LOCUS       NM_020570               3230 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus X-ray repair complementing defective repair in Chinese
            hamster cells 2 (Xrcc2), mRNA.
ACCESSION   NM_020570
VERSION     NM_020570.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3230)
  AUTHORS   Yang,Y., Guo,J., Dai,L., Zhu,Y., Hu,H., Tan,L., Chen,W., Liang,D.,
            He,J., Tu,M., Wang,K. and Wu,L.
  TITLE     XRCC2 mutation causes meiotic arrest, azoospermia and infertility
  JOURNAL   J Med Genet 55 (9), 628-636 (2018)
   PUBMED   30042186
  REMARK    GeneRIF: The homozygotes (knock-in mice with
            Xrcc2-c.T41C/p.Leu14Pro mutation) survived and exhibited meiotic
            arrest, azoospermia, premature ovarian failure and infertility.
REFERENCE   2  (bases 1 to 3230)
  AUTHORS   Pieraccioli,M., Nicolai,S., Antonov,A., Somers,J., Malewicz,M.,
            Melino,G. and Raschella,G.
  TITLE     ZNF281 contributes to the DNA damage response by controlling the
            expression of XRCC2 and XRCC4
  JOURNAL   Oncogene 35 (20), 2592-2601 (2016)
   PUBMED   26300006
  REMARK    GeneRIF: involvement of ZNF281 in the cellular response to
            genotoxic stress through the control exercised on the expression of
            genes that act in different repair mechanisms
REFERENCE   3  (bases 1 to 3230)
  AUTHORS   Lee,Y., Brown,E.J., Chang,S. and McKinnon,P.J.
  TITLE     Pot1a prevents telomere dysfunction and ATM-dependent neuronal loss
  JOURNAL   J Neurosci 34 (23), 7836-7844 (2014)
   PUBMED   24899707
REFERENCE   4  (bases 1 to 3230)
  AUTHORS   Barlow,J.H., Faryabi,R.B., Callen,E., Wong,N., Malhowski,A.,
            Chen,H.T., Gutierrez-Cruz,G., Sun,H.W., McKinnon,P., Wright,G.,
            Casellas,R., Robbiani,D.F., Staudt,L., Fernandez-Capetillo,O. and
            Nussenzweig,A.
  TITLE     Identification of early replicating fragile sites that contribute
            to genome instability
  JOURNAL   Cell 152 (3), 620-632 (2013)
   PUBMED   23352430
  REMARK    Review article
REFERENCE   5  (bases 1 to 3230)
  AUTHORS   Cappelli,E., Townsend,S., Griffin,C. and Thacker,J.
  TITLE     Homologous recombination proteins are associated with centrosomes
            and are required for mitotic stability
  JOURNAL   Exp Cell Res 317 (8), 1203-1213 (2011)
   PUBMED   21276791
  REMARK    GeneRIF: Data show that XRCC2 and other homologous recombination
            proteins, including the key recombinase RAD51, co-localize with the
            centrosome, potentially to coordinate the deployment of a DNA
            damage response at vulnerable phases of the cell cycle.
REFERENCE   6  (bases 1 to 3230)
  AUTHORS   Orii,K.E., Lee,Y., Kondo,N. and McKinnon,P.J.
  TITLE     Selective utilization of nonhomologous end-joining and homologous
            recombination DNA repair pathways during nervous system development
  JOURNAL   Proc Natl Acad Sci U S A 103 (26), 10017-10022 (2006)
   PUBMED   16777961
REFERENCE   7  (bases 1 to 3230)
  AUTHORS   Griffin,C., Waard,Hd., Deans,B. and Thacker,J.
  TITLE     The involvement of key DNA repair pathways in the formation of
            chromosome rearrangements in embryonic stem cells
  JOURNAL   DNA Repair (Amst) 4 (9), 1019-1027 (2005)
   PUBMED   15979950
REFERENCE   8  (bases 1 to 3230)
  AUTHORS   Deans,B., Griffin,C.S., O'Regan,P., Jasin,M. and Thacker,J.
  TITLE     Homologous recombination deficiency leads to profound genetic
            instability in cells derived from Xrcc2-knockout mice
  JOURNAL   Cancer Res 63 (23), 8181-8187 (2003)
   PUBMED   14678973
  REMARK    GeneRIF: Order-of-magnitude higher levels of chromosomal
            alterations are sustained in primary or immortal Xrcc2(-/-)
            embryonic fibroblasts.
REFERENCE   9  (bases 1 to 3230)
  AUTHORS   Deans,B., Griffin,C.S., Maconochie,M. and Thacker,J.
  TITLE     Xrcc2 is required for genetic stability, embryonic neurogenesis and
            viability in mice
  JOURNAL   EMBO J 19 (24), 6675-6685 (2000)
   PUBMED   11118202
REFERENCE   10 (bases 1 to 3230)
  AUTHORS   Cartwright,R., Tambini,C.E., Simpson,P.J. and Thacker,J.
  TITLE     The XRCC2 DNA repair gene from human and mouse encodes a novel
            member of the recA/RAD51 family
  JOURNAL   Nucleic Acids Res 26 (13), 3084-3089 (1998)
   PUBMED   9628903
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC033417.1.
            
            On Jun 9, 2003 this sequence version replaced NM_020570.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC033417.1, Y17040.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN04095720 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
FEATURES             Location/Qualifiers
     source          1..3230
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 12.35 cM"
     gene            1..3230
                     /gene="Xrcc2"
                     /gene_synonym="4921524O04Rik; 8030409M04Rik; RAD51; RecA"
                     /note="X-ray repair complementing defective repair in
                     Chinese hamster cells 2"
                     /db_xref="GeneID:57434"
                     /db_xref="MGI:MGI:1927345"
     exon            1..120
                     /gene="Xrcc2"
                     /gene_synonym="4921524O04Rik; 8030409M04Rik; RAD51; RecA"
                     /inference="alignment:Splign:2.1.0"
     CDS             82..918
                     /gene="Xrcc2"
                     /gene_synonym="4921524O04Rik; 8030409M04Rik; RAD51; RecA"
                     /note="recA/RAD51 family protein; X-ray repair
                     cross-complementing protein 2"
                     /codon_start=1
                     /product="DNA repair protein XRCC2"
                     /protein_id="NP_065595.2"
                     /db_xref="CCDS:CCDS19135.1"
                     /db_xref="GeneID:57434"
                     /db_xref="MGI:MGI:1927345"
                     /translation="MCSDFRRAESGTELLARLEGRSSLKELEPNLFADEDSPVHGDIF
                     EFHGPEGTGKTEMLYHLTARCILPKSEGGLQIEVLFIDTDYHFDMLRLVTVLEHRLSQ
                     SSEEAMKLCLARLFLAYCSSSMQLLLTLHSLEALLCSRPSLCLLIVDSLSSFYWIDRV
                     SGGESVALQESTLQKCSQLLERLVTEYRLLLFATTQSLMQKGSDSADGPSSSKHPCDG
                     DMGYRAYLCKAWQRVVKHRVIFSRDDEAKSSRFSLVSRHLKSNSLKKHSFMVRESGVE
                     FC"
     exon            121..202
                     /gene="Xrcc2"
                     /gene_synonym="4921524O04Rik; 8030409M04Rik; RAD51; RecA"
                     /inference="alignment:Splign:2.1.0"
     exon            203..3217
                     /gene="Xrcc2"
                     /gene_synonym="4921524O04Rik; 8030409M04Rik; RAD51; RecA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3188..3193
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Xrcc2"
                     /gene_synonym="4921524O04Rik; 8030409M04Rik; RAD51; RecA"
                     /note="hexamer: AATAAA"
     polyA_site      3217
                     /gene="Xrcc2"
                     /gene_synonym="4921524O04Rik; 8030409M04Rik; RAD51; RecA"
                     /note="major polyA site"
ORIGIN      
        1 gctttgactg gctgcgtctt tcgcgctttt gctaaatggc gttgctggcg ggtaggttga
       61 acccgcggag ctggccgggc gatgtgtagc gactttcgca gagcggaatc cgggacagag
      121 ctccttgccc gacttgaagg cagaagctcg ttgaaagaac tagaacccaa cctgtttgct
      181 gatgaagatt caccagtgca cggtgatatt tttgaatttc atggtccaga aggaacgggg
      241 aaaacagaaa tgctttatca tttaacagcc cgatgtatac ttccaaaatc agagggtgga
      301 ctgcaaatag aagtcttatt tattgataca gattaccact ttgacatgct acggctcgtg
      361 acagttcttg aacacagact ctcgcaaagc tccgaggaag ccatgaagct gtgcctagcc
      421 aggttgttcc tggcgtactg cagcagcagc atgcagttac tgctcacgct gcactccctg
      481 gaagccctgc tctgcagtcg cccctctctc tgccttctca ttgtggacag cctgtcgtct
      541 ttttactgga tagaccgagt cagtggagga gagagtgtgg ccctgcagga gtcaacgctg
      601 cagaagtgct ctcagctcct agagcggctt gtcactgagt accgcttgct gctttttgcg
      661 acaacgcaga gtctaatgca gaaaggctca gactctgcag acgggccttc ttcctccaag
      721 cacccatgcg atggagacat gggctacaga gcctatctct gcaaggcctg gcagagggtc
      781 gtgaagcaca gggtcatctt ctccagggac gacgaggcca agagcagccg gttctcatta
      841 gtttcacgtc atttaaaaag taacagttta aaaaaacaca gttttatggt cagagaaagt
      901 ggggtggagt tttgttgatc tctatcatca aaaaggcttt taggtgcact aaggcaagtc
      961 tttaaaagtc ctttataggc taaagtggtt tgattctaaa gtttgtaatt ctggggaaat
     1021 taaatagtac agaaaaactc gaagctgttc tgtccccttc aaggtgtgga aggtcagtca
     1081 gaacatgcta aactccaccg agcttgtctt gaagctcaaa ccatgataca catttcagac
     1141 taggtcactt tctgcatact ttaggaaggg ttcaccgctg gtcccttggc tcctagaggc
     1201 tgtggctgga gagagtgcac agagctgtta ctctaatcaa aggaagacac acagggccac
     1261 cagctcatct gcctccctca ggaaactgga atgagctggg tgtgctgaca ggtggctctc
     1321 cgtgagctca aagcttgtct gatctagata gtgaattcca ggatagccag agctacataa
     1381 tgaggtcctg cttcaaagag ctactcagga aacagatagc taggtaaata gatgagacta
     1441 gaatgttcga gtcttcctcc ttcctctcgc ccatttttct tctttctacc tgctcccctt
     1501 gtcccaagga tgtcctatag ttcaggcaag tcttcatcac atttctgcct ctgaggtagc
     1561 caggtaaaca atgttgctcc ttggagctga gaattctgat aagttgcact tgaagatgaa
     1621 tgtctatgat ttggggttct gtgtaatttt tcacacacag ggaaatgatg tactcacttt
     1681 cgaattcgga agttcatttt ggaatgttca tctcactaat tgatagatct gaagagttat
     1741 actagatgcc ttggaacatc taggctgtta tttccagctg tgcgctgagg gagacttggc
     1801 actgctcagg aggtgtccta gtgaagatta ctgttgtcat gaccaagcac tgtgagcaaa
     1861 agactgttgg agaggaaagg gtttgttata aggtttacac ttctcttgta tattgtagtc
     1921 catatttgaa ggaagtcagg acaggaactt aggaagggca ggaactttga ggcaggtgtc
     1981 aatacaaagt ccatggaggg tgctgcttcc tggtttgctc cacgattgat cataatgcct
     2041 actgcctgat cttatggaga catcttctca actgaagctc cctcctctct ggtgactcta
     2101 gtttgtgtca agctgacata aaactagccg gcacagagta cctgtaggaa gaaggcttta
     2161 gaaaatccct ttacatcttc tgacccaggg aaaggcccac atgtgagttc agactaactg
     2221 ctattctcaa acctgttaat gcctatgtca caaacgatcc tgtttccctt tgttcttgtg
     2281 gctttgttca ctcattacca caggtttatg agttaaaaag catcctgttg agaagctgag
     2341 actaaagttc ttcactatga aggcacagcc atgtaacttg ctgtctgtgc cctacctgtg
     2401 tccctgggcc tgcttgtatt taccccaggg cttctgaggc tgtgttctgt gcctagagcc
     2461 tgctggcctg cctgcgggct gagctggaca gtccttttgt tgtttttttt tgagacaggg
     2521 tttttctctg tagccctggc tgtcctggaa ctcactctgt agaccaggct ggcctcgaac
     2581 tcagaaatcc gcctgcctct gcctcccaag tgctgagatt aaagatgtgc gccaccaccg
     2641 cccagcctgg gttggacagt ccttaagcag agaaggtagg agctgacttc ctgacttcct
     2701 cagccactgc aaggtggaca gccagttact tcagtaatgc ttccctcggg gtatcatgct
     2761 ccccagttaa ctcttctcaa agactaatca gtgagaagga agacttttta acccagggtc
     2821 tcactgtgta gctccggctg ccctcctagt tgcaggcatt aaagatgagt tctggtctgc
     2881 ttggctcatt attataattt aaaaaatagt ttggcatttc taggagccag tcttacagca
     2941 gacatcccat tctctggctc ttatagtctt tccgcccctt ctgagatgct acagccctga
     3001 gccttgatgc aggatgtact gtagacagat gatgggccgg gcatctcatg ctcgcttgtt
     3061 cccttcatct tgatctctgt ggttttctgt aatgatttct gtggcaaaga gacatttctt
     3121 tgttgaggaa tgagagctat acttaatctt tgtatattta caatgcacag aggaattatg
     3181 ctgctttaat aaagtggttt attaatacaa tttaaaaaaa aaaaaaaaaa
//
