LOCUS       NM_001205132            4146 bp    mRNA    linear   ROD 30-JUL-2024
DEFINITION  Mus musculus YES proto-oncogene 1, Src family tyrosine kinase
            (Yes1), transcript variant 2, mRNA.
ACCESSION   NM_001205132
VERSION     NM_001205132.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4146)
  AUTHORS   Trittmann,J.K., Jin,Y., Liu,Y. and Nelin,L.D.
  TITLE     Differential effects of the Src family tyrosine kinases Yes and Fyn
            on lipopolysaccharide-induced lung injury in mice
  JOURNAL   Am J Physiol Lung Cell Mol Physiol 321 (2), L392-L403 (2021)
   PUBMED   34105991
  REMARK    GeneRIF: Differential effects of the Src family tyrosine kinases
            Yes and Fyn on lipopolysaccharide-induced lung injury in ice.
            Erratum:[Am J Physiol Lung Cell Mol Physiol. 2021 Nov
            1;321(5):L988. doi: 10.1152/ajplung.00181.2020_COR. PMID: 34748448]
REFERENCE   2  (bases 1 to 4146)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4146)
  AUTHORS   Francisco,J., Zhang,Y., Nakada,Y., Jeong,J.I., Huang,C.Y.,
            Ivessa,A., Oka,S., Babu,G.J. and Del Re,D.P.
  TITLE     AAV-mediated YAP expression in cardiac fibroblasts promotes
            inflammation and increases fibrosis
  JOURNAL   Sci Rep 11 (1), 10553 (2021)
   PUBMED   34006931
  REMARK    GeneRIF: AAV-mediated YAP expression in cardiac fibroblasts
            promotes inflammation and increases fibrosis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4146)
  AUTHORS   Ye,C., Duan,J., Zhang,X., Yao,L., Song,Y., Wang,G., Li,Q., Wang,B.,
            Ai,D., Wang,C. and Zhu,Y.
  TITLE     Cold-induced Yes-associated-protein expression through miR-429
            mediates the browning of white adipose tissue
  JOURNAL   Sci China Life Sci 64 (3), 404-418 (2021)
   PUBMED   32804340
  REMARK    GeneRIF: Cold-induced Yes-associated-protein expression through
            miR-429 mediates the browning of white adipose tissue.
REFERENCE   5  (bases 1 to 4146)
  AUTHORS   Isago,H., Mitani,A., Mikami,Y., Horie,M., Urushiyama,H.,
            Hamamoto,R., Terasaki,Y. and Nagase,T.
  TITLE     Epithelial Expression of YAP and TAZ Is Sequentially Required in
            Lung Development
  JOURNAL   Am J Respir Cell Mol Biol 62 (2), 256-266 (2020)
   PUBMED   31486675
  REMARK    GeneRIF: a novel insight into the molecular mechanisms underlying
            lung development and contribute to a better understanding of the
            characteristics of TAZ-transcriptional coactivator with PDZ-binding
            motif and YAP
REFERENCE   6  (bases 1 to 4146)
  AUTHORS   Alexandropoulos,K., Cheng,G. and Baltimore,D.
  TITLE     Proline-rich sequences that bind to Src homology 3 domains with
            individual specificities
  JOURNAL   Proc Natl Acad Sci U S A 92 (8), 3110-3114 (1995)
   PUBMED   7536925
REFERENCE   7  (bases 1 to 4146)
  AUTHORS   Stein,P.L., Vogel,H. and Soriano,P.
  TITLE     Combined deficiencies of Src, Fyn, and Yes tyrosine kinases in
            mutant mice
  JOURNAL   Genes Dev 8 (17), 1999-2007 (1994)
   PUBMED   7958873
REFERENCE   8  (bases 1 to 4146)
  AUTHORS   Hebert,B., Bergeron,J., Tijssen,P. and Potworowski,E.F.
  TITLE     Protein tyrosine kinases transcribed in a murine thymic medullary
            epithelial cell line
  JOURNAL   Gene 143 (2), 257-260 (1994)
   PUBMED   8206383
REFERENCE   9  (bases 1 to 4146)
  AUTHORS   Guy,C.T., Muthuswamy,S.K., Cardiff,R.D., Soriano,P. and Muller,W.J.
  TITLE     Activation of the c-Src tyrosine kinase is required for the
            induction of mammary tumors in transgenic mice
  JOURNAL   Genes Dev 8 (1), 23-32 (1994)
   PUBMED   7507074
REFERENCE   10 (bases 1 to 4146)
  AUTHORS   Dymecki,S.M., Niederhuber,J.E. and Desiderio,S.V.
  TITLE     Specific expression of a tyrosine kinase gene, blk, in B lymphoid
            cells
  JOURNAL   Science 247 (4940), 332-336 (1990)
   PUBMED   2404338
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC091274.11 and AC166934.3.
            
            Transcript Variant: This variant (2) differs in the 5' UTR,
            compared to variant 1. Variants 1, 2 and 3 encode the same protein.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK052478.1, SRR10662774.1374009.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-205               AC091274.11        145489-145693
            206-478             AC091274.11        174649-174921
            479-578             AC091274.11        179326-179425
            579-677             AC091274.11        185975-186073
            678-781             AC091274.11        187281-187384
            782-931             AC091274.11        187475-187624
            932-1087            AC091274.11        189424-189579
            1088-1267           AC091274.11        189746-189925
            1268-1344           AC091274.11        193353-193429
            1345-1498           AC091274.11        195070-195223
            1499-1630           AC091274.11        198587-198718
            1631-4146           AC166934.3         25071-27586         c
FEATURES             Location/Qualifiers
     source          1..4146
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 17.33 cM"
     gene            1..4146
                     /gene="Yes1"
                     /gene_synonym="p61-Yes; Yes"
                     /note="YES proto-oncogene 1, Src family tyrosine kinase"
                     /db_xref="GeneID:22612"
                     /db_xref="MGI:MGI:99147"
     exon            1..205
                     /gene="Yes1"
                     /gene_synonym="p61-Yes; Yes"
                     /inference="alignment:Splign:2.1.0"
     exon            206..478
                     /gene="Yes1"
                     /gene_synonym="p61-Yes; Yes"
                     /inference="alignment:Splign:2.1.0"
     exon            479..578
                     /gene="Yes1"
                     /gene_synonym="p61-Yes; Yes"
                     /inference="alignment:Splign:2.1.0"
     exon            579..677
                     /gene="Yes1"
                     /gene_synonym="p61-Yes; Yes"
                     /inference="alignment:Splign:2.1.0"
     exon            678..781
                     /gene="Yes1"
                     /gene_synonym="p61-Yes; Yes"
                     /inference="alignment:Splign:2.1.0"
     exon            782..931
                     /gene="Yes1"
                     /gene_synonym="p61-Yes; Yes"
                     /inference="alignment:Splign:2.1.0"
     exon            932..1087
                     /gene="Yes1"
                     /gene_synonym="p61-Yes; Yes"
                     /inference="alignment:Splign:2.1.0"
     exon            1088..1267
                     /gene="Yes1"
                     /gene_synonym="p61-Yes; Yes"
                     /inference="alignment:Splign:2.1.0"
     exon            1268..1344
                     /gene="Yes1"
                     /gene_synonym="p61-Yes; Yes"
                     /inference="alignment:Splign:2.1.0"
     exon            1345..1498
                     /gene="Yes1"
                     /gene_synonym="p61-Yes; Yes"
                     /inference="alignment:Splign:2.1.0"
     exon            1499..1630
                     /gene="Yes1"
                     /gene_synonym="p61-Yes; Yes"
                     /inference="alignment:Splign:2.1.0"
     exon            1631..4146
                     /gene="Yes1"
                     /gene_synonym="p61-Yes; Yes"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4115..4120
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Yes1"
                     /gene_synonym="p61-Yes; Yes"
                     /note="hexamer: AATAAA"
     polyA_site      4137
                     /gene="Yes1"
                     /gene_synonym="p61-Yes; Yes"
                     /note="major polyA site"
ORIGIN      
        1 gaggaggaga gagggaggcc gcggggtgcg ggcgtccggg agttccctcc tcctcaagta
       61 aagcgtcccg ggccggctgc gccgccgtcg ctgcctcctg gcgccccgcg acctggaggt
      121 ggagaaggga gagggacccg cgggcgtcca cctcggccgg ccgccttctc cccgcggcga
      181 cccgtgcgag tgcggccgga ctcagatttg ataatgggct gcattaaaag taaagaaaac
      241 aaaagtccag ccataaaata cacaccggaa aatcttacag agcctgtaag cccaagtgcc
      301 agtcattatg gagtggaaca tgctacagtt gccccgacct cttccacaaa gggagcatca
      361 gttaatttta acagtctttc catgacaccc tttggagggt cctcaggggt gactcctttt
      421 ggaggagcgt cttcctcatt ctcagtggtg tcaagttcat atcctacagg tttaacaggt
      481 ggtgtcacta tatttgtggc cttgtatgat tatgaagcta gaactacaga agacctttcc
      541 tttaagaagg gtgaacgatt tcaaataatt aacaatacgg aaggagactg gtgggaagca
      601 agatcaattg ctaccggaaa gagtggttat atccctagca attacgtagt gcctgcagat
      661 tccattcagg cagaagaatg gtattttggc aaaatgggga gaaaagatgc ggaaagatta
      721 cttctgaatc ctgggaatca gcgaggtatt ttcttagtaa gagaaagtga aactactaaa
      781 ggtgcttact ccctctcaat ccgtgattgg gatgaggtga ggggtgacaa tgtgaagcat
      841 tacaagatca gaaaacttga caatggtggc tactacatca cgaccagagc tcagtttgat
      901 acactgcaga agctggtgaa gcactacaca gaacatgctg atggattatg ccacaagtta
      961 acaactgtgt gtcctactgt gaaaccccag actcaaggtc tggcaaaaga tgcttgggaa
     1021 atccctcgag aatcattgcg actagaggtg aaactaggtc aaggatgctt tggggaagtg
     1081 tggatgggaa catggaatgg aactacaaaa gtagcaatca aaacactaaa gccaggtaca
     1141 atgatgccag aagcattcct tcaagaagct cagataatga aaaagctaag acacgataaa
     1201 cttgttccac tctatgcagt tgtttctgaa gagcccattt atattgtcac cgagtttatg
     1261 tcaaaaggaa gcttgttaga tttccttaaa gaaggagatg gaaagtattt gaagcttcca
     1321 cagctggttg atatggctgc tcagatcgct gatggcatgg cgtatattga aagaatgaac
     1381 tatattcacc gagatctccg agctgctaat attcttgtag gagaaaatct tatatgcaaa
     1441 atagcagatt ttggcttagc aagattaatt gaagacaatg aatacacggc aagacaaggt
     1501 gcaaaatttc caatcaagtg gacagctcct gaggctgctc tgtatggtcg atttacaata
     1561 aagtcagatg tgtggtcatt tggaattcta cagacagagc tggtaacaaa aggaagagtg
     1621 ccatatccag gtatggtaaa ccgtgaagta ttggaacaag tagagcgggg atacagaatg
     1681 ccttgccccc agggctgtcc cgaatccctc catgaattga tgaatctttg ctggaagaag
     1741 gatcctgatg aaagaccaac atttgaatat attcagtcct tcttggaaga ctacttcact
     1801 gctacagagc cacagtacca accaggagaa aatttataat ccaagtaacc tgtgtgcaca
     1861 gatctgccaa aacagagaga ccttgtgtga gttcttcctg cacagaaatg agaagatatg
     1921 cttcactcgg catgtttctt atggtaaact ggaattccag atacggttac tcaaaaccac
     1981 tttttttttc tccaagcatt aaactctaaa gtaccaatga tgcatcttac agcatacttc
     2041 agggtccaga gaaagtagag ctagagagtg tgattgtggg tgtagcatgg taagaaagag
     2101 caacaggact actggtcatt gccttttctt ccccaaactt gccaagagaa aactacttct
     2161 tggtatgtat aaaacttggc tgttactcca caggaaaatt ctaagatcaa agaacttcat
     2221 gggaccaaat aattccattc cagtttttta aattttctag aatttttttt ctcaaagttt
     2281 ttttttgttt gttttgttct gttttttccc tgtttaatag tcaacatgca ctcctatcag
     2341 aggcctcctt ttgtgtgaaa atgggccaag tcttccaaat gcaaaggaat ggattataaa
     2401 cagcatcaaa aacattgatt taaaaagcca tggaagttag aagcataata cagtatgctc
     2461 acactttgtc cagagaactg gaaagcaaaa caaatttttc atatcagtca tgtcttaaat
     2521 tgttcagctt tgaataatga aggtaaccag aaagtggatt aatcttttta caagggtgta
     2581 ttaattttta aagggttata tacaattgaa attattctat ccagtccaag agaaaaatct
     2641 tttaatattt gcatagcata aaaataaaaa acaaacctaa catttaagca gtcaattttt
     2701 aaacaataag tggagtacta tgaggtgttg ctagtatgtt tttatgatta tgggctccac
     2761 aaatagaaaa catcactaga tcagggactt gaatgcactt tgcttatatt gagtatagaa
     2821 taggagagaa gaaaatgtat ttaaagaaat atgagagacg acatgtgaaa gttctacagg
     2881 tattgggatg gggtgggatg tctaatgttg gtgttgtaga gaaacaacat ggctttctgg
     2941 cactcaaaac tcctcattag ctgttttctt ataccttaaa agttttaaag tatgattgta
     3001 aaactaattt tcttatcata tacactgttt tatctcctca aaatagtgag gataaggctc
     3061 taccctaatt tcagtggccc agcttttata cagaacctct tagaacacca agtttcaaat
     3121 ccctgttgga aactttactt acattacaac tatacttgat ggttatcata ttttcctttt
     3181 ataattaatt tgaggaaaaa tacttactga gtaactgtaa tataaagggg ggattttgcc
     3241 catttaaagt acaggtgtaa agcatttaaa atgagagttt ttctaactca gaaattatga
     3301 aatattaatt tgaactgagt agtattaaca gtttaaggat ctagcaagag gaaaatggag
     3361 tctgctaaaa gtctaatatt tatgttttaa aatatattat tttatagtta tactttaagg
     3421 cattatatca agttcttttt attttcagaa tataattttg aactaccatc agtaaatgta
     3481 aaaatgtgtg ccatggtaaa catgttcaaa ttttaaatgt gacaagtgaa cttcatgcaa
     3541 attggcaaaa gttctggtac taaaagttgt atttgttttt cttttactta acctattcag
     3601 tactgactcc tctgccaaga gggtctcctg agaagactgg gtcctcttgc cctgatgtct
     3661 actctgtgac atgagtgttt taaagggctt catgtgaact atggtattat agtgtatgta
     3721 agcattcatt aaagggtaat aaaatatgtt tatgtactaa agctgatcag aaaaataagg
     3781 cagaaaaatt gatggcattc tttagatttt aactaaatgg agcagctcct tataatacaa
     3841 attgtatagt aaggatacaa cactaattaa tatgttttca gtttaatttg ttatgtattt
     3901 tttaattatc aagaaaaaga aacagttttg tacatttgag gatttttttt tcaacagctt
     3961 tcatctgtat tgtcttaacg tggaacttta acacaccaga aacgaaagtt gttaaaagca
     4021 gccttctagc acaaacactt ttttaagtaa ataatggtag cctaaaactt aatattttta
     4081 taaaatattg taatattgtt ttatgaatta ttaaaataaa attctttgtt gaatgcatct
     4141 atgtat
//
