LOCUS       NM_028875               2479 bp    mRNA    linear   ROD 06-AUG-2023
DEFINITION  Mus musculus X-ray repair complementing defective repair in Chinese
            hamster cells 3 (Xrcc3), mRNA.
ACCESSION   NM_028875
VERSION     NM_028875.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2479)
  AUTHORS   Prakash R, Freyer L, Saiz N, Gavrilov S, Wang RQ, Romanienko PJ,
            Lacy E, Hadjantonakis AK and Jasin M.
  TITLE     XRCC3 loss leads to midgestational embryonic lethality in mice
  JOURNAL   DNA Repair (Amst) 108, 103227 (2021)
   PUBMED   34601382
  REMARK    GeneRIF: XRCC3 loss leads to midgestational embryonic lethality in
            mice.
REFERENCE   2  (bases 1 to 2479)
  AUTHORS   Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK,
            Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L,
            Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre
            JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A,
            Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ,
            Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall
            S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA,
            Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR,
            Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana
            S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, MacArthur DG,
            Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC,
            Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL,
            de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown
            SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bucan M and Murray
            SA.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. PMID: 29144450]
REFERENCE   3  (bases 1 to 2479)
  AUTHORS   Koscielny G, Yaikhom G, Iyer V, Meehan TF, Morgan H,
            Atienza-Herrero J, Blake A, Chen CK, Easty R, Di Fenza A, Fiegel T,
            Grifiths M, Horne A, Karp NA, Kurbatova N, Mason JC, Matthews P,
            Oakley DJ, Qazi A, Regnart J, Retha A, Santos LA, Sneddon DJ,
            Warren J, Westerberg H, Wilson RJ, Melvin DG, Smedley D, Brown SD,
            Flicek P, Skarnes WC, Mallon AM and Parkinson H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   4  (bases 1 to 2479)
  AUTHORS   Yokoyama S, Ito Y, Ueno-Kudoh H, Shimizu H, Uchibe K, Albini S,
            Mitsuoka K, Miyaki S, Kiso M, Nagai A, Hikata T, Osada T, Fukuda N,
            Yamashita S, Harada D, Mezzano V, Kasai M, Puri PL, Hayashizaki Y,
            Okado H, Hashimoto M and Asahara H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   5  (bases 1 to 2479)
  AUTHORS   Liu Y, Tarsounas M, O'regan P and West SC.
  TITLE     Role of RAD51C and XRCC3 in genetic recombination and DNA repair
  JOURNAL   J Biol Chem 282 (3), 1973-1979 (2007)
   PUBMED   17114795
  REMARK    GeneRIF: the RAD51C-XRCC3-associated Holliday junction resolvase
            complex associates with crossovers and may play an essential role
            in the resolution of recombination intermediates prior to
            chromosome segregation
REFERENCE   6  (bases 1 to 2479)
  AUTHORS   Rafii S, Lindblom A, Reed M, Meuth M and Cox A.
  TITLE     A naturally occurring mutation in an ATP-binding domain of the
            recombination repair gene XRCC3 ablates its function without
            causing cancer susceptibility
  JOURNAL   Hum Mol Genet 12 (8), 915-923 (2003)
   PUBMED   12668615
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC152065.4, BY275474.1,
            AK014491.1 and BC043073.1.
            
            [WARNING] On Jan 23, 2024 this sequence was replaced by
            NM_028875.4.
            
            On Sep 19, 2015 this sequence version replaced NM_028875.2.
            
            Summary: This gene encodes a member of the RecA/Rad51-related
            protein family that participates in homologous recombination to
            maintain chromosome stability and repair DNA damage. This gene
            functionally complements Chinese hamster irs1SF, a repair-deficient
            mutant that exhibits hypersensitivity to a number of different
            DNA-damaging agents and is chromosomally unstable. Allelic variants
            in the human gene are associated with susceptibility to breast
            cancer and cutaneous malignant melanoma. [provided by RefSeq, Sep
            2015].
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK014491.1, SRR7345562.1806465.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164143 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                AC152065.4         93422-93433
            13-38               BY275474.1         9-34
            39-2460             AK014491.1         1-2422
            2461-2479           BC043073.1         2300-2318
FEATURES             Location/Qualifiers
     source          1..2479
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 61.14 cM"
     gene            1..2479
                     /gene="Xrcc3"
                     /note="X-ray repair complementing defective repair in
                     Chinese hamster cells 3"
                     /db_xref="GeneID:74335"
                     /db_xref="MGI:MGI:1921585"
     exon            1..55
                     /gene="Xrcc3"
                     /inference="alignment:Splign:2.1.0"
     exon            56..214
                     /gene="Xrcc3"
                     /inference="alignment:Splign:2.1.0"
     CDS             160..1209
                     /gene="Xrcc3"
                     /note="X-ray repair cross-complementing protein 3"
                     /codon_start=1
                     /product="DNA repair protein XRCC3"
                     /protein_id="NP_083151.1"
                     /db_xref="CCDS:CCDS26187.1"
                     /db_xref="GeneID:74335"
                     /db_xref="MGI:MGI:1921585"
                     /translation="MDLDQLDLNPRITAAVKRGRLKSVKEILCYSGPDLQRLTGLPSH
                     DVQCLLRAASLHLRGSRVLSALHLFQQKESFPEQHQRLSLGCPVLDQFLGGGLPLEGI
                     TGLAGCSSAGKTQLALQLCLAVQFPRQYGGLEAGAVYICTEDAFPSKRLWQLIAQQRR
                     LRTDAPEELIEKIRFSNHIFIEHAADVDTLLECVSKKVPILLSRGMARLVVVDSIAAP
                     FRCEFHLQASAIRAKLLLSLGATLRRLSSTFRSPVLCINQVTDMVEDQQSVSRSLGAS
                     EERLSPALGITWANQLLMRLMVDRTHEDDVTTGLPRSPVRTLRVLFAPHLPLSSCCYT
                     VSGEGIRGMPGTQSY"
     exon            215..352
                     /gene="Xrcc3"
                     /inference="alignment:Splign:2.1.0"
     exon            353..565
                     /gene="Xrcc3"
                     /inference="alignment:Splign:2.1.0"
     exon            566..720
                     /gene="Xrcc3"
                     /inference="alignment:Splign:2.1.0"
     exon            721..933
                     /gene="Xrcc3"
                     /inference="alignment:Splign:2.1.0"
     exon            934..980
                     /gene="Xrcc3"
                     /inference="alignment:Splign:2.1.0"
     exon            981..2461
                     /gene="Xrcc3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcttcagga gcgggcggag cgcgcgggag acttgcgggg tcgctgatcc gggaggaagt
       61 ctgagttggt gtgtgtcacc atccgtcgct gtgtgcctgt cagctctgct gtgtgctgtc
      121 accgtcagct ctgcatgccc ctgctgagac cacttaggaa tggacttgga tcagctggac
      181 ctaaaccccc gaattactgc tgcggttaag aggggcagac tgaagtcagt gaaggagatt
      241 ctgtgctact ccggaccaga cttgcagcgg ctcaccggcc tgcccagcca cgatgtgcag
      301 tgcctgctga gagctgcctc tctacacctt cggggaagcc gcgtcctctc agcactgcat
      361 ctgttccagc agaaggagag cttccctgag cagcatcaac gcctgagcct aggctgccct
      421 gtcctggatc agttcctggg tggaggcctg cccctggagg gcatcactgg cctggctggc
      481 tgcagctcag caggaaagac ccagctggcg ctacagctct gcctggctgt gcagttccca
      541 agacaatatg gaggcctaga ggccggggct gtctacatct gcacagaaga tgccttcccc
      601 agcaagcggc tgtggcagct catcgcgcag cagcggaggc tgcggacaga cgcgcctgag
      661 gagctgatcg agaagatcag gttcagcaac cacatcttca ttgaacacgc ggccgacgtg
      721 gacaccttgt tggagtgtgt gagtaagaaa gtccccatcc tgctgtcgag gggcatggcc
      781 cgcctggtgg tggttgactc cattgcagcc ccatttcgtt gtgagttcca ccttcaggcc
      841 tcagccatca gggcgaagct cctgctctcg ctgggggcca cactgcgaag actgagcagc
      901 accttcagga gcccagtgct gtgcatcaac caggtgacag acatggtgga ggaccagcag
      961 tctgtgtcca ggtcactagg ggcttcagaa gagcgcctct ctccagccct tggcatcacc
     1021 tgggctaacc agctcctgat gcgactgatg gttgaccgca cccatgagga cgatgttacc
     1081 acaggcttgc ccagaagccc agttcggact ctccgagtgc tcttcgcccc ccacctaccc
     1141 ctctcctcct gctgctacac agtcagtggg gaaggcatta gggggatgcc aggaacacag
     1201 tcctactaac agtgagacca gtgggtcagc ctgagcaggt cccaaggaac cctgattctg
     1261 atgactcttt ccaacaacct gtcagtcagt ggcacctggt gaacaggcac ccagtgacgg
     1321 ttagtctgtc agtatctgct ctctcctccc tggggttcac ctacccatta gaggatgact
     1381 gagcagcagg agctctggca gcccagaggg cgtctccgta ggaccccaaa atgacaagac
     1441 tcagctcttc tctcttctgc tttctgcctg ggactcagca gcttggtggg gcctaccctc
     1501 ctgcaggatg gtcttaactc cccccaaccc actatacaca cacacacaca tacacacata
     1561 cacacataca cacacacaca cacacacaca cacacacaca cacacacaca cacacataca
     1621 cagtaacacc taccactcag gccaagcatg gcttgcagtg agacactccc cgactgggct
     1681 cctccccaca catatacacc attttagggc agagtggaga aaactgtccg aggaagagag
     1741 atgggccagg cccaacccag ctgtctaggc taagtggctt tgggcaactt atgaaaggga
     1801 cacccggaaa caggtgtgtg tgctcactaa ggcctggcag gtgttcctgg caactcggct
     1861 gggcggtgca tccaggctgg aaggcaccac aaagcaccca acaggactgt gtacacactc
     1921 agccagcagg taggcctcct ggtaacatgt gctctggact cagaatcaac accttgtgga
     1981 cttgaggctc agcagtaagc aatgggtgtg gcctctgtag acagggctgt gtgttgacgc
     2041 acaggtagca caggctccca ccagcaagtg tgccaagtgg accttcacca aggagtcctg
     2101 ttgctccagt agtgtctgac tccttaaacc aggacataca ctgtcactgt ccccactcca
     2161 gtagggaaaa cagtccactt atggtatata ccatgacatc ttcagggcgg ccctatcctc
     2221 ttatgagctc atcgtttcaa aggcccctgg ggctcctacc cgctgtggca atcctgcaga
     2281 ctaaacctag ggcctcctgc atgcaagtgt tctacactga gctatgaccc actgacccgt
     2341 gcctgagagc tgaggatgag gggacacaca gctgcttggg tggggtggtt cacataaaac
     2401 agctctgcag aactggaggg ctttagaccc ggaaataaaa ctttattttt gtaacaaagt
     2461 aaaaaaaaaa aaaaaaaaa
//
