaggcaa ccgggacagg gtgtttgtga ggccaggaag
     3421 cagtcgggat aaaataccag gtggcctaca agacagccag gacagtagag ccaacagccg
     3481 agaaaggggg ccacctcgca gggctggcag tcaggagaga ggacctcctc gaagggctgg
     3541 aagtagagag agagtacccc ctcaaagagc tggaagcagg gagagggtac cacctcgtgg
     3601 tccaggtagt cgagaaaggg ggttaggaag gccagatttt ggtcatgata gagttccatt
     3661 cagatcagaa ctaggagatg gtggagacaa agtgtatcct tatcaccgag atgaaccttc
     3721 tagggcttcg tggaaccatg gagaagagag aggacatgaa gagttcccag tagatggtag
     3781 aaatgctcca attgagcgag aaagactcga tgactgggat agaaagagat actggagaga
     3841 gtgtgaacgt gactatcaag atgatacact agattcatac agcagagagg acaggttctc
     3901 agcaccacca tcacggtctc atgatggaga caggcgaggc ccttggtggg atgattggga
     3961 aagagatcag gatatggatg agggttatgg tagggaaatg gacagggact tagacagaga
     4021 tgtggatcgc attagaagac ctttggatat atatgataga aatgtggata acgagtggga
     4081 cagagattat gggagaccac tggatgaaca agaatcacag tttcgtgaac gagatattcc
     4141 atctcttcca cctttaccac ccctcccacc tcttccacct ttggatagat atcgggatga
     4201 tagatggaga gaagaaagaa atcgagacca tgggtatgac cgagatttcc gtgatagggg
     4261 tgagttgagg attcgagagt atccagaaag aggagataca tggcgggaaa agcgagatta
     4321 tgttcctgac agaatggact gggaaagaga acggttgtca gacagatggt acccatctga
     4381 tgtggataga cattccccca tggcggaaca tatgccatcc tcacatcatt cctctgaaat
     4441 gatggggtcc gatgcaaact tagactctga ccaaggcctt ggaggggtaa tggttctcag
     4501 tcagaggcag cacgaaatca ttttgaaagc tgcacaagaa ttgaaaatgc ttcgagaaca
     4561 gaaagagcag cttcaaaagt tgaaagactt tgggtctgag ccacagatgg ctgaccatct
     4621 accaccccca gactcaagac tacagaatcc atcaagacct gggatgtatc cgcctccagg
     4681 atcctataga ccaccccctc ctatgggtaa gccacctggg tcaattgtaa gaccctctgc
     4741 tccaccagca agatcatcta ttcctatgac taggcctcct gtgccaatac caccaccgcc
     4801 tcctccacct ccaccaccac cacctcctcc tccagttata aagtcaaaaa cctcatctgt
     4861 gaaacaggaa cgctgggatg aagattcttt ctttgggctc tgggatacaa atgatgatca
     4921 aggactgaat tcagaattta agcgagacac tgcaacaatt ccgtctgctc cggtgttacc
     4981 acccccacct gttcattctt ccattccccc tcctggccca atgcctatgg gtatgccacc
     5041 aatgtccaaa ccaccaccag tgcagcatac agttgactat ggccatggcc gagatatgcc
     5101 tactaataaa gttgaacaga taccatatgg agaaagaata actctacgtc cagatccatt
     5161 acctgaaagg tcaacttttg atgcagatca tgcaggccag cgtgatcgct atgatagaga
     5221 tagagaccgt gaaccttatt ttgaccgtcc aagtaatata acagatcatc gagattttaa
     5281 aagggaccga gagacacata gagatagaga ccgagatcgt gttcttgact atgagcggga
     5341 ccgatttgac agagagcgca gaccccgaga tgacaggaat caatcatatc gagacaaaaa
     5401 agaccattct tcatccagaa gaggagggtt tgacaggcca tcctatgacc ggaagtctga
     5461 tagaccaccc tatgaaggcc cacccatgtt tggaggagaa cgaagaactt acccagagga
     5521 gcgcatgccc cttccagctc ctgccctggg ccaccagcca cctccagttc ctcgggttga
     5581 gaagaagccg gagtccaaaa atgtggatga cattctgaaa ccgccgggcc gggagagccg
     5641 gcctgaaaga attgttgtta taatgagagg attgcctggc agtggaaaga cacatgttgc
     5701 aaaacttatc cgggataagg aagtagaatt tggaggacct gcccccaggg ttttaagtct
     5761 agatgattat ttcatcgctg aagtagaaaa agaagaaaaa gatccagatt ctggaaagaa
     5821 agtaaaaaag aaggtaatgg aatatgaata tgaagctgac atggaagaga cttatcgcac
     5881 cagcatgttc aaaactttca aaaagactct agatgacggc tttttccctt tcattattct
     5941 ggatgctatc aatgacagag ttagacattt tgatcagttt tggagtgcag cgaaaaccaa
     6001 gggttttgag gtgtatttgg ctgaaatgag tgctgataac cagacttgtg gcaagagaaa
     6061 tattcatgga agaaagctta aagaaataaa caagatggct gaacactggg aagttgcacc
     6121 tcgtcacatg atgcgtctag acatccgctc cctgctacaa gatgctgcga ttgaagaagt
     6181 agagatggaa gattttgatg ctaacattga agaccagaag gaagaaaaga aagatgcaga
     6241 agaagaggaa agcgaactgg gttacattcc gaaaagcaaa tgggagatgg acacttctga
     6301 ggcaaagcta gacaagttgg atggcttgag gactggtact aaaaggaagc gagactggga
     6361 ggcgattgcc agcagaatgg aggattacct tcagctccct gacgactacg agactcgcgc
     6421 ttctgagcct gggaagaaga gggtgagatg ggcagaccta gaagaaaaga aggatgcaga
     6481 taggaaaagg gccataggtt ttgtggtcgg acagactgat tgggagaaga tcacagatga
     6541 gagtggtcac ctggctgaaa gagccctcaa tcggaccaaa tatatatgag acttagtttt
     6601 gaatggagtc atgttcctct aaggtggttc gatgtgaggc gacctgaagc tcagccctcg
     6661 ggaagcttct tgtgtctgga agcttcttgt gtctccacgt ttcaattttg ttttgtttta
     6721 ccactttcat ttttaaacgt tttccagtat cccccccaaa attttagaat cttgctatat
     6781 ccaagcaaga cattattaat atttttttta aactaatttg gggagggagg gttagcttaa
     6841 gtgctaagtc aggtgtggat ccacaggagg gttccaacag agtgtttcct ccactgtata
     6901 ctgtcacaga ctatcatcat tgctttgtgg ctggttttgt ttttttactg tatgtaacaa
     6961 gtagctgatt gtacttggat aaaaaacaat aaactttcac tataaagcca atgagattca
     7021 taggctgtac agtatgggcc cttttctctt attttcttac atttattttt attgttaatt
     7081 aaatgcagta tgtcctgctt gctgaccacc cccaaaccac ctctttacta ttgaatatta
     7141 gcacagctgt ttggtagcac attgtaaaac tccatgattg caaagtgtcc agtgatgacc
     7201 aaaacattca actttataga tggagttctc tttctttgtg tcttaaagac taacagaatc
     7261 aagtctaaat atccatcaat tttctgagac atctctctct ctctctctct ccctctctct
     7321 ctctctctct ctccctccct ccctcccccc tcaggagggg gaaatacggt gttacctctt
     7381 tattcttcct ttctctttgt gctaccttgt ttgatttcct ccctctcccc cccccccctt
     7441 tagctggttt taaatacagg tgaacagaaa tgatacattc catagaactc aagttgttgc
     7501 cttgttttga acttgaatcg ttgctttcta agacaggatc atggtaaagg agtatgaaaa
     7561 gtctccagcc ctctggcaag cagtctttga gcctggccag cttttcaggc tcttgccaga
     7621 ttgctcatta ttgtaaaact tggccttcag catagaattt catctcctgt ggataatccc
     7681 actcagaacc cagaagcaga gcttacatcc agataacatt cttccttaag tatagaaagg
     7741 aggtgcttgc tttttatcag tcttcacaga tagagatgaa ctttcttcct caaacactat
     7801 ttcttggtgg caagccagct caacaacttg ggaacatgtt aacagatgac ctcagcatta
     7861 tgtcatggtt ggaaatcttt agtttttcaa tctacattaa atactgtgct tggagctaat
     7921 atttcttagc agttcaggag tgttactttg ggttcagtaa tgaccttctc agactgaagg
     7981 cactaatcgt aacatcttcc tgtacttttc cctcaaattc tgaatgttta tgcctaaaag
     8041 actaggttca ttaacaagtt aatattgaat gtataatttg cttaatttaa tgatttgcac
     8101 tgtttgtaat gtttaataat ctattttggt ggctaaggac tgtaatctat ttctgcatat
     8161 ggatccatct tagctacctt tattatactg gaaaatgtta catggtaaga tagccaaata
     8221 gagctattgt ttgtacaaag actcatttaa cacttatctt ttcttactaa agtaagactt
     8281 gtaaagttat tttcctgctt gagaagaaaa gaaggcctct ttgttcctca cctttaacct
     8341 ttgtgtagca tttgaaacac ccgagagatg agtgttggtt acccacgaat catgggtctc
     8401 agcatcgtca gccatggcct gtggcagttt tcagaaagta gttagaggag ccacagtcaa
     8461 gagctgcctg ctttcagaag tgggttcatc tacagagagt cagaaaaaag aaccagaaag
     8521 cagtaaggaa gataaccaat taatacttga ttctacaagg ccagtaggaa actcttaaga
     8581 aatcctaatt tttattatca cctaaaccaa cagaatagaa ggtcaagtgg tatcttgggg
     8641 agttttgggt tgggtaaaca ttttgtagtg agtcaactct tcttagttac agtacaaacc
     8701 tagagtctgt gtgtttgcag atttattact gttatctttc ttatttcaga aagcaatccg
     8761 gtattatttt gcatttgtat ttaaatcatt ttagttgtgg tttcttttat ctggctggat
     8821 ttatttcact tatggcagaa agagcaagtc aaagacccca tccagagtat tgactataca
     8881 ttttaaattg aactaatagt tttccacttg ggtttccttg gtttggagcc acttggagtt
     8941 tgtgttaaat gttttatcct ggtaaccaca agttacaggt atttgttaat gggcgtctag
     9001 agctgggcta ggactataaa ggcagcaagt tctcaggagc agactggcag atcttagaat
     9061 tttagctgaa gtgttaaagc aggctaagga aggggaatga ttccttgttt ttgtattgat
     9121 agattgtcat acaaactctg ttcctctctc agaacctatg tgacctcaag tgactcttaa
     9181 ctttctgaac accagtttca tctgtagata tgaaaatgga attataaatg cctttttgcc
     9241 taatacggat catagtaaaa cacacctcac tattctgagg ataaaattgg actattatgc
     9301 tctgctgctg tcataggacc cagccacaaa gtaaaagata aaaatcagta gtcgtgcatg
     9361 atacaggcct ttaatccctg gcagagacaa gtagatccct gtgttttcaa ggacagcttg
     9421 ctctccacag agaagccttg tcttggaaaa cagaaacaaa acaaaaagca aatcagtagt
     9481 aaattactta actttttctc ggatgcttct gaaactctta cttcccagct gtcctaaaga
     9541 gagttctgcc accgtatagc tgctatagat tgagctgagc catggaaaca gtgcagggtg
     9601 tgaggaggtg gaagagttga aagcatctgt aggaagctgg tggcctatcc tcaggaccag
     9661 cgtggaagct tgaggggctc aagagcaaag caggagtcat gacaggatgg aatcgccaga
     9721 ccgtgggcat gagcacagat aacatgaaaa acaccacggt gcttatgaga atgtgtcccg
     9781 ctcatatggt gtaaaattgg aaatggtcag gaatgtcata aacactgtca cctgcccccc
     9841 tcccccagct tcccactgca cctagagcca acattaaaag ctaattttat gctttttaag
     9901 aaaattctgt gggttggcta agtagtcact ttgtcagcgg tctttatgga ctactttgtt
     9961 ttccttttaa gagtgaggtt tagtggccat tcaaatcata cataaaatat ttctgttatc
    10021 tccctttagt ttcccaaagt taacgtctta ttattaaagg gtattttcgg aaaactttca
    10081 gaaatggttt caactaaatc actattgttt ttgtggcatt gagcacatga tagagatgtt
    10141 acacaagtct cagcacttgc tggtttgaga agtcacccct aaagcccctt gcacatttga
    10201 ttttagacag ccaccattct gttttccatt tgtatactct cgtcatttaa agaatattac
    10261 acatgtaaaa tacattacat agtcctttgg gattggtgga accttttgtc attggcctag
    10321 ttcctttgag gctttttcaa attgtcatgt atatctgtta atcaatttaa tgatgactag
    10381 ccttagatcc cattctctct tgtggctgta tcatataatc gacatgatta tgaaaattta
    10441 cttaccaggt ctcaattgtt tggtactttt cctgtctttt gctgctctaa attgtgaagt
    10501 ttctttgcac tcaatctgcc ttcctacacc tacctaattt ccagcaatga agaaacaata
    10561 ccagtggcat cctttgcaca gatgtcctca aactgtaaca ctccacacag catagcacag
    10621 tggtagactg ctatcaagag accacgactt taaggaggtg acaacgacag acttgcttcc
    10681 ctagaaaacc cttcatgatt gaattgtgac aaaacgggga cctgaatgat cagagactca
    10741 tgcctccctg atccatacat gacttgagag ttgagactcc tagctgctgt ccatgggacc
    10801 tgtacctcaa ggcgtggacc gatgtcagtt atgcagcctg ttgctgaaag tctggaagga
    10861 agatggtggt gctctgcagt gatggatcgc gctctggatg catgccacag ggcacctgag
    10921 aacttaatgc tttacgatgt aggtaaagct taactgagtc ttccacttaa gaaacttgaa
    10981 tgttctccca gatatccata accttgtttc tgagcgtaaa gcatagatag taataaaaga
    11041 aaatctttct ta
//
