LOCUS       NM_175645               3070 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus xylosyltransferase 1 (Xylt1), mRNA.
ACCESSION   NM_175645 XM_921912
VERSION     NM_175645.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3070)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3070)
  AUTHORS   Taieb,M., Ghannoum,D., Barre,L. and Ouzzine,M.
  TITLE     Xylosyltransferase I mediates the synthesis of proteoglycans with
            long glycosaminoglycan chains and controls chondrocyte hypertrophy
            and collagen fibers organization of in the growth plate
  JOURNAL   Cell Death Dis 14 (6), 355 (2023)
   PUBMED   37296099
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3070)
  AUTHORS   Rios,J.J., Denton,K., Russell,J., Kozlitina,J., Ferreira,C.R.,
            Lewanda,A.F., Mayfield,J.E., Moresco,E., Ludwig,S., Tang,M., Li,X.,
            Lyon,S., Khanshour,A., Paria,N., Khalid,A., Li,Y., Xie,X.,
            Feng,J.Q., Xu,Q., Lu,Y., Hammer,R.E., Wise,C.A. and Beutler,B.
  TITLE     Germline Saturation Mutagenesis Induces Skeletal Phenotypes in Mice
  JOURNAL   J Bone Miner Res 36 (8), 1548-1565 (2021)
   PUBMED   33905568
REFERENCE   4  (bases 1 to 3070)
  AUTHORS   Ferencz,B., Condac,E., Poudel,N., Munteanu,M.C., Sivasami,P.,
            Choudhury,B., Naidu,N.N., Zhang,F., Breshears,M., Linhardt,R.J. and
            Hinsdale,M.E.
  TITLE     Xylosyltransferase 2 deficiency and organ homeostasis
  JOURNAL   Glycoconj J 37 (6), 755-765 (2020)
   PUBMED   32965647
  REMARK    GeneRIF: Xylosyltransferase 2 deficiency and organ homeostasis.
REFERENCE   5  (bases 1 to 3070)
  AUTHORS   Patras,K.A., Coady,A., Babu,P., Shing,S.R., Ha,A.D., Rooholfada,E.,
            Brandt,S.L., Geriak,M., Gallo,R.L. and Nizet,V.
  TITLE     Host Cathelicidin Exacerbates Group B Streptococcus Urinary Tract
            Infection
  JOURNAL   mSphere 5 (2), e00932-19 (2020)
   PUBMED   32321824
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3070)
  AUTHORS   Cuellar,K., Chuong,H., Hubbell,S.M. and Hinsdale,M.E.
  TITLE     Biosynthesis of chondroitin and heparan sulfate in chinese hamster
            ovary cells depends on xylosyltransferase II
  JOURNAL   J Biol Chem 282 (8), 5195-5200 (2007)
   PUBMED   17189266
  REMARK    Erratum:[J Biol Chem. 2007 Jun 22;282(25):18660]
REFERENCE   7  (bases 1 to 3070)
  AUTHORS   Schon,S., Prante,C., Bahr,C., Kuhn,J., Kleesiek,K. and Gotting,C.
  TITLE     Cloning and recombinant expression of active full-length
            xylosyltransferase I (XT-I) and characterization of subcellular
            localization of XT-I and XT-II
  JOURNAL   J Biol Chem 281 (20), 14224-14231 (2006)
   PUBMED   16569644
REFERENCE   8  (bases 1 to 3070)
  AUTHORS   Muller,S., Schottler,M., Schon,S., Prante,C., Brinkmann,T.,
            Kuhn,J., Gotting,C. and Kleesiek,K.
  TITLE     Human xylosyltransferase I: functional and biochemical
            characterization of cysteine residues required for enzymic activity
  JOURNAL   Biochem J 386 (Pt 2), 227-236 (2005)
   PUBMED   15461586
REFERENCE   9  (bases 1 to 3070)
  AUTHORS   Mu,X., Zhao,S., Pershad,R., Hsieh,T.F., Scarpa,A., Wang,S.W.,
            White,R.A., Beremand,P.D., Thomas,T.L., Gan,L. and Klein,W.H.
  TITLE     Gene expression in the developing mouse retina by EST sequencing
            and microarray analysis
  JOURNAL   Nucleic Acids Res 29 (24), 4983-4993 (2001)
   PUBMED   11812828
REFERENCE   10 (bases 1 to 3070)
  AUTHORS   Gotting,C., Kuhn,J., Zahn,R., Brinkmann,T. and Kleesiek,K.
  TITLE     Molecular cloning and expression of human UDP-d-Xylose:proteoglycan
            core protein beta-d-xylosyltransferase and its first isoform XT-II
  JOURNAL   J Mol Biol 304 (4), 517-528 (2000)
   PUBMED   11099377
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK033309.1, CJ128023.1, AJ291750.1, AC102076.9, BM964190.1,
            BI990840.1 and AC122836.4.
            
            On Dec 29, 2006 this sequence version replaced NM_175645.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ539164.1, SRR11927932.2399631.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-83                AK033309.1         3-85
            84-371              CJ128023.1         61-348
            372-1769            AK033309.1         374-1771
            1770-2031           AJ291750.1         1087-1348
            2032-2180           AC102076.9         180214-180362
            2181-2442           BM964190.1         145-406
            2443-2739           BI990840.1         1-297
            2740-3070           AC122836.4         84898-85228         c
FEATURES             Location/Qualifiers
     source          1..3070
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 62.93 cM"
     gene            1..3070
                     /gene="Xylt1"
                     /gene_synonym="8030490L12"
                     /note="xylosyltransferase 1"
                     /db_xref="GeneID:233781"
                     /db_xref="MGI:MGI:2451073"
     exon            1..542
                     /gene="Xylt1"
                     /gene_synonym="8030490L12"
                     /inference="alignment:Splign:2.1.0"
     CDS             201..3062
                     /gene="Xylt1"
                     /gene_synonym="8030490L12"
                     /EC_number="2.4.2.26"
                     /note="xylosyltransferase I; peptide O-xylosyltransferase
                     1"
                     /codon_start=1
                     /product="xylosyltransferase 1"
                     /protein_id="NP_783576.2"
                     /db_xref="CCDS:CCDS40101.1"
                     /db_xref="GeneID:233781"
                     /db_xref="MGI:MGI:2451073"
                     /translation="MVAAPCARRLARRSHSALLAALMVLLLQTLVVWNFSSLDSGAGE
                     QRRAGAAAGAAEQQQPAAPRRERRDLAAHLPAARGGPGGRAGGGGARGGGPGGARAQQ
                     PASRGALASRARDPQPSPLITLETQDGYFSHRPKEKVRTDSNNENSVPKDFENVDNSN
                     FAPRTQKQKHQPELAKKPPSRQKEHLQRKLDAQDKRQGQSVLGKGPKEVLPPREKATG
                     NSSQGKDLSRHSHARKSGGGGSPETKSDQAPKCDISGKEAISALTRAKSKHCRQEIAE
                     TYCRHKLGLLMPEKVARFCPLEGKANKNVQWDEDAVEYMPANPVRIAFVLVVHGRASR
                     QLQRMFKAIYHKDHFYYIHVDKRSNYLHRQVLQFSRQYDNVRVTSWRMATIWGGASLL
                     STYLQSMRDLLEMTDWPWDFFINLSAADYPIRTNDQLVAFLSRYRDMNFLKSHGRDNA
                     RFIRKQGLDRLFLECDTHMWRLGDRRIPEGIAVDGGSDWFLLNRKFVEYVAFSTDDLV
                     TKMKQFYSYTLLPAESFFHTVLENSPHCDTMVDNNLRITNWNRKLGCKCQYKHIVDWC
                     GCSPNDFKPQDFHRFQQTARPTFFARKFEAIVNQEIIGQLDSYLYGNYPAGTPGLRSY
                     WENVYDEPDGIHTLSDVALTLYHSFIRLGLRRAESSLHTDGENSCRYYPMGHPASVHL
                     YFLADRFQGFLIKHHVTNLAVSKLETLETWMMPKKVFKVASPPSDFGRLQFSEVGTDW
                     DAKERLFRNFGGLLGPMDEPVGMQKWGKGPNVTVTVIWVDPVNVIAATYDILIESTAE
                     FTHYKPPLNLPLRPGVWTVKILHHWVPVAETKFLVAPLTFSNKQPIKPEEALKLHNGP
                     PRSAYMEQSFQSLNPVLSLHINPAQVEQARKNAAFTGTALEAWLDSLVGGTWTAMDIC
                     TTGPTACPVMQTCSQTAWSSFSPDPKSELGAVKPDGRLR"
     exon            543..581
                     /gene="Xylt1"
                     /gene_synonym="8030490L12"
                     /inference="alignment:Splign:2.1.0"
     exon            582..1095
                     /gene="Xylt1"
                     /gene_synonym="8030490L12"
                     /inference="alignment:Splign:2.1.0"
     exon            1096..1268
                     /gene="Xylt1"
                     /gene_synonym="8030490L12"
                     /inference="alignment:Splign:2.1.0"
     exon            1269..1471
                     /gene="Xylt1"
                     /gene_synonym="8030490L12"
                     /inference="alignment:Splign:2.1.0"
     exon            1472..1552
                     /gene="Xylt1"
                     /gene_synonym="8030490L12"
                     /inference="alignment:Splign:2.1.0"
     exon            1553..1769
                     /gene="Xylt1"
                     /gene_synonym="8030490L12"
                     /inference="alignment:Splign:2.1.0"
     exon            1770..1946
                     /gene="Xylt1"
                     /gene_synonym="8030490L12"
                     /inference="alignment:Splign:2.1.0"
     exon            1947..2209
                     /gene="Xylt1"
                     /gene_synonym="8030490L12"
                     /inference="alignment:Splign:2.1.0"
     exon            2210..2405
                     /gene="Xylt1"
                     /gene_synonym="8030490L12"
                     /inference="alignment:Splign:2.1.0"
     exon            2406..2739
                     /gene="Xylt1"
                     /gene_synonym="8030490L12"
                     /inference="alignment:Splign:2.1.0"
     exon            2740..3070
                     /gene="Xylt1"
                     /gene_synonym="8030490L12"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aaaactccgc gccgcggcgg tggaggaggc ggcggcggcg gcagaggagg aaagggagga
       61 ggaggtggtg gaggagagga gcaggaggag gagcagcggc gagcccgggc gacgtcggcg
      121 gggcccgagc gcggagcccc cgggatagag cgcgcaccgg ggtgtcccgg caccccgctc
      181 gccccgggcc gccgcggaag atggtggcgg cgccgtgcgc ccggaggctg gcgcggcgct
      241 cgcactcggc gctgctggcg gcgctcatgg tgctgctgct gcagacgctg gtggtgtgga
      301 atttcagcag cctggactcc ggggctggag agcagcggcg cgcgggggca gcggcgggag
      361 cagccgagca gcagcagccc gcggccccgc gccgggagcg cagggacctg gctgcccatc
      421 tgcccgcagc ccgcggagga cctggaggcc gagccggcgg aggaggagca cggggaggcg
      481 gccccggagg agcccgcgca cagcagcctg ccagccgcgg ggcactagcc tcccgggcga
      541 gggatccaca accaagtcca ctgatcaccc tagagaccca ggatggctac ttctctcacc
      601 gtcccaaaga gaaagttcgg accgacagca acaatgagaa ctcagtcccc aaggactttg
      661 agaatgtgga taacagcaac ttcgccccca ggacccagaa gcagaaacac cagccagagc
      721 tggcaaagaa gccccccagc aggcagaaag agcatttgca gagaaagctg gatgcccagg
      781 acaaacgaca gggccagtca gtcctgggga aaggccccaa ggaggtgctg cctcctcggg
      841 agaaagccac aggcaacagt agccaaggga aggatctctc aagacacagc catgccagga
      901 agagtggtgg tggtgggtcc cccgaaacca agtctgacca ggcccccaag tgtgatatct
      961 ctggcaagga ggccatctca gcactgaccc gcgctaagtc caagcattgt cgccaggaga
     1021 ttgcagaaac ctactgtcgc cacaagctgg ggctgctgat gccagagaag gtggctcgat
     1081 tctgtcccct agaaggcaaa gccaacaaga atgtccagtg ggatgaggat gctgtggagt
     1141 acatgcctgc caacccagtc agaatcgcct ttgtcctggt ggtccatggc cgtgcctctc
     1201 gacagctaca gcgcatgttc aaggccatct accacaaaga ccatttctac tatatccatg
     1261 tggataagcg ttccaattac ctgcatcggc aagtgctcca gttctccagg cagtacgaca
     1321 atgtccgagt cacctcctgg aggatggcca ccatttgggg tggagccagc ctcctgtcca
     1381 cctacctgca gagcatgcgg gatctactag agatgactga ctggccctgg gacttcttca
     1441 tcaacctcag tgctgctgac taccccatca ggacaaatga ccagctggta gcatttcttt
     1501 ccagatatcg agatatgaac ttcctgaagt cacatggccg ggacaatgca aggttcatcc
     1561 ggaagcaggg cctggaccgc ctcttcctgg agtgtgatac acacatgtgg cgcctggggg
     1621 accggcggat cccagagggc attgctgtgg atggtggttc tgattggttc ctgctaaaca
     1681 ggaagtttgt agagtatgtg gcattctcca cagatgacct ggtgaccaag atgaagcagt
     1741 tctactctta cacccttctc cctgctgagt cctttttcca cacggttcta gagaacagcc
     1801 cccactgtga caccatggtg gataacaacc tgcgcatcac caactggaac cgcaagctgg
     1861 gctgcaagtg ccagtacaag catatcgtgg actggtgcgg ctgctctccc aatgacttca
     1921 agcctcagga cttccatcgc ttccagcaga cagcccggcc caccttcttt gcccgaaagt
     1981 tcgaagccat agtgaaccag gagatcattg ggcagctgga ctcttacctg tacgggaact
     2041 atcctgcggg caccccgggc ctccgctcct actgggagaa tgtctacgat gaaccagatg
     2101 gcatccacac cctcagcgat gtagccctca ccctgtacca ttccttcatc cgtctgggtc
     2161 ttcgaagagc tgagtcatcc ctacacacgg atggggagaa cagctgcagg tactacccaa
     2221 tgggccaccc agcttctgtc catctctact tccttgctga ccgattccag ggctttctga
     2281 tcaagcatca cgtgaccaac cttgctgtga gcaaactgga gacactggag acatggatga
     2341 tgccaaagaa agtcttcaag gtcgcaagtc cccccagtga ctttggaagg cttcagtttt
     2401 ctgaggttgg cactgactgg gatgccaagg agaggctgtt ccggaacttt ggtggtcttt
     2461 tggggcccat ggatgagccg gtggggatgc agaaatgggg aaaggggccc aatgtgaccg
     2521 tgactgttat ttgggtggat cctgtcaacg tcattgcagc cacctatgat atcctgattg
     2581 agtccactgc ggaattcaca cactacaagc cccctttgaa tctgcctctg aggcctgggg
     2641 tctggacagt gaagattctc catcactggg tgccagtggc agagaccaaa ttccttgtgg
     2701 cacctttgac cttttccaac aagcagccca tcaaaccaga ggaggctttg aagctgcaca
     2761 atgggccacc tcgcagtgcc tacatggagc agagtttcca gagcctgaac ccagtcctca
     2821 gcctgcacat caatcctgcc caagtcgaac aggcccggaa gaatgcagcc ttcaccggga
     2881 cagcgctaga agcctggctg gactcgctgg tgggtgggac ttggactgcc atggacatct
     2941 gcaccacagg ccccaccgcc tgcccagtca tgcagacctg cagccaaaca gcctggagtt
     3001 ccttcagccc tgatcccaag tcagagctgg gtgcagtcaa acctgacgga cggctcaggt
     3061 agcactggcc
//
