LOCUS       NM_028012               1557 bp    mRNA    linear   ROD 14-JAN-2025
DEFINITION  Mus musculus X-ray repair complementing defective repair in Chinese
            hamster cells 4 (Xrcc4), mRNA.
ACCESSION   NM_028012 XM_003689283 XM_003689284 XM_003689285 XM_003689286
            XM_003689287 XM_003689288 XM_006543098 XM_011245793
VERSION     NM_028012.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1557)
  AUTHORS   Zhu,Y., Jiang,W., Lee,B.J., Li,A., Gershik,S. and Zha,S.
  TITLE     Phosphorylation of DNA-PKcs at the S2056 cluster ensures efficient
            and productive lymphocyte development in XLF-deficient mice
  JOURNAL   Proc Natl Acad Sci U S A 120 (25), e2221894120 (2023)
   PUBMED   37307443
REFERENCE   2  (bases 1 to 1557)
  AUTHORS   Vincendeau,E., Wei,W., Zhang,X., Planchais,C., Yu,W.,
            Lenden-Hasse,H., Cokelaer,T., Pipoli da Fonseca,J., Mouquet,H.,
            Adams,D.J., Alt,F.W., Jackson,S.P., Balmus,G., Lescale,C. and
            Deriano,L.
  TITLE     SHLD1 is dispensable for 53BP1-dependent V(D)J recombination but
            critical for productive class switch recombination
  JOURNAL   Nat Commun 13 (1), 3707 (2022)
   PUBMED   35764636
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1557)
  AUTHORS   Wang,X.S., Menolfi,D., Wu-Baer,F., Fangazio,M., Meyer,S.N.,
            Shao,Z., Wang,Y., Zhu,Y., Lee,B.J., Estes,V.M., Cupo,O.M.,
            Gautier,J., Pasqualucci,L., Dalla-Favera,R., Baer,R. and Zha,S.
  TITLE     DNA damage-induced phosphorylation of CtIP at a conserved ATM/ATR
            site T855 promotes lymphomagenesis in mice
  JOURNAL   Proc Natl Acad Sci U S A 118 (38) (2021)
   PUBMED   34521752
REFERENCE   4  (bases 1 to 1557)
  AUTHORS   Roch,B., Abramowski,V., Etienne,O., Musilli,S., David,P.,
            Charbonnier,J.B., Callebaut,I., Boussin,F.D. and de Villartay,J.P.
  TITLE     An XRCC4 mutant mouse, a model for human X4 syndrome, reveals
            interplays with Xlf, PAXX, and ATM in lymphoid development
  JOURNAL   Elife 10, e69353 (2021)
   PUBMED   34519267
  REMARK    GeneRIF: An XRCC4 mutant mouse, a model for human X4 syndrome,
            reveals interplays with Xlf, PAXX, and ATM in lymphoid development.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1557)
  AUTHORS   Maruoka,M., Zhang,P., Mori,H., Imanishi,E., Packwood,D.M.,
            Harada,H., Kosako,H. and Suzuki,J.
  TITLE     Caspase cleavage releases a nuclear protein fragment that
            stimulates phospholipid scrambling at the plasma membrane
  JOURNAL   Mol Cell 81 (7), 1397-1410 (2021)
   PUBMED   33725486
  REMARK    GeneRIF: Caspase cleavage releases a nuclear protein fragment that
            stimulates phospholipid scrambling at the plasma membrane.
REFERENCE   6  (bases 1 to 1557)
  AUTHORS   Gao,Y., Sun,Y., Frank,K.M., Dikkes,P., Fujiwara,Y., Seidl,K.J.,
            Sekiguchi,J.M., Rathbun,G.A., Swat,W., Wang,J., Bronson,R.T.,
            Malynn,B.A., Bryans,M., Zhu,C., Chaudhuri,J., Davidson,L.,
            Ferrini,R., Stamato,T., Orkin,S.H., Greenberg,M.E. and Alt,F.W.
  TITLE     A critical role for DNA end-joining proteins in both lymphogenesis
            and neurogenesis
  JOURNAL   Cell 95 (7), 891-902 (1998)
   PUBMED   9875844
REFERENCE   7  (bases 1 to 1557)
  AUTHORS   Barnes,D.E., Stamp,G., Rosewell,I., Denzel,A. and Lindahl,T.
  TITLE     Targeted disruption of the gene encoding DNA ligase IV leads to
            lethality in embryonic mice
  JOURNAL   Curr Biol 8 (25), 1395-1398 (1998)
   PUBMED   9889105
REFERENCE   8  (bases 1 to 1557)
  AUTHORS   Frank,K.M., Sekiguchi,J.M., Seidl,K.J., Swat,W., Rathbun,G.A.,
            Cheng,H.L., Davidson,L., Kangaloo,L. and Alt,F.W.
  TITLE     Late embryonic lethality and impaired V(D)J recombination in mice
            lacking DNA ligase IV
  JOURNAL   Nature 396 (6707), 173-177 (1998)
   PUBMED   9823897
REFERENCE   9  (bases 1 to 1557)
  AUTHORS   Li,Z., Otevrel,T., Gao,Y., Cheng,H.L., Seed,B., Stamato,T.D.,
            Taccioli,G.E. and Alt,F.W.
  TITLE     The XRCC4 gene encodes a novel protein involved in DNA
            double-strand break repair and V(D)J recombination
  JOURNAL   Cell 83 (7), 1079-1089 (1995)
   PUBMED   8548796
REFERENCE   10 (bases 1 to 1557)
  AUTHORS   Yamano,M. and Tohyama,M.
  TITLE     Distribution of corticotropin-releasing factor and calcitonin
            gene-related peptide in the developing mouse cerebellum
  JOURNAL   Neurosci Res 19 (4), 387-396 (1994)
   PUBMED   8090368
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY774472.1, AK009951.1 and AW455986.1.
            
            On or before Feb 15, 2015 this sequence version replaced
            XM_011245793.1, XM_006543098.1, XM_003689283.1, XM_003689284.1,
            XM_003689285.1, XM_003689286.1, XM_003689287.1, XM_003689288.1,
            NM_028012.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB055154.1, AK088281.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-85                BY774472.1         1-85
            86-1538             AK009951.1         3-1455
            1539-1557           AW455986.1         1-19                c
FEATURES             Location/Qualifiers
     source          1..1557
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 45.5 cM"
     gene            1..1557
                     /gene="Xrcc4"
                     /gene_synonym="2310057B22Rik"
                     /note="X-ray repair complementing defective repair in
                     Chinese hamster cells 4"
                     /db_xref="GeneID:108138"
                     /db_xref="MGI:MGI:1333799"
     exon            1..112
                     /gene="Xrcc4"
                     /gene_synonym="2310057B22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            113..261
                     /gene="Xrcc4"
                     /gene_synonym="2310057B22Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             123..1103
                     /gene="Xrcc4"
                     /gene_synonym="2310057B22Rik"
                     /note="X-ray repair cross-complementing protein 4"
                     /codon_start=1
                     /product="DNA repair protein XRCC4"
                     /protein_id="NP_082288.1"
                     /db_xref="CCDS:CCDS26673.1"
                     /db_xref="GeneID:108138"
                     /db_xref="MGI:MGI:1333799"
                     /translation="MERKVSRIYLASEPNVPYFLQVSWERTIGSGFVITLTDGHSAWT
                     ATVSELEISQEADDMAMEKGKYIDELRKALVPGSGAAGTYKFLFSKESRHFSLEKELK
                     DVSFRLGSFNLDKVSNSAEVIRDLICYCLDTITEKQAKNEHLQKENERLLRDWNDVQG
                     RFEKCVSAKEALEADLYQRFILVLNEKKTKIRSLHKLLNEVQQLEESTKPERENPCSD
                     KTPEEHGLYDGSTDEESGAPVQAAETLHKDDSIFSSPDVTDIAPSRKRRHRMQKNLGT
                     EPKMAPQELPLQEKERLASSLPQTLKEESTSAENMSLETLRNSSPEDLFD"
     exon            262..437
                     /gene="Xrcc4"
                     /gene_synonym="2310057B22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            438..604
                     /gene="Xrcc4"
                     /gene_synonym="2310057B22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            605..757
                     /gene="Xrcc4"
                     /gene_synonym="2310057B22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            758..849
                     /gene="Xrcc4"
                     /gene_synonym="2310057B22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            850..997
                     /gene="Xrcc4"
                     /gene_synonym="2310057B22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            998..1547
                     /gene="Xrcc4"
                     /gene_synonym="2310057B22Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1522..1527
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Xrcc4"
                     /gene_synonym="2310057B22Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1547
                     /gene="Xrcc4"
                     /gene_synonym="2310057B22Rik"
                     /note="major polyA site"
ORIGIN      
        1 ggacttggcc gacgactcgc aaaccacggt attagcggat tctctcattg ggcgcatcgg
       61 tttatctctg gcgtccacaa tttttagaag accggaagtg gagtactgag aggtagccag
      121 aaatggaaag gaaagtaagc agaatctatc ttgcttctga acccaacgta ccttattttc
      181 tgcaagtgtc ttgggagaga acaataggat ccggctttgt tattacactt actgacggcc
      241 attcagcctg gactgcaaca gtttctgaat tggagatttc ccaagaagct gatgacatgg
      301 ctatggagaa aggaaaatac attgatgagc tgagaaaggc actggtgcca gggtcaggag
      361 cagctggtac atacaagttc ctcttttcta aggagtctcg gcatttctcc cttgagaaag
      421 aactgaaaga tgtttcattc agacttggtt ccttcaacct agacaaagtt tcaaactcag
      481 ctgaagtcat aagagatctc atttgttact gcctggacac cattacagaa aagcaagcca
      541 aaaacgagca cctgcagaaa gaaaatgaaa ggctcctgag agactggaat gatgttcaag
      601 gccgatttga gaaatgtgtg agtgccaaag aagccttgga ggctgatttg tatcaaagat
      661 ttatcttggt gctgaatgag aagaaaacaa agatccggag cttgcataaa ttgctaaatg
      721 aagtccagca gctggaggag agtaccaaac ctgaaaggga aaatccgtgt tctgacaaaa
      781 cacctgagga gcatgggctt tatgatggaa gcaccgatga agaaagtgga gcccctgtgc
      841 aggctgcaga aactcttcat aaggatgatt ccatattttc aagtccggat gtcactgaca
      901 ttgcaccaag taggaagagg agacaccgaa tgcagaagaa tcttgggaca gaacctaaaa
      961 tggctccaca ggagttgccg ctacaggaga aggaaaggct tgcctcttca ctaccccaga
     1021 ccttgaaaga ggagagcacc tctgctgaaa acatgtcttt agaaaccctg agaaacagca
     1081 gcccagaaga tctctttgat tagatataaa ccctagaaaa cagcactggt gttcaatgaa
     1141 ctatattctt tatccagttc ctttggatga gaagacaggc tttcaactta gcagccatgg
     1201 ttactatgtc ttgcaacttt actatatgta cccaatgaat catactagta tgtgacagtc
     1261 agatggaatg tcagagggac acttttctcc ctttcttaat taaatctgag ttttgttgca
     1321 aaaggcacat atatcatatt tgtttataca tttttgtaac tttctaattg actcttggaa
     1381 gattttggaa atagaacaaa atatctttaa cactttttta gttgcacttt aaattatctt
     1441 tgttgaagca tttaatttat gatgtgacac atataaaata catctttatc ttgtgtgtaa
     1501 acagtctgaa atctgatagt taataaaagt ttgtgttctc aaaagaaaaa aaaaaaa
//
