LOCUS       NP_001192061             541 aa            linear   ROD 10-FEB-2025
DEFINITION  tyrosine-protein kinase Yes [Mus musculus].
ACCESSION   NP_001192061
VERSION     NP_001192061.1
DBSOURCE    REFSEQ: accession NM_001205132.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 541)
  AUTHORS   Trittmann,J.K., Jin,Y., Liu,Y. and Nelin,L.D.
  TITLE     Differential effects of the Src family tyrosine kinases Yes and Fyn
            on lipopolysaccharide-induced lung injury in mice
  JOURNAL   Am J Physiol Lung Cell Mol Physiol 321 (2), L392-L403 (2021)
   PUBMED   34105991
  REMARK    GeneRIF: Differential effects of the Src family tyrosine kinases
            Yes and Fyn on lipopolysaccharide-induced lung injury in ice.
            Erratum:[Am J Physiol Lung Cell Mol Physiol. 2021 Nov
            1;321(5):L988. doi: 10.1152/ajplung.00181.2020_COR.. PMID:
            34748448]
REFERENCE   2  (residues 1 to 541)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 541)
  AUTHORS   Francisco,J., Zhang,Y., Nakada,Y., Jeong,J.I., Huang,C.Y.,
            Ivessa,A., Oka,S., Babu,G.J. and Del Re,D.P.
  TITLE     AAV-mediated YAP expression in cardiac fibroblasts promotes
            inflammation and increases fibrosis
  JOURNAL   Sci Rep 11 (1), 10553 (2021)
   PUBMED   34006931
  REMARK    GeneRIF: AAV-mediated YAP expression in cardiac fibroblasts
            promotes inflammation and increases fibrosis.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 541)
  AUTHORS   Ye,C., Duan,J., Zhang,X., Yao,L., Song,Y., Wang,G., Li,Q., Wang,B.,
            Ai,D., Wang,C. and Zhu,Y.
  TITLE     Cold-induced Yes-associated-protein expression through miR-429
            mediates the browning of white adipose tissue
  JOURNAL   Sci China Life Sci 64 (3), 404-418 (2021)
   PUBMED   32804340
  REMARK    GeneRIF: Cold-induced Yes-associated-protein expression through
            miR-429 mediates the browning of white adipose tissue.
REFERENCE   5  (residues 1 to 541)
  AUTHORS   Isago,H., Mitani,A., Mikami,Y., Horie,M., Urushiyama,H.,
            Hamamoto,R., Terasaki,Y. and Nagase,T.
  TITLE     Epithelial Expression of YAP and TAZ Is Sequentially Required in
            Lung Development
  JOURNAL   Am J Respir Cell Mol Biol 62 (2), 256-266 (2020)
   PUBMED   31486675
  REMARK    GeneRIF: a novel insight into the molecular mechanisms underlying
            lung development and contribute to a better understanding of the
            characteristics of TAZ-transcriptional coactivator with PDZ-binding
            motif and YAP
REFERENCE   6  (residues 1 to 541)
  AUTHORS   Alexandropoulos,K., Cheng,G. and Baltimore,D.
  TITLE     Proline-rich sequences that bind to Src homology 3 domains with
            individual specificities
  JOURNAL   Proc Natl Acad Sci U S A 92 (8), 3110-3114 (1995)
   PUBMED   7536925
REFERENCE   7  (residues 1 to 541)
  AUTHORS   Stein,P.L., Vogel,H. and Soriano,P.
  TITLE     Combined deficiencies of Src, Fyn, and Yes tyrosine kinases in
            mutant mice
  JOURNAL   Genes Dev 8 (17), 1999-2007 (1994)
   PUBMED   7958873
REFERENCE   8  (residues 1 to 541)
  AUTHORS   Hebert,B., Bergeron,J., Tijssen,P. and Potworowski,E.F.
  TITLE     Protein tyrosine kinases transcribed in a murine thymic medullary
            epithelial cell line
  JOURNAL   Gene 143 (2), 257-260 (1994)
   PUBMED   8206383
REFERENCE   9  (residues 1 to 541)
  AUTHORS   Guy,C.T., Muthuswamy,S.K., Cardiff,R.D., Soriano,P. and Muller,W.J.
  TITLE     Activation of the c-Src tyrosine kinase is required for the
            induction of mammary tumors in transgenic mice
  JOURNAL   Genes Dev 8 (1), 23-32 (1994)
   PUBMED   7507074
REFERENCE   10 (residues 1 to 541)
  AUTHORS   Dymecki,S.M., Niederhuber,J.E. and Desiderio,S.V.
  TITLE     Specific expression of a tyrosine kinase gene, blk, in B lymphoid
            cells
  JOURNAL   Science 247 (4940), 332-336 (1990)
   PUBMED   2404338
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC091274.11 and AC166934.3.
            
            Transcript Variant: This variant (2) differs in the 5' UTR,
            compared to variant 1. Variants 1, 2 and 3 encode the same protein.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK052478.1, SRR10662774.1374009.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..541
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 17.33 cM"
     Protein         1..541
                     /product="tyrosine-protein kinase Yes"
                     /EC_number="2.7.10.2"
                     /note="viral oncogene yes homolog; proto-oncogene
                     tyrosine-protein kinase Yes; proto-oncogene c-Yes;
                     Yamaguchi sarcoma viral (v-yes) oncogene homolog 1"
                     /calculated_mol_wt=60499
     Site            32
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000269|PubMed:9058199; propagated from
                     UniProtKB/Swiss-Prot (Q04736.3)"
     Region          92..149
                     /region_name="SH3_Yes"
                     /note="Src homology 3 domain of Yes Protein Tyrosine
                     Kinase; cd12007"
                     /db_xref="CDD:212940"
     Site            order(98,100,103..104,107,124..126,139,141,143..144)
                     /site_type="other"
                     /note="peptide ligand binding site [polypeptide binding]"
                     /db_xref="CDD:212940"
     Region          152..251
                     /region_name="SH2_Src_family"
                     /note="Src homology 2 (SH2) domain found in the Src family
                     of non-receptor tyrosine kinases; cd09933"
                     /db_xref="CDD:199827"
     Site            order(163,183,185..188,193,209,211,244)
                     /site_type="other"
                     /note="autoinhibitory site [polypeptide binding]"
                     /db_xref="CDD:199827"
     Site            order(163,183,185..187,193,209..211)
                     /site_type="other"
                     /note="phosphotyrosine binding pocket [polypeptide
                     binding]"
                     /db_xref="CDD:199827"
     Site            order(222,238,243..245)
                     /site_type="other"
                     /note="hydrophobic binding pocket [polypeptide binding]"
                     /db_xref="CDD:199827"
     Region          262..540
                     /region_name="PTKc_Yes"
                     /note="Catalytic domain of the Protein Tyrosine Kinase,
                     Yes; cd05069"
                     /db_xref="CDD:270654"
     Site            order(281,283..285,289,301,303,346..349,353,394,398..399,
                     401,412,429..433,442,476)
                     /site_type="active"
                     /db_xref="CDD:270654"
     Site            order(281,284,289,301,303,346..349,353,394,396,399,401,
                     412)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270654"
     Site            order(295,297,329,332,334,347,373,377,405,525)
                     /site_type="other"
                     /note="SH3/SH2 domain interface [polypeptide binding]"
                     /db_xref="CDD:270654"
     Site            334
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000250|UniProtKB:P07947; propagated from
                     UniProtKB/Swiss-Prot (Q04736.3)"
     Site            343
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000250|UniProtKB:P07947; propagated from
                     UniProtKB/Swiss-Prot (Q04736.3)"
     Site            order(383,386..387,450,512..514,516,518..519,522,526,
                     529..530,534)
                     /site_type="other"
                     /note="CSK binding interface [polypeptide binding]"
                     /db_xref="CDD:270654"
     Site            order(394,398,429..433,442,476)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270654"
     Site            411..435
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270654"
     Site            424
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine, by autocatalysis.
                     /evidence=ECO:0000250|UniProtKB:P07947; propagated from
                     UniProtKB/Swiss-Prot (Q04736.3)"
     Site            535
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0007744|PubMed:18034455; propagated from
                     UniProtKB/Swiss-Prot (Q04736.3)"
     CDS             1..541
                     /gene="Yes1"
                     /gene_synonym="p61-Yes; Yes"
                     /coded_by="NM_001205132.1:214..1839"
                     /db_xref="CCDS:CCDS39061.1"
                     /db_xref="GeneID:22612"
                     /db_xref="MGI:MGI:99147"
ORIGIN      
        1 mgcikskenk spaikytpen ltepvspsas hygvehatva ptsstkgasv nfnslsmtpf
       61 ggssgvtpfg gasssfsvvs ssyptgltgg vtifvalydy earttedlsf kkgerfqiin
      121 ntegdwwear siatgksgyi psnyvvpads iqaeewyfgk mgrkdaerll lnpgnqrgif
      181 lvresettkg ayslsirdwd evrgdnvkhy kirkldnggy yittraqfdt lqklvkhyte
      241 hadglchklt tvcptvkpqt qglakdawei preslrlevk lgqgcfgevw mgtwngttkv
      301 aiktlkpgtm mpeaflqeaq imkklrhdkl vplyavvsee piyivtefms kgslldflke
      361 gdgkylklpq lvdmaaqiad gmayiermny ihrdlraani lvgenlicki adfglarlie
      421 dneytarqga kfpikwtape aalygrftik sdvwsfgilq telvtkgrvp ypgmvnrevl
      481 eqvergyrmp cpqgcpeslh elmnlcwkkd pderptfeyi qsfledyfta tepqyqpgen
      541 l
//
