LOCUS       NM_198626               3111 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus xyloside xylosyltransferase 1 (Xxylt1), mRNA.
ACCESSION   NM_198626 XM_193839
VERSION     NM_198626.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3111)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3111)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3111)
  AUTHORS   Yu,H., Takeuchi,M., LeBarron,J., Kantharia,J., London,E.,
            Bakker,H., Haltiwanger,R.S., Li,H. and Takeuchi,H.
  TITLE     Notch-modifying xylosyltransferase structures support an SNi-like
            retaining mechanism
  JOURNAL   Nat Chem Biol 11 (11), 847-854 (2015)
   PUBMED   26414444
REFERENCE   4  (bases 1 to 3111)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC090430.7 and AC126280.4.
            
            [WARNING] On May 24, 2024 this sequence was replaced by
            NM_198626.3.
            
            On Aug 21, 2009 this sequence version replaced NM_198626.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK154256.1, BC031419.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-598               AC090430.7         98599-99196         c
            599-746             AC090430.7         68396-68543         c
            747-879             AC126280.4         6237-6369
            880-3111            AC126280.4         56349-58580
FEATURES             Location/Qualifiers
     source          1..3111
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 21.34 cM"
     gene            1..3111
                     /gene="Xxylt1"
                     /note="xyloside xylosyltransferase 1"
                     /db_xref="GeneID:268880"
                     /db_xref="MGI:MGI:2146443"
     exon            1..598
                     /gene="Xxylt1"
                     /inference="alignment:Splign:2.1.0"
     CDS             98..1276
                     /gene="Xxylt1"
                     /EC_number="2.4.2.62"
                     /note="UDP-xylose:alpha-xyloside
                     alpha-1,3-xylosyltransferase"
                     /codon_start=1
                     /product="xyloside xylosyltransferase 1"
                     /protein_id="NP_941028.2"
                     /db_xref="CCDS:CCDS49822.1"
                     /db_xref="GeneID:268880"
                     /db_xref="MGI:MGI:2146443"
                     /translation="MGLLRGGAACARAMARLGALRSHYCALLLAAALAVCAFYYLGSG
                     RETFSSATKRLKEARAGAAAPTPPAPELARGSAAPASGAKAKSLEGGVVVPVDYHLLM
                     MFTKAEHNAPLQAKARVALSSLLRLAKFEAHEVLNLHFVSEEASREVAKALLRELLPP
                     AAGFKCKVIFHDVAVLTDKLFPVVEAMQKYFSAGSGTYYSDSIFFLSVAMHQIMPKEI
                     PRIIQLDLDLKYKTNIRELFEEFDNFLPGAVIGIAREMQPVYRHTFWQFRHENPKTRV
                     GDPPPEGLPGFNSGVMLLNLEAMRQSPLYSHLLEPSWVQQLADKYHFRGHLGDQDFFT
                     MIGMEHPELFHVLDCTWNRQLCTWWRDHGYSDVFQAYFRCEGHVKIYHGNCNTPIPED
                     "
     exon            599..746
                     /gene="Xxylt1"
                     /inference="alignment:Splign:2.1.0"
     exon            747..879
                     /gene="Xxylt1"
                     /inference="alignment:Splign:2.1.0"
     exon            880..3111
                     /gene="Xxylt1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2967..2972
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Xxylt1"
                     /note="hexamer: AGTAAA"
     polyA_site      2987
                     /gene="Xxylt1"
                     /note="major polyA site"
     regulatory      3050..3055
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Xxylt1"
                     /note="hexamer: CATAAA"
     polyA_site      3092
                     /gene="Xxylt1"
     polyA_site      3111
                     /gene="Xxylt1"
ORIGIN      
        1 ggccccgccc cctccatggc cgccgccggc tgcggggctt ggggccctag agtgctgctc
       61 tgagtgggcc cggctgctgg gccgccggct ccggcgcatg ggcctcctcc gaggcggagc
      121 tgcgtgcgct cgggccatgg cgcgcctggg cgcgttgcgc tcgcactact gcgcgctgct
      181 gctggccgcg gcgctggcgg tgtgcgcctt ctactacctg ggctcaggcc gggagacctt
      241 ctccagcgcc accaagaggc tgaaggaggc ccgcgccggg gccgccgcgc ccacgccgcc
      301 cgcacccgag ctggcccggg gctccgcggc gccggcctcc ggggccaagg ccaagagcct
      361 ggagggcggc gtggtggtcc cggtggacta ccacctgctg atgatgttca ccaaggcgga
      421 gcacaacgcg ccgctgcagg ccaaggctcg ggtggcgctg agctccctgc tgcgcctcgc
      481 caaattcgag gcgcacgagg tgcttaacct ccacttcgtg agcgaagagg ccagccgcga
      541 ggtggccaag gccctgctgc gggagctcct gccgcccgcc gccggcttca agtgcaaggt
      601 catcttccat gatgttgctg tgctgacaga taagctcttc cccgtcgtgg aggccatgca
      661 gaagtacttc agtgctggct cggggaccta ctacagcgac tccatcttct tcctctcggt
      721 tgccatgcac cagatcatgc ccaaagagat cccgaggatc atccagctgg accttgacct
      781 gaagtataag accaacatcc gagagctgtt tgaggagttc gacaactttc tgccaggcgc
      841 tgttatcggc atagccagag agatgcagcc tgtgtacagg cacacgttct ggcagttccg
      901 ccatgagaac cccaagacca gagttgggga ccctccgcct gaaggactcc ctggcttcaa
      961 cagtggagtg atgttgctga acctggaggc catgcgccag tctccgctct acagccatct
     1021 gctggaacct tcgtgggtac agcagcttgc tgacaagtac cacttccggg gccacctggg
     1081 ggaccaggac ttcttcacca tgattggcat ggagcaccct gaactcttcc atgtgctgga
     1141 ctgcacctgg aaccggcagc tgtgcacctg gtggagggac catggctaca gcgatgtctt
     1201 ccaggcatac ttccgctgtg agggccacgt caagatctac catgggaact gcaacacacc
     1261 catcccagag gactaggcac cagctcaccc gcgatgctgg tggggctccc gggcctgggg
     1321 aagaaagaga gactctgcta ggacactctt taggggtgag gtgctgcaga cctcccagct
     1381 ggctggctcc tatccagcca atatccaaag aagcttagct gagccttgct gctgctcgag
     1441 ctgttttcct ccagggcagc ccgaaggact gacacgggtg tcttccagga ggtggtcgaa
     1501 gatacggaag gaaggagaat tgcacccttg tccacacgga atcaaaaccc ttgtaaagaa
     1561 ctggctttgc tagaccaact aagcatttca agcggcaggc tctaatgctt ggtgagagaa
     1621 gaggtgggtg ctactgtggc tcccagtgag cactgaatgc ctagtcaggg ttttaacaag
     1681 cagcccaggg cttgagcctc caaaggaatg ccacagtccc acatcctttc ccaggaggct
     1741 ttgtacctcc tccagatgtt catgttgctt ggtgctggct tcaagagcag cacctcatta
     1801 gataaagact gaacacataa aaaaaaccct tactatagtg tccagagctc ttatccctcc
     1861 tctatcccag aaccccacct tctcttgtct gtctacctgc tccaggtgac ctgacttcta
     1921 ctaaagaatc aaacccgtca tccaaggaca gaggttggcc atgccggggc atgcactaga
     1981 ttcactccaa ggaattcact ccaagtctaa agtactgggt cacaagtaca attggggggg
     2041 cttgggaaag ggtggcctcc tgctctcatt gtagtctctg gagaagaaag aaaaccaaac
     2101 tcgtaattgt ccactgtgtc atgccagccc ctaccccttc ccagaagtga gtaccatttc
     2161 tctgtgtgct tgagacgggc tttgtgagtc agctgcccac atgaagcccc acaggccgtg
     2221 tctgcacagt ccagctcatg tcctcaggca agaaatggga gattcttatt gtatatagtc
     2281 agtaccatga gcgacagaca ctagctgatg aatagacttt gagaactctt gagtcacggt
     2341 gtttgttctc tggccagtgt tcagggctct ggatgggcag taggatcagc atcaagcaga
     2401 aggcctaaga ggcccaaccg gcaggcctgc acgtgggcgc agtgggtggt aggtactgcc
     2461 ctgtttgctt ccaggtgcag aactatctcg ttctagctct tagcaggctc atcccctgcc
     2521 gggaacaagc tcagaagtct ctggctcctt agcccagacc tcccagttcc attcatgctg
     2581 gtgagtggca cactccttca ctggccctct gccgggccca gttcctctgt tctccttgct
     2641 acttgatttc ctattcatag tgtctggtta ttagatgcct gcgtgcgcca ggcatcgtct
     2701 tcaggattta tatgtgccct agataatatt catgaaaacc tcatccagtt cactccagct
     2761 ctaaaactga tggatgaaaa cagagacacg gacaggttct ctgctgtgct gtttactgaa
     2821 gctttttact gtgcaaaaat gttggaaaca gcttaaaatg ttggctagag aagcagataa
     2881 ataatgcata ctgcaaccgt atggtggaat atatcgcaaa tcatttgaag gaatatttaa
     2941 tgtaccagga aatgcttatg ctagtgagta aagaatacac aatataagat tgtattgtgt
     3001 ccttttattt ttaattacat atatgtgtgc atctatatat atatttttgc ataaacaggt
     3061 acatacgtga aatgcatatg tatgggtgaa aagagaaaaa tttaaaaaca a
//
