LOCUS       NM_198246               1587 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus tyrosyl-tRNA synthetase 2 (mitochondrial) (Yars2),
            transcript variant 1, mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_198246 XM_148054 XM_358768
VERSION     NM_198246.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1587)
  AUTHORS   Zurkirchen,L., Varum,S., Giger,S., Klug,A., Hausel,J., Bossart,R.,
            Zemke,M., Cantu,C., Atak,Z.K., Zamboni,N., Basler,K. and Sommer,L.
  TITLE     Yin Yang 1 sustains biosynthetic demands during brain development
            in a stage-specific manner
  JOURNAL   Nat Commun 10 (1), 2192 (2019)
   PUBMED   31097699
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK083653.1, BC060295.1 and AC112943.12.
            
            On Mar 25, 2011 this sequence version replaced NM_198246.1.
            
            Transcript Variant: This variant (1) encodes a functional protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC060295.1, AK039123.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-17                AK083653.1         3-19
            18-1575             BC060295.1         1-1558
            1576-1587           AC112943.12        167643-167654
FEATURES             Location/Qualifiers
     source          1..1587
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 10.11 cM"
     gene            1..1587
                     /gene="Yars2"
                     /gene_synonym="2210023C10Rik; tyrRS"
                     /note="tyrosyl-tRNA synthetase 2 (mitochondrial)"
                     /db_xref="GeneID:70120"
                     /db_xref="MGI:MGI:1917370"
     exon            1..783
                     /gene="Yars2"
                     /gene_synonym="2210023C10Rik; tyrRS"
                     /inference="alignment:Splign:2.1.0"
     CDS             20..1438
                     /gene="Yars2"
                     /gene_synonym="2210023C10Rik; tyrRS"
                     /EC_number="6.1.1.1"
                     /codon_start=1
                     /product="tyrosine--tRNA ligase, mitochondrial"
                     /protein_id="NP_937889.1"
                     /db_xref="CCDS:CCDS27983.1"
                     /db_xref="GeneID:70120"
                     /db_xref="MGI:MGI:1917370"
                     /translation="MAAPMLRRLCRVPQSLVWLRGSRAVRPGARGMLVAPRARGLFKE
                     FFPESGTKTELPELFDRRRAGSSPQTVYCGFDPTGDSLHVGHLLTLLGLFHFQRAGHN
                     VIALVGGSTALLGDPSGRTKGREALSAECVRANAHALRRGLEALAANHARLFADGRPW
                     GSFTVLDNAAWFQEQHLVDFLATVGGHFRMGTLLSRLSVQSRLKSPEGMSLAEFFYQV
                     LQAYDFYYLFQHYGCRVQLGGSDQLGNIMSGYEFIHKLTGEDVFGITVPLITSTTGAK
                     LGKSAGNAVWLNREKTSPFELYQFFVRQQDDSVERYLKLFTFLPLPEIDHIMQLHVKE
                     PEKRVAQKRLAAEVTKLVHGQEGLDSAKRCTQALYHSSIEALEVMSDQELKELFKEAS
                     FSELVLDPGTSVIDTCRKANAIPDGPRGYRMITEGGVSINHRQVTNPESVLVIGQHIL
                     KNGLSLLKIGKRNFYIIKWLQL"
     exon            784..951
                     /gene="Yars2"
                     /gene_synonym="2210023C10Rik; tyrRS"
                     /inference="alignment:Splign:2.1.0"
     exon            952..1107
                     /gene="Yars2"
                     /gene_synonym="2210023C10Rik; tyrRS"
                     /inference="alignment:Splign:2.1.0"
     exon            1108..1278
                     /gene="Yars2"
                     /gene_synonym="2210023C10Rik; tyrRS"
                     /inference="alignment:Splign:2.1.0"
     exon            1279..1587
                     /gene="Yars2"
                     /gene_synonym="2210023C10Rik; tyrRS"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1554..1559
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Yars2"
                     /gene_synonym="2210023C10Rik; tyrRS"
                     /note="hexamer: AATAAA"
     polyA_site      1575
                     /gene="Yars2"
                     /gene_synonym="2210023C10Rik; tyrRS"
                     /note="major polyA site"
ORIGIN      
        1 gccttgcgtg tcccgcaaga tggcggcgcc catgctgagg cgcctgtgcc gcgttccgca
       61 gtccctggtc tggctacgag ggtcgcgtgc ggtgcgcccg ggcgcgcggg gaatgctggt
      121 ggcaccgagg gcccgcggct tgttcaagga gttcttcccc gagagcggca cgaagacaga
      181 gctccccgaa ctctttgacc gccgcagggc gggctcgtcc ccccagacgg tgtactgcgg
      241 cttcgacccc acgggcgact cgctccacgt ggggcacctg ctaactctgt tggggctctt
      301 ccacttccag cgagccggcc acaacgtgat cgcgctcgtg ggaggctcca cggccctcct
      361 gggggacccc agcggccgga ccaaggggcg cgaggcgctg agcgccgagt gcgtgcgggc
      421 caacgcgcac gccctgcggc gagggctcga ggccctggcg gccaaccacg cgcgcctctt
      481 cgcggacggc cggccctggg gctctttcac ggtgctggac aacgcggcct ggttccagga
      541 gcagcacctg gtggatttcc tggccacggt gggcggccac ttccgcatgg gcactctgct
      601 gagccggctg agcgtgcagt cgcgtctcaa gagccccgag ggcatgagct tggcggagtt
      661 cttttaccag gtgctccagg cctatgactt ctactacctt ttccagcact atggatgccg
      721 ggtccaactg ggcggatcag atcagttggg caacatcatg tctggctacg agttcatcca
      781 caagttgact ggagaggatg tgtttggaat cactgtacct ctaattacaa gtacaactgg
      841 agcaaagctg ggaaagtctg ctggcaatgc ggtttggcta aacagagaga aaacatcacc
      901 gtttgaactt tatcagttct ttgtcagaca gcaagatgat tccgtagaaa ggtacctgaa
      961 gcttttcact ttccttcccc tcccagagat cgatcacatc atgcagctac atgtcaaaga
     1021 accagaaaag cgagttgctc agaaacgact tgctgcagaa gtaacaaagc ttgttcacgg
     1081 acaagaaggt ctggactctg ctaaaaggtg tacacaagcc ctttaccata gcagcataga
     1141 ggcactggag gtcatgtctg accaagagtt aaaagaattg tttaaagaag cttcattttc
     1201 tgaattagtt cttgatcctg gaacgagtgt catagacaca tgccgtaaag caaatgccat
     1261 tcctgatggc cctcgagggt atcggatgat aacagaaggt ggagtcagta taaatcacag
     1321 acaggtaaca aatcctgaaa gtgttctagt aattggacaa catattctca agaatggact
     1381 ttccttactt aaaataggaa aaaggaattt ctacattata aaatggcttc agttgtgaaa
     1441 ggttttgtcc aaatttgtcc atcatccatt ttcaaaatgt ggaggtcttc ggaaacccaa
     1501 gagtggaata tacacaaggc ccctcacaat gtaaatactc atgtgcattt caaaataaaa
     1561 tgttacttaa ttgtagttca tttcttt
//
