LOCUS       NM_207633               5195 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus Yip1 domain family, member 6 (Yipf6), mRNA.
ACCESSION   NM_207633 XM_135983
VERSION     NM_207633.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5195)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5195)
  AUTHORS   Wang,L., Mazagova,M., Pan,C., Yang,S., Brandl,K., Liu,J.,
            Reilly,S.M., Wang,Y., Miao,Z., Loomba,R., Lu,N., Guo,Q., Liu,J.,
            Yu,R.T., Downes,M., Evans,R.M., Brenner,D.A., Saltiel,A.R.,
            Beutler,B. and Schnabl,B.
  TITLE     YIPF6 controls sorting of FGF21 into COPII vesicles and promotes
            obesity
  JOURNAL   Proc Natl Acad Sci U S A 116 (30), 15184-15193 (2019)
   PUBMED   31289229
  REMARK    GeneRIF: YIPF6 controls sorting of FGF21 into COPII vesicles and
            promotes obesity in mice.
REFERENCE   3  (bases 1 to 5195)
  AUTHORS   Brandl,K., Tomisato,W., Li,X., Neppl,C., Pirie,E., Falk,W., Xia,Y.,
            Moresco,E.M., Baccala,R., Theofilopoulos,A.N., Schnabl,B. and
            Beutler,B.
  TITLE     Yip1 domain family, member 6 (Yipf6) mutation induces spontaneous
            intestinal inflammation in mice
  JOURNAL   Proc Natl Acad Sci U S A 109 (31), 12650-12655 (2012)
   PUBMED   22802641
  REMARK    GeneRIF: a tissue- and organ-specific function for Yipf6 in the
            maintenance of intestinal homeostasis and implicate the orthologous
            human gene as a disease susceptibility locus.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB642656.1, AK030473.1 and AL672103.10.
            
            On Sep 26, 2005 this sequence version replaced NM_207633.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660821.175723.1,
                                           SRR1660817.262325.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-637               BB642656.1         22-658
            638-2976            AK030473.1         640-2978
            2977-5195           AL672103.10        134094-136312
FEATURES             Location/Qualifiers
     source          1..5195
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 43.19 cM"
     gene            1..5195
                     /gene="Yipf6"
                     /gene_synonym="A430107J06Rik"
                     /note="Yip1 domain family, member 6"
                     /db_xref="GeneID:77929"
                     /db_xref="MGI:MGI:1925179"
     exon            1..508
                     /gene="Yipf6"
                     /gene_synonym="A430107J06Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             452..1162
                     /gene="Yipf6"
                     /gene_synonym="A430107J06Rik"
                     /note="YIP1 family member 6"
                     /codon_start=1
                     /product="protein YIPF6"
                     /protein_id="NP_997516.1"
                     /db_xref="CCDS:CCDS30296.1"
                     /db_xref="GeneID:77929"
                     /db_xref="MGI:MGI:1925179"
                     /translation="MAEAEDSPGEQEAAASKPLFAGLSDVSISQDIPIEGEITIPSRA
                     RAQEHDSSTLNESIRRTIMRDLKAVGRKFMHVLYPRKSNALLRDWDLWGPLILCVTLA
                     LMLQKSSIDGKNDGGGPEFAEVFVIIWFGAVTITLNSKLLGGNISFFQSLCVLGYCIL
                     PLNIAMLICRLLLLAGQGPINFMIRLFVVLLMFAWSVVASTAFLADSQPPNRKALAVY
                     PVFLFYFVISWMILTFTP"
     exon            509..637
                     /gene="Yipf6"
                     /gene_synonym="A430107J06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            638..716
                     /gene="Yipf6"
                     /gene_synonym="A430107J06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            717..759
                     /gene="Yipf6"
                     /gene_synonym="A430107J06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            760..888
                     /gene="Yipf6"
                     /gene_synonym="A430107J06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            889..1046
                     /gene="Yipf6"
                     /gene_synonym="A430107J06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1047..5195
                     /gene="Yipf6"
                     /gene_synonym="A430107J06Rik"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1749
                     /gene="Yipf6"
                     /gene_synonym="A430107J06Rik"
                     /note="major polyA site"
     regulatory      4292..4297
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Yipf6"
                     /gene_synonym="A430107J06Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      4316
                     /gene="Yipf6"
                     /gene_synonym="A430107J06Rik"
                     /note="major polyA site"
     regulatory      5039..5044
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Yipf6"
                     /gene_synonym="A430107J06Rik"
                     /note="hexamer: AATAAA"
     regulatory      5056..5061
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Yipf6"
                     /gene_synonym="A430107J06Rik"
                     /note="hexamer: AATAAA"
     polyA_site      5061
                     /gene="Yipf6"
                     /gene_synonym="A430107J06Rik"
     polyA_site      5091
                     /gene="Yipf6"
                     /gene_synonym="A430107J06Rik"
     regulatory      5118..5123
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Yipf6"
                     /gene_synonym="A430107J06Rik"
                     /note="hexamer: AATAAA"
     polyA_site      5146
                     /gene="Yipf6"
                     /gene_synonym="A430107J06Rik"
     regulatory      5171..5176
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Yipf6"
                     /gene_synonym="A430107J06Rik"
                     /note="hexamer: AATAAA"
     polyA_site      5191
                     /gene="Yipf6"
                     /gene_synonym="A430107J06Rik"
                     /note="major polyA site"
ORIGIN      
        1 aagttcggct aagttcagct aggttcggct gaatgccact tggctcggct aagtttggct
       61 ggggcctctg ggctcgattg ggttcggctg agcatcacgg ggctcgattg ggttcagctg
      121 agcatcactg ggctccattg ggttcggctg ggagtttgct ggagcctggg gcaccgctgg
      181 gcgagccggc gcttctagcc tgcactctca gtgggcgtgg aaggcggagc gccccctagc
      241 gaaactgcgt ccccaaacag tgagcaaata ggctcgcgct cgagcctcgg aggctaccgg
      301 agcaccggaa ctcggctggg cgccgcagca gccagcctca ggcgccggcg gtgacgccgt
      361 cttaacgcga ccgcgcgctg accagccccg gtctccacgt ctcaggtttc gcagagacgc
      421 atgggagggg agcagttgga ggtttatcaa gatggcggaa gcggaggact ctccgggaga
      481 acaggaggca gcggcatcca agcccctgtt tgcagggttg tctgatgtgt caatttctca
      541 ggacattccc atagaagggg agattaccat cccctccaga gctcgtgctc aagaacatga
      601 cagctccaca ctgaatgaat ccattcgtcg gaccattatg cgagatctaa aagctgtggg
      661 aaggaaattt atgcatgttt tatatccaag gaagagtaat gcactgttaa gagactggga
      721 cctgtggggc ccattgatac tttgtgtgac acttgcattg atgttacaga aaagttccat
      781 tgatgggaag aatgatggcg gaggcccaga attcgcagaa gtatttgtta tcatctggtt
      841 tggagcagtt accatcacgc tgaattccaa acttcttggc ggaaacattt ctttttttca
      901 gagtctctgt gtattagggt actgcattct tcctttgaac atcgcaatgc tgatctgccg
      961 cttgctgctt ttggctggac agggaccaat aaacttcatg attcggcttt ttgtagtgtt
     1021 gttgatgttc gcttggtccg tggtggcatc tacagcattc cttgctgaca gccagcctcc
     1081 aaacagaaaa gccctggcag tgtatcctgt ctttttattc tactttgtca tcagttggat
     1141 gatactcacg ttcacgccat gagtcaggat acacacattc aacaccaatg aactgaaggc
     1201 tcacctgaaa gataatggtt atcaacaaca acaacttctc ccactcttgt acaattgttg
     1261 gggtattaaa agggggccac atgccactgt tgtcatttat ataagaaact gatatttgca
     1321 aggctgtcct tttcctctta atgttattct tttcaaatac ttgtacatcc catagatagt
     1381 aacatgcctc cttaaggcat gatgaagcta ttcgtgtgac ccagtgactc gagcaagtgg
     1441 atccactcta cagattacag agttggtgac catcttcagc ttggagaaga tttgttcagg
     1501 tgcagctctt aaacacattg ccttatgact attagaatat gcctcttttc ataaataaca
     1561 gtctgtatcc attgattttc ttttctcccc caaactcgag aaggcaacag caagaggtta
     1621 ggaacgaggt ttgtagatgt gggaagagaa aacgtgttaa ctagtttcag attttgatca
     1681 gaggtaccgc tgtacttggt ttgtcgtttg tttttaagca aataacatct aaggaatccg
     1741 cttttaaaat atttttgtat acttactttt ctgtcacgtg taacagaggc tccgcttaca
     1801 ttctagtttt taacctttca tacagtgaca gcagtcaaac atgcaactct aactgaagtg
     1861 cttgatggtt taatgcttga gctttcctaa gtagtagagg atcagaaatc gaggtttatg
     1921 gtttgtagtg catattgtca tgtgggtacc ttcctttaag gtatagcttg gctattgcgt
     1981 atttaaaaga atctattttg tacaacccag cctcagatta gaaagaaagg ctacatcaga
     2041 agcgtgcatt taaccaaatg gacatagaga tctagtgttc tgaagactgg ataatggaag
     2101 aatgcgtaca tacatgatga agggttagtt gagtttatag ctgctgcctt tccatagtgg
     2161 gctcagcagg gtttttttgt ttttgtttgt ttgttttgat tatatatgga ggaatttttt
     2221 tttttggagt tgggggctag ggaataacaa tttttttgtg tgttttagac tttatttgta
     2281 aagctaatta gcttcccttt agatatgtac attttgcaca tgtgcatcta cctgtcctct
     2341 cagatattta cgcacaagag tgaaggcttt tcagggaaca gaacatctag ggcaggctga
     2401 ttttcagcta aacaggactc ctgtaagata gtaagcaccg atgccttctg tatgtgtcat
     2461 attgaactct aatagatgaa gattaggagt cagagaacat tcattgtaaa tatgcactta
     2521 cttgtaaaga tagaaatgtc ttattccatg tgttttatca tagaattgaa atatttattg
     2581 atttttgtat ttaaagacta ccttcatata aatatataac tctaaaaaca taatttttct
     2641 cattctcaaa gtaaccaaat gagcaacact aggccaaatg ggttcatggg atgagttaca
     2701 aagcattgct gagtttatcc tctctgtccc aaccttactt acctaatggt ttggagatat
     2761 agatttgaat tcattgtaat ttatgtttta aattataaac cttgtaagga taaatctggt
     2821 atttcaatct tgaaaacttt aaaactaacc ctaatatttg aaatttgtca taaaatatca
     2881 tttctttcct gtatcgaaaa ttttaaactt tcccttcaaa tatcttccct aagttgtttc
     2941 ataatatgcc caagtaatta taataacaaa gtaaccatac ttctcaaatt tagtctttac
     3001 tggattttac tcaggtgaaa catttcctct gaaattccta aggccacaag ccgtaagggt
     3061 tttggagggt taaacacgtt ggatataagg cagcttgatc ctgtgtgtgt taatctgttg
     3121 cccttgggtg atttgctgaa tggtttttat atggcttaaa aggggaattt aggactgagg
     3181 ctgtagttca gtgatagagc attagccagg catgcacagc actctaggtt caatcctggg
     3241 cattgccaaa aaaaaaaggt ggataaactg gaggcctaat ttcttttttt ctggaattaa
     3301 atgatcagag gatataaata ttttaatata tgcaaaaaat ctgttgcttt ctatgacaaa
     3361 tgaagtcctg actctggaag ttgtaatcta gcttttcctg gttcgctaca aaggcacatg
     3421 gttgactgta gaaatgaggc ctggaagggc agaagcgccc agggaaggac ctcctgttct
     3481 aagatggtgc agtttcatgc tgctggtgag tttgaagctt ttttgcagac tgcgcatggc
     3541 tattgtagcc gactccgacg atcacctgct gcttccacat ctcagaccat gacactgttt
     3601 tacatggctt agcaatagga agagtagaga cttgatttaa ttgggcttca gattacaaaa
     3661 tctctagtga tgacaatgtc tttgaatgtt ttatatgttt ataatcagat attgaggtgt
     3721 gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtttggtttg gcttcaaagt
     3781 tatgtaagtt gaatttgatc ttttcattgt gggatctttc ttttcgttgg gcaaagttac
     3841 gtggcatgag actaatgata agctgttgac tctcttttat aaatagtacc ctcaaaaatg
     3901 tgattagaag actactaagc ctatacttgg agatataatc tgctgactta ctgcatttta
     3961 gctgcctgct tattcctgga gatgaaaatg aaattttgtt ggttgatatt tttgggtacc
     4021 atcaagtcgt gttagtatgg tttgaacact gaagtgatct ttaactagac tgttggtttc
     4081 tatgatggtt ggatggaagt aaataaatgt atgaatgttg atggatccat gtatgtaaat
     4141 tagaggtcct cctctagatt ctgtgtgctt ttgttataaa tatagaactg acagggacaa
     4201 taatttatga ttattaataa ctaacagtta ttgggcattt actgtatacc aatttactat
     4261 tctaatttta aaagaacttt tgtaatgctt tattaaagtc cactttacca tgaaaattca
     4321 tcctttcaag gtgtacaatt cagcagtcct tactatcttt acggaattac gcaagcagca
     4381 ccactattta atttgagaat gtctgtatca ctgtgcagag aaacaagcca ctcctgttct
     4441 ctctgcacct ccagtccctg tggactacca gtctgctttc tatccatctt ggccaggtac
     4501 tattctcaat gcctggttcc tccactcttc aacagaaagt gctacaattc tcattttaca
     4561 gtagaaaatt taggcacaga aatgtaattg cccaagatca tgtattgatg catgcaagtg
     4621 aattgatggt aagaacacat tagatgaaat gcagtttgta ttacactctt aggcacatag
     4681 aatgagcaca ttccttccca gagtatgccc cctcttactc acctttgcat cctggaactg
     4741 attggacgta gatatgtctt tttttttttt ccagagtaat gacctctggc atctgagcac
     4801 acaaagcagg cagacttaaa aagacaggtt tacggccctt actcctcatt gacccccccc
     4861 cccgtttcct ctcttcacac acacacaatc aatttttcct taagcttgaa gagtcaaact
     4921 actacttaaa aatcttccat ttcacgttta ccacttaggg tactgggtct atttctaaga
     4981 cttaagatta aagtcattca agtactgaat gcctttctat tcggatagat gtgatgagaa
     5041 taaagacttt gccttaataa agcttgttcc tttctggtct ttggtactct actctagtcc
     5101 tggtctttcc tatgagcaat aaacctgtgc aaagaaacct ggaaaatggt ttgtggatgt
     5161 tatatgtgcc aataaatcca ttagaaagag ataaa
//
