LOCUS       NM_024189               2248 bp    mRNA    linear   ROD 03-SEP-2024
DEFINITION  Mus musculus YY1 associated factor 2 (Yaf2), transcript variant 1,
            mRNA.
ACCESSION   NM_024189 XM_909714
VERSION     NM_024189.6
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2248)
  AUTHORS   Liu,Y., Hu,G., Yang,S., Yao,M., Liu,Z., Yan,C., Wen,Y., Ping,W.,
            Wang,J., Song,Y., Dong,X., Pan,G. and Yao,H.
  TITLE     Functional dissection of PRC1 subunits RYBP and YAF2 during neural
            differentiation of embryonic stem cells
  JOURNAL   Nat Commun 14 (1), 7164 (2023)
   PUBMED   37935677
  REMARK    GeneRIF: Functional dissection of PRC1 subunits RYBP and YAF2
            during neural differentiation of embryonic stem cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2248)
  AUTHORS   Sawai,A., Pfennig,S., Bulajic,M., Miller,A., Khodadadi-Jamayran,A.,
            Mazzoni,E.O. and Dasen,J.S.
  TITLE     PRC1 sustains the integrity of neural fate in the absence of PRC2
            function
  JOURNAL   Elife 11, e72769 (2022)
   PUBMED   34994686
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2248)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2248)
  AUTHORS   Zhao,J., Wang,M., Chang,L., Yu,J., Song,A., Liu,C., Huang,W.,
            Zhang,T., Wu,X., Shen,X., Zhu,B. and Li,G.
  TITLE     RYBP/YAF2-PRC1 complexes and histone H1-dependent chromatin
            compaction mediate propagation of H2AK119ub1 during cell division
  JOURNAL   Nat Cell Biol 22 (4), 439-452 (2020)
   PUBMED   32203418
  REMARK    GeneRIF: The results suggest that histone H1-dependent chromatin
            compaction plays a critical role in the stable propagation of
            H2AK119ub1 by RYBP/YAF2-PRC1 during cell division.
REFERENCE   5  (bases 1 to 2248)
  AUTHORS   Elsen,G.E., Bedogni,F., Hodge,R.D., Bammler,T.K., MacDonald,J.W.,
            Lindtner,S., Rubenstein,J.L.R. and Hevner,R.F.
  TITLE     The Epigenetic Factor Landscape of Developing Neocortex Is
            Regulated by Transcription Factors Pax6--> Tbr2--> Tbr1
  JOURNAL   Front Neurosci 12, 571 (2018)
   PUBMED   30186101
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2248)
  AUTHORS   Wilkinson,F., Pratt,H. and Atchison,M.L.
  TITLE     PcG recruitment by the YY1 REPO domain can be mediated by Yaf2
  JOURNAL   J Cell Biochem 109 (3), 478-486 (2010)
   PUBMED   19960508
  REMARK    GeneRIF: Yaf2 acts as a functional, likely molecular, link between
            YY1 and the Polycomb proteins.  It is proposed to mediate the DNA
            binding activity of YY1 and recruitment of Polycomb proteins to the
            regulatory region of target genes.
REFERENCE   7  (bases 1 to 2248)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   8  (bases 1 to 2248)
  AUTHORS   Tamplin,O.J., Kinzel,D., Cox,B.J., Bell,C.E., Rossant,J. and
            Lickert,H.
  TITLE     Microarray analysis of Foxa2 mutant mouse embryos reveals novel
            gene expression and inductive roles for the gastrula organizer and
            its derivatives
  JOURNAL   BMC Genomics 9, 511 (2008)
   PUBMED   18973680
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 2248)
  AUTHORS   Kaji,K., Nichols,J. and Hendrich,B.
  TITLE     Mbd3, a component of the NuRD co-repressor complex, is required for
            development of pluripotent cells
  JOURNAL   Development 134 (6), 1123-1132 (2007)
   PUBMED   17287250
REFERENCE   10 (bases 1 to 2248)
  AUTHORS   Kaneko,T., Miyagishima,H., Hasegawa,T., Mizutani-Koseki,Y.,
            Isono,K. and Koseki,H.
  TITLE     The mouse YAF2 gene generates two distinct transcripts and is
            expressed in pre-and postimplantation embryos
  JOURNAL   Gene 315, 183-192 (2003)
   PUBMED   14557078
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK011702.1 and AK148634.1.
            
            On Aug 15, 2009 this sequence version replaced NM_024189.5.
            
            Transcript Variant: This variant (1) represents the shorter
            transcript and is protein-coding.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK148634.1, AB100452.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-57                AK011702.1         2-58
            58-2248             AK148634.1         2-2192
FEATURES             Location/Qualifiers
     source          1..2248
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 47.39 cM"
     gene            1..2248
                     /gene="Yaf2"
                     /gene_synonym="2810021M11Rik"
                     /note="YY1 associated factor 2"
                     /db_xref="GeneID:67057"
                     /db_xref="MGI:MGI:1914307"
     exon            1..179
                     /gene="Yaf2"
                     /gene_synonym="2810021M11Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             154..693
                     /gene="Yaf2"
                     /gene_synonym="2810021M11Rik"
                     /codon_start=1
                     /product="YY1-associated factor 2"
                     /protein_id="NP_077151.3"
                     /db_xref="CCDS:CCDS27765.1"
                     /db_xref="GeneID:67057"
                     /db_xref="MGI:MGI:1914307"
                     /translation="MGDKKSPTRPKRQPKPASDEGYWDCSVCTFRNSAEAFKCMMCDV
                     RKGTSTRKPRPVSQLVAQQVTQQFVPPTQSKKEKKDRVEKDKSEKEAASKKNCHKKTR
                     PRLKNVDRSSAQHLEVTVGDLTVIITDFKEKAKSAPASSAAGDQHSQGSCSSDSTERG
                     VSRSSSPRGEASSLNGESH"
     exon            180..305
                     /gene="Yaf2"
                     /gene_synonym="2810021M11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            306..458
                     /gene="Yaf2"
                     /gene_synonym="2810021M11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            459..2248
                     /gene="Yaf2"
                     /gene_synonym="2810021M11Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1211..1216
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Yaf2"
                     /gene_synonym="2810021M11Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1234
                     /gene="Yaf2"
                     /gene_synonym="2810021M11Rik"
                     /note="major polyA site"
     regulatory      1779..1784
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Yaf2"
                     /gene_synonym="2810021M11Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1803
                     /gene="Yaf2"
                     /gene_synonym="2810021M11Rik"
     regulatory      2169..2174
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Yaf2"
                     /gene_synonym="2810021M11Rik"
                     /note="hexamer: AGTAAA"
     polyA_site      2189
                     /gene="Yaf2"
                     /gene_synonym="2810021M11Rik"
ORIGIN      
        1 gcgtgggatc cggcggcggc ggcggcagcg gcggcggcga cggcggcggc ggcggctgca
       61 gctcgcggcg cggccttccc cgccccctcg cctccgcgct tccgccggcc cctcaccccg
      121 gcgctgacag accggcgcgc gtcggcagcg agcatgggcg acaagaagag ccccaccagg
      181 ccgaagcggc agccgaagcc cgcctcggat gagggctact gggactgcag tgtctgcacc
      241 ttccggaaca gcgccgaggc cttcaagtgc atgatgtgcg atgtgcggaa gggcacctcc
      301 acccggaagc cacgccctgt ctcccagctg gtcgcacagc aggtcacgca gcagttcgtg
      361 ccccctaccc agtcgaagaa agagaagaaa gaccgagtag agaaggacaa gagtgagaag
      421 gaagctgcta gcaaaaagaa ctgtcacaag aaaaccagac caagattaaa aaatgtggat
      481 cggagtagcg ctcagcattt ggaagtcact gttggagatc taacagtcat tatcacagac
      541 tttaaggaga aagccaagtc agcgcctgcg tccagcgctg ctggcgatca gcacagccag
      601 ggcagctgca gctcggacag cactgagcgg ggtgtgtcca ggtcctcctc gccgcgggga
      661 gaagcctcct ccctcaacgg agagtctcac taaccgttct tgctccactt agtcatgcct
      721 gtcctccatg gagatgcaga gtatgccaac aactaccaca ttttcatgac agacacactc
      781 atgcataacc tataatttga gttttacacg aaatacgaat ttgccaggat ttattagatt
      841 ttattgcagt gtaagctacc aaacatttcc agagttaaca ttttggtctc tgctgttaaa
      901 tgccatgaaa atgtggttga attattcatt atgcagtgtt attggtaagt ctattttcac
      961 ttatagttta gtgaattcta acacataatt attgaattct ctactattgg catgtaatga
     1021 gtttaaattt tttattacat agtgcaagct gcctaaatat gtattatttg agaattgtga
     1081 aacaaatagt tatatgtatg caagtcagag atcaacttaa tcaactattg ctgcaacagg
     1141 attttcttaa tggttatcct cttaatgcac ctgctggtac ttggtgtgat taaataggaa
     1201 gttgttatta aataaagaat ttgtatgaat ctttgccaat gttttttgac atgtttttac
     1261 taaattattg tttctgagtt atgttttatc cattttttgc agtttatgtt tgttagtttg
     1321 cttatttttc aaagcatcaa tttattgtac tgttcactag tagacagtac gacgtggctt
     1381 gtttagcttt ctgatcaggg ttagcgctgt tgtcgttgaa cactggtatt tcctgcatcc
     1441 tctaagacat tagagttaaa gaagcaagca tctggcagaa gcaggaaaga acttgccata
     1501 cttgcaaacg ctctaactta atgatagttt tatcactgtc tccctgttcc aaccctaccc
     1561 agggtcacag acatgtgact ctagttgata taaacatgta actattacac agaactgagg
     1621 tgtcactcct aagtcagctt aattggcctt ttactaaata aaacaattca tatggaaacc
     1681 acagtactct agttccagat acaaccttca atttatgcac ttatcaatat cttgaaataa
     1741 aaagtattta cggccccact cacttatgta taatcaccaa taaaatattt tttatgactt
     1801 acagttttgc attttgttta caactaaatg gagtgtgtta tgttgtattt gaaaatacat
     1861 cttagaaact acatgctcta tcttattctc ctcaggttct cttgtttttg ctagccattt
     1921 gcttaatata tatctgccta tgggggtggg gggagcttct gaaatgtaaa ttaacctaaa
     1981 gataaaacgt accttgaata tcatctacca cataaaagac atcatggcaa catttgaagg
     2041 aaaatctgtg gtccctgaca gttgtgatac ttggtttctc atggtaatgt cactgttgaa
     2101 atgcagttcg tttcattggc acagtggtac tcttgtaacg tgctagttgt gaatagttta
     2161 ttgcatacag taaaaatctg tgatgaaaac gctcagatac ctcattcttc agtgttgtta
     2221 aatgaaggct taaaacttgt tttattct
//
