LOCUS       NM_134151               2399 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus tyrosyl-tRNA synthetase 1 (Yars1), transcript variant
            1, mRNA.
ACCESSION   NM_134151 XM_109408
VERSION     NM_134151.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2399)
  AUTHORS   Jones,J.A., Zhou,J., Dong,J., Huitron-Resendiz,S., Boussaty,E.,
            Chavez,E., Wei,N., Dumitru,C.D., Morodomi,Y., Kanaji,T., Ryan,A.F.,
            Friedman,R., Zhou,T., Kanaji,S., Wortham,M., Schenk,S.,
            Roberts,A.J. and Yang,X.L.
  TITLE     Murine nuclear tyrosyl-tRNA synthetase deficiency leads to fat
            storage deficiency and hearing loss
  JOURNAL   J Biol Chem 300 (10), 107756 (2024)
   PUBMED   39260699
REFERENCE   2  (bases 1 to 2399)
  AUTHORS   Rhymes,E.R., Simkin,R.L., Qu,J., Villarroel-Campos,D., Surana,S.,
            Tong,Y., Shapiro,R., Burgess,R.W., Yang,X.L., Schiavo,G. and
            Sleigh,J.N.
  TITLE     Boosting BDNF in muscle rescues impaired axonal transport in a
            mouse model of DI-CMTC peripheral neuropathy
  JOURNAL   Neurobiol Dis 195, 106501 (2024)
   PUBMED   38583640
REFERENCE   3  (bases 1 to 2399)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 2399)
  AUTHORS   Hines,T.J., Tadenev,A.L.D., Lone,M.A., Hatton,C.L., Bagasrawala,I.,
            Stum,M.G., Miers,K.E., Hornemann,T. and Burgess,R.W.
  TITLE     Precision mouse models of Yars/dominant intermediate
            Charcot-Marie-Tooth disease type C and Sptlc1/hereditary sensory
            and autonomic neuropathy type 1
  JOURNAL   J Anat 241 (5), 1169-1185 (2022)
   PUBMED   34875719
REFERENCE   5  (bases 1 to 2399)
  AUTHORS   Spaulding,E.L., Hines,T.J., Bais,P., Tadenev,A.L.D., Schneider,R.,
            Jewett,D., Pattavina,B., Pratt,S.L., Morelli,K.H., Stum,M.G.,
            Hill,D.P., Gobet,C., Pipis,M., Reilly,M.M., Jennings,M.J.,
            Horvath,R., Bai,Y., Shy,M.E., Alvarez-Castelao,B., Schuman,E.M.,
            Bogdanik,L.P., Storkebaum,E. and Burgess,R.W.
  TITLE     The integrated stress response contributes to tRNA
            synthetase-associated peripheral neuropathy
  JOURNAL   Science 373 (6559), 1156-1161 (2021)
   PUBMED   34516839
REFERENCE   6  (bases 1 to 2399)
  AUTHORS   Tsukahara,T., Yamagishi,S., Neyama,H. and Ueda,H.
  TITLE     Tyrosyl-tRNA synthetase: A potential kyotorphin synthetase in
            mammals
  JOURNAL   Peptides 101, 60-68 (2018)
   PUBMED   29289698
  REMARK    GeneRIF: conclusion is further supported by a positive correlation
            across brain regions between TyrRS expression and
            arginine-accelerated KTP production.
REFERENCE   7  (bases 1 to 2399)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   8  (bases 1 to 2399)
  AUTHORS   Wei,N., Shi,Y., Truong,L.N., Fisch,K.M., Xu,T., Gardiner,E., Fu,G.,
            Hsu,Y.O., Kishi,S., Su,A.I., Wu,X. and Yang,X.L.
  TITLE     Oxidative stress diverts tRNA synthetase to nucleus for protection
            against DNA damage
  JOURNAL   Mol Cell 56 (2), 323-332 (2014)
   PUBMED   25284223
REFERENCE   9  (bases 1 to 2399)
  AUTHORS   Jordanova,A., Irobi,J., Thomas,F.P., Van Dijck,P., Meerschaert,K.,
            Dewil,M., Dierick,I., Jacobs,A., De Vriendt,E., Guergueltcheva,V.,
            Rao,C.V., Tournev,I., Gondim,F.A., D'Hooghe,M., Van Gerwen,V.,
            Callaerts,P., Van Den Bosch,L., Timmermans,J.P., Robberecht,W.,
            Gettemans,J., Thevelein,J.M., De Jonghe,P., Kremensky,I. and
            Timmerman,V.
  TITLE     Disrupted function and axonal distribution of mutant tyrosyl-tRNA
            synthetase in dominant intermediate Charcot-Marie-Tooth neuropathy
  JOURNAL   Nat Genet 38 (2), 197-202 (2006)
   PUBMED   16429158
REFERENCE   10 (bases 1 to 2399)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL606977.28.
            
            On Mar 18, 2019 this sequence version replaced NM_134151.4.
            
            Transcript Variant: This variant (1) represents the protein-coding
            transcript.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK145356.1, AK043837.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on single protein-coding
                                                transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-170               AL606977.28        136317-136486
            171-317             AL606977.28        143244-143390
            318-493             AL606977.28        143527-143702
            494-623             AL606977.28        147140-147269
            624-704             AL606977.28        152543-152623
            705-797             AL606977.28        154355-154447
            798-933             AL606977.28        156066-156201
            934-1019            AL606977.28        156907-156992
            1020-1155           AL606977.28        160363-160498
            1156-1253           AL606977.28        161072-161169
            1254-1447           AL606977.28        161640-161833
            1448-1589           AL606977.28        163092-163233
            1590-2399           AL606977.28        164845-165654
FEATURES             Location/Qualifiers
     source          1..2399
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 63.05 cM"
     gene            1..2399
                     /gene="Yars1"
                     /gene_synonym="Yars"
                     /note="tyrosyl-tRNA synthetase 1"
                     /db_xref="GeneID:107271"
                     /db_xref="MGI:MGI:2147627"
     exon            1..170
                     /gene="Yars1"
                     /gene_synonym="Yars"
                     /inference="alignment:Splign:2.1.0"
     CDS             114..1700
                     /gene="Yars1"
                     /gene_synonym="Yars"
                     /EC_number="6.1.1.1"
                     /note="tyrosyl-tRNA synthetase, cytoplasmic; tyrRS;
                     tyrosyl--tRNA ligase"
                     /codon_start=1
                     /product="tyrosine--tRNA ligase, cytoplasmic"
                     /protein_id="NP_598912.5"
                     /db_xref="CCDS:CCDS18685.2"
                     /db_xref="GeneID:107271"
                     /db_xref="MGI:MGI:2147627"
                     /translation="MGDAPSPEEKLHLITRNLQEVLGEEKLKEILKERELKVYWGTAT
                     TGKPHVAYFVPMSKIADFLKAGCEVTILFADLHAYLDNMKAPWELLELRTSYYENVIK
                     AMLESIGVPLEKLKFIKGTDYQLSKEYTLDVYRLSSVVTQHDAKKAGAEVVKQVEHPL
                     LSGLLYPGLQALDEEYLKVDAQFGGVDQRKIFTFAEKYLPALGYSKRVHLMNPMVPGL
                     TGSKMSSSEEESKIDLLDRKEDVKKKLKKAFCEPGNVENNGVLSFIKHVLFPLKSEFV
                     ILRDEKWGGNKTYTVYLELEKDFAAEVVHPGDLKNSVEVALNKLLDPIREKFNTPALK
                     KLASAAYPDPSKQKPPAKGPAKNSEPEEVIPSRLDIRVGKILSVEKHPDADSLYVEKI
                     DVGEAEPRTVVSGLVQFVPKEELQDRLVVVLCNLKPQKMRGVDSQGMLLCASVEGVSR
                     QVEPLDPPAGSAPGERVFVQGYEKGQPDEELKPKKKVFEKLQADFKISEECIAQWKQT
                     NFMTKLGFVSCKSLKGGNIS"
     exon            171..317
                     /gene="Yars1"
                     /gene_synonym="Yars"
                     /inference="alignment:Splign:2.1.0"
     exon            318..493
                     /gene="Yars1"
                     /gene_synonym="Yars"
                     /inference="alignment:Splign:2.1.0"
     exon            494..623
                     /gene="Yars1"
                     /gene_synonym="Yars"
                     /inference="alignment:Splign:2.1.0"
     exon            624..704
                     /gene="Yars1"
                     /gene_synonym="Yars"
                     /inference="alignment:Splign:2.1.0"
     exon            705..797
                     /gene="Yars1"
                     /gene_synonym="Yars"
                     /inference="alignment:Splign:2.1.0"
     exon            798..933
                     /gene="Yars1"
                     /gene_synonym="Yars"
                     /inference="alignment:Splign:2.1.0"
     exon            934..1019
                     /gene="Yars1"
                     /gene_synonym="Yars"
                     /inference="alignment:Splign:2.1.0"
     exon            1020..1155
                     /gene="Yars1"
                     /gene_synonym="Yars"
                     /inference="alignment:Splign:2.1.0"
     exon            1156..1253
                     /gene="Yars1"
                     /gene_synonym="Yars"
                     /inference="alignment:Splign:2.1.0"
     exon            1254..1447
                     /gene="Yars1"
                     /gene_synonym="Yars"
                     /inference="alignment:Splign:2.1.0"
     exon            1448..1589
                     /gene="Yars1"
                     /gene_synonym="Yars"
                     /inference="alignment:Splign:2.1.0"
     exon            1590..2399
                     /gene="Yars1"
                     /gene_synonym="Yars"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2376..2381
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Yars1"
                     /gene_synonym="Yars"
                     /note="hexamer: AATAAA"
     polyA_site      2395
                     /gene="Yars1"
                     /gene_synonym="Yars"
                     /note="major polyA site"
ORIGIN      
        1 agctgatgca acccgacggg actagcgtga cagttcccgg cacgcggaga cgacggcgaa
       61 cgaggaaagg gcgcgggtgc cggctgagcg cgggaaacag agacagcgga gccatgggtg
      121 atgctccaag ccctgaggag aagctgcatc ttatcacccg gaacctgcag gaggttctag
      181 gggaagagaa gctgaaggag atcctgaagg agcgggaact taaagtttac tggggcacgg
      241 ccaccacggg caagccacac gtggcttact ttgtacccat gtccaagatc gctgactttt
      301 tgaaggcagg gtgtgaggta accatcctgt ttgcagacct ccatgcatac ctggacaaca
      361 tgaaagcccc ctgggagctt ctagaacttc gaaccagtta ctatgagaat gtgatcaagg
      421 ccatgctgga gagtattggc gtgcccttgg agaagctcaa gtttatcaaa ggcaccgact
      481 accagctcag caaagagtac acactggatg tgtaccgact gtcctctgtg gtcacacaac
      541 acgacgccaa gaaagcgggg gctgaggttg tgaagcaggt ggaacaccct ttgctgagtg
      601 gtctgctgta ccccggtctg caggctttgg atgaagagta cttaaaagta gacgcccagt
      661 tcggcggtgt tgatcagagg aagattttta cctttgcaga gaagtatctt cctgcacttg
      721 gctactcaaa acgggtccac ctgatgaatc ccatggtccc tgggttaact gggagcaaaa
      781 tgagctcgtc agaagaggag tccaaaatcg acctccttga tcggaaggag gacgtgaaga
      841 aaaagctgaa gaaggccttc tgtgagcccg gcaatgtgga gaacaacggg gttctgtcct
      901 tcatcaagca tgtcctcttt cccctcaagt ctgagtttgt gatcctgaga gatgagaagt
      961 ggggtggaaa caagacctac accgtttacc tagagctgga gaaggacttc gctgctgagg
     1021 tcgtacaccc tggagaccta aagaattctg ttgaagtcgc cctgaacaag ttgctggacc
     1081 ccattagaga gaagtttaat actccagccc tgaagaagct ggccagtgct gcctacccag
     1141 atccttcaaa gcagaagcct cctgccaaag gccctgccaa gaactcagaa ccagaggaag
     1201 tcatcccatc ccggctggat atccgtgtgg gcaaaatcct cagcgtggag aagcacccag
     1261 atgcagatag cctttatgtg gagaagattg atgtggggga agctgaaccc aggactgtgg
     1321 tgagcggcct cgtacagttt gtgcccaaag aagaactgca ggacaggctg gtggtggtgc
     1381 tgtgcaatct gaaaccccag aagatgagag gcgtggactc gcagggcatg ctactgtgtg
     1441 cttctgtaga aggggtgagc cgccaggttg aacctctgga ccctcctgct ggctctgctc
     1501 ctggtgaacg agtgttcgta cagggctatg agaagggcca gccagatgag gagctcaagc
     1561 ccaagaagaa agtctttgag aagctgcagg ccgactttaa aatttctgag gagtgcatcg
     1621 cacagtggaa gcaaaccaac ttcatgacca agctgggatt cgtctcctgt aaatcactaa
     1681 aagggggtaa catcagctag ccagctctgt gccctcccac catcccgtct gccggctcga
     1741 cttgttgcat ctctcacccg ctcccaccag gtctgaactg ctgacaaggt gcaggacttg
     1801 gaaagggaca gctcaccttc ctactgtgtg ggatcaccca gcctggctga aaggaaacgg
     1861 agtgcctggg ctaaggagat gctgcccagc ggcagactgg ccctaccttc ttcccttggc
     1921 agctgacttg agaaatctgg tttcaataga acccacagaa aaagtttatt ccatggtccc
     1981 tgtaattgga aaaacactgg ttcccaagtt tccatggggt tttccctgca gctgtactag
     2041 ctgagatcga gtgcctggtc tgagctaatt acagcttctc cccgtcagga aattgtggga
     2101 tttgaaaaga agggaaagag agcctagagg tctcccaagc tctccagggc tggcagcatt
     2161 ctccaggctt ccaaacctga ggcttggcac cagaggcagg acttgccctg gctctcttgg
     2221 ggttcccttg atctggctag attggacact ccctaaacaa gccagctgtg ttagcagcag
     2281 gatggagatg gactgaaact gtggagcttt cttcagaatg tgagatactc cataaagcat
     2341 ctcaagcaaa tccctaaccg ccactgtcaa gttcaaataa agtgtctgaa aaggctttc
//
