LOCUS       NM_001033209            3860 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus xylulokinase homolog (H. influenzae) (Xylb),
            transcript variant 1, mRNA.
ACCESSION   NM_001033209 XM_135223 XM_902948 XM_902949 XM_902950 XM_902951
            XM_902953 XM_902954 XM_916628 XM_924356 XM_924359 XM_924362
            XM_924365
VERSION     NM_001033209.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3860)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3860)
  AUTHORS   Man,J.C.K., Mohan,R.A., Boogaard,M.V.D., Hilvering,C.R.E.,
            Jenkins,C., Wakker,V., Bianchi,V., Laat,W., Barnett,P.,
            Boukens,B.J. and Christoffels,V.M.
  TITLE     An enhancer cluster controls gene activity and topology of the
            SCN5A-SCN10A locus in vivo
  JOURNAL   Nat Commun 10 (1), 4943 (2019)
   PUBMED   31666509
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3860)
  AUTHORS   Bunker,R.D., Bulloch,E.M., Dickson,J.M., Loomes,K.M. and Baker,E.N.
  TITLE     Structure and function of human xylulokinase, an enzyme with
            important roles in carbohydrate metabolism
  JOURNAL   J Biol Chem 288 (3), 1643-1652 (2013)
   PUBMED   23179721
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK143476.1 and AK165759.1.
            
            On Dec 9, 2010 this sequence version replaced NM_001033209.2.
            
            Transcript Variant: This variant (1) encodes the longer protein
            (isoform 1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK143476.1, AK165518.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3251              AK143476.1         1-3251
            3252-3860           AK165759.1         3096-3704
FEATURES             Location/Qualifiers
     source          1..3860
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 71.33 cM"
     gene            1..3860
                     /gene="Xylb"
                     /note="xylulokinase homolog (H. influenzae)"
                     /db_xref="GeneID:102448"
                     /db_xref="MGI:MGI:2142985"
     exon            1..327
                     /gene="Xylb"
                     /inference="alignment:Splign:2.1.0"
     CDS             226..1881
                     /gene="Xylb"
                     /EC_number="2.7.1.17"
                     /note="isoform 1 is encoded by transcript variant 1;
                     xylulose kinase"
                     /codon_start=1
                     /product="xylulose kinase isoform 1"
                     /protein_id="NP_001028381.1"
                     /db_xref="CCDS:CCDS23614.1"
                     /db_xref="GeneID:102448"
                     /db_xref="MGI:MGI:2142985"
                     /translation="MDARTHRRAAGTPRALAERAGRRCCLGWDFSTQQVKVVAVDAEL
                     NVFYEDSVHFDRDLPEFGTQGGVHVHKDRLTVTSPVLMWVQALDLILGKMKSSGFDFS
                     QVLALSGAGQQHGSVYWKTGASLALSSLSPALPLHQQLQSCFSISDCPIWMDSSTTAQ
                     CHQLEAAVGGAQALSCLTGSRAYERFTGNQIAKLFQKNPEAYSHSERISLVSSFAASL
                     FLGGYSPIDYSDGSGMNLLQIQEKVWSQACLDVCAPHLEEKLGSPVPSCSVVGTISSY
                     YVQRYGFPPGCKVVAFSGDNPASLAGMRLEEGDIAVSLGTSDTLFLWLQKPMPALEGH
                     IFCNPVDPQHYMALLCFKNGSLMREKIRDESASCSWNKFSKALKSTAMGNNGNLGFYF
                     DVMEITPEIIGRHRFNAENMEVSAFPGDVEIRALIEGQFMAKRIHAEGLGYRVMPKTK
                     ILATGGASHNKDILQVLADVFGAPVYVIDTTSSACVGSAYRAFHGLAGGTGVAFSEVV
                     KSAPQPSLAATPNPGASQVYAALLPRYSALEQRILSTAQRPLE"
     exon            328..410
                     /gene="Xylb"
                     /inference="alignment:Splign:2.1.0"
     exon            411..480
                     /gene="Xylb"
                     /inference="alignment:Splign:2.1.0"
     exon            481..561
                     /gene="Xylb"
                     /inference="alignment:Splign:2.1.0"
     exon            562..648
                     /gene="Xylb"
                     /inference="alignment:Splign:2.1.0"
     exon            649..777
                     /gene="Xylb"
                     /inference="alignment:Splign:2.1.0"
     exon            778..843
                     /gene="Xylb"
                     /inference="alignment:Splign:2.1.0"
     exon            844..916
                     /gene="Xylb"
                     /inference="alignment:Splign:2.1.0"
     exon            917..1035
                     /gene="Xylb"
                     /inference="alignment:Splign:2.1.0"
     exon            1036..1117
                     /gene="Xylb"
                     /inference="alignment:Splign:2.1.0"
     exon            1118..1158
                     /gene="Xylb"
                     /inference="alignment:Splign:2.1.0"
     exon            1159..1274
                     /gene="Xylb"
                     /inference="alignment:Splign:2.1.0"
     exon            1275..1390
                     /gene="Xylb"
                     /inference="alignment:Splign:2.1.0"
     exon            1391..1464
                     /gene="Xylb"
                     /inference="alignment:Splign:2.1.0"
     exon            1465..1561
                     /gene="Xylb"
                     /inference="alignment:Splign:2.1.0"
     exon            1562..1620
                     /gene="Xylb"
                     /inference="alignment:Splign:2.1.0"
     exon            1621..1708
                     /gene="Xylb"
                     /inference="alignment:Splign:2.1.0"
     exon            1709..1803
                     /gene="Xylb"
                     /inference="alignment:Splign:2.1.0"
     exon            1804..3860
                     /gene="Xylb"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3368..3373
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Xylb"
                     /note="hexamer: AATAAA"
     polyA_site      3396
                     /gene="Xylb"
                     /note="major polyA site"
ORIGIN      
        1 ggtggagtga aattggaggg aagccactgc gctgccttgc tggtgggtag cgaccactaa
       61 gtgccccagc cagacgcagt cccactcgcg accttcccgc aggcggcgcc agagggcatt
      121 cccgcctcgt gactccagtc cagagtcctg cggggcgtgg cgaaaggcgg gctctggcgt
      181 ctctgagcga cggagcgcag cgacagtctc gccgctgcag tacacatgga cgcacggacg
      241 cacagacggg cggcgggaac ccccagggcc ctggcggagc gcgcggggcg ccgctgttgc
      301 ctgggctggg acttcagcac gcagcaggtt aaagttgttg ctgttgatgc agagttgaac
      361 gtcttctatg aggacagcgt gcattttgac agagaccttc cggaatttgg aactcagggc
      421 ggtgtccatg tacacaagga caggctgacg gtcacctctc cggtcctgat gtgggtccag
      481 gctctggacc tgatcctggg gaagatgaag tcttctggct ttgacttctc tcaagttcta
      541 gccttatctg gagcaggcca gcaacacgga agtgtttact ggaagactgg agccagcctg
      601 gccctgtcaa gcttgtcacc agctcttcca ttacatcagc agctgcagag ctgcttctcc
      661 atcagcgact gcccaatatg gatggactcc agtaccacag cccagtgcca ccagctggag
      721 gctgccgtgg gtggggccca ggctctcagc tgcctcacag gatcccgggc ctatgagcgt
      781 ttcacgggga accagatagc gaagcttttc cagaagaacc ctgaggccta ctcacactct
      841 gagagaattt ccttggtcag cagctttgct gcctcgctgt tcctgggtgg gtactcgccc
      901 atcgactaca gtgatgggtc cggaatgaat ctgttgcaga tccaggaaaa agtctggtcc
      961 caggcttgtc tggatgtctg tgctccccat ttggaggaga agctgggctc accggtccct
     1021 tcctgttcag ttgtgggaac catttcttcc tactacgtcc agcgctatgg attccctcca
     1081 ggatgcaaag tggtggcctt cagtggggac aacccagcgt cactggccgg catgaggctg
     1141 gaggaaggag atattgcggt cagcctgggc accagcgaca ccctgtttct ctggctccag
     1201 aagcccatgc ctgccttgga aggccacatc ttctgcaacc cagtggatcc gcagcattac
     1261 atggcgcttc tatgctttaa aaacggctcc ctcatgagag agaagatccg agatgagtcg
     1321 gcctcctgtt cctggaacaa gttctctaag gccctgaagt ccacggcgat ggggaacaac
     1381 ggaaacttgg gtttttattt cgatgtaatg gagatcaccc ctgaaattat tgggcgtcat
     1441 aggtttaatg cggaaaacat ggaggtttca gcattccctg gggatgtgga gatccgagca
     1501 ctgattgaag gacaattcat ggccaagagg attcatgcag aaggcctagg ctacagagtc
     1561 atgcccaaga caaagattct ggccacggga ggagcatctc acaataaaga catcttgcag
     1621 gtgcttgcag atgtttttgg ggcccccgta tacgtcatag acaccaccag ttcagcctgc
     1681 gtcggctccg cataccgagc ttttcatggc cttgcaggag ggacaggtgt ggccttttcg
     1741 gaggttgtga aatcagcacc tcagcccagc ctggctgcca cccccaaccc aggagcttcc
     1801 caggtctatg cggcccttct ccctcgatac tctgcactgg aacagagaat cttgtccacc
     1861 gcccagaggc ctctggaatg aattcttccg gcccagacac cctgctgcct ccccagtggc
     1921 actagtcctt gtgcttggtc tgaacagctc ggctgtgctc tgtggagcgc tcctgccctg
     1981 tcctggacca tcctgaagcc atgactcctt ggagacacgt gggctacatg tcctgggatg
     2041 gaaaagcaat ttctcctttt ctgtctttca ttcaagaaaa cactgtaggg tatggccacc
     2101 aaagacagcc atgttcccct tttaaaggga ccaaacagca gaacaaaggg accaaacagc
     2161 ctttccctga ctctgaccac tcctccttcc tcaccttcag ccacctcccc tattctgcaa
     2221 cctccccctc catccttaaa ccagactaaa gcacttctct cctgcctgtg accctcctgt
     2281 ttctgtaagt gtcttcccgg ggctctcttc tctctgccta tctcctcctt catcttccct
     2341 ccctatatgt acctggtgta acttcccact caagacgacc ttcattggcc tggtgaatct
     2401 ccttcctccc ctccccctgc tctgccatag agacttcctg actgggtttc ctgggtgaca
     2461 tctcctaggc taagcacttc ccagttcaca caatgacata attgtgtgtt tcgtgaagtt
     2521 tctaaattct ggctttcttt ttcttttgtt tctttggagc caaagatgac cttaagcata
     2581 tgatcttcct gttgccaccc cccaagtatg ggccaccaca cctggtttat gcgatatcag
     2641 ggattgaacc catgcactct aggcaggcac tctacctgcc gagccacaca cccagcttgg
     2701 gttccctttt tacttggcat actttgtgac tctcacttct gcacatccta ctatgtttga
     2761 gctgtgtcct ccctctccac ccctgtttta cttgtcctcg ctcccagatc accccccaaa
     2821 gttttcctct gccacaaggc tgggctgaac tcaggaccac tggatctgac aggtggcaag
     2881 atcagatgtt gcagacaggt gggagaccag gatcagagca ctgactactg ggaaatcaaa
     2941 agggcagagc acagatggaa agagagttgt gtgtagacat gaggtcgctt ggaaggctct
     3001 gcctgtgagc gggggagaag caacaatcgg ccatcttgcc cacagcaaac tcacagtgca
     3061 gaaggaaacg gccattgggc tgtggcttct tacagagggt ttacactacc aaccaaccgc
     3121 aaaggcatct gggaccacaa aacagttaac caggacgaca ttccagcaga tcctacaata
     3181 agtcagacaa ttgtggatga aaaaggccac cgtaagtgac aacttaaaaa acaaatccaa
     3241 atggaaacac agcaagctta tgtgagaaga cactgatccg gagacctgac aggaagttca
     3301 aggaggcgcc aggaaagaag ggaggagagt aaagacaaga tccctgatga tatttaggat
     3361 ttcccaaaat aaacataatt ttgaaaacac ctaaaatcca cctctccttg cttccctgtt
     3421 gttggtgcag gggtttgaac ctgtgacttt gaaaatgctg ggcaaaccct ctcttactga
     3481 gatgttccac aggcttcaca aacgtgtttt gaaagagtct accttgtaat ttagaagtgg
     3541 tctagcagtg ttttgagatt tgtatatcac tgacccaaca tcaaaaggct tagaccgtaa
     3601 aacaaaatga ggccgtgtgg gggtagggag ggtgtttggt ggagagatgc ctcaagggtt
     3661 aaaagcactg gctgttcctc cagagaacct gagttctgtt cctagcacac acacagcagc
     3721 tcacaactgt ctgtgactcc agtcccagaa ggatctgatg gcctctctat actccaagtg
     3781 atacacacac acaagaagga agacagccat acatatataa aaatatggtt aaggtaaaaa
     3841 taaagtttga agaaaactct
//
